Member Publications

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135 Member Publications for July 2017

Methyl-Specific Isotope Labeling Strategies for NMR Studies of Membrane Proteins.
1. Methods Mol Biol - published July 30, 2017
2. Kurauskas V, Schanda P, Sounier R
An entry-competent intermediate state of the HIV-1 envelope glycoproteins.
1. Receptors Clin Investig - published July 29, 2017
2. Herschhorn A, Sodroski J
Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice.
1. PLoS One - published July 14, 2017
2. Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C
Using Clickable NAD⁺ Analogs to Label Substrate Proteins of PARPs.
1. Methods Mol Biol - published July 12, 2017
2. Zhang L, Lin H
Purification of DNA Damage-Dependent PARPs from E. coli for Structural and Biochemical Analysis.
1. Methods Mol Biol - published July 12, 2017
2. Langelier MF, Steffen JD, Riccio AA, McCauley M, Pascal JM
Biochemical and Biophysical Methods for Analysis of Poly(ADP-Ribose) Polymerase 1 and Its Interactions with Chromatin.
1. Methods Mol Biol - published July 12, 2017
2. Chassé MH, Muthurajan UM, Clark NJ, Kramer MA, Chakravarthy S, Irving T, Luger K
Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1.
1. PLoS One - published July 11, 2017
2. Abeyrathne PD, Grigorieff N
Enzymology of Microbial Dimethylsulfoniopropionate Catabolism.
1. Adv Protein Chem Struct Biol - published July 8, 2017
2. Dey M
Filovirus Strategies to Escape Antiviral Responses.
1. Curr Top Microbiol Immunol - published July 8, 2017
2. Olejnik J, Hume AJ, Leung DW, Amarasinghe GK, Basler CF, Mühlberger E
Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins.
1. Mol Cell - published July 8, 2017
2. Wohlever ML, Mateja A, McGilvray PT, Day KJ, Keenan RJ
Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4.
1. Biochemistry - published July 7, 2017
2. Fulton MD, Zhang J, He M, Ho MC, Zheng YG
Deconstruction of the Ras switching cycle through saturation mutagenesis.
1. Elife - published July 7, 2017
2. Bandaru P, Shah NH, Bhattacharyya M, Barton JP, Kondo Y, Cofsky JC, Gee CL, Chakraborty AK, Kortemme T, Ranganathan R, Kuriyan J
The Structure of RbmB from Streptomyces ribosidificus, an Aminotransferase Involved in the Biosynthesis of Ribostamycin.
1. Protein Sci - published July 7, 2017
2. Zachman-Brockmeyer TR, Thoden JB, Holden HM
Supramolecular organization and functional implications of K+ channel clusters in membranes.
1. Angew Chem Int Ed Engl - published July 7, 2017
2. Visscher K, Medeiros-Silva J, Mance D, Rodrigues JPGLM, Daniëls M, Bonvin AMJJ, Baldus M, Weingarth M
Post-transcriptional regulation of PARG mRNA by HuR facilitates DNA repair and resistance to PARP inhibitors.
1. Cancer Res - published July 7, 2017
2. Chand SN, Zarei M, Schiewer MJ, Kamath AR, Romeo C, Lal S, Cozzitorto JA, Nevler A, Scolaro L, Londin E, Jiang W, Meisner-Kober N, Pishvaian MJ, Knudsen KE, Yeo CJ, Pascal JM, Winter JM, Brody JR
Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1.
1. Mol Cell - published July 6, 2017
2. Nishimasu H, Yamano T, Gao L, Zhang F, Ishitani R, Nureki O
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC.
1. Nature - published July 6, 2017
2. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3.
1. Nature - published July 6, 2017
2. Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, Baker D, Chambers MG, Su H, Li D, Rapoport TA, Liao M
Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.
1. J Biol Chem - published July 6, 2017
2. Motl N, Skiba MA, Kabil O, Smith JL, Banerjee R
Functional characterization of a soluble NADPH-cytochrome P450 reductase from Fusarium graminearum.
1. Protein Expr Purif - published July 6, 2017
2. Etzerodt T, Wetterhorn K, Dionisio G, Rayment I
Structural and Functional Trends in Dehydrating Bimodules from trans-Acyltransferase Polyketide Synthases.
1. Structure - published July 5, 2017
2. Wagner DT, Zeng J, Bailey CB, Gay DC, Yuan F, Manion HR, Keatinge-Clay AT
Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis.
1. Biochemistry - published July 5, 2017
2. Riegert AS, Chantigian DP, Thoden JB, Tipton PA, Holden HM
The Complete Structure of the Mycobacterium smegmatis 70S Ribosome.
1. Cell Rep - published July 5, 2017
2. Hentschel J, Burnside C, Mignot I, Leibundgut M, Boehringer D, Ban N
The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles.
1. Sci Rep - published July 5, 2017
2. Wu WL, Chen MY, Tu IF, Lin YC, EswarKumar N, Chen MY, Ho MC, Wu SH
Reply to Kiser: Dioxygen binding in NOV1 crystal structures.
1. Proc Natl Acad Sci U S A - published July 5, 2017
2. McAndrew RP, Sathitsuksanoh N, Mbughuni MM, Heins RA, Pereira JH, George A, Sale KL, Fox BG, Simmons BA, Adams PD
RAP80, ubiquitin and SUMO in the DNA damage response.
1. J Mol Med (Berl) - published July 5, 2017
2. Lombardi PM, Matunis MJ, Wolberger C
Comparative interactomics provides evidence for functional specialization of the nuclear pore complex.
1. Nucleus - published July 4, 2017
2. Obado SO, Field MC, Rout MP
Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
1. J Am Chem Soc - published July 3, 2017
2. DasGupta S, Suslov NB, Piccirilli JA
Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni.
1. J Am Chem Soc - published July 3, 2017
2. Taylor ZW, Brown HA, Narindoshvili T, Wenzel CQ, Szymanski CM, Holden HM, Raushel FM
Analysis of Functional Dynamics of Modular Multidomain Proteins by SAXS and NMR.
1. Methods Enzymol - published July 3, 2017
2. Thompson MK, Ehlinger AC, Chazin WJ
MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes.
1. Methods Enzymol - published July 3, 2017
2. Gradia SD, Ishida JP, Tsai MS, Jeans C, Tainer JA, Fuss JO
What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.
1. Methods Enzymol - published July 3, 2017
2. Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA
Preface.
1. Methods Enzymol - published July 3, 2017
2. Eichman BF
Differential proteomics highlights macrophage-specific responses to amorphous silica nanoparticles.
1. Nanoscale - published July 3, 2017
2. Dalzon B, Aude-Garcia C, Collin-Faure V, Diemer H, Béal D, Dussert F, Fenel D, Schoehn G, Cianférani S, Carrière M, Rabilloud T
Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis.
1. Nat Struct Mol Biol - published July 3, 2017
2. Faehnle CR, Walleshauser J, Joshua-Tor L
Genome-wide screen for genes involved in eDNA release during biofilm formation by Staphylococcus aureus.
1. Proc Natl Acad Sci U S A - published July 3, 2017
2. DeFrancesco AS, Masloboeva N, Syed AK, DeLoughery A, Bradshaw N, Li GW, Gilmore MS, Walker S, Losick R
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis.
1. Microb Cell - published July 3, 2017
2. Kalel VC, Emmanouilidis L, Dawidowski M, Schliebs W, Sattler M, Popowicz GM, Erdmann R
Immunocapture isotope dilution mass spectrometry in response to a pandemic influenza threat.
1. Vaccine - published July 3, 2017
2. Pierce CL, Williams TL, Santana WI, Levine M, Chen LM, Cooper HC, Solano MI, Woolfitt AR, Marasco WA, Fang H, Donis RO, Barr JR
Synthesis and mechanistic evaluation of novel N'-benzylidene-carbohydrazide-1H-pyrazolo[3,4-b]pyridine derivatives as non-anionic antiplatelet agents.
1. Eur J Med Chem - published July 2, 2017
2. Lourenço AL, Salvador RRS, Silva LA, Saito MS, Mello JFR, Cabral LM, Rodrigues CR, Vera MAF, Muri EMF, de Souza AMT, Craik CS, Dias LRS, Castro HC, Sathler PC
Structural study of the Fox-1 RRM protein hydration reveals a role for key water molecules in RRM-RNA recognition.
1. Nucleic Acids Res - published July 2, 2017
2. Krepl M, Blatter M, Cléry A, Damberger FF, Allain FHT, Sponer J
Biochemical Characterization and Structural Basis of Reactivity and Regioselectivity Differences between Burkholderia thailandensis and Burkholderia glumae 1,6-Didesmethyltoxoflavin N-Methyltransferase.
1. Biochemistry - published July 2, 2017
2. Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B
Shearing and Enrichment of Extracellular Type IV Pili.
1. Methods Mol Biol - published July 2, 2017
2. Gonzalez Rivera AK, Forest KT
K_2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
1. Nature - published July 2, 2017
2. Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL Jr
Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.
1. J Am Chem Soc - published July 2, 2017
2. Cao Z, Hutchison JM, Sanders CR, Bowie JU
Reversible Protonated Resting State of the Nitrogenase Active Site.
1. J Am Chem Soc - published July 2, 2017
2. Morrison CN, Spatzal T, Rees DC
Polar delivery of Legionella type IV secretion system substrates is essential for virulence.
1. Proc Natl Acad Sci U S A - published July 2, 2017
2. Jeong KC, Ghosal D, Chang YW, Jensen GJ, Vogel JP
Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin.
1. ACS Chem Biol - published July 2, 2017
2. Wyche TP, Alvarenga RFR, Piotrowski JS, Duster MN, Warrack SR, Cornilescu G, De Wolfe TJ, Hou Y, Braun DR, Ellis GA, Simpkins SW, Nelson J, Myers CL, Steele J, Mori H, Safdar N, Markley JL, Rajski SR, Bugni TS
Antibiotic That Inhibits the ATPase Activity of an ATP-Binding Cassette Transporter by Binding to a Remote Extracellular Site.
1. J Am Chem Soc - published July 2, 2017
2. Matano LM, Morris HG, Hesser AR, Martin SES, Lee W, Owens TW, Laney E, Nakaminami H, Hooper D, Meredith TC, Walker S
Antiviral Immunity and Circular RNA: No End in Sight.
1. Mol Cell - published July 2, 2017
2. Cadena C, Hur S
The relationship between folding and activity in UreG, an intrinsically disordered enzyme.
1. Sci Rep - published July 2, 2017
2. Palombo M, Bonucci A, Etienne E, Ciurli S, Uversky VN, Guigliarelli B, Belle V, Mileo E, Zambelli B
Response to Comments on "The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport".
1. Science - published July 2, 2017
2. O'Brien E, Holt ME, Thompson MK, Salay LE, Ehlinger AC, Chazin WJ, Barton JK
Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport.
1. Biochemistry - published July 2, 2017
2. Schenck S, Kunz L, Sahlender D, Pardon E, Geertsma ER, Savtchouk I, Suzuki T, Neldner Y, Štefanić S, Steyaert J, Volterra A, Dutzler R
Structures of the CRISPR genome integration complex.
1. Science - published July 2, 2017
2. Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA
Progress in targeting the BCL-2 family of proteins.
1. Curr Opin Chem Biol - published July 2, 2017
2. Garner TP, Lopez A, Reyna DE, Spitz AZ, Gavathiotis E
Structural Biology outside the box-inside the cell.
1. Curr Opin Struct Biol - published July 2, 2017
2. Plitzko JM, Schuler B, Selenko P
Channel opening and gating mechanism in AMPA-subtype glutamate receptors.
1. Nature - published July 2, 2017
2. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Limbal Trocar-Cannulas for Complex Vitrectomy Surgery.
1. Retina - published July 2, 2017
2. Mears KA, Mahajan VB
Antibacterial photosensitization through activation of coproporphyrinogen oxidase.
1. Proc Natl Acad Sci U S A - published July 2, 2017
2. Surdel MC, Horvath DJ Jr, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP
Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association.
1. Proc Natl Acad Sci U S A - published July 2, 2017
2. Zhang W, Zheng W, Toh Y, Betancourt-Solis MA, Tu J, Fan Y, Vakharia VN, Liu J, McNew JA, Jin M, Tao YJ
Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase.
1. Elife - published July 2, 2017
2. Wasmuth EV, Zinder JC, Zattas D, Das M, Lima CD
Morphologies of synaptic protein membrane fusion interfaces.
1. Proc Natl Acad Sci U S A - published July 2, 2017
2. Gipson P, Fukuda Y, Danev R, Lai Y, Chen DH, Baumeister W, Brunger AT
Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.
1. Proc Natl Acad Sci U S A - published July 2, 2017
2. Yadav RP, Gakhar L, Yu L, Artemyev NO
Structural insights into transcription initiation by yeast RNA polymerase I.
1. EMBO J - published July 2, 2017
2. Sadian Y, Tafur L, Kosinski J, Jakobi AJ, Wetzel R, Buczak K, Hagen WJ, Beck M, Sachse C, Müller CW
Structure of the defensin NsD7 in complex with PIP2 reveals that defensin:lipid oligomer topologies are dependent on lipid type.
1. FEBS Lett - published July 2, 2017
2. Jarva M, Lay FT, Hulett MD, Kvansakul M
Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.
1. Elife - published July 2, 2017
2. Elnatan D, Betegon M, Liu Y, Ramelot T, Kennedy MA, Agard DA
Genome editing abrogates angiogenesis in vivo.
1. Nat Commun - published July 2, 2017
2. Huang X, Zhou G, Wu W, Duan Y, Ma G, Song J, Xiao R, Vandenberghe L, Zhang F, D'Amore PA, Lei H
Identification of α-helix 4 (α4) of Rab11a as a novel Rab11-binding domain (RBD): Interaction of Rab11a with the Prostacyclin Receptor.
1. Biochim Biophys Acta - published July 2, 2017
2. Mulvaney EP, O'Meara F, Khan AR, O'Connell DJ, Therese Kinsella B
Quantitative analysis of 3D alignment quality: its impact on soft-validation, particle pruning and homogeneity analysis.
1. Sci Rep - published July 2, 2017
2. Vargas J, Melero R, Gómez-Blanco J, Carazo JM, Sorzano COS
Structural origins of clustered protocadherin-mediated neuronal barcoding.
1. Semin Cell Dev Biol - published July 2, 2017
2. Rubinstein R, Goodman KM, Maniatis T, Shapiro L, Honig B
Capturing protein communities by structural proteomics in a thermophilic eukaryote.
1. Mol Syst Biol - published July 2, 2017
2. Kastritis PL, O'Reilly FJ, Bock T, Li Y, Rogon MZ, Buczak K, Romanov N, Betts MJ, Bui KH, Hagen WJ, Hennrich ML, Mackmull MT, Rappsilber J, Russell RB, Bork P, Beck M, Gavin AC
B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways.
1. Leukemia - published July 2, 2017
2. Xia F, Zhang Y, Xie L, Jiang H, Zeng H, Chen C, Liu L, He X, Hao X, Fang X, Liu X, Zhang F, Gu H, Wan J, Cheng Y, Zhang CC, Chen GQ, Lu Y, Yu Z, Zheng J
Design Considerations in Coiled-Coil Fusion Constructs for the Structural Determination of a Problematic Region of the Human Cardiac Myosin Rod.
1. J Struct Biol - published July 2, 2017
2. Andreas MP, Ajay G, Gellings JA, Rayment I
Efficient 3D-CTF correction for cryo-electron tomography using NovaCTF improves subtomogram averaging resolution to 3.4 Å.
1. J Struct Biol - published July 2, 2017
2. Turoňová B, Schur FKM, Wan W, Briggs JAG
Slow conformational exchange and overall rocking motion in ubiquitin protein crystals.
1. Nat Commun - published July 2, 2017
2. Kurauskas V, Izmailov SA, Rogacheva ON, Hessel A, Ayala I, Woodhouse J, Shilova A, Xue Y, Yuwen T, Coquelle N, Colletier JP, Skrynnikov NR, Schanda P
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
1. J Exp Med - published July 2, 2017
2. Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie ANJ, Fallon PG
Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.
1. Proc Natl Acad Sci U S A - published July 2, 2017
2. Hwang JK, Wang C, Du Z, Meyers RM, Kepler TB, Neuberg D, Kwong PD, Mascola JR, Joyce MG, Bonsignori M, Haynes BF, Yeap LS, Alt FW
CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.
1. Science - published July 2, 2017
2. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.
1. Cell - published July 2, 2017
2. Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE
The versatility of boron in biological target engagement.
1. Nat Chem - published July 2, 2017
2. Diaz DB, Yudin AK
Androgen receptor variants mediate DNA repair after prostate cancer irradiation.
1. Cancer Res - published July 2, 2017
2. Yin Y, Li R, Xu K, Ding S, Li J, Baek G, Ramanand SG, Ding S, Liu Z, Gao Y, Kanchwala MS, Li X, Hutchinson R, Liu X, Woldu SL, Xing C, Desai NB, Feng FY, Burma S, de Bono JS, Dehm SM, Mani RS, Chen BPC, Raj GV
DARC extracellular domain remodeling in maturating reticulocytes explains Plasmodium vivax tropism.
1. Blood - published July 2, 2017
2. Ovchynnikova E, Aglialoro F, Bentlage AEH, Vidarsson G, Salinas ND, von Lindern M, Tolia NH, van den Akker E
Cryo-Electron Microscopy for Structural Analysis of Dynamic Biological Macromolecules.
1. Biochim Biophys Acta - published July 2, 2017
2. Murata K, Wolf M
Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex.
1. Mol Cell - published July 2, 2017
2. Stjepanovic G, Baskaran S, Lin MG, Hurley JH
The first complete genomes of Metalmarks and the classification of butterfly families.
1. Genomics - published July 2, 2017
2. Cong Q, Shen J, Li W, Borek D, Otwinowski Z, Grishin NV
Toxicity and repair of DNA adducts produced by the natural product yatakemycin.
1. Nat Chem Biol - published July 2, 2017
2. Mullins EA, Shi R, Eichman BF
Multivalent Recruitment of Human Argonaute by GW182.
1. Mol Cell - published July 2, 2017
2. Elkayam E, Faehnle CR, Morales M, Sun J, Li H, Joshua-Tor L
KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.
1. Structure - published July 2, 2017
2. Lu J, Harrison RA, Li L, Zeng M, Gondi S, Scott D, Gray NS, Engen JR, Westover KD
Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
1. Cell Chem Biol - published July 2, 2017
2. Zeng M, Lu J, Li L, Feru F, Quan C, Gero TW, Ficarro SB, Xiong Y, Ambrogio C, Paranal RM, Catalano M, Shao J, Wong KK, Marto JA, Fischer ES, Jänne PA, Scott DA, Westover KD, Gray NS
Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.
1. J Am Soc Nephrol - published July 1, 2017
2. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D
Molecule-specific interactions of diatomic adsorbates at metal-liquid interfaces.
1. Struct Dyn - published July 1, 2017
2. Kraack JP, Kaech A, Hamm P
In vivo structures of an intact type VI secretion system revealed by electron cryotomography.
1. EMBO Rep - published July 1, 2017
2. Chang YW, Rettberg LA, Ortega DR, Jensen GJ
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
1. Nat Genet - published July 1, 2017
2. Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ
Arabidopsis FRIGIDA stimulates EFS histone H3 Lys36 methyltransferase activity.
1. Plant Cell Rep - published July 1, 2017
2. Hyun KG, Noh YS, Song JJ
Progressive Stereo Locking (PSL): A Residual Dipolar Coupling Based Force Field Method for Determining the Relative Configuration of Natural Products and Other Small Molecules.
1. ACS Chem Biol - published July 1, 2017
2. Cornilescu G, Ramos Alvarenga RF, Wyche TP, Bugni TS, Gil RR, Cornilescu CC, Westler WM, Markley JL, Schwieters CD
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin.
1. Nature - published July 1, 2017
2. Larson AG, Elnatan D, Keenen MM, Trnka MJ, Johnston JB, Burlingame AL, Agard DA, Redding S, Narlikar GJ
NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with ¹³C-methyl alanine.
1. J Biomol NMR - published July 1, 2017
2. Pederson K, Chalmers GR, Gao Q, Elnatan D, Ramelot TA, Ma LC, Montelione GT, Kennedy MA, Agard DA, Prestegard JH
Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis.
1. Biochemistry - published July 1, 2017
2. Dunsirn MM, Thoden JB, Gilbert M, Holden HM
Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens.
1. Cell Mol Life Sci - published July 1, 2017
2. Moulin M, Alguacil J, Gu S, Mehtougui A, Adams EJ, Peyrottes S, Champagne E
Structures of designed armadillo repeat proteins binding to peptides fused to globular domains.
1. Protein Sci - published July 1, 2017
2. Hansen S, Kiefer JD, Madhurantakam C, Mittl PRE, Plückthun A
Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.
1. Small GTPases - published July 1, 2017
2. Spencer-Smith R, Li L, Prasad S, Koide A, Koide S, O'Bryan JP
Allosteric sensitization of proapoptotic BAX.
1. Nat Chem Biol - published July 1, 2017
2. Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD
Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections.
1. J Am Chem Soc - published July 1, 2017
2. Srisuknimit V, Qiao Y, Schaefer K, Kahne D, Walker S
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).
1. Blood - published July 1, 2017
2. Park J, Yang J, Wenzel AT, Ramachandran A, Lee WJ, Daniels JC, Kim J, Martinez-Escala E, Amankulor N, Pro B, Guitart J, Mendillo ML, Savas JN, Boggon TJ, Choi J
Peripheral myelin protein 22 alters membrane architecture.
1. Sci Adv - published July 1, 2017
2. Mittendorf KF, Marinko JT, Hampton CM, Ke Z, Hadziselimovic A, Schlebach JP, Law CL, Li J, Wright ER, Sanders CR, Ohi MD
Exome sequencing reveals independent SGCD deletions causing limb girdle muscular dystrophy in Boston terriers.
1. Skelet Muscle - published July 1, 2017
2. Cox ML, Evans JM, Davis AG, Guo LT, Levy JR, Starr-Moss AN, Salmela E, Hytönen MK, Lohi H, Campbell KP, Clark LA, Shelton GD
Single-particle detection of transcription following rotavirus entry.
1. J Virol - published July 1, 2017
2. Salgado EN, Upadhyayula S, Harrison SC
Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures.
1. Nat Commun - published July 1, 2017
2. Hubin EA, Lilic M, Darst SA, Campbell EA
Novel function of a dynein light chain in actin assembly during clathrin-mediated endocytosis.
1. J Cell Biol - published July 1, 2017
2. Farrell KB, McDonald S, Lamb AK, Worcester C, Peersen OB, Di Pietro SM
Disabling Cas9 by an anti-CRISPR DNA mimic.
1. Sci Adv - published July 1, 2017
2. Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA
Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface.
1. J Biol Chem - published July 1, 2017
2. Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB
RNA structure refinement using NMR solvent accessibility data.
1. Sci Rep - published July 1, 2017
2. Hartlmüller C, Günther JC, Wolter AC, Wöhnert J, Sattler M, Madl T
Electrochemical and Structural Characterization of Azotobacter vinelandii Flavodoxin II.
1. Protein Sci - published July 1, 2017
2. Segal HM, Spatzal T, Hill MG, Udit AK, Rees DC
Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
1. Immunity - published July 1, 2017
2. Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA
Towards a Structural View of Drug Binding to hERG K+ Channels.
1. Trends Pharmacol Sci - published July 1, 2017
2. Vandenberg JI, Perozo E, Allen TW
Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF.
1. Nat Cell Biol - published July 1, 2017
2. Zhou BO, Yu H, Yue R, Zhao Z, Rios JJ, Naveiras O, Morrison SJ
In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing.
1. Elife - published July 1, 2017
2. Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE
A Serendipitous Scientist.
1. Annu Rev Pharmacol Toxicol - published July 1, 2017
2. Lefkowitz RJ
MEMBRANE PROTEINS STRUCTURES: A review on computational modeling tools.
1. Biochim Biophys Acta - published July 1, 2017
2. Almeida JG, Preto AJ, Koukos PI, Bonvin AMJJ, Moreira IS
Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.
1. Nature - published July 1, 2017
2. Niewoehner O, Garcia-Doval C, Rostøl JT, Berk C, Schwede F, Bigler L, Hall J, Marraffini LA, Jinek M
A shape-shifting redox foldase contributes to Proteus mirabilis copper resistance.
1. Nat Commun - published July 1, 2017
2. Furlong EJ, Lo AW, Kurth F, Premkumar L, Totsika M, Achard MES, Halili MA, Heras B, Whitten AE, Choudhury HG, Schembri MA, Martin JL
Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer.
1. Int J Cancer - published July 1, 2017
2. Wang B, Lo UG, Wu K, Kapur P, Liu X, Huang J, Chen W, Hernandez E, Santoyo J, Ma SH, Pong RC, He D, Cheng YQ, Hsieh JT
The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.
1. Nature - published July 1, 2017
2. Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, Jiang Y
CRKL Mediates p110β-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells.
1. Cell Rep - published July 1, 2017
2. Zhang J, Gao X, Schmit F, Adelmant G, Eck MJ, Marto JA, Zhao JJ, Roberts TM
Lymph node ratio, but not the total number of examined lymph nodes or lymph node metastasis, is a predictor of overall survival for pancreatic neuroendocrine neoplasms after surgical resection.
1. Oncotarget - published July 1, 2017
2. Liu P, Zhang X, Shang Y, Lu L, Cao F, Sun M, Tang Z, Vollmar B, Gong P
Structural Principles of Fluorescent RNA Aptamers.
1. Trends Pharmacol Sci - published July 1, 2017
2. Trachman RJ 3rd, Truong L, Ferré-D'Amaré AR
Structural and Functional Insights into Human Re-initiation Complexes.
1. Mol Cell - published July 1, 2017
2. Weisser M, Schäfer T, Leibundgut M, Böhringer D, Aylett CHS, Ban N
T-Cell Depletion as an Alternative Approach for Patients >55 Years Undergoing Allogeneic Stem Cell Transplantation as Curative Therapy for Hematologic Malignancies.
1. Biol Blood Marrow Transplant - published July 1, 2017
2. Jakubowski AA, Petrlik E, Maloy M, Hilden P, Papadopoulos E, Young JW, Boulad F, Castro-Malaspina H, Tamari R, Dahi PB, Goldberg J, Koehne G, Perales MA, Sauter CS, O'Reilly RJ, Giralt S
RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
1. Mol Cell - published July 1, 2017
2. Dungrawala H, Bhat KP, Le Meur R, Chazin WJ, Ding X, Sharan SK, Wessel SR, Sathe AA, Zhao R, Cortez D
Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
1. Cell - published July 1, 2017
2. Zhang Z, Liu F, Chen J
A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
1. Mol Cell - published July 1, 2017
2. Courtney AH, Amacher JF, Kadlecek TA, Mollenauer MN, Au-Yeung BB, Kuriyan J, Weiss A
CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra low density cancer epitopes.
1. Leukemia - published July 1, 2017
2. Mathias MD, Sockolosky JT, Chang AY, Tan KS, Liu C, Garcia KC, Scheinberg DA
Structural Basis for Substrate Recognition by the Ankyrin Repeat Domain of Human DHHC17 Palmitoyltransferase.
1. Structure - published July 1, 2017
2. Verardi R, Kim JS, Ghirlando R, Banerjee A
Specific Interaction of the Human Mitochondrial Uncoupling Protein 1 with Free Long-Chain Fatty Acid.
1. Structure - published July 1, 2017
2. Zhao L, Wang S, Zhu Q, Wu B, Liu Z, OuYang B, Chou JJ
Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans.
1. Sci Immunol - published July 1, 2017
2. Andrews SF, Joyce MG, Chambers MJ, Gillespie RA, Kanekiyo M, Leung K, Yang ES, Tsybovsky Y, Wheatley AK, Crank MC, Boyington JC, Prabhakaran MS, Narpala SR, Chen X, Bailer RT, Chen G, Coates E, Kwong PD, Koup RA, Mascola JR, Graham BS, Ledgerwood JE, McDermott AB
Tunable substrates improve imaging of viruses and cancer proteins.
1. Micros Today - published July 1, 2017
2. Winton CE, Gilmore BL, Tanner JR, Varano AC, Sheng Z, Kelly DF