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124 Member Publications for May 2019

Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems.
1. Front Microbiol - published May 28, 2019
2. Chen LX, Al-Shayeb B, Méheust R, Li WJ, Doudna JA, Banfield JF
Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A.
1. J Biol Chem - published May 17, 2019
2. Arenas J, Pupo E, de Jonge E, Pérez-Ortega J, Schaarschmidt J, van der Ley P, Tommassen J
High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets.
1. Methods Mol Biol - published May 16, 2019
2. Schilling B, Meyer JG, Wei L, Ott M, Verdin E
Structure and evolution of the 4-helix bundle domain of Zuotin, a J-domain protein co-chaperone of Hsp70.
1. PLoS One - published May 16, 2019
2. Shrestha OK, Sharma R, Tomiczek B, Lee W, Tonelli M, Cornilescu G, Stolarska M, Nierzwicki L, Czub J, Markley JL, Marszalek J, Ciesielski SJ, Craig EA
Physical methods for studying flavoprotein photoreceptors.
1. Methods Enzymol - published May 11, 2019
2. Yee EF, Chandrasekaran S, Lin C, Crane BR
INDRA-IPM: interactive pathway modeling using natural language with automated assembly.
1. Bioinformatics - published May 9, 2019
2. Todorov PV, Gyori BM, Bachman JA, Sorger PK
DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.
1. Nucleic Acids Res - published May 9, 2019
2. Hegge JW, Swarts DC, Chandradoss SD, Cui TJ, Kneppers J, Jinek M, Joo C, van der Oost J
Effects of α-tubulin acetylation on microtubule structure and stability.
1. Proc Natl Acad Sci U S A - published May 9, 2019
2. Eshun-Wilson L, Zhang R, Portran D, Nachury MV, Toso DB, Löhr T, Vendruscolo M, Bonomi M, Fraser JS, Nogales E
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.
1. Nat Commun - published May 9, 2019
2. Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T
Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach.
1. J Biomol NMR - published May 9, 2019
2. Kaur H, Hartmann JB, Jakob RP, Zahn M, Zimmermann I, Maier T, Seeger MA, Hiller S
How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates.
1. Autophagy - published May 8, 2019
2. Turco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers.
1. Elife - published May 8, 2019
2. Cho C, Wang Y, Smallwood PM, Williams J, Nathans J
Transient opening of trimeric prefusion RSV F proteins.
1. Nat Commun - published May 8, 2019
2. Gilman MSA, Furmanova-Hollenstein P, Pascual G, B van 't Wout A, Langedijk JPM, McLellan JS
Emerging Roles of DNA Glycosylases and the Base Excision Repair Pathway.
1. Trends Biochem Sci - published May 8, 2019
2. Mullins EA, Rodriguez AA, Bradley NP, Eichman BF
SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing.
1. Nucleic Acids Res - published May 7, 2019
2. Subramania S, Gagné LM, Campagne S, Fort V, O'Sullivan J, Mocaer K, Feldmüller M, Masson JY, Allain FHT, Hussein SM, Huot MÉ
Structural Basis of MRG15-Mediated Activation of the ASH1L Histone Methyltransferase by Releasing an Autoinhibitory Loop.
1. Structure - published May 7, 2019
2. Lee Y, Yoon E, Cho S, Schmähling S, Müller J, Song JJ
Phosphorylation of Tyr950 in the proteasome scaffolding protein RPN2 modulates its interaction with theubiquitin receptor RPN13.
1. J Biol Chem - published May 7, 2019
2. Hemmis CW, Heard SC, Hill CP
Regulation of Transmembrane Signaling by Phase Separation.
1. Annu Rev Biophys - published May 6, 2019
2. Case LB, Ditlev JA, Rosen MK
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
1. Dev Cell - published May 6, 2019
2. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA
Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.
1. Proc Natl Acad Sci U S A - published May 6, 2019
2. Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL
Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.
1. Cell - published May 6, 2019
2. Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH
Exogenous expression of the glycosyltransferase LARGE1 restores α-dystroglycan matriglycan and laminin binding in rhabdomyosarcoma.
1. Skelet Muscle - published May 4, 2019
2. Beltrán D, Anderson ME, Bharathy N, Settelmeyer TP, Svalina MN, Bajwa Z, Shern JF, Gultekin SH, Cuellar MA, Yonekawa T, Keller C, Campbell KP
Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif).
1. Anal Chim Acta - published May 3, 2019
2. Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD
Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking.
1. J Mol Biol - published May 3, 2019
2. Andres F, Iamele L, Meyer T, Stüber JC, Kast F, Gherardi E, Niemann HH, Plückthun A
Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A₂α.
1. Elife - published May 3, 2019
2. Hirano Y, Gao YG, Stephenson DJ, Vu NT, Malinina L, Simanshu DK, Chalfant CE, Patel DJ, Brown RE
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
1. Science - published May 3, 2019
2. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A
Characterization of rare NEIL1 variants found in East Asian populations.
1. DNA Repair (Amst) - published May 3, 2019
2. Minko IG, Vartanian VL, Tozaki NN, Linde OK, Jaruga P, Coskun SH, Coskun E, Qu C, He H, Xu C, Chen T, Song Q, Jiao Y, Stone MP, Egli M, Dizdaroglu M, McCullough AK, Lloyd RS
Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage.
1. Biophys J - published May 3, 2019
2. Mahadevan J, Rudolph J, Jha A, Tay JW, Dragavon J, Grumstrup EM, Luger K
Principles for Integrative Structural Biology Studies.
1. Cell - published May 3, 2019
2. Rout MP, Sali A
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
1. Elife - published May 3, 2019
2. Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P
IID in 3D: Improved Resolution of Transcription Factor Structure by Cryo-Electron Microscopy.
1. Biochemistry - published May 3, 2019
2. Feigerle JT, Kornberg RD
TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion.
1. Proc Natl Acad Sci U S A - published May 3, 2019
2. Seo H, Chen J, González-Avalos E, Samaniego-Castruita D, Das A, Wang YH, López-Moyado IF, Georges RO, Zhang W, Onodera A, Wu CJ, Lu LF, Hogan PG, Bhandoola A, Rao A
Identification of an Alternating-Access Dynamics Mutant of EmrE with Impaired Transport.
1. J Mol Biol - published May 3, 2019
2. Wu C, Wynne SA, Thomas NE, Uhlemann EM, Tate CG, Henzler-Wildman KA
Protein translocation by the SecA ATPase occurs by a power-stroke mechanism.
1. EMBO J - published May 2, 2019
2. Catipovic MA, Bauer BW, Loparo JJ, Rapoport TA
The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme.
1. Angew Chem Int Ed Engl - published May 2, 2019
2. Mazzei L, Cianci M, Benini S, Ciurli S
De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities.
1. Acc Chem Res - published May 2, 2019
2. Lombardi A, Pirro F, Maglio O, Chino M, DeGrado WF
The CXXC Motifs Are Essential for the Function of BosR in Borrelia burgdorferi.
1. Front Cell Infect Microbiol - published May 2, 2019
2. Mason C, Liu X, Prabhudeva S, Ouyang Z
Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment.
1. Cancer Discov - published May 2, 2019
2. Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I
Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin.
1. Sci Rep - published May 2, 2019
2. Chitrala KN, Yang X, Busbee B, Singh NP, Bonati L, Xing Y, Nagarkatti P, Nagarkatti M
High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.
1. PLoS One - published May 2, 2019
2. Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K
Hatchet ribozyme structure and implications for cleavage mechanism.
1. Proc Natl Acad Sci U S A - published May 2, 2019
2. Zheng L, Falschlunger C, Huang K, Mairhofer E, Yuan S, Wang J, Patel DJ, Micura R, Ren A
Late steps in bacterial translation initiation visualized using time-resolved cryo-EM.
1. Nature - published May 2, 2019
2. Kaledhonkar S, Fu Z, Caban K, Li W, Chen B, Sun M, Gonzalez RL Jr, Frank J
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
1. Nat Struct Mol Biol - published May 2, 2019
2. Yan C, Dodd T, He Y, Tainer JA, Tsutakawa SE, Ivanov I
Author Correction: Tissue clearing of both hard and soft tissue organs with the PEGASOS method.
1. Cell Res - published May 2, 2019
2. Jing D, Zhang S, Luo W, Gao X, Men Y, Ma C, Liu X, Yi Y, Bugde A, Zhou BO, Zhao Z, Yuan Q, Feng JQ, Gao L, Ge WP, Zhao H
Proteomic insight into the pathogenesis of CAPN5-vitreoretinopathy.
1. Sci Rep - published May 2, 2019
2. Velez G, Yang J, Li AS, Tsang SH, Bassuk AG, Mahajan VB
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
1. Nat Commun - published May 2, 2019
2. Lama L, Adura C, Xie W, Tomita D, Kamei T, Kuryavyi V, Gogakos T, Steinberg JI, Miller M, Ramos-Espiritu L, Asano Y, Hashizume S, Aida J, Imaeda T, Okamoto R, Jennings AJ, Michino M, Kuroita T, Stamford A, Gao P, Meinke P, Glickman JF, Patel DJ, Tuschl T
DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.
1. Nucleic Acids Res - published May 2, 2019
2. Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, Drennan CL, Essigmann JM, Wetmore SD, Li D
The extracellular gate shapes the energy profile of an ABC exporter.
1. Nat Commun - published May 2, 2019
2. Hutter CAJ, Timachi MH, Hürlimann LM, Zimmermann I, Egloff P, Göddeke H, Kucher S, Štefanić S, Karttunen M, Schäfer LV, Bordignon E, Seeger MA
Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex.
1. Nucleic Acids Res - published May 2, 2019
2. Paul Solomon Devakumar LJ, Gaubitz C, Lundblad V, Kelch BA, Kubota T
Combinatorial recognition of clustered RNA elements by the multidomain RNA-binding protein IMP3.
1. Nat Commun - published May 2, 2019
2. Schneider T, Hung LH, Aziz M, Wilmen A, Thaum S, Wagner J, Janowski R, Müller S, Schreiner S, Friedhoff P, Hüttelmaier S, Niessing D, Sattler M, Schlundt A, Bindereif A
Emerging RNA-binding roles in the TRIM family of ubiquitin ligases.
1. Biol Chem - published May 2, 2019
2. Williams FP, Haubrich K, Perez-Borrajero C, Hennig J
Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.
1. Science - published May 2, 2019
2. Black MH, Osinski A, Gradowski M, Servage KA, Pawłowski K, Tomchick DR, Tagliabracci VS
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
1. Science - published May 2, 2019
2. Mohan K, Ueda G, Kim AR, Jude KM, Fallas JA, Guo Y, Hafer M, Miao Y, Saxton RA, Piehler J, Sankaran VG, Baker D, Garcia KC
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level.
1. Cell Mol Life Sci - published May 2, 2019
2. Tewary SK, Zheng YG, Ho MC
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
1. J Exp Med - published May 2, 2019
2. von Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E
A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp.
1. Nucleic Acids Res - published May 2, 2019
2. García-Rodríguez FM, Neira JL, Marcia M, Molina-Sánchez MD, Toro N
Structural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
1. Nat Microbiol - published May 2, 2019
2. Urusova D, Carias L, Huang Y, Nicolete VC, Popovici J, Roesch C, Salinas ND, Witkowski B, Ferreira MU, Adams JH, Gross ML, King CL, Tolia NH
Mitochondrial metabolism promotes adaptation to proteotoxic stress.
1. Nat Chem Biol - published May 2, 2019
2. Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR
Gain-of-function mutations in a member of the Src family kinases cause autoinflammatory bone disease in mice and humans.
1. Proc Natl Acad Sci U S A - published May 2, 2019
2. Abe K, Cox A, Takamatsu N, Velez G, Laxer RM, Tse SML, Mahajan VB, Bassuk AG, Fuchs H, Ferguson PJ, Hrabe de Angelis M
Mantle Cell Lymphoma With Mantle Zone Growth Pattern.
1. Am J Clin Pathol - published May 2, 2019
2. Yuan J, Li S, Liu X, Su RJ, Chen M, Wu X, Zheng G, Smith LM, Wang L, Li Y, Liu C, Zhou J, Shen Q, Zhang L, Wang E, Xu ML, Pan Z
CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation.
1. Neoplasia - published May 2, 2019
2. Itkonen HM, Poulose N, Walker S, Mills IG
Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation.
1. Mol Cell - published May 2, 2019
2. Zhang W, Chuang YA, Na Y, Ye Z, Yang L, Lin R, Zhou J, Wu J, Qiu J, Savonenko A, Leahy DJ, Huganir R, Linden DJ, Worley PF
Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor γ.
1. Rapid Commun Mass Spectrom - published May 1, 2019
2. Kratochvil I, Hofmann T, Rother S, Schlichting R, Moretti R, Scharnweber D, Hintze V, Escher BI, Meiler J, Kalkhof S, von Bergen M
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma.
1. Oncogene - published May 1, 2019
2. Cannataro VL, Gaffney SG, Sasaki T, Issaeva N, Grewal NKS, Grandis JR, Yarbrough WG, Burtness B, Anderson KS, Townsend JP
BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress.
1. Cancer Discov - published May 1, 2019
2. Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L
The carbon monoxide dehydrogenase accessory protein CooJ is a histidine-rich multidomain dimer containing an unexpected Ni(II)-binding site.
1. J Biol Chem - published May 1, 2019
2. Alfano M, Pérard J, Carpentier P, Basset C, Zambelli B, Timm J, Crouzy S, Ciurli S, Cavazza C
Essential Role of Enterovirus 2A Protease in Counteracting Stress Granule Formation and the Induction of Type I Interferon.
1. J Virol - published May 1, 2019
2. Visser LJ, Langereis MA, Rabouw HH, Wahedi M, Muntjewerff EM, de Groot RJ, van Kuppeveld FJM
Enterobactin-Specific Antibodies Induced by a Novel Enterobactin Conjugate Vaccine.
1. Appl Environ Microbiol - published May 1, 2019
2. Wang H, Zeng X, Mo Y, He B, Lin H, Lin J
Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii.
1. Cell Chem Biol - published May 1, 2019
2. Wang J, Lonergan ZR, Gonzalez-Gutierrez G, Nairn BL, Maxwell CN, Zhang Y, Andreini C, Karty JA, Chazin WJ, Trinidad JC, Skaar EP, Giedroc DP
Different genetic and morphological outcomes for phages targeted by single or multiple CRISPR-Cas spacers.
1. Philos Trans R Soc Lond B Biol Sci - published May 1, 2019
2. Watson BNJ, Easingwood RA, Tong B, Wolf M, Salmond GPC, Staals RHJ, Bostina M, Fineran PC
A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
1. J Biol Chem - published May 1, 2019
2. Yu Z, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB
Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation.
1. J Mol Biol - published May 1, 2019
2. Ortíz C, Botti H, Buschiazzo A, Comini MA
BCL::Mol2D-a robust atom environment descriptor for QSAR modeling and lead optimization.
1. J Comput Aided Mol Des - published May 1, 2019
2. Vu O, Mendenhall J, Altarawy D, Meiler J
Structure of McsB, a protein kinase for regulated arginine phosphorylation.
1. Nat Chem Biol - published May 1, 2019
2. Suskiewicz MJ, Hajdusits B, Beveridge R, Heuck A, Vu LD, Kurzbauer R, Hauer K, Thoeny V, Rumpel K, Mechtler K, Meinhart A, Clausen T
ARGuing for a new kinase class.
1. Nat Chem Biol - published May 1, 2019
2. Boggon TJ
Clinical effect of postoperative chemoradiotherapy in resected advanced laryngeal squamous cell carcinoma.
1. Oncol Lett - published May 1, 2019
2. Zhang M, Deng W, Gong H, Li C, Wang Y, Liu X, Tao L, Zhou L
Structure and functional reselection of the Mango-III fluorogenic RNA aptamer.
1. Nat Chem Biol - published May 1, 2019
2. Trachman RJ 3rd, Autour A, Jeng SCY, Abdolahzadeh A, Andreoni A, Cojocaru R, Garipov R, Dolgosheina EV, Knutson JR, Ryckelynck M, Unrau PJ, Ferré-D'Amaré AR
CasX: a new and small CRISPR gene-editing protein.
1. Cell Res - published May 1, 2019
2. Yang H, Patel DJ
Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
1. J Am Chem Soc - published May 1, 2019
2. Wilson TJ, Liu Y, Li NS, Dai Q, Piccirilli JA, Lilley DMJ
Insight into microtubule nucleation from tubulin-capping proteins.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Campanacci V, Urvoas A, Cantos-Fernandes S, Aumont-Nicaise M, Arteni AA, Velours C, Valerio-Lepiniec M, Dreier B, Plückthun A, Pilon A, Poüs C, Minard P, Gigant B
The cryo-EM method microcrystal electron diffraction (MicroED).
1. Nat Methods - published May 1, 2019
2. Nannenga BL, Gonen T
Substrate Specificity in Thiol Dioxygenases.
1. Biochemistry - published May 1, 2019
2. Aloi S, Davies CG, Karplus PA, Wilbanks SM, Jameson GNL
Author Correction: Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation.
1. Nat Commun - published May 1, 2019
2. Malacaria E, Pugliese GM, Honda M, Marabitti V, Aiello FA, Spies M, Franchitto A, Pichierri P
Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Cheng S, Park Y, Kurleto JD, Jeon M, Zinn K, Thornton JW, Özkan E
Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.
1. Sci Transl Med - published May 1, 2019
2. Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB
Large-scale prediction of binding affinity in protein-small ligand complexes: the PRODIGY-LIG web server.
1. Bioinformatics - published May 1, 2019
2. Vangone A, Schaarschmidt J, Koukos P, Geng C, Citro N, Trellet ME, Xue LC, Bonvin AMJJ
A new approach to discovery of S100 protein heterodimers.
1. FEBS J - published May 1, 2019
2. Garcia V, Chazin WJ
Go go gadget glycoprotein!: HSV-1 draws on its sizeable glycoprotein tool kit to customize its diverse entry routes.
1. PLoS Pathog - published May 1, 2019
2. Hilterbrand AT, Heldwein EE
Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
1. Science - published May 1, 2019
2. Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK
Regulation of cyclic oligoadenylate synthesis by the S. epidermidis Cas10-Csm complex.
1. RNA - published May 1, 2019
2. Nasef M, Muffly MC, Beckman AB, Rowe SJ, Walker FC, Hatoum-Aslan A, Dunkle JA
Cryo-Electron Tomography and Proteomics studies of centrosomes from differentiated quiescent thymocytes.
1. Sci Rep - published May 1, 2019
2. Busselez J, Chichón FJ, Rodríguez MJ, Alpízar A, Gharbi SI, Franch M, Melero R, Paradela A, Carrascosa JL, Carazo JM
Destabilization of the human RED-SMU1 splicing complex as a basis for host-directed antiinfluenza strategy.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Ashraf U, Tengo L, Le Corre L, Fournier G, Busca P, McCarthy AA, Rameix-Welti MA, Gravier-Pelletier C, Ruigrok RWH, Jacob Y, Vidalain PO, Pietrancosta N, Crépin T, Naffakh N
Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Chung JK, Nocka LM, Decker A, Wang Q, Kadlecek TA, Weiss A, Kuriyan J, Groves JT
Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600-739 construct.
1. Biomol NMR Assign - published May 1, 2019
2. Lee W, Tonelli M, Wu C, Aceti DJ, Amarasinghe GK, Markley JL
Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
1. Nature - published May 1, 2019
2. Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ
Structures suggest a mechanism for energy coupling by a family of organic anion transporters.
1. PLoS Biol - published May 1, 2019
2. Leano JB, Batarni S, Eriksen J, Juge N, Pak JE, Kimura-Someya T, Robles-Colmenares Y, Moriyama Y, Stroud RM, Edwards RH
Structure and assembly of pilotin-dependent and -independent secretins of the type II secretion system.
1. PLoS Pathog - published May 1, 2019
2. Howard SP, Estrozi LF, Bertrand Q, Contreras-Martel C, Strozen T, Job V, Martins A, Fenel D, Schoehn G, Dessen A
DoGNet: A deep architecture for synapse detection in multiplexed fluorescence images.
1. PLoS Comput Biol - published May 1, 2019
2. Kulikov V, Guo SM, Stone M, Goodman A, Carpenter A, Bathe M, Lempitsky V
Molecular Fingerprints for a Novel Enzyme Family in Actinobacteria with Glucosamine Kinase Activity.
1. mBio - published May 1, 2019
2. Manso JA, Nunes-Costa D, Macedo-Ribeiro S, Empadinhas N, Pereira PJB
Solving the structure of Lgl2, a difficult blind test of unsupervised structure determination.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Ufimtsev IS, Almagor L, Weis WI, Levitt M
PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism.
1. Cell Rep - published May 1, 2019
2. Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC
PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling.
1. Cell Rep - published May 1, 2019
2. Shami Shah A, Batrouni AG, Kim D, Punyala A, Cao W, Han C, Goldberg ML, Smolka MB, Baskin JM
ARF GTPases and their GEFs and GAPs: concepts and challenges.
1. Mol Biol Cell - published May 1, 2019
2. Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME, Kahn RA
Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo.
1. Mol Cell Biol - published May 1, 2019
2. Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S
Receptor subtype discrimination using extensive shape complementary designed interfaces.
1. Nat Struct Mol Biol - published May 1, 2019
2. Dang LT, Miao Y, Ha A, Yuki K, Park K, Janda CY, Jude KM, Mohan K, Ha N, Vallon M, Yuan J, Vilches-Moure JG, Kuo CJ, Garcia KC, Baker D
Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.
1. Proc Natl Acad Sci U S A - published May 1, 2019
2. Almagor L, Ufimtsev IS, Ayer A, Li J, Weis WI
Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse.
1. Elife - published May 1, 2019
2. Zhang J, Li L, Huang H, Fang F, Webber HC, Zhuang P, Liu L, Dalal R, Tang PH, Mahajan VB, Sun Y, Li S, Zhang M, Goldberg JL, Hu Y
Single and dual targeting of mutant EGFR with an allosteric inhibitor.
1. Cancer Discov - published May 1, 2019
2. To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq DJH, Xu M, Wang S, Cameron MD, Heppner DE, Shin BH, Gero TW, Yang A, Dahlberg SE, Wong KK, Eck MJ, Gray NS, Janne PA
Highlight: young research groups in Germany.
1. Biol Chem - published May 1, 2019
2. GBM Young Investigators,., Hennig J, Feige MJ
Self-tolerance curtails the B cell repertoire to microbial epitopes.
1. JCI Insight - published May 1, 2019
2. Watanabe A, Su KY, Kuraoka M, Yang G, Reynolds AE, Schmidt AG, Harrison SC, Haynes BF, St Clair EW, Kelsoe G
Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
1. Cell - published May 1, 2019
2. Watanabe A, McCarthy KR, Kuraoka M, Schmidt AG, Adachi Y, Onodera T, Tonouchi K, Caradonna TM, Bajic G, Song S, McGee CE, Sempowski GD, Feng F, Urick P, Kepler TB, Takahashi Y, Harrison SC, Kelsoe G
Selective inhibitors of FKBP51 employ conformational selection of dynamic invisible states.
1. Angew Chem Int Ed Engl - published May 1, 2019
2. Kumar Ankush Jagtap P, Asami S, Sippel C, Kaila V, Hausch F, Sattler M
A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.
1. Cell - published May 1, 2019
2. Bangaru S, Lang S, Schotsaert M, Vanderven HA, Zhu X, Kose N, Bombardi R, Finn JA, Kent SJ, Gilchuk P, Gilchuk I, Turner HL, García-Sastre A, Li S, Ward AB, Wilson IA, Crowe JE Jr
Long-wavelength native-SAD phasing: opportunities and challenges.
1. IUCrJ - published May 1, 2019
2. Basu S, Olieric V, Leonarski F, Matsugaki N, Kawano Y, Takashi T, Huang CY, Yamada Y, Vera L, Olieric N, Basquin J, Wojdyla JA, Bunk O, Diederichs K, Yamamoto M, Wang M
Developing Picornaviruses for Cancer Therapy.
1. Cancers (Basel) - published May 1, 2019
2. McCarthy C, Jayawardena N, Burga LN, Bostina M
A lipid-encapsulated mRNA encoding a potently neutralizing human monoclonal antibody protects against chikungunya infection.
1. Sci Immunol - published May 1, 2019
2. Kose N, Fox JM, Sapparapu G, Bombardi R, Tennekoon RN, de Silva AD, Elbashir SM, Theisen MA, Humphris-Narayanan E, Ciaramella G, Himansu S, Diamond MS, Crowe JE Jr
Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential.
1. J Mol Biol - published May 1, 2019
2. Salina ND, Tang WK, Tolia NH
Extensive loss of cell-cycle and DNA repair genes in an ancient lineage of bipolar budding yeasts.
1. PLoS Biol - published May 1, 2019
2. Steenwyk JL, Opulente DA, Kominek J, Shen XX, Zhou X, Labella AL, Bradley NP, Eichman BF, Čadež N, Libkind D, DeVirgilio J, Hulfachor AB, Kurtzman CP, Hittinger CT, Rokas A
Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
1. Bioorg Med Chem - published May 1, 2019
2. Hopkins BT, Bame E, Bell N, Bohnert T, Bowden-Verhoek JK, Bui M, Cancilla MT, Conlon P, Cullen P, Erlanson DA, Fan J, Fuchs-Knotts T, Hansen S, Heumann S, Jenkins TJ, Marcotte D, McDowell B, Mertsching E, Negrou E, Otipoby KL, Poreci U, Romanowski MJ, Scott D, Silvian L, Yang W, Zhong M
Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction.
1. Biophys J - published May 1, 2019
2. Liu X, Golden LC, Lopez JA, Shepherd TR, Yu L, Fuentes EJ
Control of antiviral innate immune response by protein geranylgeranylation.
1. Sci Adv - published May 1, 2019
2. Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D
Reaching the End of the Line: Urinary Tract Infections.
1. Microbiol Spectr - published May 1, 2019
2. Tamadonfar KO, Omattage NS, Spaulding CN, Hultgren SJ
Binding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence.
1. Cell Chem Biol - published May 1, 2019
2. Sjekloća L, Ferré-D'Amaré AR
How mithramycin stereochemistry dictates its structure and DNA binding function.
1. Medchemcomm - published May 1, 2019
2. Hou C, Rohr J, Parkin S, Tsodikov OV