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134 Member Publications for March 2017

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy.
1. Oncoimmunology - published March 28, 2017
2. Lazear E, Ghasemi R, Hein SM, Westwick J, Watkins D, Fremont DH, Krupnick AS
Structural Perspectives on Sigma-1 Receptor Function.
1. Adv Exp Med Biol - published March 19, 2017
2. Alon A, Schmidt H, Zheng S, Kruse AC
CBFß and HIV Infection.
1. Adv Exp Med Biol - published March 17, 2017
2. Kim DY, Gross JD
A Fluorescent Probe Distinguishes between Inhibition of Early and Late Steps of Lipopolysaccharide Biogenesis in Whole Cells.
1. ACS Chem Biol - published March 9, 2017
2. Moison E, Xie R, Zhang G, Lebar MD, Meredith TC, Kahne D
Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.
1. Protein Sci - published March 9, 2017
2. Manczyk N, Yates BP, Veggiani G, Ernst A, Sicheri F, Sidhu SS
Transporters Revealed.
1. Cell - published March 9, 2017
2. Lee JY, Rosenbaum DM
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
1. Cell - published March 9, 2017
2. Ho CC, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, Weissman IL, Galli SJ, Shizuru JA, Garcia KC
Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation.
1. Cell - published March 9, 2017
2. Kim AR, Ulirsch JC, Wilmes S, Unal E, Moraga I, Karakukcu M, Yuan D, Kazerounian S, Abdulhay NJ, King DS, Gupta N, Gabriel SB, Lander ES, Patiroglu T, Ozcan A, Ozdemir MA, Garcia KC, Piehler J, Gazda HT, Klein DE, Sankaran VG
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.
1. Cell - published March 9, 2017
2. Riback JA, Katanski CD, Kear-Scott JL, Pilipenko EV, Rojek AE, Sosnick TR, Drummond DA
Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV1.2.
1. Biophys Chem - published March 9, 2017
2. Hovey L, Fowler CA, Mahling R, Lin Z, Miller MS, Marx DC, Yoder JB, Kim EH, Tefft KM, Waite BC, Feldkamp MD, Yu L, Shea MA
Molecular biology: A hidden competitive advantage of disorder.
1. Nature - published March 8, 2017
2. Chong PA, Forman-Kay JD
An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer.
1. Cancer Discov - published March 8, 2017
2. Hanker AB, Red Brewer M, Sheehan JH, Koch JP, Sliwoski GR, Nagy R, Lanman R, Berger MF, Hyman DM, Solit DB, He J, Miller V, Cutler RE, Lalani AS, Cross D, Lovly CM, Meiler J, Arteaga CL
Structure-Based Design of a Soluble Prefusion-Closed HIV-1-Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.
1. J Virol - published March 8, 2017
2. Chuang GY, Geng H, Pancera M, Xu K, Cheng C, Acharya P, Chambers M, Druz A, Tsybovsky Y, Wanninger TG, Yang Y, Doria-Rose NA, Georgiev IS, Gorman J, Joyce MG, O'Dell S, Zhou T, McDermott AB, Mascola JR, Kwong PD
Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity.
1. Cell Host Microbe - published March 8, 2017
2. Bakkers MJ, Lang Y, Feitsma LJ, Hulswit RJ, de Poot SA, van Vliet AL, Margine I, de Groot-Mijnes JD, van Kuppeveld FJ, Langereis MA, Huizinga EG, de Groot RJ
Protection of calves by a prefusion-stabilized bovine RSV F vaccine.
1. NPJ Vaccines - published March 8, 2017
2. Zhang B, Chen L, Silacci C, Thom M, Boyington JC, Druz A, Joyce MG, Guzman E, Kong WP, Lai YT, Stewart-Jones GBE, Tsybovsky Y, Yang Y, Zhou T, Baxa U, Mascola JR, Corti D, Lanzavecchia A, Taylor G, Kwong PD
Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.
1. Structure - published March 7, 2017
2. Upla P, Kim SJ, Sampathkumar P, Dutta K, Cahill SM, Chemmama IE, Williams R, Bonanno JB, Rice WJ, Stokes DL, Cowburn D, Almo SC, Sali A, Rout MP, Fernandez-Martinez J
Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles.
1. Angew Chem Int Ed Engl - published March 7, 2017
2. Lee CF, Holownia A, Bennett JM, Elkins JM, St Denis JD, Adachi S, Yudin AK
Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment.
1. Cell Rep - published March 7, 2017
2. Ondracek CR, Frappier V, Ringel AE, Wolberger C, Guarente L
Improving Prediction of Helix-Helix Packing in Membrane Proteins Using Predicted Contact Numbers as Restraints.
1. Proteins - published March 6, 2017
2. Li B, Mendenhall J, Nguyen ED, Weiner BE, Fischer AW, Meiler J
Molecular Analysis of BRCA1 in Human Breast Cancer Cells Under Oxidative Stress.
1. Sci Rep - published March 6, 2017
2. Gilmore BL, Liang Y, Winton CE, Patel K, Karageorge V, Varano AC, Dearnaley W, Sheng Z, Kelly DF
A Fast and Effective Microfluidic Spraying-Plunging Method for High-Resolution Single-Particle Cryo-EM.
1. Structure - published March 6, 2017
2. Feng X, Fu Z, Kaledhonkar S, Jia Y, Shah B, Jin A, Liu Z, Sun M, Chen B, Grassucci RA, Ren Y, Jiang H, Frank J, Lin Q
A Biotin Ligase-Based Assay for the Quantification of the Cytosolic Delivery of Therapeutic Proteins.
1. Methods Mol Biol - published March 4, 2017
2. Verdurmen WPR, Mazlami M, Plückthun A
Dynamic Control of Synaptic Adhesion and Organizing Molecules in Synaptic Plasticity.
1. Neural Plast - published March 4, 2017
2. Rudenko G
Reconstitution of TCR Signaling Using Supported Lipid Bilayers.
1. Methods Mol Biol - published March 4, 2017
2. Su X, Ditlev JA, Rosen MK, Vale RD
S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.
1. J Biol Chem - published March 3, 2017
2. Aramsangtienchai P, Spiegelman NA, Cao J, Lin H
Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (-)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents.
1. J Am Chem Soc - published March 3, 2017
2. Nicolaou KC, Liu G, Beabout K, McCurry MD, Shamoo Y
Lactoferrin binding protein B - a bi-functional bacterial receptor protein.
1. PLoS Pathog - published March 3, 2017
2. Ostan NK, Yu RH, Ng D, Lai CC, Pogoutse AK, Sarpe V, Hepburn M, Sheff J, Raval S, Schriemer DC, Moraes TF, Schryvers AB
Structural Analyses of Candida albicans Sterol 14α-Demethylase Complexed with Azole Drugs Address the Molecular Basis of Azole-mediated Inhibition of Fungal Sterol Biosynthesis.
1. J Biol Chem - published March 3, 2017
2. Hargrove TY, Friggeri L, Wawrzak Z, Qi A, Hoekstra WJ, Schotzinger RJ, York JD, Guengerich FP, Lepesheva GI
Screening for AMPA receptor auxiliary subunit specific modulators.
1. PLoS One - published March 3, 2017
2. Azumaya CM, Days EL, Vinson PN, Stauffer S, Sulikowski G, Weaver CD, Nakagawa T
Synthesizing topological structures containing RNA.
1. Nat Commun - published March 3, 2017
2. Liu D, Shao Y, Chen G, Tse-Dinh YC, Piccirilli JA, Weizmann Y
The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.
1. Am J Physiol Lung Cell Mol Physiol - published March 3, 2017
2. Bertrand CA, Mitra S, Mishra SK, Wang X, Zhao Y, Pilewski JM, Madden DR, Frizzell RA
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
1. Science - published March 3, 2017
2. Dawidowski M, Emmanouilidis L, Kalel VC, Tripsianes K, Schorpp K, Hadian K, Kaiser M, Mäser P, Kolonko M, Tanghe S, Rodriguez A, Schliebs W, Erdmann R, Sattler M, Popowicz GM
ω- versus (ω-1)-hydroxylation: Cytochrome P450 4B1 sterics make the call.
1. J Biol Chem - published March 3, 2017
2. Scott EE
Long-Range Interactions in Riboswitch Control of Gene Expression.
1. Annu Rev Biophys - published March 3, 2017
2. Jones CP, Ferré-D'Amaré AR
How α-Helical Motifs Form Functionally Diverse Lipid-Binding Compartments.
1. Annu Rev Biochem - published March 3, 2017
2. Malinina L, Patel DJ, Brown RE
CRISPR-Cas9 Structures and Mechanisms.
1. Annu Rev Biophys - published March 3, 2017
2. Jiang F, Doudna JA
Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase.
1. Structure - published March 3, 2017
2. Hvorecny KL, Bahl CD, Kitamura S, Lee KS, Hammock BD, Morisseau C, Madden DR
Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.
1. Biochemistry - published March 2, 2017
2. Stamogiannos A, Maben Z, Papakyriakou A, Mpakali A, Kokkala P, Georgiadis D, Stern LJ, Stratikos E
Mitochondrial Cysteine Desulfurase and ISD11 Coexpressed in Escherichia coli Yield Complex Containing Acyl Carrier Protein.
1. ACS Chem Biol - published March 2, 2017
2. Cai K, Frederick RO, Tonelli M, Markley JL
Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction.
1. Elife - published March 2, 2017
2. Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
1. Science - published March 2, 2017
2. Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC
Functional Regulation of the Plasma Protein Histidine-Rich Glycoprotein by Zn2+ in Settings of Tissue Injury.
1. Biomolecules - published March 2, 2017
2. Priebatsch KM, Kvansakul M, Poon IK, Hulett MD
VEGF-A Expressing Adipose Tissue Shows Rapid Beiging, Enhanced Survival After Transplantation and Confers IL4-Independent Metabolic Improvements.
1. Diabetes - published March 2, 2017
2. Park J, Kim M, Sun K, An YA, Gu X, Scherer PE
Molecular Architecture of an N-formyltransferase from Salmonella enterica O60.
1. J Struct Biol - published March 2, 2017
2. Woodford CR, Thoden JB, Holden HM
Polyphosphate granule biogenesis is temporally and functionally tied to cell cycle exit during starvation in Pseudomonas aeruginosa.
1. Proc Natl Acad Sci U S A - published March 2, 2017
2. Racki LR, Tocheva EI, Dieterle MG, Sullivan MC, Jensen GJ, Newman DK
Structural basis of transcription arrest by coliphage HK022 nun in an Escherichia coli RNA polymerase elongation complex.
1. Elife - published March 2, 2017
2. Kang JY, Olinares PD, Chen J, Campbell EA, Mustaev A, Chait BT, Gottesman ME, Darst SA
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.
1. Elife - published March 2, 2017
2. Foijer F, Albacker LA, Bakker B, Spierings DC, Yue Y, Xie SZ, Davis SH, Lutum-Jehle A, Takemoto D, Hare B, Furey B, Bronson RT, Lansdorp PM, Bradley A, Sorger PK
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
1. PLoS Biol - published March 2, 2017
2. Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate JH
β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.
1. Cell Rep - published March 2, 2017
2. Stoppel LJ, Auerbach BD, Senter RK, Preza AR, Lefkowitz RJ, Bear MF
Ion and inhibitor binding of the double-ring ion selectivity filter of the mitochondrial calcium uniporter.
1. Proc Natl Acad Sci U S A - published March 2, 2017
2. Cao C, Wang S, Cui T, Su XC, Chou JJ
Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection.
1. MBio - published March 2, 2017
2. Limoli DH, Whitfield GB, Kitao T, Ivey ML, Davis MR Jr, Grahl N, Hogan DA, Rahme LG, Howell PL, O'Toole GA, Goldberg JB
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.
1. Immunity - published March 2, 2017
2. Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC
Versatile modes of cellular regulation via cyclic dinucleotides.
1. Nat Chem Biol - published March 2, 2017
2. Krasteva PV, Sondermann H
Structural insights into adiponectin receptors suggest ceramidase activity.
1. Nature - published March 2, 2017
2. Vasiliauskaité-Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, De Colibus L, Bechara C, Saied EM, Arenz C, Leyrat C, Granier S
BST-2 Expression Modulates Small CD4 Mimetic Sensitization of HIV-1-infected cells to ADCC.
1. J Virol - published March 2, 2017
2. Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB 3rd, Sodroski J, Sauter D, Kirchhoff F, Gee K, Neil SJ, Evans DT, Finzi A
Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections.
1. Sci Transl Med - published March 2, 2017
2. Schreiber HL 4th, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, Hannan TJ, Roberts PL, Stapleton AE, Hooton TM, Livny J, Earl AM, Hultgren SJ
Interpolating and extrapolating with hmsIST: seeking a tmax for optimal sensitivity, resolution and frequency accuracy.
1. J Biomol NMR - published March 2, 2017
2. Hyberts SG, Robson SA, Wagner G
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery.
1. Nucleic Acids Res - published March 2, 2017
2. Gaj T, Staahl BT, Rodrigues GM, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV
Isolation and characterization of the E. coli membrane protein production strain Mutant56(DE3).
1. Sci Rep - published March 2, 2017
2. Baumgarten T, Schlegel S, Wagner S, Löw M, Eriksson J, Bonde I, Herrgård MJ, Heipieper HJ, Nørholm MH, Slotboom DJ, de Gier JW
A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination.
1. Cell - published March 2, 2017
2. Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD
Molecular Structure of the Human CFTR Ion Channel.
1. Cell - published March 2, 2017
2. Liu F, Zhang Z, Csanády L, Gadsby DC, Chen J
In-crystal reaction cycle of a toluene-bound diiron hydroxylase.
1. Nature - published March 2, 2017
2. Acheson JF, Bailey LJ, Brunold TC, Fox BG
A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis.
1. Nature - published March 2, 2017
2. Bridwell-Rabb J, Zhong A, Sun HG, Drennan CL, Liu HW
The function of myostatin in the regulation of fat mass in mammals.
1. Nutr Metab (Lond) - published March 2, 2017
2. Deng B, Zhang F, Wen J, Ye S, Wang L, Yang Y, Gong P, Jiang S
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
1. Nat Commun - published March 2, 2017
2. Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR
Genetic effects influencing risk for major depressive disorder in China and Europe.
1. Transl Psychiatry - published March 2, 2017
2. Bigdeli TB, Ripke S, Peterson RE, Trzaskowski M, Bacanu SA, Abdellaoui A, Andlauer TF, Beekman AT, Berger K, Blackwood DH, Boomsma DI, Breen G, Buttenschøn HN, Byrne EM, Cichon S, Clarke TK, Couvy-Duchesne B, Craddock N, de Geus EJ, Degenhardt F, Dunn EC, Edwards AC, Fanous AH, Forstner AJ, Frank J, Gill M, Gordon SD, Grabe HJ, Hamilton SP, Hardiman O, Hayward C, Heath AC, Henders AK, Herms S, Hickie IB, Hoffmann P, Homuth G, Hottenga JJ, Ising M, Jansen R, Kloiber S, Knowles JA, Lang M, Li QS, Lucae S, MacIntyre DJ, Madden PA, Martin NG, McGrath PJ, McGuffin P, McIntosh AM, Medland SE, Mehta D, Middeldorp CM, Milaneschi Y, Montgomery GW, Mors O, Müller-Myhsok B, Nauck M, Nyholt DR, Nöthen MM, Owen MJ, Penninx BW, Pergadia ML, Perlis RH, Peyrot WJ, Porteous DJ, Potash JB, Rice JP, Rietschel M, Riley BP, Rivera M, Schoevers R, Schulze TG, Shi J, Shyn SI, Smit JH, Smoller JW, Streit F, Strohmaier J, Teumer A, Treutlein J, Van der Auwera S, van Grootheest G, van Hemert AM, Völzke H, Webb BT, Weissman MM, Wellmann J, Willemsen G, Witt SH, Levinson DF, Lewis CM, Wray NR, Flint J, Sullivan PF, Kendler KS
Structures of closed and open states of a voltage-gated sodium channel.
1. Proc Natl Acad Sci U S A - published March 2, 2017
2. Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA
Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.
1. J Mol Biol - published March 2, 2017
2. Kükenshöner T, Schmit NE, Bouda E, Sha F, Pojer F, Koide A, Seeliger M, Koide S, Hantschel O
Analysis of Cardiac Myocyte Maturation Using CASAAV, A Platform for Rapid Dissection of Cardiac Myocyte Gene Function In Vivo.
1. Circ Res - published March 2, 2017
2. Guo Y, VanDusen NJ, Zhang L, Gu W, Sethi I, Guatimosim S, Ma Q, Jardin BD, Ai Y, Zhang D, Chen B, Guo A, Yuan GC, Song LS, Pu WT
Widespread changes in nucleosome accessibility without changes in nucleosome occupancy during a rapid transcriptional induction.
1. Genes Dev - published March 2, 2017
2. Mueller B, Mieczkowski J, Kundu S, Wang P, Sadreyev R, Tolstorukov MY, Kingston RE
Ubiquitin Ligases: Structure, Function, and Regulation.
1. Annu Rev Biochem - published March 2, 2017
2. Zheng N, Shabek N
Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin.
1. Bioorg Med Chem - published March 2, 2017
2. Zhao B, Sensintaffar J, Bian Z, Belmar J, Lee T, Olejniczak ET, Fesik SW
Determination of Adeno-associated Virus Rep DNA Binding Using Fluorescence Anisotropy.
1. Bio Protoc - published March 2, 2017
2. Zarate-Perez F, Santosh V, Bardelli M, Agundez L, Linden RM, Henckaerts E, Escalante CR
A divalent cation-dependent variant of the glmS ribozyme with stringent Ca2+ selectivity co-opts a preexisting nonspecific metal ion-binding site.
1. RNA - published March 1, 2017
2. Lau MW, Trachman RJ 3rd, Ferré-D'Amaré AR
The accommodation index measures the perturbation associated with insertions and deletions in coiled-coils: Application to understand signaling in histidine kinases.
1. Protein Sci - published March 1, 2017
2. Schmidt NW, Grigoryan G, DeGrado WF
Dynamics of the peptidoglycan biosynthetic machinery in the stalked budding bacterium Hyphomonas neptunium.
1. Mol Microbiol - published March 1, 2017
2. Cserti E, Rosskopf S, Chang YW, Eisheuer S, Selter L, Shi J, Regh C, Koert U, Jensen GJ, Thanbichler M
Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination.
1. J Virol - published March 1, 2017
2. Nivarthi UK, Kose N, Sapparapu G, Widman D, Gallichotte E, Pfaff JM, Doranz BJ, Weiskopf D, Sette A, Durbin AP, Whitehead SS, Baric R, Crowe JE Jr, de Silva AM
Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.
1. J Mol Biol - published March 1, 2017
2. Kellogg EH, Hejab NMA, Howes S, Northcote P, Miller JH, Díaz JF, Downing KH, Nogales E
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.
1. Nat Med - published March 1, 2017
2. Koukouli F, Rooy M, Tziotis D, Sailor KA, O'Neill HC, Levenga J, Witte M, Nilges M, Changeux JP, Hoeffer CA, Stitzel JA, Gutkin BS, DiGregorio DA, Maskos U
Diversity and evolution of class 2 CRISPR-Cas systems.
1. Nat Rev Microbiol - published March 1, 2017
2. Shmakov S, Smargon A, Scott D, Cox D, Pyzocha N, Yan W, Abudayyeh OO, Gootenberg JS, Makarova KS, Wolf YI, Severinov K, Zhang F, Koonin EV
Depupylase Dop Requires Inorganic Phosphate in the Active Site for Catalysis.
1. J Biol Chem - published March 1, 2017
2. Bolten M, Vahlensieck C, Lipp C, Leibundgut M, Ban N, Weber-Ban E
Eukaryotic aspects of translation initiation brought into focus.
1. Philos Trans R Soc Lond B Biol Sci - published March 1, 2017
2. Aylett CH, Ban N
The translation elongation cycle-capturing multiple states by cryo-electron microscopy.
1. Philos Trans R Soc Lond B Biol Sci - published March 1, 2017
2. Frank J
Transcription control by the ENL YEATS domain in acute leukaemia.
1. Nature - published March 1, 2017
2. Erb MA, Scott TG, Li BE, Xie H, Paulk J, Seo HS, Souza A, Roberts JM, Dastjerdi S, Buckley DL, Sanjana NE, Shalem O, Nabet B, Zeid R, Offei-Addo NK, Dhe-Paganon S, Zhang F, Orkin SH, Winter GE, Bradner JE
The molecular architecture of lamins in somatic cells.
1. Nature - published March 1, 2017
2. Turgay Y, Eibauer M, Goldman AE, Shimi T, Khayat M, Ben-Harush K, Dubrovsky-Gaupp A, Sapra KT, Goldman RD, Medalia O
Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.
1. Proc Natl Acad Sci U S A - published March 1, 2017
2. Weijman JF, Kumar A, Jamieson SA, King CM, Caradoc-Davies TT, Ledgerwood EC, Murphy JM, Mace PD
Monobodies and Other Synthetic Binding Proteins for Expanding Protein Science.
1. Protein Sci - published March 1, 2017
2. Sha F, Salzman G, Gupta A, Koide S
Conformational states of a soluble, uncleaved HIV-1 envelope trimer.
1. J Virol - published March 1, 2017
2. Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B
Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity.
1. PLoS Pathog - published March 1, 2017
2. Rout MP, Obado SO, Schenkman S, Field MC
Chloroplast preproteins bind to the dimer interface of the Toc159 receptor during import.
1. Plant Physiol - published March 1, 2017
2. Chang JS, Chen LJ, Yeh YH, Hsiao CD, Li HM
Architecture of the Flagellar Switch Complex of Escherichia coli: Conformational Plasticity of FliG and Implications for Adaptive Remodeling.
1. J Mol Biol - published March 1, 2017
2. Kim EA, Panushka J, Meyer T, Carlisle R, Baker S, Ide N, Lynch M, Crane BR, Blair DF
Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.
1. J Med Chem - published March 1, 2017
2. Curreli F, Kwon YD, Belov DS, Ramesh RR, Kurkin AV, Altieri A, Kwong PD, Debnath AK
The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase.
1. RNA Biol - published March 1, 2017
2. Shu B, Gong P
Iron acquisition through the bacterial transferrin receptor.
1. Crit Rev Biochem Mol Biol - published March 1, 2017
2. Pogoutse AK, Moraes TF
Structure and assembly of scalable porous protein cages.
1. Nat Commun - published March 1, 2017
2. Sasaki E, Böhringer D, van de Waterbeemd M, Leibundgut M, Zschoche R, Heck AJ, Ban N, Hilvert D
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
1. Nat Commun - published March 1, 2017
2. Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, Wilmanns M, Schliebs W, Erdmann R, Sattler M
Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning.
1. Science - published March 1, 2017
2. Lau MS, Schwartz MG, Kundu S, Savol AJ, Wang PI, Marr SK, Grau DJ, Schorderet P, Sadreyev RI, Tabin CJ, Kingston RE
Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals.
1. Elife - published March 1, 2017
2. Fung HY, Fu SC, Chook YM
Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target.
1. BMC Cancer - published March 1, 2017
2. Roberts CM, Shahin SA, Loeza J, Dellinger TH, Williams JC, Glackin CA
Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells.
1. Proc Natl Acad Sci U S A - published March 1, 2017
2. Mognol GP, Spreafico R, Wong V, Scott-Browne JP, Togher S, Hoffmann A, Hogan PG, Rao A, Trifari S
Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.
1. Cell Chem Biol - published March 1, 2017
2. Wang Y, Fung YME, Zhang W, He B, Chung MWH, Jin J, Hu J, Lin H, Hao Q
Two alternative binding mechanisms connect the protein translocation Sec71/Sec72 complex with heat shock proteins.
1. J Biol Chem - published March 1, 2017
2. Tripathi A, Mandon EC, Gilmore R, Rapoport TA
Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2017
2. San Martin F, Mechaly AE, Larrieux N, Wunder EA Jr, Ko AI, Picardeau M, Trajtenberg F, Buschiazzo A
Rational Design of Protein C Activators.
1. Sci Rep - published March 1, 2017
2. Barranco-Medina S, Murphy M, Pelc L, Chen Z, Di Cera E, Pozzi N
Microtubule dynamics: 50 years after the discovery of tubulin and still going strong.
1. Mol Biol Cell - published March 1, 2017
2. Pigino G, Roll-Mecak A
Distinct recognition of complement iC3b by integrins αXβ2 and αMβ2.
1. Proc Natl Acad Sci U S A - published March 1, 2017
2. Xu S, Wang J, Wang JH, Springer TA
Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0.
1. Biophys J - published March 1, 2017
2. Saboe PO, Rapisarda C, Kaptan S, Hsiao YS, Summers SR, De Zorzi R, Dukovski D, Yu J, de Groot BL, Kumar M, Walz T
LIN28 Zinc Knuckle Domain Is Required and Sufficient to Induce let-7 Oligouridylation.
1. Cell Rep - published March 1, 2017
2. Wang L, Nam Y, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P
Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
1. Cell Rep - published March 1, 2017
2. Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K
Structure of the Complex between a Heparan Sulfate Octasaccharide and Mycobacterial Heparin-Binding Hemagglutinin.
1. Angew Chem Int Ed Engl - published March 1, 2017
2. Huang TY, Irene D, Zulueta MM, Tai TJ, Lain SH, Cheng CP, Tsai PX, Lin SY, Chen ZG, Ku CC, Hsiao CD, Chyan CL, Hung SC
Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
1. Sci Transl Med - published March 1, 2017
2. Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, Xia SM, Cooper M, Louder MK, McKee K, Bailer RT, Pier BW, Jette CA, Kelsoe G, Williams WB, Morris L, Kappes J, Wagh K, Kamanga G, Cohen MS, Hraber PT, Montefiori DC, Trama A, Liao HX, Kepler TB, Moody MA, Gao F, Danishefsky SJ, Mascola JR, Shaw GM, Hahn BH, Harrison SC, Korber BT, Haynes BF
A human antibody against Zika virus crosslinks the E protein to prevent infection.
1. Nat Commun - published March 1, 2017
2. Hasan SS, Miller A, Sapparapu G, Fernandez E, Klose T, Long F, Fokine A, Porta JC, Jiang W, Diamond MS, Crowe JE Jr, Kuhn RJ, Rossmann MG
Dengue Virus NS2B/NS3 Protease Inhibitors Exploiting the Prime Side.
1. J Virol - published March 1, 2017
2. Lin KH, Ali A, Rusere L, Soumana DI, Yilmaz NK, Schiffer CA
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
1. Sci Transl Med - published March 1, 2017
2. Alam SM, Aussedat B, Vohra Y, Ryan Meyerhoff R, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF
Mechanism of ribosome rescue by ArfA and RF2.
1. Elife - published March 1, 2017
2. Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA
Mechanisms of Autophagy Initiation.
1. Annu Rev Biochem - published March 1, 2017
2. Hurley JH, Young LN
Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO).
1. PLoS One - published March 1, 2017
2. Cox AJ, Darbro BW, Laxer RM, Velez G, Bing X, Finer AL, Erives A, Mahajan VB, Bassuk AG, Ferguson PJ
Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing.
1. FEBS Lett - published March 1, 2017
2. Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ
Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.
1. Mol Cell - published March 1, 2017
2. Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C
Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems.
1. Mol Cell - published March 1, 2017
2. Yamada M, Watanabe Y, Gootenberg JS, Hirano H, Ran FA, Nakane T, Ishitani R, Zhang F, Nishimasu H, Nureki O
Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1.
1. Chem Commun (Camb) - published March 1, 2017
2. Li A, Yadav R, White JK, Herroon MK, Callahan BP, Podgorski I, Turro C, Scott EE, Kodanko JJ
DNA sequence-dependent epigenetic inheritance of gene silencing and histone H3K9 methylation.
1. Science - published March 1, 2017
2. Wang X, Moazed D
Insights into the molecular architecture and histone H3-H4 deposition mechanism of yeast Chromatin assembly factor 1.
1. Elife - published March 1, 2017
2. Sauer PV, Timm J, Liu D, Sitbon D, Boeri-Erba E, Velours C, Mücke N, Langowski J, Ochsenbein F, Almouzni G, Panne D
DNA-mediated association of two histone-bound CAF-1 complexes drives tetrasome assembly in the wake of DNA replication.
1. Elife - published March 1, 2017
2. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K
Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition.
1. Methods - published March 1, 2017
2. Schlundt A, Tants JN, Sattler M
Architecture and mechanism of the central gear in an ancient molecular timer.
1. J R Soc Interface - published March 1, 2017
2. Egli M
Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.
1. Glycobiology - published March 1, 2017
2. McMillan BJ, Zimmerman B, Egan ED, Lofgren M, Xu X, Hesser A, Blacklow SC
Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.
1. Protein Eng Des Sel - published March 1, 2017
2. Anderson KS
The mechanism of translation.
1. F1000Res - published March 1, 2017
2. Frank J
Glutamine Metabolism in Cancer: Understanding the Heterogeneity.
1. Trends Cancer - published March 1, 2017
2. Cluntun AA, Lukey MJ, Cerione RA, Locasale JW
Characterizing aliphatic moieties in hydrocarbons with atomic force microscopy.
1. Chem Sci - published March 1, 2017
2. Schuler B, Zhang Y, Collazos S, Fatayer S, Meyer G, Pérez D, Guitián E, Harper MR, Kushnerick JD, Peña D, Gross L
X-ray transparent microfluidic chips for high-throughput screening and optimization of in meso membrane protein crystallization.
1. Biomicrofluidics - published March 1, 2017
2. Schieferstein JM, Pawate AS, Sun C, Wan F, Sheraden PN, Broecker J, Ernst OP, Gennis RB, Kenis PJA
Homology Modeling of Human Concentrative Nucleoside Transporters (hCNTs) and Validation by Virtual Screening and Experimental Testing to Identify Novel hCNT1 Inhibitors.
1. Drug Des - published March 1, 2017
2. Kumar Deokar H, Barch HP, Buolamwini JK
Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b]indole Derivatives as Broad-Spectrum Potent Anticancer Agents.
1. Drug Des - published March 1, 2017
2. Patil SA, Addo JK, Deokar H, Sun S, Wang J, Li W, Suttle DP, Wang W, Zhang R, Buolamwini JK