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135 Member Publications for May 2017

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
1. PLoS One - published May 26, 2017
2. Pellegrini E, Signor L, Singh S, Boeri Erba E, Cusack S
Molecular and Cellular Mechanisms of Synaptopathies.
1. Neural Plast - published May 26, 2017
2. Ardiles AO, Grabrucker AM, Scholl FG, Rudenko G, Borsello T
D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain.
1. PLoS One - published May 26, 2017
2. Vakkasoglu AS, Srikant S, Gaudet R
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.
1. Front Immunol - published May 26, 2017
2. Sheng Z, Schramm CA, Kong R, NISC Comparative Sequencing Program., Mullikin JC, Mascola JR, Kwong PD, Shapiro L
Membrane protein contact and structure prediction using co-evolution in conjunction with machine learning.
1. PLoS One - published May 26, 2017
2. Teixeira PL, Mendenhall JL, Heinze S, Weiner B, Skwark MJ, Meiler J
DNA recognition by an RNA-guided bacterial Argonaute.
1. PLoS One - published May 19, 2017
2. Doxzen KW, Doudna JA
SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.
1. PLoS One - published May 17, 2017
2. Huber S, Casagrande F, Hug MN, Wang L, Heine P, Kummer L, Plückthun A, Hennig M
Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens.
1. J Toxicol Environ Health B Crit Rev - published May 17, 2017
2. Kim KB, Kim YW, Lim SK, Roh TH, Bang DY, Choi SM, Lim DS, Kim YJ, Baek SH, Kim MK, Seo HS, Kim MH, Kim HS, Lee JY, Kacew S, Lee BM
The Structure, Function and Roles of the Archaeal ESCRT Apparatus.
1. Subcell Biochem - published May 14, 2017
2. Samson RY, Dobro MJ, Jensen GJ, Bell SD
SAS profile correlations reveal SAS hierarchical nature and information content.
1. PLoS One - published May 12, 2017
2. Spill YG, Nilges M
Relationship between recombinant protein expression and host metabolome as determined by two-dimensional NMR spectroscopy.
1. PLoS One - published May 10, 2017
2. Chae YK, Kim SH, Markley JL
Protein Tunnels: The Case of Urease Accessory Proteins.
1. J Chem Theory Comput - published May 9, 2017
2. Musiani F, Gioia D, Masetti M, Falchi F, Cavalli A, Recanatini M, Ciurli S
Halogen bonding in medicinal chemistry: from observation to prediction.
1. Future Med Chem - published May 9, 2017
2. Ho PS
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
1. Nat Chem Biol - published May 8, 2017
2. Park J, Gasparrini AJ, Reck MR, Symister CT, Elliott JL, Vogel JP, Wencewicz TA, Dantas G, Tolia NH
Functional mapping of yeast genomes by saturated transposition.
1. Elife - published May 8, 2017
2. Michel AH, Hatakeyama R, Kimmig P, Arter M, Peter M, Matos J, De Virgilio C, Kornmann B
Atypical interactions of integrin αVβ8 with pro-TGF-β1.
1. Proc Natl Acad Sci U S A - published May 8, 2017
2. Wang J, Dong X, Zhao B, Li J, Lu C, Springer TA
Biomolecular NMR: Past and future.
1. Arch Biochem Biophys - published May 8, 2017
2. Markley JL, Westler WM
Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion.
1. Elife - published May 6, 2017
2. Sitarska E, Xu J, Park S, Liu X, Quade B, Stepien K, Sugita K, Brautigam CA, Sugita S, Rizo J
Amphoteric Borylketenimines: Versatile Intermediates in the Synthesis of Borylated Heterocycles.
1. Chemistry - published May 5, 2017
2. Yudin AK, Kaldas SJ, O'Keefe KTV, Rodrigo MS
The molecular mechanism of the type IVa pilus motors.
1. Nat Commun - published May 5, 2017
2. McCallum M, Tammam S, Khan A, Burrows LL, Howell PL
MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma.
1. Stem Cell Res - published May 5, 2017
2. Panaccione A, Zhang Y, Ryan M, Moskaluk CA, Anderson KS, Yarbrough WG, Ivanov SV
Analysis of Replicative Intermediates of Adeno-associated Virus through Hirt Extraction and Southern Blotting.
1. Bio Protoc - published May 5, 2017
2. Bardelli M, Zarate-Perez F, Agundez L, Jolinon N, Michael Linden R, Escalante CR, Henckaerts E
Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance.
1. JCI Insight - published May 4, 2017
2. Bailey JR, Flyak AI, Cohen VJ, Li H, Wasilewski LN, Snider AE, Wang S, Learn GH, Kose N, Loerinc L, Lampley R, Cox AL, Pfaff JM, Doranz BJ, Shaw GM, Ray SC, Crowe JE Jr
International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases.
1. Am J Hum Genet - published May 4, 2017
2. Boycott KM, Rath A, Chong JX, Hartley T, Alkuraya FS, Baynam G, Brookes AJ, Brudno M, Carracedo A, den Dunnen JT, Dyke SOM, Estivill X, Goldblatt J, Gonthier C, Groft SC, Gut I, Hamosh A, Hieter P, Höhn S, Hurles ME, Kaufmann P, Knoppers BM, Krischer JP, Macek M Jr, Matthijs G, Olry A, Parker S, Paschall J, Philippakis AA, Rehm HL, Robinson PN, Sham PC, Stefanov R, Taruscio D, Unni D, Vanstone MR, Zhang F, Brunner H, Bamshad MJ, Lochmüller H
Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex.
1. Cell - published May 4, 2017
2. Bodnar NO, Rapoport TA
Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.
1. Mol Cell - published May 4, 2017
2. Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.
1. Cell - published May 4, 2017
2. Robbiani DF, Bozzacco L, Keeffe JR, Khouri R, Olsen PC, Gazumyan A, Schaefer-Babajew D, Avila-Rios S, Nogueira L, Patel R, Azzopardi SA, Uhl LFK, Saeed M, Sevilla-Reyes EE, Agudelo M, Yao KH, Golijanin J, Gristick HB, Lee YE, Hurley A, Caskey M, Pai J, Oliveira T, Wunder EA Jr, Sacramento G, Nery N Jr, Orge C, Costa F, Reis MG, Thomas NM, Eisenreich T, Weinberger DM, de Almeida ARP, West AP Jr, Rice CM, Bjorkman PJ, Reyes-Teran G, Ko AI, MacDonald MR, Nussenzweig MC
RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.
1. Mol Cell - published May 4, 2017
2. East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA
Water Distribution, Dynamics, and Interactions with Alzheimer's β-Amyloid Fibrils Investigated by Solid-State NMR.
1. J Am Chem Soc - published May 3, 2017
2. Wang T, Jo H, DeGrado WF, Hong M
Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
1. Nature - published May 3, 2017
2. Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ
Single-protein detection in crowded molecular environments in cryo-EM images.
1. Elife - published May 3, 2017
2. Rickgauer JP, Grigorieff N, Denk W
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.
1. Nature - published May 3, 2017
2. Janda CY, Dang LT, You C, Chang J, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li X, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ, Garcia KC
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes.
1. Neuron - published May 3, 2017
2. Twomey EC, Yelshanskaya MV, Grassucci RA, Frank J, Sobolevsky AI
Antibody-induced internalization of the human respiratory syncytial virus fusion protein.
1. J Virol - published May 3, 2017
2. Leemans A, De Schryver M, Van der Gucht W, Heykers A, Pintelon I, Hotard AL, Moore ML, Melero JA, McLellan JS, Graham BS, Broadbent L, Power UF, Caljon G, Cos P, Maes L, Delputte P
A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants.
1. Sci Transl Med - published May 3, 2017
2. Zhu Q, McLellan JS, Kallewaard NL, Ulbrandt ND, Palaszynski S, Zhang J, Moldt B, Khan A, Svabek C, McAuliffe JM, Wrapp D, Patel NK, Cook KE, Richter BWM, Ryan PC, Yuan AQ, Suzich JA
ALDH1A3 in CSCs.
1. Aging (Albany NY) - published May 3, 2017
2. Sullivan KE, Cerione RA, Wilson KF
Unexpected mutations after CRISPR-Cas9 editing in vivo.
1. Nat Methods - published May 3, 2017
2. Schaefer KA, Wu WH, Colgan DF, Tsang SH, Bassuk AG, Mahajan VB
X-ray Scattering Studies of Protein Structural Dynamics.
1. Chem Rev - published May 3, 2017
2. Meisburger SP, Thomas WC, Watkins MB, Ando N
Brucella abortus induces a Warburg shift in host metabolism that is linked to enhanced intracellular survival of the pathogen.
1. J Bacteriol - published May 3, 2017
2. Czyż DM, Willett J, Crosson S
Identification of the gene that codes for the σ2 receptor.
1. Proc Natl Acad Sci U S A - published May 3, 2017
2. Alon A, Schmidt HR, Wood MD, Sahn JJ, Martin SF, Kruse AC
Structural Basis for Regulation of ESCRT-III Complexes by Lgd.
1. Cell Rep - published May 3, 2017
2. McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T
Structural basis for anion conduction in the calcium-activated chloride channel TMEM16A.
1. Elife - published May 3, 2017
2. Paulino C, Neldner Y, Lam AK, Kalienkova V, Brunner JD, Schenck S, Dutzler R
Structural and Mechanistic Insights into Protein Translocation.
1. Annu Rev Cell Dev Biol - published May 3, 2017
2. Rapoport TA, Li L, Park E
Timing and Reset Mechanism of GTP Hydrolysis-Driven Conformational Changes of Atlastin.
1. Structure - published May 3, 2017
2. O'Donnell JP, Cooley RB, Kelly CM, Miller K, Andersen OS, Rusinova R, Sondermann H
Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.
1. Virus Res - published May 2, 2017
2. Li W, Luo R, He Q, van Kuppeveld FJM, Rottier PJM, Bosch BJ
Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy.
1. Angew Chem Int Ed Engl - published May 2, 2017
2. Lin CW, Mensa B, Barniol-Xicota M, DeGrado WF, Gai F
A genetic variant of the sperm-specific SLO3 K⁺ channel has altered pH and Ca²⁺ sensitivities.
1. J Biol Chem - published May 2, 2017
2. Geng Y, Ferreira JJ, Dzikunu V, Butler A, Lybaert P, Yuan P, Magleby KL, Salkoff L, Santi CM
Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex.
1. Proc Natl Acad Sci U S A - published May 2, 2017
2. Seok SH, Lee W, Jiang L, Molugu K, Zheng A, Li Y, Park S, Bradfield CA, Xing Y
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor.
1. J Med Chem - published May 2, 2017
2. Zhao Y, Bai L, Liu L, McEachern D, Stuckey JA, Meagher JL, Yang CY, Ran X, Zhou B, Hu Y, Li X, Wen B, Zhao T, Li S, Sun D, Wang S
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
1. J Biol Chem - published May 2, 2017
2. Zhang J, Johnson JL, He J, Napolitano G, Ramadass M, Rocca C, Kiosses WB, Bucci C, Xin Q, Gavathiotis E, Cuervo AM, Cherqui S, Catz SD
Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.
1. Sci Signal - published May 2, 2017
2. Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC
Induced Fit Is a Special Case of Conformational Selection.
1. Biochemistry - published May 2, 2017
2. Chakraborty P, Di Cera E
A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases.
1. Elife - published May 2, 2017
2. Bradshaw N, Levdikov VM, Zimanyi CM, Gaudet R, Wilkinson AJ, Losick R
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.
1. Nat Commun - published May 2, 2017
2. An J, Ponthier CM, Sack R, Seebacher J, Stadler MB, Donovan KA, Fischer ES
Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions.
1. PLoS Negl Trop Dis - published May 2, 2017
2. Sheikh A, Rashu R, Begum YA, Kuhlman FM, Ciorba MA, Hultgren SJ, Qadri F, Fleckenstein JM
Unique identifiers for small molecules enable rigorous labeling of their atoms.
1. Sci Data - published May 2, 2017
2. Dashti H, Westler WM, Markley JL, Eghbalnia HR
Converting lymphoma cells into potent antigen-presenting cells for interferon-induced tumor regression.
1. Cancer Immunol Res - published May 2, 2017
2. Liao J, Luan Y, Ren Z, Liu X, Xue D, Xu H, Sun Z, Yang K, Peng H, Fu YX
Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.
1. Proc Natl Acad Sci U S A - published May 2, 2017
2. Huber FM, Greenblatt SM, Davenport AM, Martinez C, Xu Y, Vu LP, Nimer SD, Hoelz A
Composition-dependent electronic energy relaxation dynamics of metal domains as revealed by bimetallic Au144-xAgx(SC8H9)60 monolayer-protected clusters.
1. Phys Chem Chem Phys - published May 2, 2017
2. Zheng H, Tofanelli MA, Ackerson CJ, Knappenberger KL
Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus.
1. Nat Commun - published May 2, 2017
2. Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI
Structural Insights into the Eukaryotic Transcription Initiation Machinery.
1. Annu Rev Biophys - published May 2, 2017
2. Nogales E, Louder RK, He Y
Molecular basis for PrimPol recruitment to replication forks by RPA.
1. Nat Commun - published May 2, 2017
2. Guilliam TA, Brissett NC, Ehlinger A, Keen BA, Kolesar P, Taylor EM, Bailey LJ, Lindsay HD, Chazin WJ, Doherty AJ
Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I.
1. Proc Natl Acad Sci U S A - published May 2, 2017
2. Shi Y, Hellinga HW, Beese LS
The COMPLEXity in herpesvirus entry.
1. Curr Opin Virol - published May 2, 2017
2. Sathiyamoorthy K, Chen J, Longnecker R, Jardetzky TS
A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor.
1. Sci Signal - published May 2, 2017
2. Dhindwal S, Lobo J, Cabra V, Santiago DJ, Nayak AR, Dryden K, Samsó M
Ensemble cryo-EM elucidates the mechanism of translation fidelity.
1. Nature - published May 2, 2017
2. Loveland AB, Demo G, Grigorieff N, Korostelev AA
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
1. Nature - published May 2, 2017
2. Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G
Observation of CH⋅⋅⋅π Interactions between Methyl and Carbonyl Groups in Proteins.
1. Angew Chem Int Ed Engl - published May 2, 2017
2. Perras FA, Marion D, Boisbouvier J, Bryce DL, Plevin MJ
Improved prefusion stability, optimized codon-usage, and augmented virion packaging enhance the immunogenicity of respiratory syncytial virus (RSV) fusion protein in a vectored vaccine candidate.
1. J Virol - published May 2, 2017
2. Liang B, Ngwuta JO, Surman S, Kabatova B, Liu X, Lingemann M, Liu X, Yang L, Herbert R, Swerczek J, Chen M, Moin SM, Kumar A, McLellan JS, Kwong PD, Graham BS, Collins PL, Munir S
Prostaglandin E2 glyceryl ester is an endogenous agonist of the nucleotide receptor P2Y6.
1. Sci Rep - published May 2, 2017
2. Brüser A, Zimmermann A, Crews BC, Sliwoski G, Meiler J, König GM, Kostenis E, Lede V, Marnett LJ, Schöneberg T
Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation.
1. Elife - published May 2, 2017
2. Steinert H, Sochor F, Wacker A, Buck J, Helmling C, Hiller F, Keyhani S, Noeske J, Grimm S, Rudolph MM, Keller H, Mooney RA, Landick R, Suess B, Fürtig B, Wöhnert J, Schwalbe H
Discovery of a Prefusion RSV F-Specific Monoclonal Antibody that Provides Greater in vivo Protection than the Murine Precursor of Palivizumab.
1. J Virol - published May 2, 2017
2. Zhao M, Zheng ZZ, Chen M, Modjarrad K, Zhang W, Zhan LT, Cao JL, Sun YP, McLellan JS, Graham BS, Xia NS
Functional Analysis of Human Cytochrome P450 21A2 Variants Involved in Congenital Adrenal Hyperplasia.
1. J Biol Chem - published May 2, 2017
2. Wang C, Pallan PS, Zhang W, Lei L, Yoshimoto FK, Waterman MR, Egli M, Guengerich FP
The Individual and Population Genetics of Antibody Immunity.
1. Trends Immunol - published May 2, 2017
2. Watson CT, Glanville J, Marasco WA
Asymmetric recognition of HIV-1 Envelope trimer by V1V2 loop-targeting antibodies.
1. Elife - published May 2, 2017
2. Wang H, Gristick HB, Scharf L, West AP, Galimidi RP, Seaman MS, Freund NT, Nussenzweig MC, Bjorkman PJ
RNA polymerase motions during promoter melting.
1. Science - published May 2, 2017
2. Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R, Darst SA
Transposable phages, DNA reorganization and transfer.
1. Curr Opin Microbiol - published May 2, 2017
2. Toussaint A, Rice PA
Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation.
1. Cell Mol Immunol - published May 2, 2017
2. Li X, Lamothe PA, Walker BD, Wang JH
Structural basis for high-affinity fluorophore binding and activation by RNA Mango.
1. Nat Chem Biol - published May 2, 2017
2. Trachman RJ 3rd, Demeshkina NA, Lau MWL, Panchapakesan SSS, Jeng SCY, Unrau PJ, Ferré-D'Amaré AR
Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams.
1. Nat Chem Biol - published May 2, 2017
2. Qiao Y, Srisuknimit V, Rubino F, Schaefer K, Ruiz N, Walker S, Kahne D
Neural immunoglobulin superfamily interaction networks.
1. Curr Opin Neurobiol - published May 2, 2017
2. Zinn K, Özkan E
Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients.
1. Bioessays - published May 2, 2017
2. Hegemann B, Peter M
Protein tentacles.
1. J Struct Biol - published May 2, 2017
2. Harrison SC
Flow Cytometric Analysis of Drug-induced HIV-1 Transcriptional Activity in A2 and A72 J-Lat Cell Lines.
1. Bio Protoc - published May 2, 2017
2. Boehm D, Ott M
Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering.
1. J Mech Behav Biomed Mater - published May 1, 2017
2. Pensalfini M, Ehret AE, Stüdeli S, Marino D, Kaech A, Reichmann E, Mazza E
Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2.
1. FASEB J - published May 1, 2017
2. Yaseen S, Demopulos G, Dudler T, Yabuki M, Wood CL, Cummings WJ, Tjoelker LW, Fujita T, Sacks S, Garred P, Andrew P, Sim RB, Lachmann PJ, Wallis R, Lynch N, Schwaeble WJ
Mutation of the Second Sialic Acid-Binding Site, Resulting in Reduced Neuraminidase Activity, Preceded the Emergence of H7N9 Influenza A Virus.
1. J Virol - published May 1, 2017
2. Dai M, McBride R, Dortmans JCFM, Peng W, Bakkers MJG, de Groot RJ, van Kuppeveld FJM, Paulson JC, de Vries E, de Haan CAM
In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography.
1. EMBO Rep - published May 1, 2017
2. Ghosal D, Chang YW, Jeong KC, Vogel JP, Jensen GJ
Inositol phosphate multikinase dependent transcriptional control.
1. Adv Biol Regul - published May 1, 2017
2. Hatch AJ, Odom AR, York JD
RNA activation-independent DNA targeting of the Type III CRISPR-Cas system by a Csm complex.
1. EMBO Rep - published May 1, 2017
2. Park KH, An Y, Jung TY, Baek IY, Noh H, Ahn WC, Hebert H, Song JJ, Kim JH, Oh BH, Woo EJ
Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors.
1. Cancer Res - published May 1, 2017
2. Kosaka T, Tanizaki J, Paranal RM, Endoh H, Lydon C, Capelletti M, Repellin CE, Choi J, Ogino A, Calles A, Ercan D, Redig AJ, Bahcall M, Oxnard GR, Eck MJ, Jänne PA
NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate.
1. Nucleic Acids Res - published May 1, 2017
2. Harjes S, Jameson GB, Filichev VV, Edwards PJB, Harjes E
How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.
1. Curr Opin HIV AIDS - published May 1, 2017
2. Pancera M, Changela A, Kwong PD
Crystal structure of the new investigational drug candidate VT-1598 in complex with Aspergillus fumigatus sterol 14α-demethylase provides insights into its broad-spectrum antifungal activity.
1. Antimicrob Agents Chemother - published May 1, 2017
2. Hargrove TY, Garvey EP, Hoekstra WJ, Yates CM, Wawrzak Z, Rachakonda G, Villalta F, Lepesheva GI
Ten simple rules to consider regarding preprint submission.
1. PLoS Comput Biol - published May 1, 2017
2. Bourne PE, Polka JK, Vale RD, Kiley R
Probing the Effects of Gating on the Ion Occupancy of the K+ Channel Selectivity Filter Using Two-Dimensional Infrared Spectroscopy.
1. J Am Chem Soc - published May 1, 2017
2. Kratochvil HT, Maj M, Matulef K, Annen AW, Ostmeyer J, Perozo E, Roux B, Valiyaveetil FI, Zanni MT
Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation.
1. Biochemistry - published May 1, 2017
2. Bacik JP, Mekasha S, Forsberg Z, Kovalevsky AY, Vaaje-Kolstad G, Eijsink VGH, Nix JC, Coates L, Cuneo MJ, Unkefer CJ, Chen JC
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.
1. Nature - published May 1, 2017
2. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J
SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
1. Cell Host Microbe - published May 1, 2017
2. Boehm D, Jeng M, Camus G, Gramatica A, Schwarzer R, Johnson JR, Hull PA, Montano M, Sakane N, Pagans S, Godin R, Deeks SG, Krogan NJ, Greene WC, Ott M
Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses.
1. Viruses - published May 1, 2017
2. Bào Y, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Dolnik O, Dye JM, Ebihara H, Formenty P, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, Patterson JL, Paweska JT, Smither SJ, Takada A, Towner JS, Volchkov VE, Wahl-Jensen V, Kuhn JH
Induction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States.
1. J Virol - published May 1, 2017
2. Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith AB 3rd, Madani N, Sodroski J, Haim H
BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks.
1. Nat Commun - published May 1, 2017
2. Yan WX, Mirzazadeh R, Garnerone S, Scott D, Schneider MW, Kallas T, Custodio J, Wernersson E, Li Y, Gao L, Federova Y, Zetsche B, Zhang F, Bienko M, Crosetto N
Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers.
1. Elife - published May 1, 2017
2. Moraga I, Spangler JB, Mendoza JL, Gakovic M, Wehrman TS, Krutzik P, Garcia KC
Fundamental trade-offs between information flow in single cells and cellular populations.
1. Proc Natl Acad Sci U S A - published May 1, 2017
2. Suderman R, Bachman JA, Smith A, Sorger PK, Deeds EJ
Enhanced FIB-SEM systems for large-volume 3D imaging.
1. Elife - published May 1, 2017
2. Xu CS, Hayworth KJ, Lu Z, Grob P, Hassan AM, García-Cerdán JG, Niyogi KK, Nogales E, Weinberg RJ, Hess HF
Structural insights into reptarenavirus cap-snatching machinery.
1. PLoS Pathog - published May 1, 2017
2. Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Günther S, Reindl S
Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.
1. Nat Cell Biol - published May 1, 2017
2. Liu X, Zhang Y, Ni M, Cao H, Signer RAJ, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, DeBerardinis RJ, Zhou F, Shao Z, Xu J
The mitochondrial respiratory chain is essential for haematopoietic stem cell function.
1. Nat Cell Biol - published May 1, 2017
2. Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS
Structural basis of cooperativity in kinesin revealed by 3D reconstruction of a two-head-bound state on microtubules.
1. Elife - published May 1, 2017
2. Liu D, Liu X, Shang Z, Sindelar CV
An evolutionary switch in ND2 enables Src kinase regulation of NMDA receptors.
1. Nat Commun - published May 1, 2017
2. Scanlon DP, Bah A, Krzeminski M, Zhang W, Leduc-Pessah HL, Dong YN, Forman-Kay JD, Salter MW
Direct observation of structure and dynamics during phase separation of an elastomeric protein.
1. Proc Natl Acad Sci U S A - published May 1, 2017
2. Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S
Structural and Biochemical Insights into Dimethylsulfoniopropionate Cleavage by Cofactor-bound DddK from the Prolific Marine Bacterium Pelagibacter.
1. Biochemistry - published May 1, 2017
2. Schnicker NJ, De Silva SM, Todd JD, Dey M
Functional RNA structures throughout the Hepatitis C Virus genome.
1. Curr Opin Virol - published May 1, 2017
2. Adams RL, Pirakitikulr N, Pyle AM
CryoEM structure of an influenza virus receptor-binding site antibody-antigen interface.
1. J Mol Biol - published May 1, 2017
2. Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N
Molecular Simulation and Biochemical Studies Support an Elevator-Type Transport Mechanism in EIIC.
1. Biophys J - published May 1, 2017
2. Lee J, Ren Z, Zhou M, Im W
The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.
1. Cell Rep - published May 1, 2017
2. Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P
Mammalian O-mannosylation of Cadherins and Plexins is Independent of Protein O-mannosyltransferase 1 and 2.
1. J Biol Chem - published May 1, 2017
2. Larsen ISB, Narimatsu Y, Joshi HJ, Yang Z, Harrison OJ, Brasch J, Shapiro L, Honig B, Vakhrushev SY, Clausen H, Halim A
Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop.
1. Immunity - published May 1, 2017
2. Cale EM, Gorman J, Radakovich NA, Crooks ET, Osawa K, Tong T, Li J, Nagarajan R, Ozorowski G, Ambrozak DR, Asokan M, Bailer RT, Bennici AK, Chen X, Doria-Rose NA, Druz A, Feng Y, Joyce MG, Louder MK, O'Dell S, Oliver C, Pancera M, Connors M, Hope TJ, Kepler TB, Wyatt RT, Ward AB, Georgiev IS, Kwong PD, Mascola JR, Binley JM
Signal Transduction: Notch catches a Jagged edge.
1. Nat Chem Biol - published May 1, 2017
2. Blacklow SC
Selective BET bromodomain inhibition as an antifungal therapeutic strategy.
1. Nat Commun - published May 1, 2017
2. Mietton F, Ferri E, Champleboux M, Zala N, Maubon D, Zhou Y, Harbut M, Spittler D, Garnaud C, Courçon M, Chauvel M, d'Enfert C, Kashemirov BA, Hull M, Cornet M, McKenna CE, Govin J, Petosa C
Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif.
1. Nat Commun - published May 1, 2017
2. de Opakua AI, Parag-Sharma K, DiGiacomo V, Merino N, Leyme A, Marivin A, Villate M, Nguyen LT, de la Cruz-Morcillo MA, Blanco-Canosa JB, Ramachandran S, Baillie GS, Cerione RA, Blanco FJ, Garcia-Marcos M
Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor.
1. Virology - published May 1, 2017
2. Espy N, Pacheco B, Sodroski J
Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change.
1. J Struct Biol - published May 1, 2017
2. Kalbermatter D, Chiu PL, Jeckelmann JM, Ucurum Z, Walz T, Fotiadis D
Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.
1. Nat Commun - published May 1, 2017
2. Jomaa A, Fu YH, Boehringer D, Leibundgut M, Shan SO, Ban N
Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination.
1. Sci Rep - published May 1, 2017
2. Bouillot S, Munro P, Gallet B, Reboud E, Cretin F, Golovkine G, Schoehn G, Attrée I, Lemichez E, Huber P
ATP controls the crowd.
1. Science - published May 1, 2017
2. Rice AM, Rosen MK
Molecular assembly of rhodopsin with G protein-coupled receptor kinases.
1. Cell Res - published May 1, 2017
2. He Y, Gao X, Goswami D, Hou L, Pal K, Yin Y, Zhao G, Ernst OP, Griffin P, Melcher K, Xu HE
The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand.
1. Curr Opin Struct Biol - published May 1, 2017
2. Zhao C, Pyle AM
Optimization of the process of inverted peptides (PIPEPLUS) to screen PDZ domain ligands.
1. Bioorg Med Chem Lett - published May 1, 2017
2. Seisel Q, Rädisch M, Gill NP, Madden DR, Boisguerin P
Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase.
1. Structure - published May 1, 2017
2. Mechaly AE, Soto Diaz S, Sassoon N, Buschiazzo A, Betton JM, Alzari PM
CRISPR-Cas Genome Surgery in Ophthalmology.
1. Transl Vis Sci Technol - published May 1, 2017
2. DiCarlo JE, Sengillo JD, Justus S, Cabral T, Tsang SH, Mahajan VB
Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.
1. Chem Sci - published May 1, 2017
2. Bondalapati S, Eid E, Mali SM, Wolberger C, Brik A
Intratumoral delivery of inactivated modified vaccinia virus Ankara (iMVA) induces systemic antitumor immunity via STING and Batf3-dependent dendritic cells.
1. Sci Immunol - published May 1, 2017
2. Dai P, Wang W, Yang N, Serna-Tamayo C, Ricca JM, Zamarin D, Shuman S, Merghoub T, Wolchok JD, Deng L
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.
1. Medchemcomm - published May 1, 2017
2. Porta EOJ, Jäger SN, Nocito I, Lepesheva GI, Serra EC, Tekwani BL, Labadie GR
Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations.
1. Medchemcomm - published May 1, 2017
2. Swier LJYM, Monjas L, Reeßing F, Oudshoorn RC, Aisyah, Primke T, Bakker MM, van Olst E, Ritschel T, Faustino I, Marrink SJ, Hirsch AKH, Slotboom DJ