Member Publications

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160 Member Publications for June 2015

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
1. PLoS ONE - published June 30, 2015
2. Trésaugues L, Lundbäck T, Welin M, Flodin S, Nyman T, Silvander C, Gräslund S, Nordlund P
Proteolysis of EphA2 converts it from a tumor suppressor to an oncoprotein.
1. Cancer Res. - published June 30, 2015
2. Koshikawa N, Hoshino D, Taniguchi H, Minegishi T, Tomari T, Nam SO, Aoki M, Sueta T, Nakagawa T, Miyamoto S, Nabeshima K, Weaver AM, Seiki M
Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli.
1. MBio - published June 30, 2015
2. Greene SE, Hibbing ME, Janetka J, Chen SL, Hultgren SJ
Group II Intron Lariat: Structural insights into the spliceosome.
1. RNA Biol - published June 29, 2015
2. Peters JK, Toor N
Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
1. Nat. Methods - published June 29, 2015
2. Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, Lin ZY, Lopez MF, Loppnau P, Miersch S, Nguyen T, Olsen JB, Paduch M, Ravichandran M, Seitova A, Vadali G, Vogelsang MS, Whiteaker JR, Zhong G, Zhong N, Zhao L, Aebersold R, Arrowsmith CH, Emili A, Frappier L, Gingras AC, Gstaiger M, Paulovich AG, Koide S, Kossiakoff AA, Sidhu SS, Wodak SJ, Gräslund S, Greenblatt JF, Edwards AM
Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 29, 2015
2. Willett JW, Herrou J, Briegel A, Rotskoff G, Crosson S
Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 29, 2015
2. Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW
Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex.
1. Nature - published June 29, 2015
2. Wang L, Zhou Y, Xu L, Xiao R, Lu X, Chen L, Chong J, Li H, He C, Fu XD, Wang D
Analysis of the role of the C-terminal tail in the regulation of the epidermal growth factor receptor.
1. Mol. Cell. Biol. - published June 29, 2015
2. Kovacs E, Das R, Wang Q, Collier TS, Cantor A, Huang Y, Wong K, Mirza A, Barros T, Grob P, Jura N, Bose R, Kuriyan J
The ribosomal S10 protein is a general target for decreased tigecycline susceptibility.
1. Antimicrob. Agents Chemother. - published June 29, 2015
2. Beabout K, Hammerstrom TG, Perez AM, Magalhães BF, Prater AG, Clements TP, Arias CA, Saxer G, Shamoo Y
Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining.
1. Nucleic Acids Res. - published June 29, 2015
2. Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T
Structure and gating of the nuclear pore complex.
1. Nat Commun - published June 27, 2015
2. Eibauer M, Pellanda M, Turgay Y, Dubrovsky A, Wild A, Medalia O
Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
1. Nucleic Acids Res. - published June 27, 2015
2. Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN
The unexplored relationship between urinary tract infections and the autonomic nervous system.
1. Auton Neurosci - published June 26, 2015
2. Hibbing ME, Conover MS, Hultgren SJ
STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition.
1. Science - published June 26, 2015
2. Jiang F, Zhou K, Ma L, Gressel S, Doudna JA
Wiring of Photosystem II to Hydrogenase for Photoelectrochemical Water Splitting.
1. J. Am. Chem. Soc. - published June 25, 2015
2. Mersch D, Lee CY, Zhang JZ, Brinkert K, Fontecilla-Camps JC, Rutherford AW, Reisner E
Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors.
1. J. Med. Chem. - published June 25, 2015
2. Ran X, Zhao Y, Liu L, Bai L, Yang CY, Zhou B, Meagher JL, Chinnaswamy K, Stuckey JA, Wang S
Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics.
1. PLoS One - published June 25, 2015
2. Widjaja I, Rigter A, Jacobino S, van Kuppeveld FJ, Leenhouts K, Palomo C, Melero JA, Leusen JH, Haijema BJ, Rottier PJ, de Haan CA
Synthesis of Previously Inaccessible Borylated Heterocycle Motifs Using Novel Boron-Containing Amphoteric Molecules.
1. Angew. Chem. Int. Ed. Engl. - published June 25, 2015
2. Trinchera P, Corless VB, Yudin AK
Effect of the cytoplasmic domain on antigenic characteristics of HIV-1 envelope glycoprotein.
1. Science - published June 25, 2015
2. Chen J, Kovacs JM, Peng H, Rits-Volloch S, Lu J, Park D, Zablowsky E, Seaman MS, Chen B
The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism.
1. Biochemistry - published June 24, 2015
2. Gibson MI, Brignole EJ, Pierce E, Can M, Ragsdale SW, Drennan CL
Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion.
1. J. Cereb. Blood Flow Metab. - published June 24, 2015
2. Hung VK, Yeung PK, Lai AK, Ho MC, Lo AC, Chan KC, Wu EX, Chung SS, Cheung CW, Chung SK
Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle.
1. Diabetes - published June 24, 2015
2. Ramirez-Correa GA, Ma J, Slawson C, Zeidan Q, Lugo-Fagundo NS, Xu M, Shen X, Gao WD, Caceres V, Chakir K, DeVine L, Cole R, Marchionni L, Paolocci N, Hart GW, Murphy AM
The great (nuclear) escape: new insights into the role of the nuclear egress complex of herpesviruses.
1. J. Virol. - published June 24, 2015
2. Bigalke JM, Heldwein EE
Structural Basis for the Stereochemical Control of Amine Installation in Nucleotide Sugar Aminotransferases.
1. ACS Chem. Biol. - published June 23, 2015
2. Wang F, Singh S, Xu W, Helmich KE, Miller MD, Cao H, Bingman CA, Thorson JS, Phillips GN
A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus.
1. PLoS ONE - published June 23, 2015
2. Stewart-Jones GB, Thomas PV, Chen M, Druz A, Joyce MG, Kong WP, Sastry M, Soto C, Yang Y, Zhang B, Chen L, Chuang GY, Georgiev IS, McLellan JS, Srivatsan S, Zhou T, Baxa U, Mascola JR, Graham BS, Kwong PD
Retrovirus-Mediated Expression of E2A-PBX1 Blocks Lymphoid Fate but Permits Retention of Myeloid Potential in Early Hematopoietic Progenitors.
1. PLoS ONE - published June 23, 2015
2. Woodcroft MW, Nanan K, Thompson P, Tyryshkin K, Smith SP, Slany RK, LeBrun DP
Affinity Purification of a Recombinant Protein Expressed as a Fusion with the Maltose-Binding Protein (MBP) Tag.
1. Methods Enzymol - published June 23, 2015
2. Duong-Ly KC, Gabelli SB
Affinity Purification of Protein Complexes Using TAP Tags.
1. Meth. Enzymol. - published June 23, 2015
2. Gerace E, Moazed D
Affinity Pull-Down of Proteins Using Anti-FLAG M2 Agarose Beads.
1. Meth. Enzymol. - published June 23, 2015
2. Gerace E, Moazed D
A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterization of bacterial free oligosaccharides.
1. Anal Bioanal Chem - published June 23, 2015
2. Jang KS, Nani RR, Kalli A, Levin S, Müller A, Hess S, Reisman SE, Clemons WM
Less than the sum of its parts, a leinamycin precursor has superior properties.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 23, 2015
2. Katt WP, Cerione RA
Establishment and Characterization of UTI and CAUTI in a Mouse Model.
1. J Vis Exp - published June 23, 2015
2. Conover MS, Flores-Mireles AL, Hibbing ME, Dodson K, Hultgren SJ
Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
1. Dev. Cell - published June 22, 2015
2. Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC
A fast iterative convolution weighting approach for gridding-based direct Fourier three-dimensional reconstruction with correction for the contrast transfer function.
1. Ultramicroscopy - published June 22, 2015
2. Abrishami V, Bilbao-Castro JR, Vargas J, Marabini R, Carazo JM, Sorzano CO
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
1. Nat. Struct. Mol. Biol. - published June 22, 2015
2. Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD
Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.
1. Nat. Med. - published June 22, 2015
2. Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP
Human neutralizing antibodies against MERS coronavirus: implications for future immunotherapy.
1. Immunotherapy - published June 22, 2015
2. Tang XC, Marasco WA
X-ray structure of a mammalian stearoyl-CoA desaturase.
1. Nature - published June 22, 2015
2. Bai Y, McCoy JG, Levin EJ, Sobrado P, Rajashankar KR, Fox BG, Zhou M
TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.
1. EMBO J. - published June 22, 2015
2. Fletcher AJ, Christensen DE, Nelson C, Tan CP, Schaller T, Lehner PJ, Sundquist WI, Towers GJ
Induced folding in RNA recognition by Arabidopsis thaliana DCL1.
1. Nucleic Acids Res. - published June 22, 2015
2. Suarez IP, Burdisso P, Benoit MP, Boisbouvier J, Rasia RM
Cyclic di-GMP-regulated periplasmic proteolysis of a Pseudomonas aeruginosa type Vb secretion system substrate.
1. J. Bacteriol. - published June 22, 2015
2. Cooley RB, Smith TJ, Leung W, Tierney V, Borlee BR, O'Toole GA, Sondermann H
Even with nonnative interactions, the updated folding transition states of the homologs Proteins G & L are extensive and similar.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 22, 2015
2. Baxa MC, Yu W, Adhikari AN, Ge L, Xia Z, Zhou R, Freed KF, Sosnick TR
Simultaneous Utilization of Cellobiose, Xylose, and Acetic Acid from Lignocellulosic Biomass for Biofuel Production by an Engineered Yeast Platform.
1. ACS Synth Biol - published June 19, 2015
2. Wei N, Oh EJ, Million G, Cate JH, Jin YS
Excited State Relaxation of Neutral and Basic 8-Oxoguanine.
1. J Phys Chem B - published June 19, 2015
2. Lu Z, Beckstead AA, Kohler B, Matsika S
Genomic Heterogeneity of Methicillin Resistant Staphylococcus aureus Associated with Variation in Severity of Illness among Children with Acute Hematogenous Osteomyelitis.
1. PLoS ONE - published June 19, 2015
2. Gaviria-Agudelo C, Aroh C, Tareen N, Wakeland EK, Kim M, Copley LA
Structural Analysis of the Roles of Influenza A Virus Membrane-Associated Proteins in Assembly and Morphology.
1. J. Virol. - published June 19, 2015
2. Chlanda P, Schraidt O, Kummer S, Riches J, Oberwinkler H, Prinz S, Kräusslich HG, Briggs JA
PROTEIN DESIGN. Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces.
1. Science - published June 19, 2015
2. Gonen S, DiMaio F, Gonen T, Baker D
CELL BIOLOGY. An ESCRT to seal the envelope.
1. Science - published June 19, 2015
2. Sundquist WI, Ullman KS
Structural D/E-rich repeats play multiple roles especially in gene regulation through DNA/RNA mimicry.
1. Mol Biosyst - published June 19, 2015
2. Chou CC, Wang AH
ENDOCYTOSIS. Endocytic sites mature by continuous bending and remodeling of the clathrin coat.
1. Science - published June 19, 2015
2. Avinoam O, Schorb M, Beese CJ, Briggs JA, Kaksonen M
Graded requirement for the spliceosome in cell cycle progression.
1. Cell Cycle - published June 18, 2015
2. Karamysheva Z, Díaz-Martínez LA, Warrington R, Yu H
HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.
1. Mol. Cell - published June 18, 2015
2. Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA
nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2.
1. ChemMedChem - published June 18, 2015
2. Neumann W, Xu S, Sárosi MB, Scholz MS, Crews BC, Ghebreselasie K, Banerjee S, Marnett LJ, Hey-Hawkins HC
Radicals Are Required for Thiol Etching of Gold Particles.
1. Angew. Chem. Int. Ed. Engl. - published June 18, 2015
2. Dreier TA, Ackerson CJ
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.
1. Cell - published June 18, 2015
2. Dosenovic P, von Boehmer L, Escolano A, Jardine J, Freund NT, Gitlin AD, McGuire AT, Kulp DW, Oliveira T, Scharf L, Pietzsch J, Gray MD, Cupo A, van Gils MJ, Yao KH, Liu C, Gazumyan A, Seaman MS, Björkman PJ, Sanders RW, Moore JP, Stamatatos L, Schief WR, Nussenzweig MC
Bending Forks and Wagging Dogs--It's about the DNA 3' Tail.
1. Mol. Cell - published June 18, 2015
2. Tsutakawa SE, Tainer JA
Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.
1. Mol. Med. - published June 18, 2015
2. Choi HW, Tian M, Song F, Venereau E, Preti A, Park SW, Hamilton K, Swapna GV, Manohar M, Moreau M, Agresti A, Gorzanelli A, De Marchis F, Wang H, Antonyak M, Micikas RJ, Gentile DR, Cerione RA, Schroeder FC, Montelione GT, Bianchi ME, Klessig DF
MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin.
1. Neuron - published June 17, 2015
2. Maro GS, Gao S, Olechwier AM, Hung WL, Liu M, Özkan E, Zhen M, Shen K
Base-Displaced Intercalated Conformation of the 2-Amino-3-methylimidazo[4,5-f]quinoline N(2)-dG DNA Adduct Positioned at the Nonreiterated G(1) in the NarI Restriction Site.
1. Chem. Res. Toxicol. - published June 17, 2015
2. Stavros KM, Hawkins EK, Rizzo CJ, Stone MP
Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9).
1. J. Biol. Chem. - published June 17, 2015
2. Knockenhauer KE, Schwartz TU
Co-crystal structures of antibody N60-i3 and antibody JR4 in complex with gp120 define more Cluster A epitopes involved in effective antibody-dependent effector function against HIV-1.
1. J. Virol. - published June 17, 2015
2. Gohain N, Tolbert WD, Acharya P, Yu L, Liu T, Zhao P, Orlandi C, Visciano ML, Kamin-Lewis R, Sajadi MM, Martin L, Robinson JE, Kwong PD, DeVico AL, Ray K, Lewis GK, Pazgier M
The ERdj5 reductase cooperates with PDI to promote SV40 ER membrane translocation.
1. J. Virol. - published June 17, 2015
2. Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B
Structure of C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus-1.
1. J. Virol. - published June 17, 2015
2. Patel V, Dahlroth SL, Rajakannan V, Ho HT, Cornvik T, Nordlund P
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
1. Biochim. Biophys. Acta - published June 16, 2015
2. Almeida B, Abreu IA, Matos CA, Fraga JS, Fernandes S, Macedo MG, Gutiérrez-Gallego R, Pereira PJ, Carvalho AL, Macedo-Ribeiro S
Twisted amide electrophiles enable cyclic peptide sequencing.
1. Org. Biomol. Chem. - published June 16, 2015
2. Zaretsky S, Rai V, Gish G, Forbes MW, Kofler M, Yu JC, Tan J, Hickey JL, Pawson T, Yudin AK
Direct Staudinger-Phosphonite Reaction Provides Methylphosphonamidates as Inhibitors of CE4 De-N-acetylases.
1. Chembiochem - published June 15, 2015
2. Ariyakumaran R, Pokrovskaya V, Little DJ, Howell PL, Nitz M
Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y₂ Receptor Binding and Activation.
1. Angew. Chem. Int. Ed. Engl. - published June 15, 2015
2. Kaiser A, Müller P, Zellmann T, Scheidt HA, Thomas L, Bosse M, Meier R, Meiler J, Huster D, Beck-Sickinger AG, Schmidt P
Correction for ingale et Al., hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies.
1. J. Virol. - published June 15, 2015
2. Ingale J, Tran K, Kong L, Dey B, McKee K, Schief W, Kwong PD, Mascola JR, Wyatt RT
Identification of Poly-N-acetyl Glucosamine as a Major Polysaccharide Component of the Bacillus Subtilis Biofilm Matrix.
1. J. Biol. Chem. - published June 15, 2015
2. Roux D, Cywes-Bentley C, Zhang YF, Pons S, Konkol M, Kearns DB, Little DJ, Howell PL, Skurnik D, Pier GB
Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 15, 2015
2. Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN, Rosenkilde MM
Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2.
1. Genes Dev. - published June 15, 2015
2. Chen S, Rufiange A, Huang H, Rajashankar KR, Nourani A, Patel DJ
Nuclear localization signals for four distinct karyopherin-β nuclear import systems.
1. Biochem. J. - published June 15, 2015
2. Soniat M, Chook YM
Combining NMR and EPR to Determine Structures of Large RNAs and Protein-RNA Complexes in Solution.
1. Methods Enzymol - published June 13, 2015
2. Duss O, Yulikov M, Allain FHT, Jeschke G
One, Two, Three, Four! How Multiple RRMs Read the Genome Sequence.
1. Methods Enzymol - published June 13, 2015
2. Afroz T, Cienikova Z, Cléry A, Allain FHT
Native Purification and Analysis of Long RNAs.
1. Methods Enzymol - published June 13, 2015
2. Chillón I, Marcia M, Legiewicz M, Liu F, Somarowthu S, Pyle AM
Novel antigens for RSV vaccines.
1. Curr. Opin. Immunol. - published June 13, 2015
2. Graham BS, Modjarrad K, McLellan JS
In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target.
1. Meth. Enzymol. - published June 13, 2015
2. Anders C, Niewoehner O, Jinek M
Structural Analysis of Protein-RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements.
1. Meth. Enzymol. - published June 13, 2015
2. Hennig J, Warner LR, Simon B, Geerlof A, Mackereth CD, Sattler M
Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo.
1. Mol. Cancer - published June 12, 2015
2. Chang DK, Moniz RJ, Xu Z, Sun J, Signoretti S, Zhu Q, Marasco WA
Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly.
1. J. Virol. - published June 12, 2015
2. VanBlargan LA, Davis KA, Dowd KA, Akey DL, Smith JL, Pierson TC
Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C.
1. Science - published June 12, 2015
2. Ji Z, Gao H, Yu H
BAF250a regulates nucleosome occupancy and histone modifications in priming embryonic stem cell differentiation.
1. J. Biol. Chem. - published June 12, 2015
2. Lei I, West J, Yan Z, Gao X, Fang P, Dennis JH, Gnatovskiy L, Wang W, Kingston RE, Wang Z
Structural Determinants of the Mechanical Stability of Alpha Catenin.
1. J. Biol. Chem. - published June 12, 2015
2. Li J, Newhall J, Ishiyama N, Gottardi C, Ikura M, Leckband DE, Tajkhorshid E
The Supramolecular Organization of a Peptide-Based Nanocarrier at High Molecular Detail.
1. J. Am. Chem. Soc. - published June 11, 2015
2. Rad-Malekshahi M, Visscher KM, Rodrigues JP, de Vries R, Hennink WE, Baldus M, Bonvin AM, Mastrobattista E, Weingarth M
A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family.
1. Int J Mol Sci - published June 11, 2015
2. Wu J, Liu W, Gong P
Ligand regulation of a constitutively dimeric EGF receptor.
1. Nat Commun - published June 11, 2015
2. Freed DM, Alvarado D, Lemmon MA
Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII.
1. Blood - published June 11, 2015
2. Yee A, Oleskie AN, Dosey AM, Kretz CA, Gildersleeve RD, Dutta S, Su M, Ginsburg D, Skiniotis G
Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry.
1. Blood - published June 11, 2015
2. Chiu PL, Bou-Assaf GM, Chhabra ES, Chambers MG, Peters RT, Kulman JD, Walz T
Functional Characterization of a Dehydratase Domain from the Pikromycin Polyketide Synthase.
1. J. Am. Chem. Soc. - published June 10, 2015
2. Li Y, Dodge GJ, Fiers WD, Fecik RA, Smith JL, Aldrich CC
Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals.
1. PLoS One - published June 10, 2015
2. Stutz K, Kaech A, Aebi M, Künzler M, Hengartner MO
Editorial overview: Theory and simulation.
1. Curr. Opin. Struct. Biol. - published June 10, 2015
2. Lesieur C, Schulten K
Splitting up the powerhouse: structural insights into the mechanism of mitochondrial fission.
1. Cell. Mol. Life Sci. - published June 10, 2015
2. Richter V, Singh AP, Kvansakul M, Ryan MT, Osellame LD
Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly.
1. Nat Commun - published June 10, 2015
2. Male G, von Appen A, Glatt S, Taylor NM, Cristovao M, Groetsch H, Beck M, Müller CW
Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 9, 2015
2. Hubin EA, Tabib-Salazar A, Humphrey LJ, Flack JE, Olinares PD, Darst SA, Campbell EA, Paget MS
The pilus usher controls protein interactions via domain masking and is functional as an oligomer.
1. Nat. Struct. Mol. Biol. - published June 9, 2015
2. Werneburg GT, Henderson NS, Portnoy EB, Sarowar S, Hultgren SJ, Li H, Thanassi DG
Editorial overview: Virus structure and expression.
1. Curr Opin Virol - published June 9, 2015
2. Jan E, Tao YJ
Identification of bromodomain-containing protein 4 (BRD4) as a novel marker and epigenetic target in mast cell leukemia.
1. Leukemia - published June 9, 2015
2. Wedeh G, Cerny-Reiterer S, Eisenwort G, Herrmann H, Blatt K, Hadzijusufovic E, Sadovnik I, Müllauer L, Schwaab J, Hoffmann T, Bradner JE, Radia D, Sperr WR, Hoermann G, Reiter A, Horny HP, Zuber J, Arock M, Valent P
Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.
1. Proteins - published June 9, 2015
2. Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN
Rampant parasexuality evolves in a hospital pathogen during antibiotic selection.
1. Mol. Biol. Evol. - published June 9, 2015
2. Beabout K, Hammerstrom TG, Wang TT, Bhatty M, Christie PJ, Saxer G, Shamoo Y
Regulation of mitochondrial ceramide distribution by members of the BCL-2 family.
1. J. Lipid Res. - published June 9, 2015
2. Zhang T, Barclay L, Walensky LD, Saghatelian A
Protein Crystallography in Vaccine Research and Development.
1. Int J Mol Sci - published June 9, 2015
2. Malito E, Carfi A, Bottomley MJ
Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis.
1. Elife - published June 8, 2015
2. Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, Gauquier A, Cabochette P, Fukuhara S, Mochizuki N, Nathans J, Stainier DY
Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface.
1. J. Biol. Chem. - published June 8, 2015
2. Zackular JP, Chazin WJ, Skaar EP
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 8, 2015
2. Boopathy S, Silvas TV, Tischbein M, Jansen S, Shandilya SM, Zitzewitz JA, Landers JE, Goode BL, Schiffer CA, Bosco DA
Pre-TCR ligand binding impacts thymocyte development before αβTCR expression.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 8, 2015
2. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL
Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology.
1. Bioessays - published June 8, 2015
2. Hennig J, Sattler M
Coordinated Ribosomal L4 Protein Assembly into the Pre-Ribosome Is Regulated by Its Eukaryote-Specific Extension.
1. Mol. Cell - published June 4, 2015
2. Stelter P, Huber FM, Kunze R, Flemming D, Hoelz A, Hurt E
Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.
1. Cell - published June 4, 2015
2. Gerlach P, Malet H, Cusack S, Reguera J
Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
1. Cell - published June 4, 2015
2. Zhou T, Lynch RM, Chen L, Acharya P, Wu X, Doria-Rose NA, Joyce MG, Lingwood D, Soto C, Bailer RT, Ernandes MJ, Kong R, Longo NS, Louder MK, McKee K, O'Dell S, Schmidt SD, Tran L, Yang Z, Druz A, Luongo TS, Moquin S, Srivatsan S, Yang Y, Zhang B, Zheng A, Pancera M, Kirys T, Georgiev IS, Gindin T, Peng HP, Yang AS, NISC Comparative Sequencing Program, Mullikin JC, Gray MD, Stamatatos L, Burton DR, Koff WC, Cohen MS, Haynes BF, Casazza JP, Connors M, Corti D, Lanzavecchia A, Sattentau QJ, Weiss RA, West AP, Bjorkman PJ, Scheid JF, Nussenzweig MC, Shapiro L, Mascola JR, Kwong PD
Notch Transmembrane Domain: Secondary Structure and Topology.
1. Biochemistry - published June 4, 2015
2. Deatherage CL, Lu Z, Kim JH, Sanders CR
Dying mRNA Tells a Story of Its Life.
1. Cell - published June 4, 2015
2. Wallace EW, Drummond DA
Allosteric Regulation in Gating the Central Channel of the Nuclear Pore Complex.
1. Cell - published June 4, 2015
2. Koh J, Blobel G
CATNAP: a tool to compile, analyze and tally neutralizing antibody panels.
1. Nucleic Acids Res. - published June 4, 2015
2. Yoon H, Macke J, West AP, Foley B, Bjorkman PJ, Korber B, Yusim K
An RNA-binding protein, Lin28, recognizes and remodels G-quartets in the miRNAs and mRNAs it regulates.
1. J. Biol. Chem. - published June 4, 2015
2. O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J
Structural evidence for Scc4-dependent localization of cohesin loading.
1. Elife - published June 3, 2015
2. Hinshaw SM, Makrantoni V, Kerr A, Marston AL, Harrison SC
NMR Exchange Format: a unified and open standard for representation of NMR restraint data.
1. Nat. Struct. Mol. Biol. - published June 3, 2015
2. Gutmanas A, Adams PD, Bardiaux B, Berman HM, Case DA, Fogh RH, Güntert P, Hendrickx PM, Herrmann T, Kleywegt GJ, Kobayashi N, Lange OF, Markley JL, Montelione GT, Nilges M, Ragan TJ, Schwieters CD, Tejero R, Ulrich EL, Velankar S, Vranken WF, Wedell JR, Westbrook J, Wishart DS, Vuister GW
Fetuses of Mothers with Thyroid Disease May Be at Higher Risk of Developing Supraventricular Tachycardia.
1. Am J Perinatol - published June 3, 2015
2. Johnson JA, Williams P, Lu Z, Kavanaugh-McHugh A, Fish FA, Killen SA
Broadly neutralizing human immunodeficiency virus type 1 antibody gene transfer protects non-human primates from mucosal simian-human immunodeficiency virus infection.
1. J. Virol. - published June 3, 2015
2. Saunders KO, Wang L, Joyce MG, Yang ZY, Balazs AB, Cheng C, Ko SY, Kong WP, Rudicell RS, Georgiev IS, Duan L, Foulds KE, Donaldson M, Xu L, Schmidt SD, Todd JP, Baltimore D, Roederer M, Haase AT, Kwong PD, Rao SS, Mascola JR, Nabel GJ
Cloning and variation of ground state intestinal stem cells.
1. Nature - published June 3, 2015
2. Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W
Inhibition of O-linked N-acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.
1. J. Virol. - published June 3, 2015
2. Angelova M, Ortiz-Meoz RF, Walker S, Knipe DM
Clinical and MRI phenotype of children with MOG antibodies.
1. Mult. Scler. - published June 3, 2015
2. Fernandez-Carbonell C, Vargas-Lowy D, Musallam A, Healy B, McLaughlin K, Wucherpfennig KW, Chitnis T
Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.
1. Cell Rep - published June 3, 2015
2. Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, Huizinga EG, Chen X, Varki A, Kamerling JP, de Groot RJ
Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh.
1. J Biol Chem - published June 2, 2015
2. Hänelt I, Jensen S, Wunnicke D, Slotboom DJ
Efficient Estimation of Three-Dimensional Covariance and its Application in the Analysis of Heterogeneous Samples in Cryo-Electron Microscopy.
1. Structure - published June 2, 2015
2. Liao HY, Hashem Y, Frank J
Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α1(2)βγδ nAChRs.
1. Structure - published June 2, 2015
2. Bourne Y, Sulzenbacher G, Radić Z, Aráoz R, Reynaud M, Benoit E, Zakarian A, Servent D, Molgó J, Taylor P, Marchot P
Structural Dynamics of Ribosome Subunit Association Studied by Mixing-Spraying Time-Resolved Cryogenic Electron Microscopy.
1. Structure - published June 2, 2015
2. Chen B, Kaledhonkar S, Sun M, Shen B, Lu Z, Barnard D, Lu TM, Gonzalez RL, Frank J
Editorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level.
1. Curr. Opin. Struct. Biol. - published June 2, 2015
2. Forest KT, Hill CP
Enzymatic modifications of exopolysaccharides enhance bacterial persistence.
1. Front Microbiol - published June 2, 2015
2. Whitfield GB, Marmont LS, Howell PL
SABR for aggressive local therapy of metastatic cancer: A new paradigm for metastatic non-small cell lung cancer.
1. Lung Cancer - published June 2, 2015
2. Westover KD, Iyengar P, Sharma AN, Timmerman R
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.
1. Sci Rep - published June 2, 2015
2. Ramanan V, Shlomai A, Cox DB, Schwartz RE, Michailidis E, Bhatta A, Scott DA, Zhang F, Rice CM, Bhatia SN
Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations.
1. Mol. Cancer Res. - published June 2, 2015
2. Hunter JC, Manandhar A, Carrasco MA, Gurbani D, Gondi S, Westover KD
Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity.
1. Proc. Natl. Acad. Sci. U.S.A. - published June 2, 2015
2. LaFrance ME, Farrow MA, Chandrasekaran R, Sheng J, Rubin DH, Lacy DB
Genome, Proteome and Structure of a T7-Like Bacteriophage of the Kiwifruit Canker Phytopathogen Pseudomonas syringae pv. actinidiae.
1. Viruses - published June 2, 2015
2. Frampton RA, Acedo EL, Young VL, Chen D, Tong B, Taylor C, Easingwood RA, Pitman AR, Kleffmann T, Bostina M, Fineran PC
Identification of proteins capable of metal reduction from the proteome of the Gram-positive bacterium Desulfotomaculum reducens MI-1 using an NADH-based activity assay.
1. Environ Microbiol - published June 1, 2015
2. Otwell AE, Sherwood RW, Zhang S, Nelson OD, Li Z, Lin H, Callister SJ, Richardson RE
Tangled web of interactions among proteins involved in iron-sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies.
1. Biochim Biophys Acta - published June 1, 2015
2. Kim JH, Bothe JR, Alderson TR, Markley JL
IscS from Archaeoglobus fulgidus has no desulfurase activity but may provide a cysteine ligand for [Fe2S2] cluster assembly.
1. Biochim Biophys Acta - published June 1, 2015
2. Pagnier A, Nicolet Y, Fontecilla-Camps JC
Structural conservation of chemotaxis machinery across Archaea and Bacteria.
1. Environ Microbiol Rep - published June 1, 2015
2. Briegel A, Ortega DR, Huang AN, Oikonomou CM, Gunsalus RP, Jensen GJ
Emerging critical roles of Fe-S clusters in DNA replication and repair.
1. Biochim Biophys Acta - published June 1, 2015
2. Fuss JO, Tsai CL, Ishida JP, Tainer JA
MDA5-filament, dynamics and disease.
1. Curr Opin Virol - published June 1, 2015
2. del Toro Duany Y, Wu B, Hur S
Template-based prediction of protein function.
1. Curr Opin Struct Biol - published June 1, 2015
2. Petrey D, Chen TS, Deng L, Garzon JI, Hwang H, Lasso G, Lee H, Silkov A, Honig B
Positive Selection Drives Preferred Segment Combinations during Influenza Virus Reassortment.
1. Mol Biol Evol - published June 1, 2015
2. Zeldovich KB, Liu P, Renzette N, Foll M, Pham ST, Venev SV, Gallagher GR, Bolon DN, Kurt-Jones EA, Jensen JD, Caffrey DR, Schiffer CA, Kowalik TF, Wang JP, Finberg RW
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.
1. Biochem. J. - published June 1, 2015
2. Békés M, Rut W, Kasperkiewicz P, Mulder MP, Ovaa H, Drag M, Lima CD, Huang TT
Crystal structure of an SH2-kinase construct of c-Abl and effect of the SH2 domain on kinase activity.
1. Biochem. J. - published June 1, 2015
2. Lorenz S, Deng P, Hantschel O, Superti-Furga G, Kuriyan J
High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet.
1. Mol Cell Proteomics - published June 1, 2015
2. Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW
Patterns of structural and sequence variation within isotype lineages of the Neisseria meningitidis transferrin receptor system.
1. Microbiologyopen - published June 1, 2015
2. Adamiak P, Calmettes C, Moraes TF, Schryvers AB
Intrinsic disorder and metal binding in UreG proteins from Archae hyperthermophiles: GTPase enzymes involved in the activation of Ni(II) dependent urease.
1. J Biol Inorg Chem - published June 1, 2015
2. Miraula M, Ciurli S, Zambelli B
Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.
1. Mol Cancer Ther - published June 1, 2015
2. Fang L, Yang Z, Zhou J, Tung JY, Hsiao CD, Wang L, Deng Y, Wang P, Wang J, Lee MH
Current kinase inhibitors cover a tiny fraction of fragment space.
1. Bioorg. Med. Chem. Lett. - published June 1, 2015
2. Zhao H, Caflisch A
SEA you later alli-GATOR--a dynamic regulator of the TORC1 stress response pathway.
1. J Cell Sci - published June 1, 2015
2. Dokudovskaya S, Rout MP
Destructin-1 is a collagen-degrading endopeptidase secreted by Pseudogymnoascus destructans, the causative agent of white-nose syndrome.
1. Proc Natl Acad Sci U S A - published June 1, 2015
2. O'Donoghue AJ, Knudsen GM, Beekman C, Perry JA, Johnson AD, DeRisi JL, Craik CS, Bennett RJ
The Tyrosine Kinase c-Src Specifically Binds to the Active Integrin αIIbβ3 to Initiate Outside-in Signaling in Platelets.
1. J Biol Chem - published June 1, 2015
2. Wu Y, Span LM, Nygren P, Zhu H, Moore DT, Cheng H, Roder H, DeGrado WF, Bennett JS
The Hill analysis and co-ion-driven transporter kinetics.
1. J Gen Physiol - published June 1, 2015
2. Lolkema JS, Slotboom DJ
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution.
1. Nat. Struct. Mol. Biol. - published June 1, 2015
2. Brewer KD, Bacaj T, Cavalli A, Camilloni C, Swarbrick JD, Liu J, Zhou A, Zhou P, Barlow N, Xu J, Seven AB, Prinslow EA, Voleti R, Häussinger D, Bonvin AM, Tomchick DR, Vendruscolo M, Graham B, Südhof TC, Rizo J
Binding Mode of Acetylated Histones to Bromodomains: Variations on a Common Motif.
1. ChemMedChem - published June 1, 2015
2. Marchand JR, Caflisch A
In meso in situ serial X-ray crystallography of soluble and membrane proteins.
1. Acta Crystallogr D Biol Crystallogr - published June 1, 2015
2. Huang CY, Olieric V, Ma P, Panepucci E, Diederichs K, Wang M, Caffrey M
Human telomerase: biogenesis, trafficking, recruitment, and activation.
1. Genes Dev - published June 1, 2015
2. Schmidt JC, Cech TR
Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain.
1. Neuron - published June 1, 2015
2. Mo A, Mukamel EA, Davis FP, Luo C, Henry GL, Picard S, Urich MA, Nery JR, Sejnowski TJ, Lister R, Eddy SR, Ecker JR, Nathans J
A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
1. Cell - published June 1, 2015
2. Tagliabracci VS, Wiley SE, Guo X, Kinch LN, Durrant E, Wen J, Xiao J, Cui J, Nguyen KB, Engel JL, Coon JJ, Grishin N, Pinna LA, Pagliarini DJ, Dixon JE
De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.
1. Ann Clin Transl Neurol - published June 1, 2015
2. Esmaeeli Nieh S, Madou MR, Sirajuddin M, Fregeau B, McKnight D, Lexa K, Strober J, Spaeth C, Hallinan BE, Smaoui N, Pappas JG, Burrow TA, McDonald MT, Latibashvili M, Leshinsky-Silver E, Lev D, Blumkin L, Vale RD, Barkovich AJ, Sherr EH