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81 Member Publications for October 2013

Modulation of Protein C Activation by Histones, Platelet Factor 4, and Heparinoids: New Insights Into Activated Protein C Formation.
1. Arterioscler Thromb Vasc Biol - published October 31, 2013
2. M Poncz, S Krishnaswamy, S Marcus, 3rd David G, L Zhai, G Zhao, MA Kowalska
Isotropic bicelles stabilize the juxtamembrane region of the influenza M2 protein for solution NMR studies.
1. Biochemistry - published October 29, 2013
2. JR Schnell, DM Cooper, J Aittoniemi, JK Claridge
Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex.
1. Proc Natl Acad Sci U S A - published October 28, 2013
2. DB Lacy, JR Goldenring, SA Rutherford, JL Franklin, LA Lapierre, NM Chumbler, MA Farrow
Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non-Small Cell Lung Cancer.
1. Clin Cancer Res - published October 23, 2013
2. KK Wong, JE Bradner, AL Kung, AC Kimmelman, E Akbay, J Qi, TJ Cohoon, KA Cheng, Y Gao, JH Tchaicha, E Kikuchi, J Carretero, M Soucheray, Z Chen, T Shimamura
dPeak: high resolution identification of transcription factor binding sites from PET and SET ChIP-Seq data.
1. PLoS Comput Biol - published October 23, 2013
2. Chung D, Park D, Myers K, Grass J, Kiley P, Landick R, Keleş S
The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally.
1. PLoS Genet - published October 23, 2013
2. Park DM, Akhtar MS, Ansari AZ, Landick R, Kiley PJ
Molecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor region.
1. PLoS One - published October 23, 2013
2. Bourne Y, Renault L, Essono S, Mondielli G, Lamourette P, Boquet D, Grassi J, Marchot P
Structure of the SecY channel during initiation of protein translocation.
1. Nature - published October 23, 2013
2. CW Akey, TA Rapoport, A Whynot, W Li, SJ Ludtke, JC Gumbart, JF Ménétret, E Park
Differential Accessibility of a Rotavirus VP6 Epitope in Trimers Comprising Type I, II, or III Channels as Revealed by Binding of a Human Rotavirus VP6-Specific Antibody.
1. J Virol - published October 23, 2013
2. Jr Crowe JE, PL Stewart, S Li, T Liu, DE Lee, R Kim, DR Williams, BW Spiller, IM Eli, MS Aiyegbo
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
1. Nucleic Acids Res - published October 22, 2013
2. JA Doudna, M Jinek, O Niewoehner
Staphylococcus aureus protein SAUGI acts as a uracil-DNA glycosylase inhibitor.
1. Nucleic Acids Res - published October 22, 2013
2. AH Wang, SR Lin, TP Ko, ML Wu, JM Yang, KC Hsu, HC Wang
Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop.
1. Nat Commun - published October 18, 2013
2. KW Wucherpfennig, DA Schubert, S Gordo, DK Sethi
Crystal structure of the prothrombinase complex from the venom of Pseudonaja textilis.
1. Blood - published October 17, 2013
2. JA Huntington, RM Camire, S Krishnaswamy, TE Adams, DJ Johnson, TA Murray-Rust, BC Lechtenberg
Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions.
1. J Am Chem Soc - published October 16, 2013
2. AT Brunger, RA Pfuetzner, MS Padolina, S Shah, Y Zhang, M Zhao, DJ Cipriano, J Diao
Glycine Transporter-1 Inhibition Promotes Striatal Axon Sprouting via NMDA Receptors in Dopamine Neurons.
1. J Neurosci - published October 16, 2013
2. D Sulzer, CW Lindsley, Z Klein, JE Lizardi-Ortiz, A Mrejeru, C Castagna, Y Schmitz
Site-Specific Stabilization of DNA by a Tethered Major Groove Amine, 7-Aminomethyl-7-deaza-2'-deoxyguanosine.
1. Biochemistry - published October 16, 2013
2. MP Stone, B Gold, M Ganguly, MW Voehler, MW Szulik
Selection of Low Envelope Glycoprotein Reactivity to Soluble CD4 and Cold During Simian-Human Immunodeficiency Virus Infection of Rhesus Macaques.
1. J Virol - published October 16, 2013
2. J Sodroski, N Letvin, H Javanbakht, N Espy, B Korioth-Schmitz, H Haim, K McGee
Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics.
1. Bioorg Med Chem Lett - published October 15, 2013
2. A Caflisch, H Zhao
BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis.
1. Proc Natl Acad Sci U S A - published October 14, 2013
2. J Zimmer, V Bulone, O Mazur, H Mélida, J Strumillo, A Narahari, O Omadjela
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
1. Proc Natl Acad Sci U S A - published October 14, 2013
2. J Schlessinger, I Lax, SS Sidhu, Y Suzuki, F Tome, EM Mandel-Bausch, A Pavlenco, TJ Boggon, X Shi, B Nelson, AV Reshetnyak
Disparate Epitopes Mediating Protective Heterologous Immunity to Unrelated Viruses Share pMHC Structural Features Recognized By Cross-Reactive T Cells.
1. J Immunol - published October 14, 2013
2. TT Nguyen, ZT Shen, LJ Stern, RM Welsh, KA Daniels
RNA-Seq reveals differential gene expression in Staphylococcus aureus with single-nucleotide resolution.
1. PLoS One - published October 12, 2013
2. Osmundson J, Dewell S, Darst SA
Structural insights into transcriptional repression by noncoding RNAs that bind to human Pol II.
1. J Mol Biol - published October 9, 2013
2. Kassube SA, Fang J, Grob P, Yakovchuk P, Goodrich JA, Nogales E
Exploration of Allosteric Agonism Structure-Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu₅) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinamide (ML254).
1. J Med Chem - published October 9, 2013
2. SR Stauffer, CW Lindsley, PJ Conn, J Meiler, CM Niswender, C Jones, JS Daniels, TM Bridges, Z Xiang, KK Gogi, JM Rook, PN Vinson, KJ Gregory, ED Nguyen, RD Gogliotti, Y Zhou, A Chun, MJ Noetzel, M Turlington
Lipid droplets and viral infections.
1. Methods Cell Biol - published October 9, 2013
2. Camus G, Vogt DA, Kondratowicz AS, Ott M
Detergent quantification in membrane protein samples and its application to crystallization experiments.
1. Amino Acids - published October 9, 2013
2. Z Jia, CC Prince
Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action.
1. J Neurosci - published October 9, 2013
2. Ferguson D, Koo JW, Feng J, Heller E, Rabkin J, Heshmati M, Renthal W, Neve R, Liu X, Shao N, Sartorelli V, Shen L, Nestler EJ
Visualization of Synaptic Inhibition with an Optogenetic Sensor Developed by Cell-Free Protein Engineering Automation.
1. J Neurosci - published October 9, 2013
2. GJ Augustine, HW Hellinga, LS Beese, L Wen, W Wang, L Li, JS Grimley
Functional diversity of tandem substrate-binding domains in ABC transporters from pathogenic bacteria.
1. Structure - published October 8, 2013
2. Fulyani F, Schuurman-Wolters GK, Zagar AV, Guskov A, Slotboom DJ, Poolman B
Structure and nucleic acid binding activity of the nucleoporin Nup157.
1. Proc Natl Acad Sci U S A - published October 8, 2013
2. G Blobel, NZ Jankovic, BJ Blus, HS Seo
Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion.
1. Proc Natl Acad Sci U S A - published October 8, 2013
2. Li Y, Altorelli NL, Bahna F, Honig B, Shapiro L, Palmer AG 3rd
De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.
1. Proc Natl Acad Sci U S A - published October 8, 2013
2. L Shapiro, JR Mascola, PD Kwong, JC Mullikin, Program NISC Comparative Sequencing, JP Casazza, T Zhou, C Soto, S O'Dell, K McKee, B Zhang, X Wu, J Zhu
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.
1. Elife - published October 8, 2013
2. Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM
Depurination of N7-Methylguanine by DNA Glycosylase AlkD Is Dependent on the DNA Backbone.
1. Biochemistry - published October 7, 2013
2. BF Eichman, PP Christov, EH Rubinson
Mechanism for recognition of an unusual mycobacterial glycolipid by the macrophage receptor mincle.
1. J Biol Chem - published October 4, 2013
2. Feinberg H, Jégouzo SA, Rowntree TJ, Guan Y, Brash MA, Taylor ME, Weis WI, Drickamer K
A comparative CEST NMR study of slow conformational dynamics of small GTPases complexed with GTP and GTP analogues.
1. Angew Chem Int Ed Engl - published October 4, 2013
2. Long D, Marshall CB, Bouvignies G, Mazhab-Jafari MT, Smith MJ, Ikura M, Kay LE
A β-Boronopeptide Bundle of Known Structure As a Vehicle for Polyol Recognition.
1. Org Lett - published October 4, 2013
2. A Schepartz, RH Baxter, SJ Miller, AS Walker, J Chu, MS Melicher
Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
1. ACS Med Chem Lett - published October 4, 2013
2. Zaware N, Sharma H, Yang J, Devambatla RK, Queener SF, Anderson KS, Gangjee A
First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling.
1. Biochemistry - published October 3, 2013
2. KS Anderson, KA Spasov, MA Vargo, MJ Landau, H Sharma
Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters.
1. Nature - published October 3, 2013
2. Erkens GB, Hänelt I, Goudsmits JM, Slotboom DJ, van Oijen AM
Biophysics: Rough passage across a barrier.
1. Nature - published October 3, 2013
2. Schuler B, Clarke J
In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities.
1. J Mol Biol - published October 2, 2013
2. Czudnochowski N, Wang AL, Finer-Moore J, Stroud RM
Intramolecular distances and dynamics from the combined photon statistics of single-molecule FRET and photoinduced electron transfer.
1. J Phys Chem B - published October 2, 2013
2. Haenni D, Zosel F, Reymond L, Nettels D, Schuler B
Mechanistic implications of persulfenate and persulfide binding in the active site of cysteine dioxygenase.
1. Biochemistry - published October 2, 2013
2. Souness RJ, Kleffmann T, Tchesnokov EP, Wilbanks SM, Jameson GB, Jameson GN
Snapshot of a DNA polymerase while incorporating two consecutive C5-modified nucleotides.
1. J Am Chem Soc - published October 2, 2013
2. Obeid S, Bußkamp H, Welte W, Diederichs K, Marx A
Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
1. Proc Natl Acad Sci U S A - published October 2, 2013
2. Donaldson JM, Zer C, Avery KN, Bzymek KP, Horne DA, Williams JC
Evidence for phenylalanine zipper-mediated dimerization in the X-ray crystal structure of a magainin 2 analogue.
1. J Am Chem Soc - published October 2, 2013
2. Hayouka Z, Mortenson DE, Kreitler DF, Weisblum B, Forest KT, Gellman SH
High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio.
1. Proc Natl Acad Sci U S A - published October 2, 2013
2. Arigovindan M, Fung JC, Elnatan D, Mennella V, Chan YH, Pollard M, Branlund E, Sedat JW, Agard DA
Functional role of the flexible N-terminal extension of FKBP38 in catalysis.
1. Sci Rep - published October 2, 2013
2. Kang C, Ye H, Chia J, Choi BH, Dhe-Paganon S, Simon B, Schütz U, Sattler M, Yoon HS
A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.
1. Dev Cell - published October 2, 2013
2. Zhang Y, Tang W, Zhang H, Niu X, Xu Y, Zhang J, Gao K, Pan W, Boggon TJ, Toomre D, Min W, Wu D
CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis.
1. Cell - published October 2, 2013
2. Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T
Ranking TEM cameras by their response to electron shot noise.
1. Ultramicroscopy - published October 1, 2013
2. Grob P, Bean D, Typke D, Li X, Nogales E, Glaeser RM
Chromatin in a marine picoeukaryote is a disordered assemblage of nucleosomes.
1. Chromosoma - published October 1, 2013
2. Gan L, Ladinsky MS, Jensen GJ
From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections.
1. Curr Urol Rep - published October 1, 2013
2. Silverman JA, Schreiber HL 4th, Hooton TM, Hultgren SJ
Effect of cardiorespiratory fitness on short-term morbidity and mortality after coronary artery bypass grafting.
1. Am J Cardiol - published October 1, 2013
2. Smith JL, Verrill TA, Boura JA, Sakwa MP, Shannon FL, Franklin BA
A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.
1. Antimicrob Agents Chemother - published October 1, 2013
2. van der Schaar HM, Leyssen P, Thibaut HJ, de Palma A, van der Linden L, Lanke KH, Lacroix C, Verbeken E, Conrath K, Macleod AM, Mitchell DR, Palmer NJ, van de Poël H, Andrews M, Neyts J, van Kuppeveld FJ
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
1. Nucleic Acids Res - published October 1, 2013
2. Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR
Pilin and sortase residues critical for endocarditis- and biofilm-associated pilus biogenesis in Enterococcus faecalis.
1. J Bacteriol - published October 1, 2013
2. Nielsen HV, Flores-Mireles AL, Kau AL, Kline KA, Pinkner JS, Neiers F, Normark S, Henriques-Normark B, Caparon MG, Hultgren SJ
Teichoic acid biosynthesis as an antibiotic target.
1. Curr Opin Microbiol - published October 1, 2013
2. Pasquina LW, Santa Maria JP, Walker S
Automated and assisted RNA resonance assignment using NMR chemical shift statistics.
1. Nucleic Acids Res - published October 1, 2013
2. Aeschbacher T, Schmidt E, Blatter M, Maris C, Duss O, Allain FH, Güntert P, Schubert M
In silico optimization of a fragment-based hit yields biologically active, high-efficiency inhibitors for glutamate racemase.
1. ChemMedChem - published October 1, 2013
2. Whalen KL, Chau AC, Spies MA
Substituted pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis thymidylate synthase inhibitors.
1. Bioorg Med Chem Lett - published October 1, 2013
2. KS Anderson, A Gangjee, HK Jain, Y Wang, KM Frey, VP Kumar
Nature-inspired design of motif-specific antibody scaffolds.
1. Nat Biotechnol - published October 1, 2013
2. Koerber JT, Thomsen ND, Hannigan BT, Degrado WF, Wells JA
Heterogeneous seeding of a prion structure by a generic amyloid form of the fungal prion-forming domain HET-s(218-289).
1. J Biol Chem - published October 1, 2013
2. Wan W, Bian W, McDonald M, Kijac A, Wemmer DE, Stubbs G
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.
1. Nat Struct Mol Biol - published October 1, 2013
2. Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ
Crystal structure of a substrate-free aspartate transporter.
1. Nat Struct Mol Biol - published October 1, 2013
2. Jensen S, Guskov A, Rempel S, Hänelt I, Slotboom DJ
A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
1. Proc Natl Acad Sci U S A - published October 1, 2013
2. Lande-Diner L, Boyault C, Kim JY, Weitz CJ
Structural features of Argonaute-GW182 protein interactions.
1. Proc Natl Acad Sci U S A - published October 1, 2013
2. Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.
1. Proc Natl Acad Sci U S A - published October 1, 2013
2. Rattner A, Yu H, Williams J, Smallwood PM, Nathans J
X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.
1. Proc Natl Acad Sci U S A - published October 1, 2013
2. CL Drennan, SJ Booker, TL Grove, PJ Goldman
Structure and expression of a novel compact myelin protein - small VCP-interacting protein (SVIP).
1. Biochem Biophys Res Commun - published October 1, 2013
2. Wu J, Peng D, Voehler M, Sanders CR, Li J
An Iml3-Chl4 heterodimer links the core centromere to factors required for accurate chromosome segregation.
1. Cell Rep - published October 1, 2013
2. Hinshaw SM, Harrison SC
Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase.
1. Cell Res - published October 1, 2013
2. N Zheng, W Xing, S Nangle
Revealing what gets buried first in protein folding.
1. Proc Natl Acad Sci U S A - published October 1, 2013
2. Sosnick TR, Baxa MC
Structure of the Sgt2 dimerization domain complexed with the Get5 UBL domain involved in the targeting of tail-anchored membrane proteins to the endoplasmic reticulum.
1. Acta Crystallogr D Biol Crystallogr - published October 1, 2013
2. Tung JY, Li YC, Lin TW, Hsiao CD
The bacterial effector VopL organizes actin into filament-like structures.
1. Cell - published October 1, 2013
2. Zahm JA, Padrick SB, Chen Z, Pak CW, Yunus AA, Henry L, Tomchick DR, Chen Z, Rosen MK
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma.
1. Cancer Cell - published October 1, 2013
2. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA
HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.
1. Front Immunol - published October 1, 2013
2. Yin L, Stern LJ
Impact of new sequencing technologies on studies of the human B cell repertoire.
1. Curr Opin Immunol - published October 1, 2013
2. Finn JA, Crowe JE Jr
Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.
1. ACS Med Chem Lett - published October 1, 2013
2. Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, Hopkins AL, Lefkowitz RJ, Navratilova I
Nexus between protein-ligand affinity rank-ordering, biophysical approaches, and drug discovery.
1. ACS Med Chem Lett - published October 1, 2013
2. Spies MA