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123 Member Publications for December 2016

Structure determination of a human virus by the combination of cryo-EM and X-ray crystallography.
1. Biophys Rep - published December 27, 2016
2. Liu Z, Guu TS, Cao J, Li Y, Cheng L, Tao YJ, Zhang J
Bioinformatics Tools and Resources for Analyzing Protein Structures.
1. Methods Mol Biol - published December 16, 2016
2. Paxman JJ, Heras B
Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon.
1. PLoS One - published December 9, 2016
2. Oren DA, Wei Y, Skrabanek L, Chow BK, Mommsen T, Mojsov S
A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions.
1. PLoS One - published December 9, 2016
2. Stockman VB, Ghamsari L, Lasso G, Honig B, Shapira SD, Wang HH
Structure of the transporter associated with antigen processing trapped by herpes simplex virus.
1. Elife - published December 9, 2016
2. Oldham ML, Grigorieff N, Chen J
Structural basis for subtype-specific inhibition of the P2X7 receptor.
1. Elife - published December 9, 2016
2. Karasawa A, Kawate T
Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy.
1. Lab Chip - published December 9, 2016
2. DiMemmo LM, Cameron Varano A, Haulenbeek J, Liang Y, Patel K, Dukes MJ, Zheng S, Hubert M, Piccoli SP, Kelly DF
The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance.
1. Cancers (Basel) - published December 9, 2016
2. Kreger BT, Johansen ER, Cerione RA, Antonyak MA
Defining the hierarchical organisation of collagen VI microfibrils at nanometre to micrometre length scales.
1. Acta Biomater - published December 9, 2016
2. R F Godwin A, Starborg T, Sherratt MJ, Roseman AM, Baldock C
Structure-guided development of covalent TAK1 inhibitors.
1. Bioorg Med Chem - published December 9, 2016
2. Tan L, Gurbani D, Weisberg EL, Hunter JC, Li L, Jones DS, Ficarro SB, Mowafy S, Tam CP, Rao S, Du G, Griffin JD, Sorger PK, Marto JA, Westover KD, Gray NS
Protein Complex Affinity Capture from Cryomilled Mammalian Cells.
1. J Vis Exp - published December 9, 2016
2. LaCava J, Jiang H, Rout MP
Structural Studies of ERK2 Protein Complexes.
1. Methods Mol Biol - published December 8, 2016
2. Weijman JF, Riedl SJ, Mace PD
Implications of the differing roles of the β1 and β3 transmembrane and cytosplasmic domains for integrin function.
1. Elife - published December 8, 2016
2. Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Faessler R, Pozzi A, Sanders CR, Zent R
Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.
1. Nat Commun - published December 8, 2016
2. Sathiyamoorthy K, Hu YX, Möhl BS, Chen J, Longnecker R, Jardetzky TS
Divalent metal binding by histidine-rich glycoprotein (HRG) differentially regulates higher order oligomerisation and proteolytic processing.
1. FEBS Lett - published December 8, 2016
2. Priebatsch KM, Poon IK, Patel KK, Kvansakul M, Hulett MD
Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen.
1. J Biomol Screen - published December 8, 2016
2. Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J
Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.
1. J Med Chem - published December 8, 2016
2. Garzan A, Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S
Implementation Science Supports Core Clinical Competencies: An Overview and Clinical Example.
1. Prim Care Companion CNS Disord - published December 8, 2016
2. Kirchner JE, Woodward EN, Smith JL, Curran GM, Kilbourne AM, Owen RR, Bauer MS
Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single-cell Imaging.
1. Curr Protoc Chem Biol - published December 7, 2016
2. Lin JR, Fallahi-Sichani M, Chen JY, Sorger PK
Multiple selection filters ensure accurate tail-anchored membrane protein targeting.
1. Elife - published December 7, 2016
2. Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO
Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection.
1. JAMA Cardiol - published December 7, 2016
2. Tawakol A, Ishai A, Li D, Takx RA, Hur S, Kaiser Y, Pampaloni M, Rupert A, Hsu D, Sereti I, Fromentin R, Chomont N, Ganz P, Deeks SG, Hsue PY
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors.
1. Bioorg Med Chem - published December 7, 2016
2. Tan L, Gurbani D, Weisberg EL, Jones DS, Rao S, Singer WD, Bernard FM, Mowafy S, Jenney A, Du G, Nonami A, Griffin JD, Lauffenburger DA, Westover KD, Sorger PK, Gray NS
Six-Transmembrane Epithelial Antigen of Prostate 1 (STEAP1) Has a Single b Heme and Is Capable of Reducing Metal Ion Complexes and Oxygen.
1. Biochemistry - published December 6, 2016
2. Kim K, Mitra S, Wu G, Berka V, Song J, Yu Y, Poget S, Wang DN, Tsai AL, Zhou M
Transcriptomics and neuroanatomy of the clonal raider ant implicate an expanded clade of odorant receptors in chemical communication.
1. Proc Natl Acad Sci U S A - published December 6, 2016
2. McKenzie SK, Fetter-Pruneda I, Ruta V, Kronauer DJ
Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex.
1. Structure - published December 6, 2016
2. Cheng S, Seven AB, Wang J, Skiniotis G, Özkan E
The GET system inserts the tail-anchored SYP72 protein into endoplasmic reticulum membranes.
1. Plant Physiol - published December 6, 2016
2. Srivistava R, Zalisko BE, Keenan RJ, Howell SH
The DisVis and PowerFit web servers: Explorative and Integrative Modeling of Biomolecular Complexes.
1. J Mol Biol - published December 6, 2016
2. van Zundert GC, Trellet M, Schaarschmidt J, Kurkcuoglu Z, David M, Verlato M, Rosato A, Bonvin AM
Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.
1. Structure - published December 6, 2016
2. Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ
Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer.
1. Nat Struct Mol Biol - published December 5, 2016
2. Shen G, Cui W, Zhang H, Zhou F, Huang W, Liu Q, Yang Y, Li S, Bowman GR, Sadler JE, Gross ML, Li W
Effects of Increasing the Affinity of CarD for RNA Polymerase on Mycobacterium tuberculosis Growth, rRNA Transcription, and Virulence.
1. J Bacteriol - published December 5, 2016
2. Garner AL, Rammohan J, Huynh JP, Onder LM, Chen J, Bae B, Jensen D, Weiss LA, Ruiz Manzano A, Darst SA, Campbell EA, Nickels BE, Galburt EA, Stallings CL
The Varied Roles of Notch in Cancer.
1. Annu Rev Pathol - published December 5, 2016
2. Aster JC, Pear WS, Blacklow SC
Effects of Bni5 Binding on Septin Filament Organization.
1. J Mol Biol - published December 4, 2016
2. Booth EA, Sterling SM, Dovala D, Nogales E, Thorner J
An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.
1. J Biol Chem - published December 3, 2016
2. Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA
Recognition of ubiquitinated nucleosomes.
1. Curr Opin Struct Biol - published December 3, 2016
2. Morgan MT, Wolberger C
Co-Folding of a FliF-FliG Split Domain Forms the Basis of the MS:C Ring Interface within the Bacterial Flagellar Motor.
1. Structure - published December 3, 2016
2. Lynch MJ, Levenson R, Kim EA, Sircar R, Blair DF, Dahlquist FW, Crane BR
Cellular entry of the porcine epidemic diarrhea virus.
1. Virus Res - published December 2, 2016
2. Li W, van Kuppeveld FJM, He Q, Rottier PJM, Bosch BJ
Crystal structure of Arabidopsis thaliana SNC1 TIR domain.
1. Biochem Biophys Res Commun - published December 2, 2016
2. Hyun KG, Lee Y, Yoon J, Yi H, Song JJ
An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma.
1. Proc Natl Acad Sci U S A - published December 2, 2016
2. Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH
Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease.
1. Science - published December 2, 2016
2. Akiyama BM, Laurence HM, Massey AR, Costantino DA, Xie X, Yang Y, Shi PY, Nix JC, Beckham JD, Kieft JS
Structural Roles of Noncoding RNAs in the Heart of Enzymatic Complexes.
1. Biochemistry - published December 2, 2016
2. Martin WJ, Reiter NJ
Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.
1. Sci Adv - published December 2, 2016
2. You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.
1. Elife - published December 2, 2016
2. Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, Holtzman MJ, Brett TJ
Single Nucleotide Polymorphisms and Domain/Splice Variants Modulate Assembly and Elastomeric Properties of Human Elastin. Implications for Tissue Specificity and Durability of Elastic Tissue.
1. Biopolymers - published December 2, 2016
2. Miao M, Reichheld SE, Muiznieks LD, Sitarz EE, Sharpe S, Keeley FW
Structure of a CLC chloride ion channel by cryo-electron microscopy.
1. Nature - published December 2, 2016
2. Park E, Campbell EB, MacKinnon R
Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.
1. Sci Rep - published December 2, 2016
2. Rivera-Monroy J, Musiol L, Unthan-Fechner K, Farkas Á, Clancy A, Coy-Vergara J, Weill U, Gockel S, Lin SY, Corey DP, Kohl T, Ströbel P, Schuldiner M, Schwappach B, Vilardi F
The nuclear pore complex: understanding its function through structural insight.
1. Nat Rev Mol Cell Biol - published December 2, 2016
2. Beck M, Hurt E
Inhibition of memory by a microRNA negative feedback loop that downregulates SNARE-mediated vesicle transport.
1. Elife - published December 2, 2016
2. Mathew RS, Tatarakis A, Rudenko A, Johnson-Venkatesh EM, Yang YJ, Murphy EA, Todd TP, Schepers SP, Siuti N, Martorell AJ, Falls WA, Hammack SE, Walsh CA, Tsai LH, Umemori H, Bouton ME, Moazed D
Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
1. Nature - published December 2, 2016
2. Lukarska M, Fournier G, Pflug A, Resa-Infante P, Reich S, Naffakh N, Cusack S
Coincidence detection and bi-directional transmembrane signaling control a bacterial second messenger receptor.
1. Elife - published December 2, 2016
2. Cooley RB, O'Donnell JP, Sondermann H
Progress in ciliary ion channel physiology.
1. J Gen Physiol - published December 2, 2016
2. Pablo JL, DeCaen PG, Clapham DE
Comment on "A small-molecule antivirulence agent for treating Clostridium difficile infection".
1. Sci Transl Med - published December 2, 2016
2. Beilhartz GL, Tam J, Zhang Z, Melnyk RA
Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-directed Inhibitors.
1. J Virol - published December 2, 2016
2. Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB 3rd, Sodroski J, Finzi A
Truncated Latrunculins as Actin Inhibitors Targeting Plasmodium falciparum Motility and Host Cell Invasion.
1. J Med Chem - published December 2, 2016
2. Johnson S, Rahmani R, Drew DR, Williams MJ, Wilkinson M, Tan YH, Huang JX, Tonkin CJ, Beeson JG, Baum J, Smith BJ, Baell JB
New CRISPR-Cas systems from uncultivated microbes.
1. Nature - published December 2, 2016
2. Burstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna JA, Banfield JF
Key Residues at Third CDR3β Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs.
1. J Immunol - published December 2, 2016
2. Chamoto K, Guo T, Scally SW, Kagoya Y, Ancruzowski M, Wang CH, Rahman MA, Saso K, Butler MO, Chiu PP, Julien JP, Hirano N
Cornerstones of CRISPR-Cas in drug discovery and therapy.
1. Nat Rev Drug Discov - published December 2, 2016
2. Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE
Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
1. Science - published December 2, 2016
2. Jiao L, Liu X
The complete structure of the chloroplast 70S ribosome in complex with translation factor pY.
1. EMBO J - published December 2, 2016
2. Bieri P, Leibundgut M, Saurer M, Boehringer D, Ban N
Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria.
1. Elife - published December 2, 2016
2. Bergé M, Campagne S, Mignolet J, Holden S, Théraulaz L, Manley S, Allain FH, Viollier PH
Structural snapshots of Xer recombination reveal activation by synaptic complex remodeling and DNA bending.
1. Elife - published December 2, 2016
2. Bebel A, Karaca E, Kumar B, Stark WM, Barabas O
Phosphatidylserine stimulates ceramide-1-phosphate (C1P) intermembrane transfer by C1P transfer proteins.
1. J Biol Chem - published December 2, 2016
2. Zhai X, Gao YG, Mishra SK, Simanshu DK, Boldyrev IA, Benson LM, Bergen HR 3rd, Malinina L, Mundy J, Molotkovsky JG, Patel DJ, Brown RE
Nano-scale actin-network characterization of fibroblast cells lacking functional Arp2/3 complex.
1. J Struct Biol - published December 2, 2016
2. Anderson KL, Page C, Swift MF, Suraneni P, E W Janssen M, Pollard TD, Li R, Volkmann N, Hanein D
The Human Orexin/Hypocretin Receptor Crystal Structures.
1. Curr Top Behav Neurosci - published December 2, 2016
2. Yin J, Rosenbaum DM
Structural Investigation on WlaRG from Campylobacter jejuni: A Sugar Aminotransferase.
1. Protein Sci - published December 2, 2016
2. Dow GT, Gilbert M, Thoden JB, Holden HM
CD74 is a novel transcription regulator.
1. Proc Natl Acad Sci U S A - published December 2, 2016
2. Gil-Yarom N, Radomir L, Sever L, Kramer MP, Lewinsky H, Bornstein C, Blecher-Gonen R, Barnett-Itzhaki Z, Mirkin V, Friedlander G, Shvidel L, Herishanu Y, Lolis EJ, Becker-Herman S, Amit I, Shachar I
The replication initiator of the cholera pathogen's second chromosome shows structural similarity to plasmid initiators.
1. Nucleic Acids Res - published December 2, 2016
2. Orlova N, Gerding M, Ivashkiv O, Olinares PD, Chait BT, Waldor MK, Jeruzalmi D
Crystal structure of Staphylococcus aureus Zn-glyoxalase I: new subfamily of glyoxalase I family.
1. J Biomol Struct Dyn - published December 2, 2016
2. Chirgadze YN, Boshkova EA, Battaile KP, Mendes VG, Lam R, Chan TS, Romanov V, Pai EF, Chirgadze NY
STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.
1. Structure - published December 2, 2016
2. Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC
Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes.
1. Anal Chem - published December 2, 2016
2. Ficarro SB, Browne CM, Card JD, Alexander WM, Zhang T, Park E, McNally R, Dhe-Paganon S, Seo HS, Lamberto I, Eck MJ, Buhrlage SJ, Gray NS, Marto JA
OptSSeq: High-Throughput Sequencing Readout of Growth Enrichment Defines Optimal Gene Expression Elements for Homoethanologenesis.
1. ACS Synth Biol - published December 1, 2016
2. Ghosh IN, Landick R
LARGE2-dependent glycosylation confers laminin-binding ability on proteoglycans.
1. Glycobiology - published December 1, 2016
2. Inamori KI, Beedle AM, de Bernabé DB, Wright ME, Campbell KP
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.
1. Nucleic Acids Res - published December 1, 2016
2. Maishman L, Obado SO, Alsford S, Bart JM, Chen WM, Ratushny AV, Navarro M, Horn D, Aitchison JD, Chait BT, Rout MP, Field MC
Nickel impact on human health: An intrinsic disorder perspective.
1. Biochim Biophys Acta - published December 1, 2016
2. Zambelli B, Uversky VN, Ciurli S
Cbr1 is a Dph3 reductase required for the tRNA wobble uridine modification.
1. Nat Chem Biol - published December 1, 2016
2. Lin Z, Dong M, Zhang Y, Lee EA, Lin H
Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.
1. ACS Chem Biol - published December 1, 2016
2. Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL
Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation.
1. Nucleic Acids Res - published December 1, 2016
2. Kuznedelov K, Mekler V, Lemak S, Tokmina-Lukaszewska M, Datsenko KA, Jain I, Savitskaya E, Mallon J, Shmakov S, Bothner B, Bailey S, Yakunin AF, Severinov K, Semenova E
Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer.
1. Nucleic Acids Res - published December 1, 2016
2. Lin JL, Wu CC, Yang WZ, Yuan HS
Biochemical characterization and zinc binding group (ZBGs) inhibition studies on the catalytic domain of MMP7 (cdMMP7).
1. J Inorg Biochem - published December 1, 2016
2. Meng F, Yang H, Jack C, Zhang H, Moller A, Spivey D, Page RC, Tierney DL, Crowder MW
Design and characterization of bivalent BET inhibitors.
1. Nat Chem Biol - published December 1, 2016
2. Tanaka M, Roberts JM, Seo HS, Souza A, Paulk J, Scott TG, DeAngelo SL, Dhe-Paganon S, Bradner JE
Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates.
1. AIDS Res Hum Retroviruses - published December 1, 2016
2. Ding S, Verly MM, Princiotto A, Melillo B, Moody AM, Bradley T, Easterhoff D, Roger M, Hahn BH, Madani N, Smith AB 3rd, Haynes BF, Sodroski J, Finzi A
Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication.
1. J Exp Med - published December 1, 2016
2. Khan S, Woodruff EM, Trapecar M, Fontaine KA, Ezaki A, Borbet TC, Ott M, Sanjabi S
Oxadiazole grafts in peptide macrocycles.
1. Nat Chem - published December 1, 2016
2. Frost JR, Scully CC, Yudin AK
Cell biology: Double agents for mitochondrial division.
1. Nature - published December 1, 2016
2. McBride HM, Frost A
Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.
1. PLoS One - published December 1, 2016
2. Fitzsimmons CM, Fujimori DG
EstDZ3: A New Esterolytic Enzyme Exhibiting Remarkable Thermostability.
1. Front Microbiol - published December 1, 2016
2. Zarafeta D, Szabo Z, Moschidi D, Phan H, Chrysina ED, Peng X, Ingham CJ, Kolisis FN, Skretas G
Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption.
1. Elife - published December 1, 2016
2. Jimah JR, Salinas ND, Sala-Rabanal M, Jones NG, Sibley LD, Nichols CG, Schlesinger PH, Tolia NH
Determining Functional Aptamer-Protein Interaction by Biolayer Interferometry.
1. Curr Protoc Nucleic Acid Chem - published December 1, 2016
2. Lou X, Egli M, Yang X
Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.
1. Cell - published December 1, 2016
2. Zhang Z, Chen J
Do we know whether potential G-quadruplexes actually form in long functional RNA molecules?
1. Biochem Soc Trans - published December 1, 2016
2. Weldon C, Eperon IC, Dominguez C
Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1. Corrigendum.
1. Acta Crystallogr F Struct Biol Commun - published December 1, 2016
2. Cheng L, Li SA, Wang JH, Yu Y, Chen Q
Cellular encoding of Cy dyes for single-molecule imaging.
1. Elife - published December 1, 2016
2. Leisle L, Chadda R, Lueck JD, Infield DT, Galpin JD, Krishnamani V, Robertson JL, Ahern CA
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action.
1. Elife - published December 1, 2016
2. Trajtenberg F, Imelio JA, Machado MR, Larrieux N, Marti MA, Obal G, Mechaly AE, Buschiazzo A
Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis.
1. PLoS Pathog - published December 1, 2016
2. Chandrasekaran R, Kenworthy AK, Lacy DB
LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.
1. J Cell Biol - published December 1, 2016
2. Lawrence KS, Tapley EC, Cruz VE, Li Q, Aung K, Hart KC, Schwartz TU, Starr DA, Engebrecht J
eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.
1. Elife - published December 1, 2016
2. Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjević K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M
Vinylogous Dehydration by a Polyketide Dehydratase Domain in Curacin Biosynthesis.
1. J Am Chem Soc - published December 1, 2016
2. Fiers WD, Dodge GJ, Sherman DH, Smith JL, Aldrich CC
The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.
1. MBio - published December 1, 2016
2. Hanke L, Knockenhauer KE, Brewer RC, van Diest E, Schmidt FI, Schwartz TU, Ploegh HL
Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.
1. PLoS Pathog - published December 1, 2016
2. Clarke SC, Dumesic PA, Homer CM, O'Donoghue AJ, La Greca F, Pallova L, Majer P, Madhani HD, Craik CS
Towards understanding the mechanism of action of mithramycin and its analogues: dimerization and DNA binding studies.
1. Planta Med - published December 1, 2016
2. Weidenbach S, Hou C, Chen JM, Tsodikov OV, Rohr J
VP24-karyopherin alpha binding affinities differ between Ebolavirus species influencing interferon inhibition and VP24 stability.
1. J Virol - published December 1, 2016
2. Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF
Mechanism of membrane fusion induced by vesicular stomatitis virus G protein.
1. Proc Natl Acad Sci U S A - published December 1, 2016
2. Kim IS, Jenni S, Stanifer ML, Roth E, Whelan SP, van Oijen AM, Harrison SC
Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel.
1. Nature - published December 1, 2016
2. Tao X, Hite RK, MacKinnon R
Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.
1. Stem Cell Reports - published December 1, 2016
2. Meyer B, Fabbrizi MR, Raj S, Zobel CL, Hallahan DE, Sharma GG
Architecture of the yeast Elongator complex.
1. EMBO Rep - published December 1, 2016
2. Dauden MI, Kosinski J, Kolaj-Robin O, Desfosses A, Ori A, Faux C, Hoffmann NA, Onuma OF, Breunig KD, Beck M, Sachse C, Séraphin B, Glatt S, Müller CW
Structural basis for gating the high-conductance Ca2+-activated K+ channel.
1. Nature - published December 1, 2016
2. Hite RK, Tao X, MacKinnon R
Retrovirus Integration: Some Assembly Required?
1. Cell Host Microbe - published December 1, 2016
2. Ali I, Conrad RJ, Ott M
The mTOR Complex Controls HIV Latency.
1. Cell Host Microbe - published December 1, 2016
2. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E
A Linchpin Synthesis of 6-Hydroxyceramides from Aziridine Aldehydes.
1. Org Lett - published December 1, 2016
2. Liew SK, Kaldas SJ, Yudin AK
Architecture of the yeast small subunit processome.
1. Science - published December 1, 2016
2. Chaker-Margot M, Barandun J, Hunziker M, Klinge S
The structure and flexibility of conical HIV-1 capsids determined within intact virions.
1. Science - published December 1, 2016
2. Mattei S, Glass B, Hagen WJ, Kräusslich HG, Briggs JA
PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.
1. Cell - published December 1, 2016
2. Yang H, Gao P, Rajashankar KR, Patel DJ
Single-Molecule Real-Time 3D Imaging of the Transcription Cycle by Modulation Interferometry.
1. Cell - published December 1, 2016
2. Wang G, Hauver J, Thomas Z, Darst SA, Pertsinidis A
siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
1. Nucleic Acids Res - published December 1, 2016
2. Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L
SPRi-MALDI MS: characterization and identification of a kinase from cell lysate by specific interaction with different designed ankyrin repeat proteins.
1. Anal Bioanal Chem - published December 1, 2016
2. Anders U, Schaefer JV, Hibti FE, Frydman C, Suckau D, Plückthun A, Zenobi R
Targeting amino acid metabolism for cancer therapy.
1. Drug Discov Today - published December 1, 2016
2. Lukey MJ, Katt WP, Cerione RA
Metagenomic mining for thermostable esterolytic enzymes uncovers a new family of bacterial esterases.
1. Sci Rep - published December 1, 2016
2. Zarafeta D, Moschidi D, Ladoukakis E, Gavrilov S, Chrysina ED, Chatziioannou A, Kublanov I, Skretas G, Kolisis FN
Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
1. PLoS Pathog - published December 1, 2016
2. Khasnis MD, Halkidis K, Bhardwaj A, Root MJ
Designing and defining dynamic protein cage nanoassemblies in solution.
1. Sci Adv - published December 1, 2016
2. Lai YT, Hura GL, Dyer KN, Tang HY, Tainer JA, Yeates TO
A conserved ABC transport system regulated by the general stress response pathways of Alpha- and Gammaproteobacteria.
1. J Bacteriol - published December 1, 2016
2. Herrou J, Willett JW, Czyż DM, Babnigg G, Kim Y, Crosson S
Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.
1. Nucleic Acids Res - published December 1, 2016
2. Dutta A, Eckelmann B, Adhikari S, Ahmed KM, Sengupta S, Pandey A, Hegde PM, Tsai MS, Tainer JA, Weinfeld M, Hegde ML, Mitra S
Validating glycoprotein non-metastatic melanoma B (gpNMB, osteoactivin), a new biomarker of Gaucher disease.
1. Blood Cells Mol Dis - published December 1, 2016
2. Murugesan V, Liu J, Yang R, Lin H, Lischuk A, Pastores G, Zhang X, Chuang WL, Mistry PK
Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data.
1. PLoS Comput Biol - published December 1, 2016
2. Carstens S, Nilges M, Habeck M
Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors.
1. Sci Immunol - published December 1, 2016
2. Gilman MS, Castellanos CA, Chen M, Ngwuta JO, Goodwin E, Moin SM, Mas V, Melero JA, Wright PF, Graham BS, McLellan JS, Walker LM