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152 Member Publications for March 2015

Structural characterization of the late competence protein ComFB from Bacillus subtilis.
1. Biosci. Rep. - published March 31, 2015
2. Sysoeva TA, Bane LB, Xiao DY, Bose B, Chilton SS, Gaudet R, Burton BM
BILBO1 Is a Scaffold Protein of the Flagellar Pocket Collar in the Pathogen Trypanosoma brucei.
1. PLoS Pathog. - published March 31, 2015
2. Florimond C, Sahin A, Vidilaseris K, Dong G, Landrein N, Dacheux D, Albisetti A, Byard EH, Bonhivers M, Robinson DR
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.
1. Sci Rep - published March 31, 2015
2. Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH
Neutralizing epitopes on the respiratory syncytial virus fusion glycoprotein.
1. Curr Opin Virol - published March 31, 2015
2. McLellan JS
The C-terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase.
1. FEBS J. - published March 31, 2015
2. Nishino T, Okamoto K, Kawaguchi Y, Matsumura T, Eger BT, Pai EF, Nishino T
BCL::MP-fold: Membrane protein structure prediction guided by EPR restraints.
1. Proteins - published March 31, 2015
2. Fischer AW, Alexander NS, Woetzel N, Karakas M, Weiner BE, Meiler J
Codification of bidentate pMHC interaction with TCR and its co-receptor.
1. Trends Immunol. - published March 31, 2015
2. Reinherz EL, Wang JH
Integrative, dynamic structural biology at atomic resolution-it's about time.
1. Nat. Methods - published March 31, 2015
2. van den Bedem H, Fraser JS
Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity.
1. MBio - published March 31, 2015
2. Goneau LW, Hannan TJ, MacPhee RA, Schwartz DJ, Macklaim JM, Gloor GB, Razvi H, Reid G, Hultgren SJ, Burton JP
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
1. Nat. Med. - published March 30, 2015
2. Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA
Atomic structure of the Y complex of the nuclear pore.
1. Nat. Struct. Mol. Biol. - published March 30, 2015
2. Kelley K, Knockenhauer KE, Kabachinski G, Schwartz TU
CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.
1. J. Cell Biol. - published March 30, 2015
2. Draheim KM, Li X, Zhang R, Fisher OS, Villari G, Boggon TJ, Calderwood DA
Cis and trans interactions between atlastin molecules during membrane fusion.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 30, 2015
2. Liu TY, Bian X, Romano FB, Shemesh T, Rapoport TA, Hu J
Action at a Distance: Mutations of Peripheral Residues Transform Rapid Reversible Inhibitors to Slow, Tight Binders of Cyclooxygenase-2.
1. J. Biol. Chem. - published March 30, 2015
2. Blobaum AL, Xu S, Rowlinson SW, Duggan KC, Banerjee S, Kudalkar SN, Birmingham WR, Ghebreselasie K, Marnett LJ
A new platform for ultra-high density Staphylococcus aureus transposon libraries.
1. BMC Genomics - published March 29, 2015
2. Santiago M, Matano LM, Moussa SH, Gilmore MS, Walker S, Meredith TC
Liposome functionalization with copper-free "click chemistry".
1. J Control Release - published March 28, 2015
2. Oude Blenke E, Klaasse G, Merten H, Plückthun A, Mastrobattista E, Martin NI
Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
1. Biochim. Biophys. Acta - published March 28, 2015
2. Chen H, Piccirilli JA, Harris ME, York DM
Toxoplasma gondii: Biochemical and biophysical characterization of recombinant soluble dense granule proteins GRA2 and GRA6.
1. Biochem. Biophys. Res. Commun. - published March 27, 2015
2. Bittame A, Effantin G, Pètre G, Ruffiot P, Travier L, Schoehn G, Weissenhorn W, Cesbron-Delauw MF, Gagnon J, Mercier C
Biophysical characterization of interactions between the C-termini of peripheral nerve claudins and the PDZ1 domain of zonula occludens.
1. Biochem. Biophys. Res. Commun. - published March 27, 2015
2. Wu J, Peng D, Zhang Y, Lu Z, Voehler M, Sanders CR, Li J
New Insights on the Mechanism of the K+-Independent Activity of Crenarchaeota Pyruvate Kinases.
1. PLoS ONE - published March 27, 2015
2. De la Vega-Ruíz G, Domínguez-Ramírez L, Riveros-Rosas H, Guerrero-Mendiola C, Torres-Larios A, Hernández-Alcántara G, García-Trejo JJ, Ramírez-Silva L
Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function.
1. Environ. Microbiol. - published March 27, 2015
2. Leighton TL, Buensuceso RN, Howell PL, Burrows LL
Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase.
1. Nat Commun - published March 27, 2015
2. Fenwick MK, Mehta AP, Zhang Y, Abdelwahed SH, Begley TP, Ealick SE
Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells.
1. PLoS One - published March 26, 2015
2. Schulte BM, Gielen PR, Kers-Rebel ED, Schreibelt G, van Kuppeveld FJ, Adema GJ
Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer.
1. PLoS Pathog. - published March 26, 2015
2. Derking R, Ozorowski G, Sliepen K, Yasmeen A, Cupo A, Torres JL, Julien JP, Lee JH, van Montfort T, de Taeye SW, Connors M, Burton DR, Wilson IA, Klasse PJ, Ward AB, Moore JP, Sanders RW
Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis.
1. Mol. Syst. Biol. - published March 26, 2015
2. Fallahi-Sichani M, Moerke NJ, Niepel M, Zhang T, Gray NS, Sorger PK
High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins.
1. Methods Mol Biol - published March 25, 2015
2. Mishra AK, Lambright DG
Eliminating antibody polyreactivity through addition of N-linked glycosylation.
1. Protein Sci. - published March 25, 2015
2. Chuang GY, Zhang B, McKee K, O'Dell S, Kwon YD, Zhou T, Blinn J, Lloyd K, Parks R, Von Holle T, Ko SY, Kong WP, Pegu A, Wang K, Baruah K, Crispin M, Mascola JR, Moody MA, Haynes BF, Georgiev IS, Kwong PD
Testing the utility of site-specific recombinases for manipulations of genome of moenomycin producer Streptomyces ghanaensis ATCC14672.
1. J. Appl. Genet. - published March 25, 2015
2. Lopatniuk M, Ostash B, Makitrynskyy R, Walker S, Luzhetskyy A, Fedorenko V
Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 25, 2015
2. Kim J, Hudson NE, Springer TA
The 5' untranslated region of a novel infectious molecular clone of the dicistrovirus Cricket paralysis virus modulates infection.
1. J. Virol. - published March 25, 2015
2. Kerr CH, Wang QS, Keatings K, Khong A, Allan D, Yip CK, Foster LJ, Jan E
Structure of bone morphogenetic protein 9 procomplex.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 24, 2015
2. Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA
XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia.
1. Cell Rep - published March 24, 2015
2. Scheffer DI, Zhang DS, Shen J, Indzhykulian A, Karavitaki KD, Xu YJ, Wang Q, Lin JJ, Chen ZY, Corey DP
Cellular chirality arising from the self-organization of the actin cytoskeleton.
1. Nat. Cell Biol. - published March 24, 2015
2. Tee YH, Shemesh T, Thiagarajan V, Hariadi RF, Anderson KL, Page C, Volkmann N, Hanein D, Sivaramakrishnan S, Kozlov MM, Bershadsky AD
Sphingolipid transfer proteins defined by the GLTP-fold.
1. Q. Rev. Biophys. - published March 23, 2015
2. Malinina L, Simanshu DK, Zhai X, Samygina VR, Kamlekar R, Kenoth R, Ochoa-Lizarralde B, Malakhova ML, Molotkovsky JG, Patel DJ, Brown RE
The tomato defensin TPP3 binds phosphatidylinositol(4,5)-bisphosphate via a conserved dimeric cationic grip conformation to mediate cell lysis.
1. Mol. Cell. Biol. - published March 23, 2015
2. Baxter AA, Richter V, Lay FT, Poon IK, Adda CG, Veneer PK, Phan TK, Bleackley MR, Anderson MA, Kvansakul M, Hulett MD
Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis.
1. Trends Cell Biol. - published March 22, 2015
2. Paczkowski JE, Richardson BC, Fromme JC
Picosecond and Terahertz Perturbation of Interfacial Water and Electropermeabilization of Biological Membranes.
1. J. Membr. Biol. - published March 22, 2015
2. Vernier PT, Levine ZA, Ho MC, Xiao S, Semenov I, Pakhomov AG
Structure Determination of Feline Calicivirus Virus-Like Particles in the Context of a Pseudo-Octahedral Arrangement.
1. PLoS ONE - published March 21, 2015
2. Burmeister WP, Buisson M, Estrozi LF, Schoehn G, Billet O, Hannas Z, Sigoillot C, Poulet H
Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design.
1. PLoS Negl Trop Dis - published March 21, 2015
2. Chen E, Salinas ND, Ntumngia FB, Adams JH, Tolia NH
Architecture of the polyketide synthase module: surprises from electron cryo-microscopy.
1. Curr. Opin. Struct. Biol. - published March 21, 2015
2. Smith JL, Skiniotis G, Sherman DH
The Effects of Attention Pre-Allocation and Target-Background Integration on Object-Based Attention.
1. PLoS ONE - published March 20, 2015
2. Hu F, Jiao C, Zhao S, Dong H, Liu X, Yi Y, Wang J
The Inhibitory Effect of the Hepatitis B Virus Singly-Spliced RNA-Encoded p21.5 Protein on HBV Nucleocapsid Formation.
1. PLoS ONE - published March 19, 2015
2. Wang YL, Liou GG, Lin CH, Chen ML, Kuo TM, Tsai KN, Huang CC, Chen YL, Huang LR, Chou YC, Chang C
A prudent path forward for genomic engineering and germline gene modification.
1. Science - published March 19, 2015
2. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR
Site-Specific, Intramolecular Cross-Linking of Pin1 Active Site Residues by the Lipid Electrophile 4-Oxo-2-nonenal.
1. Chem. Res. Toxicol. - published March 18, 2015
2. Aluise CD, Camarillo JM, Shimozu Y, Galligan JJ, Rose KL, Tallman KA, Marnett LJ
A Small Molecule That Inhibits OGT Activity in Cells.
1. ACS Chem. Biol. - published March 18, 2015
2. Ortiz-Meoz RF, Jiang J, Lazarus MB, Orman M, Janetzko J, Fan C, Duveau DY, Tan ZW, Thomas CJ, Walker S
Intergenerational continuity of cell shape dynamics in Caulobacter crescentus.
1. Sci Rep - published March 18, 2015
2. Wright CS, Banerjee S, Iyer-Biswas S, Crosson S, Dinner AR, Scherer NF
Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.
1. Elife - published March 18, 2015
2. Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ
On the shoulders of giants.
1. RNA - published March 18, 2015
2. Ferré-D'Amaré AR
RNA quaternary structure and global symmetry.
1. Trends Biochem. Sci. - published March 18, 2015
2. Jones CP, Ferré-D'Amaré AR
Dynamic RNA world.
1. RNA - published March 18, 2015
2. Sattler M
Rediscovering RNA.
1. RNA - published March 18, 2015
2. Pyle AM
Sustained delivery of a broadly neutralizing antibody in non-human primates confers long-term protection against SHIV infection.
1. J. Virol. - published March 18, 2015
2. Saunders KO, Pegu A, Georgiev IS, Zeng M, Joyce MG, Yang ZY, Ko SY, Chen X, Schmidt SD, Haase AT, Todd JP, Bao S, Kwong PD, Rao SS, Mascola JR, Nabel GJ
Structure and dynamics of the MKK7-JNK signaling complex.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 17, 2015
2. Kragelj J, Palencia A, Nanao MH, Maurin D, Bouvignies G, Blackledge M, Jensen MR
Biophysical Analysis of Anopheles gambiae Leucine-Rich Repeat Proteins APL1A1, APLB and APL1C and Their Interaction with LRIM1.
1. PLoS ONE - published March 17, 2015
2. Williams M, Summers BJ, Baxter RH
TFIIB Is Only ∼9 Å Away from the 5'-End of a Trimeric RNA Primer in a Functional RNA Polymerase II Preinitiation Complex.
1. PLoS ONE - published March 17, 2015
2. Bick MJ, Malik S, Mustaev A, Darst SA
Timing is everything: Fine-tuned molecular machines orchestrate paramyxovirus entry.
1. Virology - published March 17, 2015
2. Bose S, Jardetzky TS, Lamb RA
Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein.
1. Biochim. Biophys. Acta - published March 17, 2015
2. Kalita MM, Griffin S, Chou JJ, Fischer WB
Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals.
1. Elife - published March 17, 2015
2. Uervirojnangkoorn M, Zeldin OB, Lyubimov AY, Hattne J, Brewster AS, Sauter NK, Brunger AT, Weis WI
[NiFe]-hydrogenases revisited: nickel-carboxamido bond formation in a variant with accrued O2-tolerance and a tentative re-interpretation of Ni-SI states.
1. Metallomics - published March 17, 2015
2. Volbeda A, Martin L, Liebgott PP, De Lacey AL, Fontecilla-Camps JC
Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8.
1. Virology - published March 16, 2015
2. Zhang S, Sodroski J
High-resolution structure of the Escherichia coli ribosome.
1. Nat. Struct. Mol. Biol. - published March 16, 2015
2. Noeske J, Wasserman MR, Terry DS, Altman RB, Blanchard SC, Cate JH
Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light.
1. Nat Nanotechnol - published March 16, 2015
2. Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA, Chen X
Metazoan Maelstrom is an RNA-binding protein that has evolved from an ancient nuclease active in protists.
1. RNA - published March 16, 2015
2. Chen KM, Campbell E, Pandey RR, Yang Z, McCarthy AA, Pillai RS
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
1. Hum. Mol. Genet. - published March 15, 2015
2. He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L
Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon.
1. J. Cell. Sci. - published March 15, 2015
2. Junne T, Wong J, Studer C, Aust T, Bauer BW, Beibel M, Bhullar B, Bruccoleri R, Eichenberger J, Estoppey D, Hartmann N, Knapp B, Krastel P, Melin N, Oakeley EJ, Oberer L, Riedl R, Roma G, Schuierer S, Petersen F, Tallarico JA, Rapoport TA, Spiess M, Hoepfner D
α-Catenin phosphorylation promotes intercellular adhesion through a dual-kinase mechanism.
1. J. Cell. Sci. - published March 15, 2015
2. Escobar DJ, Desai R, Ishiyama N, Folmsbee SS, Novak MN, Flozak AS, Daugherty RL, Mo R, Nanavati D, Sarpal R, Leckband D, Ikura M, Tepass U, Gottardi CJ
Comparison of Type 1 D-3-phosphoglycerate dehydrogenases reveals unique regulation in pathogenic Mycobacteria.
1. Arch. Biochem. Biophys. - published March 15, 2015
2. Xu XL, Chen S, Salinas ND, Tolia NH, Grant GA
Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim.
1. Cell Death Dis - published March 14, 2015
2. Marshall B, Puthalakath H, Caria S, Chugh S, Doerflinger M, Colman PM, Kvansakul M
Macular Hole Closure With Internal Limiting Membrane Abrasion Technique.
1. JAMA Ophthalmol - published March 13, 2015
2. Mahajan VB, Chin EK, Tarantola RM, Almeida DR, Somani R, Boldt HC, Folk JC, Gehrs KM, Russell SR
Seizures are regulated by ubiquitin-specific peptidase 9 X-linked (USP9X), a de-ubiquitinase.
1. PLoS Genet. - published March 13, 2015
2. Paemka L, Mahajan VB, Ehaideb SN, Skeie JM, Tan MC, Wu S, Cox AJ, Sowers LP, Gecz J, Jolly L, Ferguson PJ, Darbro B, Schneider A, Scheffer IE, Carvill GL, Mefford HC, El-Shanti H, Wood SA, Manak JR, Bassuk AG
Tunable graphene quantum point contact transistor for DNA detection and characterization.
1. Nanotechnology - published March 13, 2015
2. Girdhar A, Sathe C, Schulten K, Leburton JP
Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity.
1. Nature - published March 12, 2015
2. Nuñez JK, Lee AS, Engelman A, Doudna JA
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
1. Cell - published March 12, 2015
2. Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC
Structure-guided insights on the role of NS1 in flavivirus infection.
1. Bioessays - published March 12, 2015
2. Akey DL, Brown WC, Jose J, Kuhn RJ, Smith JL
Purification, crystallization and preliminary X-ray diffraction studies of the β-catenin homolog HMP-2 from Caenorhabditis elegans.
1. Acta Crystallogr F Struct Biol Commun - published March 12, 2015
2. Choi HJ, Weis WI
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via T regulatory cells.
1. Eur. J. Immunol. - published March 12, 2015
2. Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG
Emerging picture of the distinct traits and functions of microvesicles and exosomes.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 11, 2015
2. Antonyak MA, Cerione RA
Crystal structure of the eukaryotic origin recognition complex.
1. Nature - published March 11, 2015
2. Bleichert F, Botchan MR, Berger JM
Spliceosome assembly in the absence of stable U4/U6 RNA pairing.
1. RNA - published March 11, 2015
2. Burke JE, Butcher SE, Brow DA
Rational design of a split-Cas9 enzyme complex.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 10, 2015
2. Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA
Antibody engineering for increased potency, breadth and half-life.
1. Curr Opin HIV AIDS - published March 10, 2015
2. Sievers SA, Scharf L, West AP, Bjorkman PJ
Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.
1. Proteins - published March 10, 2015
2. Brandmann T, Jinek M
Computational and Functional Analyses of a Small-Molecule Binding Site in ROMK.
1. Biophys. J. - published March 10, 2015
2. Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS
Substrate Pathways in the Nitrogenase MoFe Protein by Experimental Identification of Small Molecule Binding Sites.
1. Biochemistry - published March 9, 2015
2. Morrison CN, Hoy JA, Zhang L, Einsle O, Rees DC
Acetylation site specificities of lysine deacetylase inhibitors in human cells.
1. Nat. Biotechnol. - published March 9, 2015
2. Schölz C, Weinert BT, Wagner SA, Beli P, Miyake Y, Qi J, Jensen LJ, Streicher W, McCarthy AR, Westwood NJ, Lain S, Cox J, Matthias P, Mann M, Bradner JE, Choudhary C
Structure of CPV17 polyhedrin determined by the improved analysis of serial femtosecond crystallographic data.
1. Nat Commun - published March 9, 2015
2. Ginn HM, Messerschmidt M, Ji X, Zhang H, Axford D, Gildea RJ, Winter G, Brewster AS, Hattne J, Wagner A, Grimes JM, Evans G, Sauter NK, Sutton G, Stuart DI
Active site and laminarin binding in glycoside hydrolase family 55.
1. J. Biol. Chem. - published March 9, 2015
2. Bianchetti CM, Takasuka TE, Deutsch S, Udell HS, Yik EJ, Bergeman LF, Fox BG
Molecular Structure of an N-formyltransferase from Providencia alcalifaciens O30.
1. Protein Sci. - published March 9, 2015
2. Genthe NA, Thoden JB, Benning MM, Holden HM
Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 9, 2015
2. Ji X, Dadon DB, Abraham BJ, Lee TI, Jaenisch R, Bradner JE, Young RA
Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.
1. J. Biol. Chem. - published March 6, 2015
2. Kuo IY, Hu J, Ha Y, Ehrlich BE
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
1. Sci Rep - published March 6, 2015
2. Bezerra GA, Dobrovetsky E, Seitova A, Fedosyuk S, Dhe-Paganon S, Gruber K
Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
1. Science - published March 6, 2015
2. Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC
Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
1. Science - published March 6, 2015
2. Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ
Nuclear pores. Architecture of the nuclear pore complex coat.
1. Science - published March 6, 2015
2. Stuwe T, Correia AR, Lin DH, Paduch M, Lu VT, Kossiakoff AA, Hoelz A
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.
1. Mol. Cell - published March 5, 2015
2. Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD
Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants.
1. J. Med. Chem. - published March 5, 2015
2. Frey KM, Puleo DE, Spasov KA, Bollini M, Jorgensen WL, Anderson KS
Structural basis for the activation and inhibition of the UCH37 deubiquitylase.
1. Mol. Cell - published March 5, 2015
2. VanderLinden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
1. Nature - published March 5, 2015
2. Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M
Virulence Regulation with Venus Flytrap Domains: Structure and Function of the Periplasmic Moiety of the Sensor-Kinase BvgS.
1. PLoS Pathog. - published March 5, 2015
2. Dupré E, Herrou J, Lensink MF, Wintjens R, Vagin A, Lebedev A, Crosson S, Villeret V, Locht C, Antoine R, Jacob-Dubuisson F
Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.
1. Blood - published March 5, 2015
2. Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, Pileri S, Agostinelli C, Ayers L, Bradner JE, Chen-Kiang S, Elemento O, Motiwala T, Majumder S, Byrd JC, Jacob S, Sif S, Li C, Baiocchi RA
A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.
1. Mol. Cell - published March 5, 2015
2. McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC
Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis.
1. J Am Chem Soc - published March 4, 2015
2. Gagnon DM, Brophy MB, Bowman SE, Stich TA, Drennan CL, Britt RD, Nolan EM
Evolutionary Conserved Tyr169 Stabilizes the β2-α2 Loop of the Prion Protein.
1. J. Am. Chem. Soc. - published March 4, 2015
2. Huang D, Caflisch A
Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor.
1. J. Am. Chem. Soc. - published March 4, 2015
2. Dziedzic P, Cisneros JA, Robertson MJ, Hare AA, Danford NE, Baxter RH, Jorgensen WL
Parallel feedback loops control the basal activity of the HOG MAPK signaling cascade.
1. Integr Biol (Camb) - published March 4, 2015
2. Sharifian H, Lampert F, Stojanovski K, Regot S, Vaga S, Buser R, Lee SS, Koeppl H, Posas F, Pelet S, Peter M
Ebola virus VP35 interaction with dynein light chain 8 regulates viral RNA synthesis.
1. J. Virol. - published March 4, 2015
2. Luthra P, Jordan DS, Leung DW, Amarasinghe GK, Basler CF
Physicochemical requirements and kinetics of membrane fusion of flavivirus-like particles.
1. J. Gen. Virol. - published March 4, 2015
2. Esposito DL, Nguyen JB, DeWitt DC, Rhoades E, Modis Y
Interolog interfaces in protein-protein docking.
1. Proteins - published March 4, 2015
2. Alsop JD, Mitchell JC
Single-chain soluble BG505.SOSIP gp140 trimers as structural and antigenic mimics of mature closed HIV-1 Env.
1. J. Virol. - published March 4, 2015
2. Georgiev IS, Joyce MG, Yang Y, Sastry M, Zhang B, Baxa U, Chen RE, Druz A, Lees CR, Narpala S, Schön A, Van Galen J, Chuang GY, Gorman J, Harned A, Pancera M, Stewart-Jones GB, Cheng C, Freire E, McDermott AB, Mascola JR, Kwong PD
A Bipartite Interaction between Hsp70 and CHIP Regulates Ubiquitination of Chaperoned Client Proteins.
1. Structure - published March 3, 2015
2. Zhang H, Amick J, Chakravarti R, Santarriaga S, Schlanger S, McGlone C, Dare M, Nix JC, Scaglione KM, Stuehr DJ, Misra S, Page RC
Structure of EspB from the ESX-1 Type VII Secretion System and Insights into its Export Mechanism.
1. Structure - published March 3, 2015
2. Solomonson M, Setiaputra D, Makepeace KA, Lameignere E, Petrotchenko EV, Conrady DG, Bergeron JR, Vuckovic M, DiMaio F, Borchers CH, Yip CK, Strynadka NC
Stress and telomere shortening among central Indian conservation refugees.
1. Proc Natl Acad Sci U S A - published March 3, 2015
2. Zahran S, Snodgrass JG, Maranon DG, Upadhyay C, Granger DA, Bailey SM
Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion.
1. Proc Natl Acad Sci U S A - published March 3, 2015
2. Osman C, Noriega TR, Okreglak V, Fung JC, Walter P
Real-time NMR monitoring of biological activities in complex physiological environments.
1. Curr. Opin. Struct. Biol. - published March 3, 2015
2. Smith MJ, Marshall CB, Theillet FX, Binolfi A, Selenko P, Ikura M
The best of both worlds: active enzymes by grafting-to followed by grafting-from a protein.
1. Chem Commun (Camb) - published March 2, 2015
2. Falatach R, McGlone C, Al-Abdul-Wahid MS, Averick S, Page RC, Berberich JA, Konkolewicz D
Structure of Salmonella FlhE, conserved member of a flagellar type III secretion operon.
1. J Mol Biol - published March 2, 2015
2. Lee J, Monzingo AF, Keatinge-Clay AT, Harshey RM
Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.
1. J Mol Biol - published March 2, 2015
2. Dalby AB, Hofr C, Cech TR
Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine.
1. Chembiochem - published March 2, 2015
2. Swier LJ, Monjas L, Guskov A, de Voogd AR, Erkens GB, Slotboom DJ, Hirsch AK
Small-RNA loading licenses Argonaute for assembly into a transcriptional silencing complex.
1. Nat. Struct. Mol. Biol. - published March 2, 2015
2. Holoch D, Moazed D
Comprehensive analysis of heterotrimeric G-protein complex diversity and their interactions with GPCRs in solution.
1. Proc. Natl. Acad. Sci. U.S.A. - published March 2, 2015
2. Hillenbrand M, Schori C, Schöppe J, Plückthun A
Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.
1. Eur J Med Chem - published March 2, 2015
2. Spencer ES, Dale EJ, Gommans AL, Rutledge MT, Vo CT, Nakatani Y, Gamble AB, Smith RA, Wilbanks SM, Hampton MB, Tyndall JD
Plant-derived antifungal agent poacic acid targets β-1,3-glucan.
1. Proc Natl Acad Sci U S A - published March 2, 2015
2. Piotrowski JS, Okada H, Lu F, Li SC, Hinchman L, Ranjan A, Smith DL, Higbee AJ, Ulbrich A, Coon JJ, Deshpande R, Bukhman YV, McIlwain S, Ong IM, Myers CL, Boone C, Landick R, Ralph J, Kabbage M, Ohya Y
Sirtuins in epigenetic regulation.
1. Chem Rev - published March 2, 2015
2. Jing H, Lin H
Structural studies of truncated forms of the prion protein PrP.
1. Biophys J - published March 2, 2015
2. Wan W, Wille H, Stöhr J, Kendall A, Bian W, McDonald M, Tiggelaar S, Watts JC, Prusiner SB, Stubbs G
Identification of binding sites and favorable ligand binding moieties by virtual screening and self-organizing map analysis.
1. BMC Bioinformatics - published March 2, 2015
2. Harigua-Souiai E, Cortes-Ciriano I, Desdouits N, Malliavin TE, Guizani I, Nilges M, Blondel A, Bouvier G
Structural insight into the PTS sugar transporter EIIC.
1. Biochim Biophys Acta - published March 1, 2015
2. McCoy JG, Levin EJ, Zhou M
Diversity of membrane transport proteins for vitamins in bacteria and archaea.
1. Biochim Biophys Acta - published March 1, 2015
2. Jaehme M, Slotboom DJ
Endogone, one of the oldest plant-associated fungi, host unique Mollicutes-related endobacteria.
1. New Phytol - published March 1, 2015
2. Desirò A, Faccio A, Kaech A, Bidartondo MI, Bonfante P
Non-interacting surface solvation and dynamics in protein-protein interactions.
1. Proteins - published March 1, 2015
2. Visscher KM, Kastritis PL, Bonvin AM
A Multivalent Clade C HIV-1 Env Trimer Cocktail Elicits a Higher Magnitude of Neutralizing Antibodies than Any Individual Component.
1. J. Virol. - published March 1, 2015
2. Bricault CA, Kovacs JM, Nkolola JP, Yusim K, Giorgi EE, Shields JL, Perry J, Lavine CL, Cheung A, Ellingson-Strouss K, Rademeyer C, Gray GE, Williamson C, Stamatatos L, Seaman MS, Korber BT, Chen B, Barouch DH
The Unusual Fold of Herpes Simplex Virus 1 UL21, a Multifunctional Tegument Protein.
1. J. Virol. - published March 1, 2015
2. Metrick CM, Chadha P, Heldwein EE
Characteristics and concepts of dynamic hub proteins in DNA processing machinery from studies of RPA.
1. Prog Biophys Mol Biol - published March 1, 2015
2. Sugitani N, Chazin WJ
Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262.
1. Proteins - published March 1, 2015
2. Kong L, Wilson IA, Kwong PD
Refinement by shifting secondary structure elements improves sequence alignments.
1. Proteins - published March 1, 2015
2. Tong J, Pei J, Otwinowski Z, Grishin NV
Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities.
1. Infect Immun - published March 1, 2015
2. Frandoloso R, Martínez-Martínez S, Calmettes C, Fegan J, Costa E, Curran D, Yu RH, Gutiérrez-Martín CB, Rodríguez-Ferri EF, Moraes TF, Schryvers AB
Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.
1. Mol Cancer Ther - published March 1, 2015
2. Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE
A mechanism of leading-edge protrusion in the absence of Arp2/3 complex.
1. Mol. Biol. Cell - published March 1, 2015
2. Suraneni P, Fogelson B, Rubinstein B, Noguera P, Volkmann N, Hanein D, Mogilner A, Li R
Electron microscopic analysis of rotavirus assembly-replication intermediates.
1. Virology - published March 1, 2015
2. Boudreaux CE, Kelly DF, McDonald SM
A novel mechanism of regulating the ATPase VPS4 by its cofactor LIP5 and the endosomal sorting complex required for transport (ESCRT)-III protein CHMP5.
1. J Biol Chem - published March 1, 2015
2. Vild CJ, Li Y, Guo EZ, Liu Y, Xu Z
Adolescent decision making about participation in a hypothetical HIV vaccine trial.
1. Vaccine - published March 1, 2015
2. Alexander AB, Ott MA, Lally MA, Sniecinski K, Baker A, Zimet GD, Adolescent Trials Network for HIV/AIDS Interventions.
Alignment of direct detection device micrographs using a robust Optical Flow approach.
1. J Struct Biol - published March 1, 2015
2. Abrishami V, Vargas J, Li X, Cheng Y, Marabini R, Sorzano CÓ, Carazo JM
Design, synthesis and evaluation of XZH-5 analogues as STAT3 inhibitors.
1. Bioorg Med Chem - published March 1, 2015
2. Daka P, Liu A, Karunaratne C, Csatary E, Williams C, Xiao H, Lin J, Xu Z, Page RC, Wang H
Challenges and opportunities in developing respiratory syncytial virus therapeutics.
1. J Infect Dis - published March 1, 2015
2. Simões EA, DeVincenzo JP, Boeckh M, Bont L, Crowe JE Jr, Griffiths P, Hayden FG, Hodinka RL, Smyth RL, Spencer K, Thirstrup S, Walsh EE, Whitley RJ
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
1. Genes Dev. - published March 1, 2015
2. Murn J, Zarnack K, Yang YJ, Durak O, Murphy EA, Cheloufi S, Gonzalez DM, Teplova M, Curk T, Zuber J, Patel DJ, Ule J, Luscombe NM, Tsai LH, Walsh CA, Shi Y
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.
1. Cell - published March 1, 2015
2. Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA
Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction.
1. PLoS Pathog - published March 1, 2015
2. Hodgson A, Wier EM, Fu K, Sun X, Yu H, Zheng W, Sham HP, Johnson K, Bailey S, Vallance BA, Wan F
Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives.
1. Biotechniques - published March 1, 2015
2. LaCava J, Molloy KR, Taylor MS, Domanski M, Chait BT, Rout MP
Altering nuclear pore complex function impacts longevity and mitochondrial function in S. cerevisiae.
1. J Cell Biol - published March 1, 2015
2. Lord CL, Timney BL, Rout MP, Wente SR
Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1.
1. mBio - published March 1, 2015
2. Reineke LC, Kedersha N, Langereis MA, van Kuppeveld FJ, Lloyd RE
The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.
1. PLoS Pathog - published March 1, 2015
2. van der Linden L, Vives-Adrián L, Selisko B, Ferrer-Orta C, Liu X, Lanke K, Ulferts R, De Palma AM, Tanchis F, Goris N, Lefebvre D, De Clercq K, Leyssen P, Lacroix C, Pürstinger G, Coutard B, Canard B, Boehr DD, Arnold JJ, Cameron CE, Verdaguer N, Neyts J, van Kuppeveld FJ
Evolution of lysine acetylation in the RNA polymerase II C-terminal domain.
1. BMC Evol Biol - published March 1, 2015
2. Simonti CN, Pollard KS, Schröder S, He D, Bruneau BG, Ott M, Capra JA
Estimating a structured covariance matrix from multi-lab measurements in high-throughput biology.
1. J Am Stat Assoc - published March 1, 2015
2. Franks AM, Csárdi G, Drummond DA, Airoldi EM