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137 Member Publications for July 2015

Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli.
1. J. Mol. Biol. - published July 31, 2015
2. Buchner S, Schlundt A, Lassak J, Sattler M, Jung K
Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1.
1. J. Mol. Biol. - published July 31, 2015
2. Owens GE, New DM, West AP, Bjorkman PJ
Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism.
1. ACS Chem. Biol. - published July 31, 2015
2. Zhao H, Palencia A, Seiradake E, Ghaemi Z, Cusack S, Luthey-Schulten Z, Martinis S
Association of VH4-59 Antibody Variable Gene Usage with Recognition of an Immunodominant Epitope on the HIV-1 Gag Protein.
1. PLoS One - published July 31, 2015
2. Chukwuma VU, Hicar MD, Chen X, Nicholas KJ, Joyner A, Kalams SA, Landucci G, Forthal DN, Spearman PW, Crowe JE Jr
The Structure of Immature Virus-Like Rous Sarcoma Virus Gag Particles Reveals a Structural Role for the p10 Domain in Assembly.
1. J. Virol. - published July 31, 2015
2. Schur FK, Dick RA, Hagen WJ, Vogt VM, Briggs JA
Unraveling the Molecular Structures of Asphaltenes by Atomic Force Microscopy.
1. J. Am. Chem. Soc. - published July 30, 2015
2. Schuler B, Meyer G, Peña D, Mullins OC, Gross L
Structured and Dynamic Disordered Domains Regulate the Activity of a Multifunctional Anti-σ Factor.
1. MBio - published July 30, 2015
2. Herrou J, Willett JW, Crosson S
Hypoxic metabolism in human hematopoietic stem cells.
1. Cell Biosci - published July 30, 2015
2. Kocabas F, Xie L, Xie J, Yu Z, DeBerardinis RJ, Kimura W, Thet S, Elshamy AF, Abouellail H, Muralidhar S, Liu X, Chen C, Sadek HA, Zhang CC, Zheng J
Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.
1. J. Biol. Chem. - published July 30, 2015
2. Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB
Tryptophan Lyase (NosL): Mechanistic Insights from Substrate Analogues and Mutagenesis.
1. Biochemistry - published July 29, 2015
2. Bhandari DM, Xu H, Nicolet Y, Fontecilla-Camps JC, Begley TP
Calmodulin and Ca(2+) control of voltage gated Na(+) channels.
1. Channels (Austin) - published July 29, 2015
2. Gabelli SB, Yoder JB, Tomaselli GF, Amzel LM
Evaluation of candidate vaccine approaches for MERS-CoV.
1. Nat Commun - published July 29, 2015
2. Wang L, Shi W, Joyce MG, Modjarrad K, Zhang Y, Leung K, Lees CR, Zhou T, Yassine HM, Kanekiyo M, Yang ZY, Chen X, Becker MM, Freeman M, Vogel L, Johnson JC, Olinger G, Todd JP, Bagci U, Solomon J, Mollura DJ, Hensley L, Jahrling P, Denison MR, Rao SS, Subbarao K, Kwong PD, Mascola JR, Kong WP, Graham BS
Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.
1. BMC Biol. - published July 29, 2015
2. Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D
Sphingomyelinase D inhibits store-operated Ca2+ entry in T lymphocytes by suppressing ORAI current.
1. J. Gen. Physiol. - published July 29, 2015
2. Combs DJ, Lu Z
The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity.
1. Front Immunol - published July 29, 2015
2. Napier RJ, Adams EJ, Gold MC, Lewinsohn DM
The STIM1-ORAI1 microdomain.
1. Cell Calcium - published July 29, 2015
2. Hogan PG
Substrate-bound Structures of Benzylsuccinate Synthase Reveal How Toluene is Activated in Anaerobic Hydrocarbon Degradation.
1. J. Biol. Chem. - published July 29, 2015
2. Funk MA, Marsh EN, Drennan CL
Structural Characterization of Interaction between Human Ubiquitin Specific Protease 7 and Immediate Early Protein ICP0 of Herpes Simplex Virus-1.
1. J. Biol. Chem. - published July 29, 2015
2. Pozhidaeva AK, Mohni KN, Dhe-Paganon S, Arrowsmith CH, Weller SK, Korzhnev DM, Bezsonova I
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection.
1. Sci Transl Med - published July 29, 2015
2. Yamamoto T, Lynch RM, Gautam R, Matus-Nicodemos R, Schmidt SD, Boswell KL, Darko S, Wong P, Sheng Z, Petrovas C, McDermott AB, Seder RA, Keele BF, Shapiro L, Douek DC, Nishimura Y, Mascola JR, Martin MA, Koup RA
One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.
1. Chembiochem - published July 27, 2015
2. Fischer M, Shoichet BK, Fraser JS
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
1. Nat. Genet. - published July 27, 2015
2. Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
1. Nat. Struct. Mol. Biol. - published July 27, 2015
2. Hodder AN, Sleebs BE, Czabotar PE, Gazdik M, Xu Y, O'Neill MT, Lopaticki S, Nebl T, Triglia T, Smith BJ, Lowes K, Boddey JA, Cowman AF
Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 27, 2015
2. Li JJ, Cao C, Fixsen SM, Young JM, Ono C, Bando H, Elde NC, Katsuma S, Dever TE, Sicheri F
Kinetic Dissection of the Pre-existing Conformational Equilibrium in the Trypsin Fold.
1. J. Biol. Chem. - published July 27, 2015
2. Vogt AD, Chakraborty P, Di Cera E
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 27, 2015
2. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A
SHIELD: an integrative gene expression database for inner ear research.
1. Database (Oxford) - published July 26, 2015
2. Shen J, Scheffer DI, Kwan KY, Corey DP
Fully Flexible Docking of Medium Sized Ligand Libraries with RosettaLigand.
1. PLoS ONE - published July 25, 2015
2. DeLuca S, Khar K, Meiler J
Structure-Function Analyses of the Interactions between Rab11 and Rab14 Small GTPases with Their Shared Effector Rab Coupling Protein (RCP).
1. J. Biol. Chem. - published July 24, 2015
2. Lall P, Lindsay AJ, Hanscom S, Kecman T, Taglauer ES, McVeigh UM, Franklin E, McCaffrey MW, Khan AR
Protein-Protein Interactions in the Cyanobacterial Circadian Clock: Structure of KaiA Dimer in Complex with C-Terminal KaiC Peptides at 2.8 Å Resolution.
1. Biochemistry - published July 24, 2015
2. Pattanayek R, Egli M
On-surface generation and imaging of arynes by atomic force microscopy.
1. Nat Chem - published July 24, 2015
2. Pavliček N, Schuler B, Collazos S, Moll N, Pérez D, Guitián E, Meyer G, Peña D, Gross L
Tubulin cofactors and Arl2 are cage-like chaperones that regulate the soluble αβ-tubulin pool for microtubule dynamics.
1. Elife - published July 24, 2015
2. Nithianantham S, Le S, Seto E, Jia W, Leary J, Corbett KD, Moore JK, Al-Bassam J
Structure of yeast Ape1 and its role in autophagic vesicle formation.
1. Autophagy - published July 24, 2015
2. Su MY, Peng WH, Ho MR, Su SC, Chang YC, Chen GC, Chang CI
Apoglobin Stability Is the Major Factor Governing both Cell-Free and In Vivo Expression of Holomyoglobin.
1. J. Biol. Chem. - published July 23, 2015
2. Samuel PP, Smith LP, Phillips GN, Olson JS
Biochemical Characterization of a Recombinant UDP-glucosyltransferase from Rice and Enzymatic Production of Deoxynivalenol-3-O-β-D-glucoside.
1. Toxins (Basel) - published July 22, 2015
2. Michlmayr H, Malachová A, Varga E, Kleinová J, Lemmens M, Newmister S, Rayment I, Berthiller F, Adam G
Noncanonical sortase-mediated assembly of pilus type 2b in group B Streptococcus.
1. FASEB J. - published July 22, 2015
2. Lazzarin M, Cozzi R, Malito E, Martinelli M, D'Onofrio M, Maione D, Margarit I, Rinaudo CD
Crystal structures of a polypeptide processing and secretion transporter.
1. Nature - published July 22, 2015
2. Lin DY, Huang S, Chen J
BpsB is a Poly-β-1,6-N-acetyl-D-glucosamine Deacetylase Required for Biofilm Formation in Bordetella bronchiseptica.
1. J. Biol. Chem. - published July 22, 2015
2. Little DJ, Milek S, Bamford NC, Ganguly T, DiFrancesco BR, Nitz M, Deora R, Howell PL
Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1.
1. ACS Cent Sci - published July 22, 2015
2. Eller CH, Chao TY, Singarapu KK, Ouerfelli O, Yang G, Markley JL, Danishefsky SJ, Raines RT
Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide.
1. ACS Chem. Biol. - published July 21, 2015
2. Edwards AL, Wachter F, Lammert M, Huhn AJ, Luccarelli J, Bird GH, Walensky LD
MolProbity for the masses-of data.
1. J. Biomol. NMR - published July 21, 2015
2. Chen VB, Wedell JR, Wenger RK, Ulrich EL, Markley JL
Toggling the Local Electric Field with an Embedded Adatom Switch.
1. Nano Lett. - published July 20, 2015
2. Steurer W, Schuler B, Pavliček N, Gross L, Scivetti I, Persson M, Meyer G
Genomic landscape of cutaneous T cell lymphoma.
1. Nat. Genet. - published July 20, 2015
2. Choi J, Goh G, Walradt T, Hong BS, Bunick CG, Chen K, Bjornson RD, Maman Y, Wang T, Tordoff J, Carlson K, Overton JD, Liu KJ, Lewis JM, Devine L, Barbarotta L, Foss FM, Subtil A, Vonderheid EC, Edelson RL, Schatz DG, Boggon TJ, Girardi M, Lifton RP
Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.
1. Nat. Biotechnol. - published July 20, 2015
2. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J
Contacts-based prediction of binding affinity in protein-protein complexes.
1. Elife - published July 20, 2015
2. Vangone A, Bonvin AM
CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 20, 2015
2. Bae B, Nayak D, Ray A, Mustaev A, Landick R, Darst SA
Toward a sustainable biomedical research enterprise: Finding consensus and implementing recommendations.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 20, 2015
2. Pickett CL, Corb BW, Matthews CR, Sundquist WI, Berg JM
Point mutations of the mTOR-RHEB pathway in renal cell carcinoma.
1. Oncotarget - published July 20, 2015
2. Ghosh AP, Marshall CB, Coric T, Shim EH, Kirkman R, Ballestas ME, Ikura M, Bjornsti MA, Sudarshan S
Conformational Changes of the Clamp of the Protein Translocation ATPase SecA.
1. J Mol Biol - published July 17, 2015
2. Chen Y, Bauer BW, Rapoport TA, Gumbart JC
A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.
1. J. Mol. Biol. - published July 17, 2015
2. Potempa M, Nalivaika E, Ragland D, Lee SK, Schiffer CA, Swanstrom R
Negative Epistasis and Evolvability in TEM-1 β-Lactamase-The Thin Line between an Enzyme's Conformational Freedom and Disorder.
1. J. Mol. Biol. - published July 17, 2015
2. Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS
Gas-Phase FRET Efficiency Measurements To Probe the Conformation of Mass-Selected Proteins.
1. Anal. Chem. - published July 17, 2015
2. Czar MF, Zosel F, König I, Nettels D, Wunderlich B, Schuler B, Zarrine-Afsar A, Jockusch RA
RNA and Nucleocapsid Are Dispensable for Mature HIV-1 Capsid Assembly.
1. J. Virol. - published July 17, 2015
2. Mattei S, Flemming A, Anders-Össwein M, Kräusslich HG, Briggs JA, Müller B
Genome-wide association analysis on Normal Hearing Function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
1. Hum. Mol. Genet. - published July 17, 2015
2. Vuckovic D, Dawson S, Scheffer DI, Rantanen T, Morgan A, Di Stazio M, Vozzi D, Nutile T, Concas MP, Biino G, Nolan L, Bahl A, Loukola A, Viljanen A, Davis A, Ciullo M, Corey DP, Pirastu M, Gasparini P, Girotto G
Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.
1. Cell - published July 16, 2015
2. Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SP
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.
1. Mol. Cell - published July 16, 2015
2. Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P
Phospholipid scrambling by rhodopsin.
1. Photochem. Photobiol. Sci. - published July 16, 2015
2. Ernst OP, Menon AK
Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain.
1. J. Med. Chem. - published July 15, 2015
2. Unzue A, Xu M, Dong J, Wiedmer L, Spiliotopoulos D, Caflisch A, Nevado C
Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.
1. J. Immunol. - published July 15, 2015
2. Sakala IG, Kjer-Nielsen L, Eickhoff CS, Wang X, Blazevic A, Liu L, Fairlie DP, Rossjohn J, McCluskey J, Fremont DH, Hansen TH, Hoft DF
Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.
1. J. Immunol. - published July 15, 2015
2. Yin L, Maben ZJ, Becerra A, Stern LJ
Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics.
1. J. Med. Chem. - published July 15, 2015
2. Xu M, Unzue A, Dong J, Spiliotopoulos D, Nevado C, Caflisch A
Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.
1. BMC Struct. Biol. - published July 15, 2015
2. Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S
Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica(¶).
1. Protein Sci. - published July 15, 2015
2. Salinger AJ, Brown HA, Thoden JB, Holden HM
Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression.
1. Protein Sci. - published July 15, 2015
2. Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D
Structures of adenovirus incomplete particles clarify capsid architecture and show maturation changes of packaging protein L1 52/55k.
1. J. Virol. - published July 15, 2015
2. Condezo GN, Marabini R, Ayora S, Carazo JM, Alba R, Chillón M, San Martín C
A coiled coil switch mediates cold sensing by the thermosensory protein DesK.
1. Mol. Microbiol. - published July 14, 2015
2. Saita E, Abriata LA, Tsai YT, Trajtenberg F, Lemmin T, Buschiazzo A, Dal Peraro M, de Mendoza D, Albanesi D
Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
1. Mol. Endocrinol. - published July 14, 2015
2. Pallan PS, Lei L, Wang C, Waterman MR, Guengerich FP, Egli M
Structure of the external aldimine form of PglE, an aminotransferase required for N,N'-diacetylbacillosamine biosynthesis.
1. Protein Sci. - published July 14, 2015
2. Riegert AS, Young NM, Watson DC, Thoden JB, Holden HM
Molecular Architecture of KedS8, a Sugar N-Methyltransferase from Streptoalloteichus sp. ATCC 53650.
1. Protein Sci. - published July 14, 2015
2. Delvaux NA, Thoden JB, Holden HM
A hybrid method for protein-protein interface prediction.
1. Protein Sci. - published July 14, 2015
2. Hwang H, Petrey D, Honig B
Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry.
1. Biochemistry - published July 13, 2015
2. Thoden JB, Vinogradov E, Gilbert M, Salinger AJ, Holden HM
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks.
1. Nat. Struct. Mol. Biol. - published July 13, 2015
2. Huang H, Strømme CB, Saredi G, Hödl M, Strandsby A, González-Aguilera C, Chen S, Groth A, Patel DJ
Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia.
1. Leukemia - published July 13, 2015
2. Wu H, Hu C, Wang A, Weisberg EL, Chen Y, Yun CH, Wang W, Liu Y, Liu X, Tian B, Wang J, Zhao Z, Liang Y, Li B, Wang L, Wang B, Chen C, Buhrlage SJ, Qi Z, Zou F, Nonami A, Li Y, Fernandes SM, Adamia S, Stone RM, Galinsky IA, Wang X, Yang G, Griffin JD, Brown JR, Eck MJ, Liu J, Gray NS, Liu Q
Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion.
1. Nat. Struct. Mol. Biol. - published July 13, 2015
2. Brüschweiler S, Yang Q, Run C, Chou JJ
Impact of the N-terminal domain of STAT3 in STAT3-dependent transcriptional activity.
1. Mol. Cell. Biol. - published July 13, 2015
2. Hu T, Yeh JE, Pinello L, Jacob J, Chakravarthy S, Yuan GC, Chopra R, Frank DA
Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 13, 2015
2. Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M
Histone Core Phosphorylation Regulates DNA Accessibility.
1. J. Biol. Chem. - published July 13, 2015
2. Brehove M, Wang T, North J, Luo Y, Dreher SJ, Shimko JC, Ottesen JJ, Luger K, Poirier MG
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
1. Cancer Cell - published July 13, 2015
2. Wu SC, Li LS, Kopp N, Montero J, Chapuy B, Yoda A, Christie AL, Liu H, Christodoulou A, van Bodegom D, van der Zwet J, Layer JV, Tivey T, Lane AA, Ryan JA, Ng SY, DeAngelo DJ, Stone RM, Steensma D, Wadleigh M, Harris M, Mandon E, Ebel N, Andraos R, Romanet V, Dölemeyer A, Sterker D, Zender M, Rodig SJ, Murakami M, Hofmann F, Kuo F, Eck MJ, Silverman LB, Sallan SE, Letai A, Baffert F, Vangrevelinghe E, Radimerski T, Gaul C, Weinstock DM
Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays.
1. Sci Rep - published July 11, 2015
2. Xiong Tan B, Brown CJ, Ferrer FJ, Yuen TY, Quah ST, Chan BH, Jansson AE, Teo HL, Nordlund P, Lane DP
Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.
1. PLoS Pathog. - published July 11, 2015
2. Gilman MS, Moin SM, Mas V, Chen M, Patel NK, Kramer K, Zhu Q, Kabeche SC, Kumar A, Palomo C, Beaumont T, Baxa U, Ulbrandt ND, Melero JA, Graham BS, McLellan JS
Writing and Reading the Tubulin Code.
1. J. Biol. Chem. - published July 10, 2015
2. Yu I, Garnham CP, Roll-Mecak A
The higher-order molecular organization of p62/SQSTM1.
1. Oncotarget - published July 10, 2015
2. Johansen T, Sachse C
CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells.
1. Sci Rep - published July 10, 2015
2. Han J, Chu J, Keung Chan W, Zhang J, Wang Y, Cohen JB, Victor A, Meisen WH, Kim SH, Grandi P, Wang QE, He X, Nakano I, Chiocca EA, Glorioso JC, Kaur B, Caligiuri MA, Yu J
Future opportunities and trends for e-infrastructures and life sciences: going beyond the grid to enable life science data analysis.
1. Front Genet - published July 10, 2015
2. Duarte AM, Psomopoulos FE, Blanchet C, Bonvin AM, Corpas M, Franc A, Jimenez RC, de Lucas JM, Nyrönen T, Sipos G, Suhr SB
PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.
1. Science - published July 10, 2015
2. Ren R, Zhou X, He Y, Ke M, Wu J, Liu X, Yan C, Wu Y, Gong X, Lei X, Yan SF, Radhakrishnan A, Yan N
Disulfide-bridged peptide macrobicycles from nature.
1. Org. Biomol. Chem. - published July 10, 2015
2. Chung BK, Yudin AK
VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly.
1. Science - published July 10, 2015
2. Dodonova SO, Diestelkoetter-Bachert P, von Appen A, Hagen WJ, Beck R, Beck M, Wieland F, Briggs JA
Rapid Filament Supramolecular Chirality Reversal of HET-s (218-289) Prion Fibrils Driven by pH Elevation.
1. J Phys Chem B - published July 9, 2015
2. Shanmugasundaram M, Kurouski D, Wan W, Stubbs G, Dukor RK, Nafie LA, Lednev IK
Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-Å resolution.
1. Nat Commun - published July 9, 2015
2. Quade N, Boehringer D, Leibundgut M, van den Heuvel J, Ban N
A Compact Structure of Cytochrome c Trapped in a Lysine-Ligated State: Loop Refolding and Functional Implications of a Conformational Switch.
1. J Am Chem Soc - published July 8, 2015
2. Amacher JF, Zhong F, Lisi GP, Zhu MQ, Alden SL, Hoke KR, Madden DR, Pletneva EV
Antibody-Drug Conjugates for Tumor Targeting-Novel Conjugation Chemistries and the Promise of non-IgG Binding Proteins.
1. Bioconjug. Chem. - published July 8, 2015
2. Merten H, Brandl F, Plückthun A, Zangemeister-Wittke U
Rate Motifs Tune Auxin/Indole-3-Acetic Acid Degradation Dynamics.
1. Plant Physiol. - published July 8, 2015
2. Moss BL, Mao H, Guseman JM, Hinds TR, Hellmuth A, Kovenock M, Noorassa A, Lanctot A, Villalobos LI, Zheng N, Nemhauser JL
Position and orientational preferences of drug-like compounds in lipid membranes: a computational and NMR approach.
1. Phys Chem Chem Phys - published July 8, 2015
2. Ma J, Domicevica L, Schnell JR, Biggin PC
Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Pre-fusion F Protein Expressed by a Vaccine Candidate.
1. J. Virol. - published July 8, 2015
2. Liang B, Surman S, Amaro-Carambot E, Kabatova B, Mackow N, Lingemann M, Yang L, McLellan JS, Graham BS, Kwong PD, Schaap-Nutt A, Collins PL, Munir S
Resolving cryptic aspects of cryptochrome signaling.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 8, 2015
2. Zoltowski BD
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
1. Cell Host Microbe - published July 8, 2015
2. Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE Jr
Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders.
1. Cell Host Microbe - published July 8, 2015
2. Spaulding CN, Dodson KW, Chapman MR, Hultgren SJ
Conformational Plasticity of the POTRA 5 Domain in the Outer Membrane Protein Assembly Factor BamA.
1. Structure - published July 7, 2015
2. Sinnige T, Weingarth M, Daniëls M, Boelens R, Bonvin AM, Houben K, Baldus M
Distinctive Properties of the Nuclear Localization Signals of Inner Nuclear Membrane Proteins Heh1 and Heh2.
1. Structure - published July 7, 2015
2. Lokareddy RK, Hapsari RA, van Rheenen M, Pumroy RA, Bhardwaj A, Steen A, Veenhoff LM, Cingolani G
Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.
1. Structure - published July 7, 2015
2. Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SC
Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity.
1. Structure - published July 7, 2015
2. Couñago RM, Knapp KM, Nakatani Y, Fleming SB, Corbett M, Wise LM, Mercer AA, Krause KL
Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections.
1. PLoS Pathog. - published July 7, 2015
2. Cho H, Jeong DW, Liu Q, Yeo WS, Vogl T, Skaar EP, Chazin WJ, Bae T
Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.
1. PLoS Comput. Biol. - published July 7, 2015
2. Sevy AM, Jacobs TM, Crowe JE, Meiler J
Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells.
1. Nat. Methods - published July 6, 2015
2. König I, Zarrine-Afsar A, Aznauryan M, Soranno A, Wunderlich B, Dingfelder F, Stüber JC, Plückthun A, Nettels D, Schuler B
Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course.
1. Biochem Mol Biol Educ - published July 6, 2015
2. Gray C, Price CW, Lee CT, Dewald AH, Cline MA, McAnany CE, Columbus L, Mura C
Biased Brownian motion as a mechanism to facilitate nanometer-scale exploration of the microtubule plus end by a kinesin-8.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 6, 2015
2. Shin Y, Du Y, Collier SE, Ohi MD, Lang MJ, Ohi R
Structure and mechanism of the ATPase that powers viral genome packaging.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 6, 2015
2. Hilbert BJ, Hayes JA, Stone NP, Duffy CM, Sankaran B, Kelch BA
Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 6, 2015
2. Taylor KC, Buvoli M, Korkmaz EN, Buvoli A, Zheng Y, Heinze NT, Cui Q, Leinwand LA, Rayment I
Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.
1. Proc. Natl. Acad. Sci. U.S.A. - published July 6, 2015
2. Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H
Transmembrane signaling: A multiplex problem with converging solutions.
1. Prog. Biophys. Mol. Biol. - published July 5, 2015
2. Chou JJ, Wang JH
MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): The new generation guideline implementation.
1. Allergy - published July 4, 2015
2. Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, Valiulis A, Wickman M, Zuberbier T, Bosnic-Anticevitch S, Bedbrook A, Bergmann KC, Caimmi D, Dahl R, Fokkens WJ, Grisle I, Lodrup Carlsen K, Mullol J, Muraro A, Palkonen S, Papadopoulos N, Passalacqua G, Ryan D, Valovirta E, Yorgancioglu A, Aberer W, Agache I, Adachi M, Akdis CA, Akdis M, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Baiardini I, Baigenzhin AK, Barbara C, Bateman ED, Beghé B, Bel EH, Ben Kheder A, Bennoor KS, Benson M, Bewick M, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Boner AL, Boulet LP, Bonini M, Bonini S, Bosse I, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Calderon MA, Camargos PA, Camuzat T, Carlsen KH, Carr W, Cepeda Sarabia AM, Chavannes NH, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Ciprandi G, Cirule I, Correia de Sousa J, Cox L, Crooks G, Costa DJ, Custovic A, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Fink Wagner A, Fletcher M, Fiocchi A, Forastiere F, Gamkrelidze A, Gemicioğlu B, Gereda JE, González Diaz S, Gotua M, Grouse L, Guzmán MA, Haahtela T, Hellquist-Dahl B, Heinrich J, Horak F, Hourihane JO, Howarth P, Humbert M, Hyland ME, Ivancevich JC, Jares EJ, Johnston SL, Joos G, Jonquet O, Jung KS, Just J, Kaidashev I, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Khaltaev N, Klimek L, Koffi N'Goran B, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LT, Lieberman P, Lipworth B, Li J, Louis R, Magard Y, Magnan A, Mahboub B, Majer I, Makela MJ, Manning P, De Manuel Keenoy E, Marshall GD, Masjedi MR, Maurer M, Mavale-Manuel S, Melén E, Melo-Gomes E, Meltzer EO, Merk H, Miculinic N, Mihaltan F, Milenkovic B, Mohammad Y, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Mösges R, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Nyembue TD, O'Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schöll I, Palmer S, Panzner P, Papi A, Park HS, Pavord I, Pawankar R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Pohl W, Popov TA, Portejoie F, Postma D, Potter P, Price D, Rabe KF, Raciborski F, Radier Pontal F, Repka-Ramirez S, Robalo-Cordeiro C, Rolland C, Rosado-Pinto J, Reitamo S, Rodenas F, Roman Rodriguez M, Romano A, Rosario N, Rosenwasser L, Rottem M, Sanchez-Borges M, Scadding GK, Serrano E, Schmid-Grendelmeier P, Sheikh A, Simons FE, Sisul JC, Skrindo I, Smit HA, Solé D, Sooronbaev T, Spranger O, Stelmach R, Strandberg T, Sunyer J, Thijs C, Todo-Bom A, Triggiani M, Valenta R, Valero AL, van Hage M, Vandenplas O, Vezzani G, Vichyanond P, Viegi G, Wagenmann M, Walker S, Wang DY, Wahn U, Williams DM, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, Mercier J
A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.
1. J. Biol. Chem. - published July 3, 2015
2. Jégouzo SA, Feinberg H, Dungarwalla T, Drickamer K, Weis WI, Taylor ME
Conformational plasticity of a native retroviral capsid revealed by x-ray crystallography.
1. Science - published July 3, 2015
2. Obal G, Trajtenberg F, Carrión F, Tomé L, Larrieux N, Zhang X, Pritsch O, Buschiazzo A
Structural Model of RNA Polymerase II Elongation Complex with Complete Transcription Bubble Reveals NTP Entry Routes.
1. PLoS Comput. Biol. - published July 3, 2015
2. Zhang L, Silva DA, Pardo-Avila F, Wang D, Huang X
Characterizing rhodopsin signaling by EPR spectroscopy: from structure to dynamics.
1. Photochem. Photobiol. Sci. - published July 3, 2015
2. Van Eps N, Caro LN, Morizumi T, Ernst OP
DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
1. Science - published July 3, 2015
2. Fibriansah G, Ibarra KD, Ng TS, Smith SA, Tan JL, Lim XN, Ooi JS, Kostyuchenko VA, Wang J, de Silva AM, Harris E, Crowe JE Jr, Lok SM
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.
1. Cell - published July 3, 2015
2. Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A
Structural Biology: A Century-long Journey into an Unseen World.
1. Interdiscip Sci Rev - published July 3, 2015
2. Curry S
Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.
1. Nature - published July 2, 2015
2. Bharat TA, Murshudov GN, Sachse C, Löwe J
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs.
1. Mol. Cell - published July 2, 2015
2. Noh KM, Wang H, Kim HR, Wenderski W, Fang F, Li CH, Dewell S, Hughes SH, Melnick AM, Patel DJ, Li H, Allis CD
Uncoupling Promoter Opening from Start-Site Scanning.
1. Mol. Cell - published July 2, 2015
2. Murakami K, Mattei PJ, Davis RE, Jin H, Kaplan CD, Kornberg RD
Molecular-Level Insight into the Differential Oxidase and Oxygenase Reactivities of de Novo Due Ferri Proteins.
1. J Am Chem Soc - published July 2, 2015
2. Snyder RA, Butch SE, Reig AJ, DeGrado WF, Solomon EI
Protective efficacy of adenovirus-protein vaccines against SIV challenges in rhesus monkeys.
1. Science - published July 2, 2015
2. Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H
AIP1 expression in tumor niche suppresses tumor progression and metastasis.
1. Cancer Res. - published July 2, 2015
2. Ji W, Li Y, He Y, Yin M, Zhou HJ, Boggon TJ, Zhang H, Min W
Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site.
1. Proc Natl Acad Sci U S A - published July 2, 2015
2. Kumar H, Finer-Moore JS, Kaback HR, Stroud RM
Vaccine-elicited antibody that neutralizes H5N1 influenza and variants binds the receptor site and polymorphic sites.
1. Proc Natl Acad Sci U S A - published July 2, 2015
2. Winarski KL, Thornburg NJ, Yu Y, Sapparapu G, Crowe JE Jr, Spiller BW
c.1058C>T variant in the SERPINC1 gene is pathogenic for antithrombin deficiency.
1. Br J Haematol - published July 1, 2015
2. Kumar R, Dawson JE, Chan AK, Forman-Kay JD, Kahr WH, Williams S
Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.
1. Glycobiology - published July 1, 2015
2. Yoshida-Moriguchi T, Campbell KP
Ecotin: Exploring a feasible antithrombotic profile.
1. Int J Biol Macromol - published July 1, 2015
2. Wermelinger LS, Frattani FS, Carneiro-Lobo TC, Craik CS, Castro HC, Zingali RB
Effect of intercalator substituent and nucleotide sequence on the stability of DNA- and RNA-naphthalimide complexes.
1. Bioorg. Med. Chem. - published July 1, 2015
2. Johnson CA, Hudson GA, Hardebeck LK, Jolley EA, Ren Y, Lewis M, Znosko BM
Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning.
1. Mol Biol Cell - published July 1, 2015
2. Peng Y, Moritz M, Han X, Giddings TH, Lyon A, Kollman J, Winey M, Yates J 3rd, Agard DA, Drubin DG, Barnes G
Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
1. J Biol Chem - published July 1, 2015
2. Callaway JB, Smith SA, McKinnon KP, de Silva AM, Crowe JE Jr, Ting JP
Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex.
1. J Biol Chem - published July 1, 2015
2. Hudson GM, Watson PJ, Fairall L, Jamieson AG, Schwabe JWR
MicroED data collection and processing.
1. Acta Crystallogr A Found Adv - published July 1, 2015
2. Hattne J, Reyes FE, Nannenga BL, Shi D, de la Cruz MJ, Leslie AG, Gonen T
Extended Conformation of the Proline-rich Domain of Human Aryl Hydrocarbon Receptor-Interacting Protein-like 1: Implications for Retina Disease.
1. J. Neurochem. - published July 1, 2015
2. Yadav RP, Majumder A, Gakhar L, Artemyev NO
CRISPR-Cas9: Prospects and Challenges.
1. Hum Gene Ther - published July 1, 2015
2. Zhang F
Temperature Accelerated Molecular Dynamics with Soft-Ratcheting Criterion Orients Enhanced Sampling by Low-Resolution Information.
1. J Chem Theory Comput - published July 1, 2015
2. Cortes-Ciriano I, Bouvier G, Nilges M, Maragliano L, Malliavin TE
Artificial Diiron Enzymes with a De Novo Designed Four-Helix Bundle Structure.
1. Eur J Inorg Chem - published July 1, 2015
2. Chino M, Maglio O, Nastri F, Pavone V, DeGrado WF, Lombardi A