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126 Member Publications for October 2016

  • Preface.

    1. Methods Enzymol - published October 30, 2016
    2. Spies M, Chemla YR

  • Measuring Membrane Protein Dimerization Equilibrium in Lipid Bilayers by Single-Molecule Fluorescence Microscopy.

    1. Methods Enzymol - published October 30, 2016
    2. Chadda R, Robertson JL

  • Endogenous Retroelements and the Host Innate Immune Sensors.

    1. Adv Immunol - published October 23, 2016
    2. Mu X, Ahmad S, Hur S

  • Optimal Bicelle q for Solution NMR Studies of Protein Transmembrane Partition.

    1. Chemistry - published October 17, 2016
    2. Piai A, Fu Q, Dev J, Chou JJ

  • Fragment-to-Lead Medicinal Chemistry Publications in 2015.

    1. J. Med. Chem. - published October 14, 2016
    2. Johnson CN, Erlanson DA, Murray CW, Rees DC

  • Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation.

    1. Science - published October 14, 2016
    2. Mylona A, Theillet FX, Foster C, Cheng TM, Miralles F, Bates PA, Selenko P, Treisman R

  • Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator.

    1. J. Biol. Chem. - published October 14, 2016
    2. Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL

  • The effect of backbone flexibility on site-selective modification of macrocycles.

    1. Org. Biomol. Chem. - published October 13, 2016
    2. Scully CC, White CJ, Yudin AK

  • Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.

    1. Cell Host Microbe - published October 12, 2016
    2. Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, Hultgren SJ

  • Insights into HIV-1 proviral transcription from the structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex.

    1. Elife - published October 12, 2016
    2. Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH

  • Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.

    1. Elife - published October 12, 2016
    2. Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Zhou Q, Zhao M, Brewster AS, Michels-Clark T, Holton JM, Sauter NK, Weis WI, Brunger AT

  • Rationale for RAS mutation-tailored therapies.

    1. Future Oncol - published October 12, 2016
    2. Montalvo SK, Li L, Westover KD

  • Charging of Proteins in Native Mass Spectrometry.

    1. J. Am. Soc. Mass Spectrom. - published October 12, 2016
    2. Susa AC, Xia Z, Tang HY, Tainer JA, Williams ER

  • Microvesicle-Mediated Wnt/b-catenin Signaling Promotes Interspecies Mammary Stem/Progenitor Cell Growth.

    1. J. Biol. Chem. - published October 12, 2016
    2. Bussche L, Rauner G, Antonyak M, Syracuse B, McDowell M, Brown AM, Cerione RA, Van de Walle GR

  • Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila.

    1. EMBO J. - published October 11, 2016
    2. Reimão-Pinto MM, Manzenreither RA, Burkard TR, Sledz P, Jinek M, Mechtler K, Ameres SL

  • Toward a Designable Extracellular Matrix: Molecular Dynamics Simulations of an Engineered Laminin-Mimetic, Elastin-Like Fusion Protein.

    1. Biomacromolecules - published October 10, 2016
    2. Tang JD, McAnany CE, Mura C, Lampe KJ

  • Importance of cycle timing for the function of the molecular chaperone Hsp90.

    1. Nat. Struct. Mol. Biol. - published October 10, 2016
    2. Zierer BK, Rübbelke M, Tippel F, Madl T, Schopf FH, Rutz DA, Richter K, Sattler M, Buchner J

  • Coordinated integrin activation by actin-dependent force during T-cell migration.

    1. Nat Commun - published October 10, 2016
    2. Nordenfelt P, Elliott HL, Springer TA

  • Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting.

    1. Oncogene - published October 10, 2016
    2. Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD

  • Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.

    1. J Mol Biol - published October 9, 2016
    2. Foglizzo M, Middleton AJ, Day CL

  • Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.

    1. J. Mol. Biol. - published October 9, 2016
    2. Shao Y, Huang H, Qin D, Li NS, Koide A, Staley JP, Koide S, Kossiakoff AA, Piccirilli JA

  • Foil-hole and data image quality assessment in 3DEM: Towards high-throughput image acquisition in the electron microscope.

    1. J. Struct. Biol. - published October 8, 2016
    2. Vargas J, Franken E, Sorzano CO, Gomez-Blanco J, Schoenmakers R, Koster AJ, Carazo JM

  • SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts.

    1. Front Immunol - published October 7, 2016
    2. Schramm CA, Sheng Z, Zhang Z, Mascola JR, Kwong PD, Shapiro L

  • Structural characterization of antibiotic self-immunity tRNA synthetase in plant tumour biocontrol agent.

    1. Nat Commun - published October 7, 2016
    2. Chopra S, Palencia A, Virus C, Schulwitz S, Temple BR, Cusack S, Reader J

  • Endotrophin, a multifaceted player in metabolic dysregulation and cancer progression, is a predictive biomarker for the response to PPARγ agonist treatment.

    1. Diabetologia - published October 7, 2016
    2. Sun K, Park J, Kim M, Scherer PE

  • DNA annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions.

    1. Sci Rep - published October 6, 2016
    2. Subramaniam S, Erler A, Fu J, Kranz A, Tang J, Gopalswamy M, Ramakrishnan S, Keller A, Grundmeier G, Müller D, Sattler M, Stewart AF

  • Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.

    1. Nat Commun - published October 6, 2016
    2. Dobosz-Bartoszek M, Pinkerton MH, Otwinowski Z, Chakravarthy S, Söll D, Copeland PR, Simonović M

  • Arginine phosphorylation marks proteins for degradation by a Clp protease.

    1. Nature - published October 6, 2016
    2. Trentini DB, Suskiewicz MJ, Heuck A, Kurzbauer R, Deszcz L, Mechtler K, Clausen T

  • Effect of Hydroxymethylcytosine on the Structure and Stability of Holliday Junctions.

    1. Biochemistry - published October 5, 2016
    2. Vander Zanden CM, Rowe RK, Broad AJ, Robertson AB, Ho PS

  • Reverse-topology membrane scission by the ESCRT proteins.

    1. Nat. Rev. Mol. Cell Biol. - published October 5, 2016
    2. Schöneberg J, Lee IH, Iwasa JH, Hurley JH

  • Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor.

    1. Nat Commun - published October 5, 2016
    2. Ramkumar K, Samanta S, Kyani A, Yang S, Tamura S, Ziemke E, Stuckey JA, Li S, Chinnaswamy K, Otake H, Debnath B, Yarovenko V, Sebolt-Leopold JS, Ljungman M, Neamati N

  • Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.

    1. J Neurosci - published October 5, 2016
    2. Früh S, Romanos J, Panzanelli P, Bürgisser D, Tyagarajan SK, Campbell KP, Santello M, Fritschy JM

  • Pre-TCRs leverage Vβ CDRs and hydrophobic patch in mechanosensing thymic self-ligands.

    1. J Biol Chem - published October 5, 2016
    2. Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL

  • The Sampling of Conformational Dynamics in Ambient-Temperature Crystal Structures of Arginine Kinase.

    1. Structure - published October 4, 2016
    2. Godsey MH, Davulcu O, Nix JC, Skalicky JJ, Brüschweiler RP, Chapman MS

  • Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

    1. Structure - published October 4, 2016
    2. Eisemann T, McCauley M, Langelier MF, Gupta K, Roy S, Van Duyne GD, Pascal JM

  • Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant.

    1. Structure - published October 4, 2016
    2. Pascolutti R, Sun X, Kao J, Maute RL, Ring AM, Bowman GR, Kruse AC

  • From Nanodiscs to Isotropic Bicelles: A Procedure for Solution Nuclear Magnetic Resonance Studies of Detergent-Sensitive Integral Membrane Proteins.

    1. Structure - published October 4, 2016
    2. Laguerre A, Löhr F, Henrich E, Hoffmann B, Abdul-Manan N, Connolly PJ, Perozo E, Moore JM, Bernhard F, Dötsch V

  • Karyopherin-β2 Recognition of a PY-NLS Variant that Lacks the Proline-Tyrosine Motif.

    1. Structure - published October 4, 2016
    2. Soniat M, Chook YM

  • Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides.

    1. ACS Chem. Biol. - published October 4, 2016
    2. Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD

  • Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.

    1. Proc Natl Acad Sci U S A - published October 4, 2016
    2. Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE Jr, Estes MK, Prasad BV

  • Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.

    1. Proc Natl Acad Sci U S A - published October 4, 2016
    2. Tukachinsky H, Petrov K, Watanabe M, Salic A

  • An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.

    1. Elife - published October 4, 2016
    2. Shah NH, Wang Q, Yan Q, Karandur D, Kadlecek TA, Fallahee IR, Russ WP, Ranganathan R, Weiss A, Kuriyan J

  • Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å.

    1. Structure - published October 4, 2016
    2. Koo J, Lamers RP, Rubinstein JL, Burrows LL, Howell PL

  • Next-Generation High-Throughput Functional Annotation of Microbial Genomes.

    1. MBio - published October 4, 2016
    2. Baric RS, Crosson S, Damania B, Miller SI, Rubin EJ

  • Identification of Nexinhibs, small-molecule inhibitors of neutrophil exocytosis and inflammation. Druggability of the small GTPase Rab27a.

    1. J Biol Chem - published October 4, 2016
    2. Johnson JL, Ramadass M, He J, Brown SJ, Zhang J, Abgaryan L, Biris N, Gavathiotis E, Rosen H, Catz SD

  • Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

    1. Nat Commun - published October 3, 2016
    2. Ploier B, Caro LN, Morizumi T, Pandey K, Pearring JN, Goren MA, Finnemann SC, Graumann J, Arshavsky VY, Dittman JS, Ernst OP, Menon AK

  • Molecular determinants for CRISPR RNA maturation in the Cas10-Csm complex and roles for non-Cas nucleases.

    1. Nucleic Acids Res. - published October 3, 2016
    2. Walker FC, Chou-Zheng L, Dunkle JA, Hatoum-Aslan A

  • Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.

    1. Nucleic Acids Res. - published October 3, 2016
    2. Biondi E, Lane JD, Das D, Dasgupta S, Piccirilli JA, Hoshika S, Bradley KM, Krantz BA, Benner SA

  • CRP-cAMP regulates csgD and biofilm formation by uropathogenic Escherichia coli.

    1. J. Bacteriol. - published October 3, 2016
    2. Hufnagel DA, Evans ML, Greene SE, Pinkner JS, Hultgren SJ, Chapman MR

  • Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination.

    1. Proc. Natl. Acad. Sci. U.S.A. - published October 3, 2016
    2. Pulivarthy SR, Lion M, Kuzu G, Matthews AG, Borowsky ML, Morris J, Kingston RE, Dennis JH, Tolstorukov MY, Oettinger MA

  • X-ray structure of the human α4β2 nicotinic receptor.

    1. Nature - published October 3, 2016
    2. Morales-Perez CL, Noviello CM, Hibbs RE

  • An acquisition and analysis pipeline for scanning angle interference microscopy.

    1. Nat Methods - published October 3, 2016
    2. Carbone CB, Vale RD, Stuurman N

  • Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).

    1. ACS Chem Biol - published October 3, 2016
    2. Won SJ, Davda D, Labby KJ, Hwang SY, Pricer R, Majmudar JD, Armacost KA, Rodriguez LA, Rodriguez CL, Chong FS, Torossian KA, Palakurthi J, Hur ES, Meagher JL, Brooks CL 3rd, Stuckey JA, Martin BR

  • Structure of the bacterial plant-ferredoxin receptor FusA.

    1. Nat Commun - published October 3, 2016
    2. Grinter R, Josts I, Mosbahi K, Roszak AW, Cogdell RJ, Bonvin AM, Milner JJ, Kelly SM, Byron O, Smith BO, Walker D

  • A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease.

    1. Nat Microbiol - published October 3, 2016
    2. O'Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ

  • Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation.

    1. Nat Chem Biol - published October 3, 2016
    2. Jones DS, Jenney AP, Swantek JL, Burke JM, Lauffenburger DA, Sorger PK

  • Structure of p300 in complex with acyl-CoA variants.

    1. Nat Chem Biol - published October 3, 2016
    2. Kaczmarska Z, Ortega E, Goudarzi A, Huang H, Kim S, Márquez JA, Zhao Y, Khochbin S, Panne D

  • Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents.

    1. ACS Med Chem Lett - published October 3, 2016
    2. Lee WG, Chan AH, Spasov KA, Anderson KS, Jorgensen WL

  • HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine.

    1. ACS Chem Biol - published October 2, 2016
    2. Aramsangtienchai P, Spiegelman NA, He B, Miller SP, Dai L, Zhao Y, Lin H

  • A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.

    1. Science - published October 2, 2016
    2. Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE Jr, Aman MJ, Dye JM, Lai JR, Chandran K

  • Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections.

    1. Cell - published October 2, 2016
    2. Gilchuk I, Gilchuk P, Sapparapu G, Lampley R, Singh V, Kose N, Blum DL, Hughes LJ, Satheshkumar PS, Townsend MB, Kondas AV, Reed Z, Weiner Z, Olson VA, Hammarlund E, Raue HP, Slifka MK, Slaughter JC, Graham BS, Edwards KM, Eisenberg RJ, Cohen GH, Joyce S, Crowe JE Jr

  • RNA Binding: Getting Specific about Specificity.

    1. Cell Chem Biol - published October 2, 2016
    2. Ferré-D'Amaré AR

  • A dual-targeting approach to inhibit Brucella abortus replication in human cells.

    1. Sci Rep - published October 2, 2016
    2. Czyż DM, Jain-Gupta N, Shuman HA, Crosson S

  • The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.

    1. Cell - published October 2, 2016
    2. Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E

  • A computational interactome and functional annotation for the human proteome.

    1. Elife - published October 2, 2016
    2. Garzón JI, Deng L, Murray D, Shapira S, Petrey D, Honig B

  • Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment.

    1. Nat Commun - published October 2, 2016
    2. Ulland TK, Jain N, Hornick EE, Elliott EI, Clay GM, Sadler JJ, Mills KA, Janowski AM, Volk AP, Wang K, Legge KL, Gakhar L, Bourdi M, Ferguson PJ, Wilson ME, Cassel SL, Sutterwala FS

  • Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses.

    1. Curr Biol - published October 2, 2016
    2. Das S, Lambright DG

  • Dynamic microfluidic control of supramolecular peptide self-assembly.

    1. Nat Commun - published October 2, 2016
    2. Arnon ZA, Vitalis A, Levin A, Michaels TC, Caflisch A, Knowles TP, Adler-Abramovich L, Gazit E

  • In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery.

    1. Nat Commun - published October 2, 2016
    2. Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM

  • γ-Protocadherin structural diversity and functional implications.

    1. Elife - published October 2, 2016
    2. Goodman KM, Rubinstein R, Thu CA, Mannepalli S, Bahna F, Ahlsén G, Rittenhouse C, Maniatis T, Honig B, Shapiro L

  • Neisseria meningitidis fac---tor H bin---ding protein bound to monoclonal antibody JAR5: implications for antibody synergy.

    1. Biochem J - published October 2, 2016
    2. Malito E, Lo Surdo P, Veggi D, Santini L, Heather Stefek H, Brunelli B, Luzzi E, Bottomley MJ, Beernink P, Scarselli M

  • Silencing c-Myc translation as a therapeutic strategy through targeting PI3K delta and CK1 epsilon in hematological malignancies.

    1. Blood - published October 2, 2016
    2. Deng C, Lipstein MR, Scotto L, Jirau Serrano XO, Mangone MA, Li S, Vendome J, Hao Y, Xu X, Deng SX, Realubit RB, Tatonetti NP, Karan C, Lentzsch S, Fruman DA, Honig B, Landry DW, O'Connor OA

  • Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.

    1. Elife - published October 2, 2016
    2. Cooper SR, Jontes JD, Sotomayor M

  • The RCSB protein data bank: integrative view of protein, gene and 3D structural information.

    1. Nucleic Acids Res - published October 2, 2016
    2. Rose PW, Prlić A, Altunkaya A, Bi C, Bradley AR, Christie CH, Costanzo LD, Duarte JM, Dutta S, Feng Z, Green RK, Goodsell DS, Hudson B, Kalro T, Lowe R, Peisach E, Randle C, Rose AS, Shao C, Tao YP, Valasatava Y, Voigt M, Westbrook JD, Woo J, Yang H, Young JY, Zardecki C, Berman HM, Burley SK

  • Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition.

    1. Proc Natl Acad Sci U S A - published October 2, 2016
    2. Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD

  • Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit.

    1. Proc Natl Acad Sci U S A - published October 2, 2016
    2. Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Ramesh M, Espina N, Sun M, Tutuncuoglu B, Madison-Antenucci S, Woolford JL Jr, Tong L, Frank J

  • New Mechanistic Insight from Substrate- and Product-Bound Structures of the Metal-Dependent Dimethylsulfoniopropionate Lyase DddQ.

    1. Biochemistry - published October 2, 2016
    2. Brummett AE, Dey M

  • Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections.

    1. MBio - published October 2, 2016
    2. Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL 4th, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG

  • Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?

    1. J Neurosci - published October 2, 2016
    2. Corey DP, Holt JR

  • The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.

    1. EMBO J - published October 2, 2016
    2. Piwko W, Mlejnkova LJ, Mutreja K, Ranjha L, Stafa D, Smirnov A, Brodersen MM, Zellweger R, Sturzenegger A, Janscak P, Lopes M, Peter M, Cejka P

  • Structural analysis of X-Linked Retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function.

    1. Hum Mol Genet - published October 2, 2016
    2. Ramsay EP, Collins RF, Owens TW, Siebert CA, Jones RP, Wang T, Roseman AM, Baldock C

  • Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials.

    1. Syst Biol - published October 2, 2016
    2. Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benkő M, Blasdell KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg CS, Collins PL, de la Torre JC, DeRisi JL, Dietzgen RG, Dolnik O, Dürrwald R, Dye JM, Easton AJ, Emonet S, Formenty P, Fouchier RA, Ghedin E, Gonzalez JP, Harrach B, Hewson R, Horie M, Jiāng D, Kobinger G, Kondo H, Kropinski AM, Krupovic M, Kurath G, Lamb RA, Leroy EM, Lukashevich IS, Maisner A, Mushegian AR, Netesov SV, Nowotny N, Patterson JL, Payne SL, Paweska JT, Peters CJ, Radoshitzky SR, Rima BK, Romanowski V, Rubbenstroth D, Sabanadzovic S, Sanfaçon H, Salvato MS, Schwemmle M, Smither SJ, Stenglein MD, Stone DM, Takada A, Tesh RB, Tomonaga K, Tordo N, Towner JS, Vasilakis N, Volchkov VE, Wahl-Jensen V, Walker PJ, Wang LF, Varsani A, Whitfield AE, Zerbini FM, Kuhn JH

  • Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.

    1. MBio - published October 2, 2016
    2. Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J

  • Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

    1. ACS Cent Sci - published October 2, 2016
    2. Palermo G, Miao Y, Walker RC, Jinek M, McCammon JA

  • Correcting mitochondrial fusion by manipulating mitofusin conformations.

    1. Nature - published October 2, 2016
    2. Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW 2nd

  • Structural/Functional Properties of Human NFU1, an Intermediate [4Fe-4S] Carrier in Human Mitochondrial Iron-Sulfur Cluster Biogenesis.

    1. Structure - published October 2, 2016
    2. Cai K, Liu G, Frederick RO, Xiao R, Montelione GT, Markley JL

  • Robust background modelling in <i>DIALS</i>.

    1. J Appl Crystallogr - published October 2, 2016
    2. Parkhurst JM, Winter G, Waterman DG, Fuentes-Montero L, Gildea RJ, Murshudov GN, Evans G

  • Proper Control of Caulobacter crescentus Cell Surface Adhesion Requires the General Protein Chaperone DnaK.

    1. J. Bacteriol. - published October 1, 2016
    2. Eaton DS, Crosson S, Fiebig A

  • Modification in hydrophobic packing of HAMP domain induces a destabilization of the auto-phosphorylation site in the histidine kinase CpxA.

    1. Biopolymers - published October 1, 2016
    2. Martinez M, Duclert-Savatier N, Betton JM, Alzari PM, Nilges M, Malliavin TE

  • Single-molecule sorting of DNA helicases.

    1. Methods - published October 1, 2016
    2. Bain FE, Wu CG, Spies M

  • G-quadruplex recognition and remodeling by the FANCJ helicase.

    1. Nucleic Acids Res - published October 1, 2016
    2. Wu CG, Spies M

  • On the role of a specific insert in acetate permeases (ActP) for tellurite uptake in bacteria: Functional and structural studies.

    1. J Inorg Biochem - published October 1, 2016
    2. Borghese R, Canducci L, Musiani F, Cappelletti M, Ciurli S, Turner RJ, Zannoni D

  • Targeting cell membrane adaptation as a novel antimicrobial strategy.

    1. Curr Opin Microbiol - published October 1, 2016
    2. Tran TT, Miller WR, Shamoo Y, Arias CA

  • Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.

    1. Antimicrob Agents Chemother - published October 1, 2016
    2. Dorobantu CM, Harak C, Klein R, van der Linden L, Strating JR, van der Schaar HM, Lohmann V, van Kuppeveld FJ

  • Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.

    1. Nucleic Acids Res - published October 1, 2016
    2. Stojković V, Noda-Garcia L, Tawfik DS, Fujimori DG

  • Identification of Residues That Affect Oligomerization and/or Enzymatic Activity of Influenza Virus H5N1 Neuraminidase Proteins.

    1. J Virol - published October 1, 2016
    2. Dai M, Guo H, Dortmans JC, Dekkers J, Nordholm J, Daniels R, van Kuppeveld FJ, de Vries E, de Haan CA

  • Effects of Membrane Charge and Order on Membrane Binding of the Retroviral Structural Protein Gag.

    1. J Virol - published October 1, 2016
    2. Wen Y, Dick RA, Feigenson GW, Vogt VM

  • Structural basis of laminin binding to the LARGE glycans on dystroglycan.

    1. Nat Chem Biol - published October 1, 2016
    2. Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP

  • Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

    1. Bioconjug Chem - published October 1, 2016
    2. Francica JR, Lynn GM, Laga R, Joyce MG, Ruckwardt TJ, Morabito KM, Chen M, Chaudhuri R, Zhang B, Sastry M, Druz A, Ko K, Choe M, Pechar M, Georgiev IS, Kueltzo LA, Seymour LW, Mascola JR, Kwong PD, Graham BS, Seder RA

  • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.

    1. Nat Genet - published October 1, 2016
    2. Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J, Donnelly LA, Kanoni S, Petersen AK, Pihur V, Strawbridge RJ, Shungin D, Hughes MF, Meirelles O, Kaakinen M, Bouatia-Naji N, Kristiansson K, Shah S, Kleber ME, Guo X, Lyytikäinen LP, Fava C, Eriksson N, Nolte IM, Magnusson PK, Salfati EL, Rallidis LS, Theusch E, Smith AJP, Folkersen L, Witkowska K, Pers TH, Joehanes R, Kim SK, Lataniotis L, Jansen R, Johnson AD, Warren H, Kim YJ, Zhao W, Wu Y, Tayo BO, Bochud M, CHARGE-EchoGen consortium., CHARGE-HF consortium., Wellcome Trust Case Control Consortium., Absher D, Adair LS, Amin N, Arking DE, Axelsson T, Baldassarre D, Balkau B, Bandinelli S, Barnes MR, Barroso I, Bevan S, Bis JC, Bjornsdottir G, Boehnke M, Boerwinkle E, Bonnycastle LL, Boomsma DI, Bornstein SR, Brown MJ, Burnier M, Cabrera CP, Chambers JC, Chang IS, Cheng CY, Chines PS, Chung RH, Collins FS, Connell JM, Döring A, Dallongeville J, Danesh J, de Faire U, Delgado G, Dominiczak AF, Doney ASF, Drenos F, Edkins S, Eicher JD, Elosua R, Enroth S, Erdmann J, Eriksson P, Esko T, Evangelou E, Evans A, Fall T, Farrall M, Felix JF, Ferrières J, Ferrucci L, Fornage M, Forrester T, Franceschini N, Duran OHF, Franco-Cereceda A, Fraser RM, Ganesh SK, Gao H, Gertow K, Gianfagna F, Gigante B, Giulianini F, Goel A, Goodall AH, Goodarzi MO, Gorski M, Gräßler J, Groves C, Gudnason V, Gyllensten U, Hallmans G, Hartikainen AL, Hassinen M, Havulinna AS, Hayward C, Hercberg S, Herzig KH, Hicks AA, Hingorani AD, Hirschhorn JN, Hofman A, Holmen J, Holmen OL, Hottenga JJ, Howard P, Hsiung CA, Hunt SC, Ikram MA, Illig T, Iribarren C, Jensen RA, Kähönen M, Kang H, Kathiresan S, Keating BJ, Khaw KT, Kim YK, Kim E, Kivimaki M, Klopp N, Kolovou G, Komulainen P, Kooner JS, Kosova G, Krauss RM, Kuh D, Kutalik Z, Kuusisto J, Kvaløy K, Lakka TA, Lee NR, Lee IT, Lee WJ, Levy D, Li X, Liang KW, Lin H, Lin L, Lindström J, Lobbens S, Männistö S, Müller G, Müller-Nurasyid M, Mach F, Markus HS, Marouli E, McCarthy MI, McKenzie CA, Meneton P, Menni C, Metspalu A, Mijatovic V, Moilanen L, Montasser ME, Morris AD, Morrison AC, Mulas A, Nagaraja R, Narisu N, Nikus K, O'Donnell CJ, O'Reilly PF, Ong KK, Paccaud F, Palmer CD, Parsa A, Pedersen NL, Penninx BW, Perola M, Peters A, Poulter N, Pramstaller PP, Psaty BM, Quertermous T, Rao DC, Rasheed A, Rayner NWNWR, Renström F, Rettig R, Rice KM, Roberts R, Rose LM, Rossouw J, Samani NJ, Sanna S, Saramies J, Schunkert H, Sebert S, Sheu WH, Shin YA, Sim X, Smit JH, Smith AV, Sosa MX, Spector TD, Stančáková A, Stanton A, Stirrups KE, Stringham HM, Sundstrom J, Swift AJ, Syvänen AC, Tai ES, Tanaka T, Tarasov KV, Teumer A, Thorsteinsdottir U, Tobin MD, Tremoli E, Uitterlinden AG, Uusitupa M, Vaez A, Vaidya D, van Duijn CM, van Iperen EPA, Vasan RS, Verwoert GC, Virtamo J, Vitart V, Voight BF, Vollenweider P, Wagner A, Wain LV, Wareham NJ, Watkins H, Weder AB, Westra HJ, Wilks R, Wilsgaard T, Wilson JF, Wong TY, Yang TP, Yao J, Yengo L, Zhang W, Zhao JH, Zhu X, Bovet P, Cooper RS, Mohlke KL, Saleheen D, Lee JY, Elliott P, Gierman HJ, Willer CJ, Franke L, Hovingh GK, Taylor KD, Dedoussis G, Sever P, Wong A, Lind L, Assimes TL, Njølstad I, Schwarz PE, Langenberg C, Snieder H, Caulfield MJ, Melander O, Laakso M, Saltevo J, Rauramaa R, Tuomilehto J, Ingelsson E, Lehtimäki T, Hveem K, Palmas W, März W, Kumari M, Salomaa V, Chen YI, Rotter JI, Froguel P, Jarvelin MR, Lakatta EG, Kuulasmaa K, Franks PW, Hamsten A, Wichmann HE, Palmer CNA, Stefansson K, Ridker PM, Loos RJF, Chakravarti A, Deloukas P, Morris AP, Newton-Cheh C, Munroe PB

  • A Chemoenzymatic Strategy for Imaging Cellular Phosphatidic Acid Synthesis.

    1. Angew Chem Int Ed Engl - published October 1, 2016
    2. Bumpus TW, Baskin JM

  • Role of Reversible Histidine Coordination in Hydroxylamine Reduction by Plant Hemoglobins (Phytoglobins).

    1. Biochemistry - published October 1, 2016
    2. Athwal NS, Alagurajan J, Andreotti AH, Hargrove MS

  • CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis.

    1. J Biomol NMR - published October 1, 2016
    2. Skinner SP, Fogh RH, Boucher W, Ragan TJ, Mureddu LG, Vuister GW

  • Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics.

    1. Proc Natl Acad Sci U S A - published October 1, 2016
    2. Subramanyam S, Ismail M, Bhattacharya I, Spies M

  • Safety Analysis From a Prospective Registry Study of Stereotactic Body Radiation Therapy for Aggressive Management of Late-Stage Disease.

    1. Int. J. Radiat. Oncol. Biol. Phys. - published October 1, 2016
    2. Maquilan G, Westover KD, Wardak Z, Timmerman RD, Hannan R, Iyengar P, Schwartz DL, Meyer JJ, Abdulrahman RE, Folkert MR, Laine AM, Desai NB, Albuquerque KV, Choy H, Ahn C, Rahimi AS

  • Predicting Distant Failure in Lung Stereotactic Body Radiation Therapy Using Multiobjective Radiomics Model.

    1. Int. J. Radiat. Oncol. Biol. Phys. - published October 1, 2016
    2. Zhou Z, Folkert MR, Iyengar P, Zhang Y, Westover KD, Wang J

  • Cryo-EM in the study of challenging systems: the human transcription pre-initiation complex.

    1. Curr Opin Struct Biol - published October 1, 2016
    2. Nogales E, Louder RK, He Y

  • ESICM LIVES 2016: part three : Milan, Italy. 1-5 October 2016.

    1. Intensive Care Med Exp - published October 1, 2016
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    1. Nat Commun - published October 1, 2016
    2. Zhou YF, Metcalf MC, Garman SC, Edmunds T, Qiu H, Wei RR

  • Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel.

    1. Phys Chem Chem Phys - published October 1, 2016
    2. Markiewicz BN, Lemmin T, Zhang W, Ahmed IA, Jo H, Fiorin G, Troxler T, DeGrado WF, Gai F

  • Directed Evolution Reveals Unexpected Epistatic Interactions That Alter Metabolic Regulation and Enable Anaerobic Xylose Use by Saccharomyces cerevisiae.

    1. PLoS Genet - published October 1, 2016
    2. Sato TK, Tremaine M, Parreiras LS, Hebert AS, Myers KS, Higbee AJ, Sardi M, McIlwain SJ, Ong IM, Breuer RJ, Avanasi Narasimhan R, McGee MA, Dickinson Q, La Reau A, Xie D, Tian M, Reed JL, Zhang Y, Coon JJ, Hittinger CT, Gasch AP, Landick R

  • Aromatic claw: A new fold with high aromatic content that evades structural prediction.

    1. Protein Sci - published October 1, 2016
    2. Sachleben JR, Adhikari AN, Gawlak G, Hoey RJ, Liu G, Joachimiak A, Montelione GT, Sosnick TR, Koide S

  • The distinct traits of extracellular vesicles generated by transformed cells.

    1. Small GTPases - published October 1, 2016
    2. Antonyak MA, Cerione RA

  • Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics.

    1. Mol Plant - published October 1, 2016
    2. Huang S, Balgi A, Pan Y, Li M, Zhang X, Du L, Zhou M, Roberge M, Li X

  • Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors.

    1. ACS Med Chem Lett - published October 1, 2016
    2. Reed NI, Tang YZ, McIntosh J, Wu Y, Molnar KS, Civitavecchia A, Sheppard D, DeGrado WF, Jo H

  • Chemosterilants for Control of Insects and Insect Vectors of Disease.

    1. Chimia (Aarau) - published October 1, 2016
    2. Baxter RH

  • Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses.

    1. PLoS Pathog - published October 1, 2016
    2. Rabouw HH, Langereis MA, Knaap RC, Dalebout TJ, Canton J, Sola I, Enjuanes L, Bredenbeek PJ, Kikkert M, de Groot RJ, van Kuppeveld FJ

  • Building Viral Replication Organelles: Close Encounters of the Membrane Types.

    1. PLoS Pathog - published October 1, 2016
    2. Nagy PD, Strating JR, van Kuppeveld FJ

  • Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM.

    1. Protein Sci - published October 1, 2016
    2. Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Sun M, Espina N, Madison-Antenucci S, Tong L, Frank J

  • Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function.

    1. MBio - published October 1, 2016
    2. Simpson BW, Owens TW, Orabella MJ, Davis RM, May JM, Trauger SA, Kahne D, Ruiz N

  • Identification of a GUAAY Pentaloop Sequence Involved in a Novel RNA Loop-Helix Interaction.

    1. J Mol Biol - published October 1, 2016
    2. Chan RT, Keating KS, Go MC, Toor N
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