Member Publications

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118 Member Publications for February 2014

HADDOCK_2P2I: A Biophysical Model for Predicting the Binding Affinity of Protein-Protein Interaction Inhibitors.
1. J Chem Inf Model - published February 27, 2014
2. PL Kastritis, JP Rodrigues, AM Bonvin
M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses.
1. ACS Chem Neurosci - published February 27, 2014
2. T Pancani, C Bolarinwa, Y Smith, CW Lindsley, PJ Conn, Z Xiang
Identification of Specific Ligand-Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site.
1. ACS Chem Neurosci - published February 26, 2014
2. KJ Gregory, ED Nguyen, C Malosh, JL Mendenhall, JZ Zic, BS Bates, MJ Noetzel, EF Squire, EM Turner, JM Rook, KA Emmitte, SR Stauffer, CW Lindsley, J Meiler, PJ Conn
Site-Specific Integration of Amino Acid Fragments into Cyclic Peptides.
1. J Am Chem Soc - published February 26, 2014
2. CJ White, JL Hickey, CC Scully, AK Yudin
M5 Receptor Activation Produces Opposing Physiological Outcomes in Dopamine Neurons Depending on the Receptor's Location.
1. J Neurosci - published February 26, 2014
2. DJ Foster, PR Gentry, JE Lizardi-Ortiz, TM Bridges, MR Wood, CM Niswender, D Sulzer, CW Lindsley, Z Xiang, PJ Conn
Crystal structure of the plant dual-affinity nitrate transporter NRT1.1.
1. Nature - published February 26, 2014
2. J Sun, JR Bankston, J Payandeh, TR Hinds, WN Zagotta, N Zheng
The stoichiometry of the Nup62 subcomplex of the nuclear pore in solution.
1. Mol Biol Cell - published February 26, 2014
2. A Ulrich, JR Partridge, TU Schwartz
Cancer and the nuclear pore complex.
1. Adv Exp Med Biol - published February 25, 2014
2. Simon DN, Rout MP
Principles of ion recognition in RNA: insights from the group II intron structures.
1. RNA - published February 25, 2014
2. M Marcia, AM Pyle
RNA-guided genome editing of mammalian cells.
1. Methods Mol Biol - published February 22, 2014
2. Pyzocha NK, Ran FA, Hsu PD, Zhang F
Studying Weak and Dynamic Interactions of Posttranslationally Modified Proteins using Expressed Protein Ligation.
1. ACS Chem Biol - published February 21, 2014
2. K Tripsianes, NK Chu, A Friberg, M Sattler, CF Becker
Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
1. Science - published February 21, 2014
2. DL Akey, WC Brown, S Dutta, J Konwerski, J Jose, TJ Jurkiw, J DelProposto, CM Ogata, G Skiniotis, RJ Kuhn, JL Smith
Divergent Regulation of RyR2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants.
1. Circ Res - published February 21, 2014
2. HS Hwang, FR Nitu, Y Yang, K Walweel, L Pereira, CN Johnson, M Faggioni, WJ Chazin, DR Laver, Jr George A, RL Cornea, DM Bers, BC Knollmann
An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.
1. J Mol Biol - published February 20, 2014
2. JM Grondin, S Chitayat, E Ficko-Blean, S Houliston, CH Arrowsmith, AB Boraston, SP Smith
Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex.
1. Mol Cell - published February 20, 2014
2. J Fan, C Shan, HB Kang, S Elf, J Xie, M Tucker, TL Gu, M Aguiar, S Lonning, H Chen, M Mohammadi, LM Britton, BA Garcia, M Alečković, Y Kang, S Kaluz, N Devi, EG Van Meir, T Hitosugi, JH Seo, S Lonial, M Gaddh, M Arellano, HJ Khoury, FR Khuri, TJ Boggon, S Kang, J Chen
A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
1. Mol Cell - published February 20, 2014
2. Y Tian, DK Simanshu, JB Ma, JE Park, I Heo, VN Kim, DJ Patel
Heterogeneous seeding of HET-s(218-289) and the mutability of prion structures.
1. Prion - published February 20, 2014
2. Wan W, Stubbs G
Structural Analysis and Identification of PhuS as a Heme-Degrading Enzyme from Pseudomonas aeruginosa.
1. J Mol Biol - published February 20, 2014
2. Lee MJ, Schep D, McLaughlin B, Kaufmann M, Jia Z
Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.
1. J Med Chem - published February 19, 2014
2. AO Frank, B Vangamudi, MD Feldkamp, EM Souza-Fagundes, JW Luzwick, D Cortez, ET Olejniczak, AG Waterson, OW Rossanese, WJ Chazin, SW Fesik
Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid.
1. J Virol - published February 19, 2014
2. CA Guth, J Sodroski
Loss of a conserved N-linked glycosylation site in the SIV envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission.
1. J Virol - published February 19, 2014
2. PJ Yen, A Herschhorn, H Haim, I Salas, C Gu, J Sodroski, D Gabuzda
Targeting Virulence not Viability in the Search for Future Antibacterials.
1. Br J Clin Pharmacol - published February 19, 2014
2. B Heras, MJ Scanlon, JL Martin
The mechanism of membrane disruption by cytotoxic amyloid oligomers formed by PrP(106-126) is dependent on bilayer composition.
1. J Biol Chem - published February 19, 2014
2. P Walsh, G Vanderlee, J Yau, J Campeau, VL Sim, CM Yip, S Sharpe
RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten-Mutant Metastasis.
1. Cancer Discov - published February 18, 2014
2. H Cho, T Herzka, W Zheng, J Qi, JE Wilkinson, JE Bradner, BD Robinson, M Castillo-Martin, C Cordon-Cardo, LC Trotman
Evidence for an evolutionary relationship between the large adaptor nucleoporin Nup192 and karyopherins.
1. Proc Natl Acad Sci U S A - published February 18, 2014
2. T Stuwe, DH Lin, LN Collins, E Hurt, A Hoelz
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.
1. Proc Natl Acad Sci U S A - published February 18, 2014
2. SG Brohawn, Z Su, R Mackinnon
Editorial overview: Nucleic acid movers and shakers.
1. Curr Opin Struct Biol - published February 18, 2014
2. K Luger, SE Phillips
Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission.
1. J Cell Biol - published February 17, 2014
2. V Richter, CS Palmer, LD Osellame, AP Singh, K Elgass, DA Stroud, H Sesaki, M Kvansakul, MT Ryan
Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer.
1. Vaccine - published February 17, 2014
2. JP Nkolola, A Cheung, JR Perry, D Carter, S Reed, H Schuitemaker, MG Pau, MS Seaman, B Chen, DH Barouch
DNA-guided DNA interference by a prokaryotic Argonaute.
1. Nature - published February 16, 2014
2. DC Swarts, MM Jore, ER Westra, Y Zhu, JH Janssen, AP Snijders, Y Wang, DJ Patel, J Berenguer, SJ Brouns, J van der Oost
First report of a novel polymer-free dual-drug eluting stent in de novo coronary artery disease: results of the first in human BICARE trial.
1. Catheter Cardiovasc Interv - published February 15, 2014
2. Yu M., Xu B., Kandzari DE., Wu Y., Yan H., Chen J., Qian J., Qiao S., Yang Y., Gao RL.
Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase.
1. Bioorg Med Chem Lett - published February 15, 2014
2. H Sharma, MJ Landau, TJ Sullivan, VP Kumar, MK Dahlgren, WL Jorgensen, KS Anderson
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: Development of a potent and CNS penetrant [3.1.0]-based lead.
1. Bioorg Med Chem Lett - published February 15, 2014
2. CK Jones, DJ Sheffler, R Williams, SB Jadhav, AS Felts, RD Morrison, CM Niswender, JS Daniels, PJ Conn, CW Lindsley
Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: Development of a [3.3.0]-based series and other piperidine bioisosteres.
1. Bioorg Med Chem Lett - published February 15, 2014
2. DJ Sheffler, MT Nedelovych, R Williams, SC Turner, BB Duerk, MR Robbins, SB Jadhav, CM Niswender, CK Jones, PJ Conn, RN Daniels, CW Lindsley
Cerebral cavernous malformation proteins at a glance.
1. J Cell Sci - published February 15, 2014
2. KM Draheim, OS Fisher, TJ Boggon, DA Calderwood
A viral RNA structural element alters host recognition of nonself RNA.
1. Science - published February 14, 2014
2. Hyde JL., Gardner CL., Kimura T., White JP., Liu G., Trobaugh DW., Huang C., Tonelli M., Paessler S., Takeda K., Klimstra WB., Amarasinghe GK., Diamond MS.
Development of the Direct Suzuki-Miyaura Cross-Coupling of Primary B-Alkyl MIDA-boronates and Aryl Bromides.
1. Org Lett - published February 14, 2014
2. JD St Denis, CC Scully, CF Lee, AK Yudin
TcaR-ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins.
1. Nucleic Acids Res - published February 14, 2014
2. YM Chang, CH Ho, CK Chen, M Maestre-Reyna, MW Chang-Chien, AH Wang
An antifreeze protein folds with an interior network of more than 400 semi-clathrate waters.
1. Science - published February 14, 2014
2. T Sun, FH Lin, RL Campbell, JS Allingham, PL Davies
A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors.
1. J Biomol Screen - published February 13, 2014
2. LC Morris, EL Days, M Turney, D Mi, CW Lindsley, CD Weaver, KD Niswender
Activation of paramyxovirus membrane fusion and virus entry.
1. Curr Opin Virol - published February 13, 2014
2. TS Jardetzky, RA Lamb
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy.
1. Cell - published February 13, 2014
2. Jr West AP, L Scharf, JF Scheid, F Klein, PJ Bjorkman, MC Nussenzweig
Structure and Functional Analysis of YcfD, a Novel 2-Oxoglutarate/Fe²⁺-Dependent Oxygenase Involved in Translational Regulation in Escherichiacoli.
1. J Mol Biol - published February 13, 2014
2. van Staalduinen LM, Novakowski SK, Jia Z
Experimental and computational study of BODIPY dye-labeled cavitand dynamics.
1. J Am Chem Soc - published February 12, 2014
2. Pochorovski I., Knehans T., Nettels D., Müller AM., Schweizer WB., Caflisch A., Schuler B., Diederich F.
Structure of a myosinbulletadaptor complex and pairing by cargo.
1. Proc Natl Acad Sci U S A - published February 12, 2014
2. H Shi, N Singh, F Esselborn, G Blobel
A requirement for ER-derived COPII vesicles in phagophore initiation.
1. Autophagy - published February 12, 2014
2. J Wang, D Tan, Y Cai, KM Reinisch, T Walz, S Ferro-Novick
A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.
1. Nat Commun - published February 11, 2014
2. M Novinec, M Korenč, A Caflisch, R Ranganathan, B Lenarčič, A Baici
Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM.
1. Structure - published February 11, 2014
2. CM Del Campo, AK Mishra, YH Wang, CR Roy, PA Janmey, DG Lambright
A new system for naming ribosomal proteins.
1. Curr Opin Struct Biol - published February 10, 2014
2. N Ban, R Beckmann, JH Cate, JD Dinman, F Dragon, SR Ellis, DL Lafontaine, L Lindahl, A Liljas, JM Lipton, MA McAlear, PB Moore, HF Noller, J Ortega, VG Panse, V Ramakrishnan, CM Spahn, TA Steitz, M Tchorzewski, D Tollervey, AJ Warren, JR Williamson, D Wilson, A Yonath, M Yusupov
The eukaryotic RNA exosome.
1. Curr Opin Struct Biol - published February 10, 2014
2. K Januszyk, CD Lima
The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1.
1. Cancer Cell - published February 10, 2014
2. J Cullis, D Meiri, MJ Sandi, N Radulovich, OA Kent, M Medrano, D Mokady, J Normand, J Larose, R Marcotte, CB Marshall, M Ikura, T Ketela, J Moffat, BG Neel, AC Gingras, MS Tsao, R Rottapel
Relating structure to evolution in class II viral membrane fusion proteins.
1. Curr Opin Virol - published February 10, 2014
2. Y Modis
A protective chaperone for the kinetochore adaptor bub3.
1. Dev Cell - published February 10, 2014
2. Z Ji, H Yu
Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance.
1. Theranostics - published February 8, 2014
2. LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF
Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke.
1. J Biol Chem - published February 7, 2014
2. RA Albright, DL Ornstein, W Cao, WC Chang, D Robert, M Tehan, D Hoyer, L Liu, P Stabach, G Yang, EM De La Cruz, DT Braddock
Structure of the TbBILBO1 Protein N-terminal Domain from Trypanosoma brucei Reveals an Essential Requirement for a Conserved Surface Patch.
1. J Biol Chem - published February 7, 2014
2. K Vidilaseris, B Morriswood, G Kontaxis, G Dong
Structural and Functional Analysis of Human SIRT1.
1. J Mol Biol - published February 6, 2014
2. AM Davenport, FM Huber, A Hoelz
Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase.
1. J Mol Biol - published February 6, 2014
2. S Vaithiyalingam, DR Arnett, A Aggarwal, BF Eichman, E Fanning, WJ Chazin
In vivo discovery of immunotherapy targets in the tumour microenvironment.
1. Nature - published February 6, 2014
2. P Zhou, DR Shaffer, DA Alvarez Arias, Y Nakazaki, W Pos, AJ Torres, V Cremasco, SK Dougan, GS Cowley, K Elpek, J Brogdon, J Lamb, SJ Turley, HL Ploegh, DE Root, JC Love, G Dranoff, N Hacohen, H Cantor, KW Wucherpfennig
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
1. Science - published February 6, 2014
2. M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, M Hauer, K Zhou, S Lin, M Kaplan, AT Iavarone, E Charpentier, E Nogales, JA Doudna
Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis.
1. J Am Chem Soc - published February 5, 2014
2. Dong M, Su X, Dzikovski B, Dando EE, Zhu X, Du J, Freed JH, Lin H
Durable Remission of Pemphigus With a Fixed-Dose Rituximab Protocol.
1. JAMA Dermatol - published February 5, 2014
2. K Heelan, F Al-Mohammedi, MJ Smith, S Knowles, P Lansang, S Walsh, NH Shear
A Self-Sequestered Calmodulin-like Ca(2+) Sensor of Mitochondrial SCaMC Carrier and Its Implication to Ca(2+)-Dependent ATP-Mg/Pi Transport.
1. Structure - published February 4, 2014
2. Q Yang, S Brüschweiler, JJ Chou
Dynamics transitions at the outer vestibule of the KcsA potassium channel during gating.
1. Proc Natl Acad Sci U S A - published February 4, 2014
2. Raghuraman H, Islam SM, Mukherjee S, Roux B, Perozo E
CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing.
1. Proc Natl Acad Sci U S A - published February 4, 2014
2. Kuscu C, Zaratiegui M, Kim HS, Wah DA, Martienssen RA, Schalch T, Joshua-Tor L
Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers.
1. Proc Natl Acad Sci U S A - published February 4, 2014
2. Y Opatowsky, I Lax, F Tome, F Bleichert, VM Unger, J Schlessinger
Structure of sugar-bound LacY.
1. Proc Natl Acad Sci U S A - published February 4, 2014
2. Kumar H, Kasho V, Smirnova I, Finer-Moore JS, Kaback HR, Stroud RM
Fluoroquinolone-Gyrase-DNA Complexes: Two Modes of Drug Binding.
1. J Biol Chem - published February 4, 2014
2. A Mustaev, M Malik, X Zhao, N Kurepina, G Luan, LM Oppegard, H Hiasa, KR Marks, RJ Kerns, JM Berger, K Drlica
Air- and Moisture-Stable Amphoteric Molecules: Enabling Reagents in Synthesis.
1. Acc Chem Res - published February 4, 2014
2. Z He, A Zajdlik, AK Yudin
Diffuse X-ray scattering to model protein motions.
1. Structure - published February 4, 2014
2. Wall ME, Adams PD, Fraser JS, Sauter NK
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia.
1. J Clin Invest - published February 3, 2014
2. Gutierrez A., Pan L., Groen RW., Baleydier F., Kentsis A., Marineau J., Grebliunaite R., Kozakewich E., Reed C., Pflumio F., Poglio S., Uzan B., Clemons P., VerPlank L., An F., Burbank J., Norton S., Tolliday N., Steen H., Weng AP., Yuan H., Bradner JE., Mitsiades C., Look AT., Aster JC.
Targeting Mcl-1 for multiple myeloma (MM) therapy: drug-induced generation of Mcl-1 fragment Mcl-1(128-350) triggers MM cell death via c-Jun upregulation.
1. Cancer Lett - published February 2, 2014
2. Fan F, Tonon G, Bashari MH, Vallet S, Antonini E, Goldschmidt H, Schulze-Bergkamen H, Opferman JT, Sattler M, Anderson KC, Jäger D, Podar K
Structural basis of regulation of von Willebrand factor binding to glycoprotein Ib.
1. J Biol Chem - published February 2, 2014
2. Blenner MA, Dong X, Springer TA
Catalytic mechanism and mode of action of the periplasmic alginate epimerase AlgG.
1. J Biol Chem - published February 2, 2014
2. Wolfram F, Kitova EN, Robinson H, Walvoort MT, Codée JD, Klassen JS, Howell PL
Photocleavable dimerizer for the rapid reversal of molecular trap antagonists.
1. J Biol Chem - published February 2, 2014
2. Ahmed S, Xie J, Horne D, Williams JC
Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.
1. Nature - published February 2, 2014
2. K Choudhuri, J Llodrá, EW Roth, J Tsai, S Gordo, KW Wucherpfennig, LC Kam, DL Stokes, ML Dustin
Production of a novel N-monomethylated dideoxysugar.
1. Biochemistry - published February 2, 2014
2. Thoden JB, Holden HM
A repulsion mechanism explains magnesium permeation and selectivity in CorA.
1. Proc Natl Acad Sci U S A - published February 2, 2014
2. Dalmas O, Sandtner W, Medovoy D, Frezza L, Bezanilla F, Perozo E
Crystal structure of Cas9 in complex with guide RNA and target DNA.
1. Cell - published February 2, 2014
2. Nishimasu H, Ran FA, Hsu PD, Konermann S, Shehata SI, Dohmae N, Ishitani R, Zhang F, Nureki O
Structural insights into ubiquinone biosynthesis in membranes.
1. Science - published February 2, 2014
2. Cheng W, Li W
Manganese graft ionomer complexes (MaGICs) for dual imaging and chemotherapy.
1. J Mater Chem B - published February 2, 2014
2. Pothayee N, Pothayee N, Hu N, Zhang R, Kelly DF, Koretsky AP, Riffle JS
Development of object control in the first year: emerging category discrimination and generalization in infants' adaptive selection of action.
1. Dev Psychol - published February 1, 2014
2. Mash C, Bornstein MH, Banerjee A
Specificity and mechanism-of-action of the JAK2 tyrosine kinase inhibitors ruxolitinib and SAR302503 (TG101348).
1. Leukemia - published February 1, 2014
2. Zhou T, Georgeon S, Moser R, Moore DJ, Caflisch A, Hantschel O
Modular peptide binding: from a comparison of natural binders to designed armadillo repeat proteins.
1. J Struct Biol - published February 1, 2014
2. Reichen C, Hansen S, Plückthun A
Detection of a novel intracellular microbiome hosted in arbuscular mycorrhizal fungi.
1. ISME J - published February 1, 2014
2. Desirò A, Salvioli A, Ngonkeu EL, Mondo SJ, Epis S, Faccio A, Kaech A, Pawlowska TE, Bonfante P
Screening protein--single stranded RNA complexes by NMR spectroscopy for structure determination.
1. Methods - published February 1, 2014
2. Foot JN, Feracci M, Dominguez C
Structural basis of PP2A activation by PTPA, an ATP-dependent activation chaperone.
1. Cell Res - published February 1, 2014
2. Guo F, Stanevich V, Wlodarchak N, Sengupta R, Jiang L, Satyshur KA, Xing Y
Essential role of conformational selection in ligand binding.
1. Biophys Chem - published February 1, 2014
2. Vogt AD, Pozzi N, Chen Z, Di Cera E
Architecture and host interface of environmental chlamydiae revealed by electron cryotomography.
1. Environ Microbiol - published February 1, 2014
2. Pilhofer M, Aistleitner K, Ladinsky MS, König L, Horn M, Jensen GJ
Telomerase in bladder cancer: back to a better future?
1. Eur Urol - published February 1, 2014
2. Theodorescu D, Cech TR
Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation.
1. Mol Cancer Ther - published February 1, 2014
2. Simon M, Stefan N, Borsig L, Plückthun A, Zangemeister-Wittke U
Co-transcriptional production of RNA-DNA hybrids for simultaneous release of multiple split functionalities.
1. Nucleic Acids Res - published February 1, 2014
2. Afonin KA, Desai R, Viard M, Kireeva ML, Bindewald E, Case CL, Maciag AE, Kasprzak WK, Kim T, Sappe A, Stepler M, Kewalramani VN, Kashlev M, Blumenthal R, Shapiro BA
Visualizing the ai5γ group IIB intron.
1. Nucleic Acids Res - published February 1, 2014
2. S Somarowthu, M Legiewicz, KS Keating, AM Pyle
The mechanism of pseudouridine synthases from a covalent complex with RNA, and alternate specificity for U2605 versus U2604 between close homologs.
1. Nucleic Acids Res - published February 1, 2014
2. Czudnochowski N, Ashley GW, Santi DV, Alian A, Finer-Moore J, Stroud RM
Effects of polymorphisms and haplotypes within the MSTN gene on duck growth trait.
1. Br Poult Sci - published February 1, 2014
2. Gong P, Yang YP, Yang Y, Ye SQ, Deng B, Wang LX, Yu T, Qian YG, Gong YZ
Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.
1. Nucleic Acids Res - published February 1, 2014
2. Langereis MA, Feng Q, Nelissen FH, Virgen-Slane R, van der Heden van Noort GJ, Maciejewski S, Filippov DV, Semler BL, van Delft FL, van Kuppeveld FJ
Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase.
1. Mol Cell Biol - published February 1, 2014
2. Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F
Quantitative phosphoproteomics reveals the role of protein arginine phosphorylation in the bacterial stress response.
1. Mol Cell Proteomics - published February 1, 2014
2. Schmidt A, Trentini DB, Spiess S, Fuhrmann J, Ammerer G, Mechtler K, Clausen T
Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2.
1. Nucleic Acids Res - published February 1, 2014
2. Clerici M, Deniaud A, Boehm V, Gehring NH, Schaffitzel C, Cusack S
Capturing enveloped viruses on affinity grids for downstream cryo-electron microscopy applications.
1. Microsc Microanal - published February 1, 2014
2. Kiss G, Chen X, Brindley MA, Campbell P, Afonso CL, Ke Z, Holl JM, Guerrero-Ferreira RC, Byrd-Leotis LA, Steel J, Steinhauer DA, Plemper RK, Kelly DF, Spearman PW, Wright ER
Structure-based model for light-harvesting properties of nucleic acid nanostructures.
1. Nucleic Acids Res - published February 1, 2014
2. Pan K, Boulais E, Yang L, Bathe M
Special issue on conformational selection.
1. Biophys Chem - published February 1, 2014
2. Di Cera E
Cancer-Derived Mutations in KEAP1 Impair NRF2 Degradation but not Ubiquitination.
1. Cancer Res - published February 1, 2014
2. BE Hast, EW Cloer, D Goldfarb, H Li, PF Siesser, F Yan, V Walter, N Zheng, DN Hayes, MB Major
Structural and mechanistic insights into prokaryotic energy-coupling factor transporters.
1. Nat Rev Microbiol - published February 1, 2014
2. Slotboom DJ
MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction.
1. Cancer Discov - published February 1, 2014
2. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP
Antibodies VRC01 and 10E8 Neutralize HIV-1 with High Breadth and Potency Even with Ig-Framework Regions Substantially Reverted to Germline.
1. J Immunol - published February 1, 2014
2. IS Georgiev, RS Rudicell, KO Saunders, W Shi, T Kirys, K McKee, S O'Dell, GY Chuang, ZY Yang, G Ofek, M Connors, JR Mascola, GJ Nabel, PD Kwong
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes.
1. Nat Struct Mol Biol - published February 1, 2014
2. Duong HA, Weitz CJ
Structural basis of lipid-driven conformational transitions in the KvAP voltage-sensing domain.
1. Nat Struct Mol Biol - published February 1, 2014
2. Li Q, Wanderling S, Sompornpisut P, Perozo E
Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli.
1. Proc Natl Acad Sci U S A - published February 1, 2014
2. Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schütz M, Plückthun A
Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T₂-weighted MRI contrast.
1. Langmuir - published February 1, 2014
2. Balasubramaniam S, Kayandan S, Lin YN, Kelly DF, House MJ, Woodward RC, St Pierre TG, Riffle JS, Davis RM
In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.
1. J Mol Biol - published February 1, 2014
2. Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK
The free energy profile of tubulin straight-bent conformational changes, with implications for microtubule assembly and drug discovery.
1. PLoS Comput Biol - published February 1, 2014
2. Peng LX, Hsu MT, Bonomi M, Agard DA, Jacobson MP
Exploring the atomic structure and conformational flexibility of a 320 Å long engineered viral fiber using X-ray crystallography.
1. Acta Crystallogr D Biol Crystallogr - published February 1, 2014
2. Bhardwaj A, Casjens SR, Cingolani G
Radiation therapy as a backbone of treatment of locally advanced non-small cell lung cancer.
1. Semin Oncol - published February 1, 2014
2. Laine AM, Westover KD, Choy H
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response.
1. PLoS Pathog - published February 1, 2014
2. Pulloor NK, Nair S, McCaffrey K, Kostic AD, Bist P, Weaver JD, Riley AM, Tyagi R, Uchil PD, York JD, Snyder SH, García-Sastre A, Potter BV, Lin R, Shears SB, Xavier RJ, Krishnan MN
Influenza virus drug resistance: a time-sampled population genetics perspective.
1. PLoS Genet - published February 1, 2014
2. Foll M, Poh YP, Renzette N, Ferrer-Admetlla A, Bank C, Shim H, Malaspinas AS, Ewing G, Liu P, Wegmann D, Caffrey DR, Zeldovich KB, Bolon DN, Wang JP, Kowalik TF, Schiffer CA, Finberg RW, Jensen JD
Crystallization and preliminary X-ray analysis of the C-type lectin domain of the spicule matrix protein SM50 from Strongylocentrotus purpuratus.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2014
2. Juneja P, Rao A, Cölfen H, Diederichs K, Welte W
Strain background determines lymphoma incidence in Atm knockout mice.
1. Neoplasia - published February 1, 2014
2. Genik PC, Bielefeldt-Ohmann H, Liu X, Story MD, Ding L, Bush JM, Fallgren CM, Weil MM