Member Publications
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75 Member Publications for August 2013
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H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation.
- PLoS Genet - published August 31, 2013
- Subramanian V, Mazumder A, Surface LE, Butty VL, Fields PA, Alwan A, Torrey L, Thai KK, Levine SS, Bathe M, Boyer LA
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Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
- EMBO Rep - published August 30, 2013
- C Löw, P Nordlund, AJ Jong, L Zhu, C Jegerschöld, P Moberg, L Trésaugues, EM Quistgaard, F Guettou
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Stereocontrolled Synthesis of 1,2- and 1,3-Diamine Building Blocks from Aziridine Aldehyde Dimers.
- J Org Chem - published August 30, 2013
- AK Yudin, JD St Denis, Z He, SK Liew
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The E3 Ubiquitin Ligase XIAP Restricts Anaplasma phagocytophilum Colonization of Ixodes scapularis Ticks.
- J Infect Dis - published August 29, 2013
- JH Pedra, G Blaha, KG Le Roch, DW Chung, G Chen, OS Sakhon, KD Stephens, A Choy, MS Severo
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Chromosome replication and segregation govern the biogenesis and inheritance of inorganic polyphosphate granules.
- Mol Biol Cell - published August 28, 2013
- S Crosson, JT Henry
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The biosynthesis and biological function of diphthamide.
- Crit Rev Biochem Mol Biol - published August 27, 2013
- Su X, Lin Z, Lin H
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Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.
- Nat Chem Biol - published August 25, 2013
- SH Orkin, LD Walensky, MA Kerenyi, G Guo, T Neff, GH Bird, W Kim
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Substituted 1-Phenyl-3-(pyridin-2-yl)urea Negative Allosteric Modulators of mGlu5: Discovery of a New Tool Compound VU0463841 with Activity in Rat Models of Cocaine Addiction.
- ACS Chem Neurosci - published August 21, 2013
- KA Emmitte, CK Jones, CW Lindsley, PJ Conn, CM Niswender, JS Daniels, FW Byers, RD Morrison, DF Venable, AL Rodriguez, AS Felts, RJ Amato
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The Sixteenth Iron in the Nitrogenase MoFe Protein.
- Angew Chem Int Ed Engl - published August 21, 2013
- KY Yang, G Meloni, JT Kaiser, L Zhang, DC Rees, JB Howard, O Einsle, SL Andrade, T Spatzal
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TagDock: An Efficient Rigid Body Docking Algorithm for Oligomeric Protein Complex Model Construction and Experiment Planning.
- Biochemistry - published August 20, 2013
- TP Lybrand, CW Moth, SJ Edwards, JA Smith
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Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5.
- Proc Natl Acad Sci U S A - published August 19, 2013
- DB Nikolov, JP Himanen, YP Chan, Y Goldgur, Y Xu, D Tzvetkova-Robev, K Xu
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Adaptation of Enterococcus faecalis to Daptomycin Reveals an Ordered Progression to Resistance.
- Antimicrob Agents Chemother - published August 19, 2013
- Y Shamoo, G Saxer, CA Arias, TT Tran, J Kong, C Miller
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Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface.
- PLoS Pathog - published August 17, 2013
- Lu G, Gong P
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De-novo design of antimicrobial peptides for plant protection.
- PLoS One - published August 17, 2013
- Zeitler B, Herrera Diaz A, Dangel A, Thellmann M, Meyer H, Sattler M, Lindermayr C
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Mapping ERβ genomic binding sites reveals unique genomic features and identifies EBF1 as an ERβ interactor.
- PLoS One - published August 17, 2013
- Le TP, Sun M, Luo X, Kraus WL, Greene GL
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The tick-derived anticoagulant madanin is processed by thrombin and factor Xa.
- PLoS One - published August 17, 2013
- Figueiredo AC, de Sanctis D, Pereira PJ
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Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli.
- Bioorg Med Chem - published August 15, 2013
- D Kahne, WA Denny, S Okuda, DJ Sherman
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Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.
- Bioorg Med Chem Lett - published August 15, 2013
- CW Lindsley, CD Weaver, GA Sulikowski, Y Du, K Kaufmann, IM Romaine, W Wu, W Wen
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Efficient Detection of Hydrogen Bonds in Dynamic Regions of RNA by Sensitivity-Optimized NMR Pulse Sequences.
- Angew Chem Int Ed Engl - published August 14, 2013
- M Sattler, W Bermel, A Pardi, H Kooshapur, MM Duszczyk, B Simon, A Dallmann
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The E3 Ubiquitin Ligase CHIP and the Molecular Chaperone Hsc70 Form a Dynamic, Tethered Complex.
- Biochemistry - published August 13, 2013
- ER Zuiderweg, JE Gestwicki, HL Paulson, DR Southworth, CA Dickey, AD Thompson, S Patury, VA Assimon, KM Scaglione, MC Smith
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Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.
- Proc Natl Acad Sci U S A - published August 12, 2013
- DG Lambright, D Lambright, B van den Berg, AW Malaby
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Membrane Binding by Prothrombin Mediates its Constrained Presentation to Prothrombinase For Cleavage.
- J Biol Chem - published August 12, 2013
- S Krishnaswamy, SJ Orcutt, HN Bradford
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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity.
- Nat Biotechnol - published August 11, 2013
- DR Liu, JA Doudna, E Ma, JP Guilinger, S Lin, V Pattanayak
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Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine.
- J Biol Chem - published August 9, 2013
- Cipriano DJ, Jung J, Vivona S, Fenn TD, Brunger AT, Bryant Z
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The unusual dynamics of parasite actin result from isodesmic polymerization.
- Nat Commun - published August 8, 2013
- Skillman KM, Ma CI, Fremont DH, Diraviyam K, Cooper JA, Sept D, Sibley LD
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Control of protein function through regulated protein degradation: biotechnological and biomedical applications.
- J Mol Microbiol Biotechnol - published August 8, 2013
- Nagpal J, Tan JL, Truscott KN, Heras B, Dougan DA
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Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins.
- Chembiochem - published August 8, 2013
- WD Fairlie, SH Gellman, M Evangelista, JW Checco, EF Lee, BJ Smith
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Structure of a truncation mutant of the nuclear export factor CRM1 provides insights into the auto-inhibitory role of its C-terminal helix.
- Structure - published August 6, 2013
- Dian C, Bernaudat F, Langer K, Oliva MF, Fornerod M, Schoehn G, Müller CW, Petosa C
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Importance of lipid-pore loop interface for potassium channel structure and function.
- Proc Natl Acad Sci U S A - published August 6, 2013
- van der Cruijsen EA, Nand D, Weingarth M, Prokofyev A, Hornig S, Cukkemane AA, Bonvin AM, Becker S, Hulse RE, Perozo E, Pongs O, Baldus M
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α-Boryl Isocyanides Enable Facile Preparation of Bioactive Boropeptides.
- Angew Chem Int Ed Engl - published August 5, 2013
- AK Yudin, AD Schimmer, A Aman, JL Hickey, Z Wang, A Zajdlik
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Substrate-selective COX-2 inhibition decreases anxiety via endocannabinoid activation.
- Nat Neurosci - published August 4, 2013
- S Patel, LJ Marnett, J Reese, RJ Colbran, PJ Kingsley, BC Shonesy, N Brown, J Gamble-George, ND Hartley, DJ Hermanson
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Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.
- J Biol Chem - published August 3, 2013
- Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC
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Structural basis of a physical blockage mechanism for the interaction of response regulator PmrA with connector protein PmrD from Klebsiella pneumoniae.
- J Biol Chem - published August 3, 2013
- Luo SC, Lou YC, Rajasekaran M, Chang YW, Hsiao CD, Chen C
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Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK.
- Oncogene - published August 2, 2013
- Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD
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CSAR benchmark exercise 2011-2012: evaluation of results from docking and relative ranking of blinded congeneric series.
- J Chem Inf Model - published August 2, 2013
- Damm-Ganamet KL, Smith RD, Dunbar JB Jr, Stuckey JA, Carlson HA
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CSAR data set release 2012: ligands, affinities, complexes, and docking decoys.
- J Chem Inf Model - published August 2, 2013
- Dunbar JB Jr, Smith RD, Damm-Ganamet KL, Ahmed A, Esposito EX, Delproposto J, Chinnaswamy K, Kang YN, Kubish G, Gestwicki JE, Stuckey JA, Carlson HA
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Pyrococcus horikoshii TET2 peptidase assembling process and associated functional regulation.
- J Biol Chem - published August 2, 2013
- Appolaire A, Rosenbaum E, Durá MA, Colombo M, Marty V, Savoye MN, Godfroy A, Schoehn G, Girard E, Gabel F, Franzetti B
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In vitro reconstitution of an Escherichia coli RNA-guided immune system reveals unidirectional, ATP-dependent degradation of DNA target.
- J Biol Chem - published August 2, 2013
- Mulepati S, Bailey S
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Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.
- J Biol Chem - published August 2, 2013
- Pozzi N, Chen Z, Gohara DW, Niu W, Heyduk T, Di Cera E
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Structural and functional characterization of Pseudomonas aeruginosa AlgX: role of AlgX in alginate acetylation.
- J Biol Chem - published August 2, 2013
- Riley LM, Weadge JT, Baker P, Robinson H, Codée JD, Tipton PA, Ohman DE, Howell PL
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Danio rerio αE-catenin is a monomeric F-actin binding protein with distinct properties from Mus musculus αE-catenin.
- J Biol Chem - published August 2, 2013
- Miller PW, Pokutta S, Ghosh A, Almo SC, Weis WI, Nelson WJ, Kwiatkowski AV
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Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive factor (NSF) is initiated by a conserved 1:1 interaction between α-soluble NSF attachment protein (SNAP) and SNARE complex.
- J Biol Chem - published August 2, 2013
- Vivona S, Cipriano DJ, O'Leary S, Li YH, Fenn TD, Brunger AT
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Plasticity of the quinone-binding site of the complex II homolog quinol:fumarate reductase.
- J Biol Chem - published August 2, 2013
- Singh PK, Sarwar M, Maklashina E, Kotlyar V, Rajagukguk S, Tomasiak TM, Cecchini G, Iverson TM
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A fluorogenic assay for screening Sirt6 modulators.
- Org Biomol Chem - published August 2, 2013
- Hu J, He B, Bhargava S, Lin H
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Optical control of mammalian endogenous transcription and epigenetic states.
- Nature - published August 2, 2013
- Konermann S, Brigham MD, Trevino A, Hsu PD, Heidenreich M, Cong L, Platt RJ, Scott DA, Church GM, Zhang F
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Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.
- Immunity - published August 2, 2013
- Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, Georgiev IS, Altae-Tran HR, Chuang GY, Joyce MG, Kwon YD, Longo NS, Louder MK, Luongo T, McKee K, Schramm CA, Skinner J, Yang Y, Yang Z, Zhang Z, Zheng A, Bonsignori M, Haynes BF, Scheid JF, Nussenzweig MC, Simek M, Burton DR, Koff WC, NISC Comparative Sequencing Program., Mullikin JC, Connors M, Shapiro L, Nabel GJ, Mascola JR, Kwong PD
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Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation.
- Proc Natl Acad Sci U S A - published August 2, 2013
- Venkatraman Girija U, Gingras AR, Marshall JE, Panchal R, Sheikh MA, Harper JA, Gál P, Schwaeble WJ, Mitchell DA, Moody PC, Wallis R
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SGK196 is a glycosylation-specific O-mannose kinase required for dystroglycan function.
- Science - published August 2, 2013
- Yoshida-Moriguchi T, Willer T, Anderson ME, Venzke D, Whyte T, Muntoni F, Lee H, Nelson SF, Yu L, Campbell KP
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Conformational selection is a dominant mechanism of ligand binding.
- Biochemistry - published August 2, 2013
- Vogt AD, Di Cera E
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Clathrin-mediated endocytosis persists during unperturbed mitosis.
- Cell Rep - published August 2, 2013
- Tacheva-Grigorova SK, Santos AJ, Boucrot E, Kirchhausen T
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Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated protein.
- Biophys J - published August 2, 2013
- Zayner JP, Antoniou C, French AR, Hause RJ Jr, Sosnick TR
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Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
- Sci Signal - published August 2, 2013
- Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH
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Universal flu vaccines: primum non nocere.
- Sci Transl Med - published August 2, 2013
- Crowe JE Jr
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S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase.
- Cell - published August 2, 2013
- Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, Danuser G
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Rotavirus core shell subdomains involved in polymerase encapsidation into virus-like particles.
- J Gen Virol - published August 1, 2013
- Boudreaux CE, Vile DC, Gilmore BL, Tanner JR, Kelly DF, McDonald SM
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The present and future of solution NMR in investigating the structure and dynamics of channels and transporters.
- Curr Opin Struct Biol - published August 1, 2013
- Oxenoid K, Chou JJ
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A highly efficient peptide substrate for EGFR activates the kinase by inducing aggregation.
- Biochem J - published August 1, 2013
- Engel K, Sasaki T, Wang Q, Kuriyan J
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A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.
- ACS Chem Biol - published August 1, 2013
- Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr
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Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
- Nucleic Acids Res - published August 1, 2013
- Kowal EA, Lad RR, Pallan PS, Dhummakupt E, Wawrzak Z, Egli M, Sturla SJ, Stone MP
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Noise models and cryo-EM drift correction with a direct-electron camera.
- Ultramicroscopy - published August 1, 2013
- Shigematsu H, Sigworth FJ
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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.
- Nucleic Acids Res - published August 1, 2013
- Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA
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Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.
- Nucleic Acids Res - published August 1, 2013
- Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna JA, Nogales E, Cate JH
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The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies.
- J Virol - published August 1, 2013
- Mou H, Raj VS, van Kuppeveld FJ, Rottier PJ, Haagmans BL, Bosch BJ
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Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection.
- J Virol - published August 1, 2013
- Sukupolvi-Petty S, Brien JD, Austin SK, Shrestha B, Swayne S, Kahle K, Doranz BJ, Johnson S, Pierson TC, Fremont DH, Diamond MS
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The Legionella pneumophila GTPase activating protein LepB accelerates Rab1 deactivation by a non-canonical hydrolytic mechanism.
- J Biol Chem - published August 1, 2013
- Mishra AK, Del Campo CM, Collins RE, Roy CR, Lambright DG
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Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.
- EMBO Mol Med - published August 1, 2013
- Emadali A, Rousseaux S, Bruder-Costa J, Rome C, Duley S, Hamaidia S, Betton P, Debernardi A, Leroux D, Bernay B, Kieffer-Jaquinod S, Combes F, Ferri E, McKenna CE, Petosa C, Bruley C, Garin J, Ferro M, Gressin R, Callanan MB, Khochbin S
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Initial activation of STIM1, the regulator of store-operated calcium entry.
- Nat Struct Mol Biol - published August 1, 2013
- Zhou Y, Srinivasan P, Razavi S, Seymour S, Meraner P, Gudlur A, Stathopulos PB, Ikura M, Rao A, Hogan PG
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Receptor tyrosine kinases with intracellular pseudokinase domains.
- Biochem Soc Trans - published August 1, 2013
- MA Lemmon, JH Park, F Shi, JM Mendrola
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Functional Characterization of Staphylococcus epidermidis IcaB, a De-N-acetylase Important for Biofilm Formation.
- Biochemistry - published August 1, 2013
- DJ Little, J Poloczek, V Pokrovskaya, M Nitz, PL Howell, H Griffiths
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Bispecific antibodies directed to CD4 domain 2 and HIV envelope exhibit exceptional breadth and picomolar potency against HIV-1.
- Proc Natl Acad Sci U S A - published August 1, 2013
- Pace CS, Song R, Ochsenbauer C, Andrews CD, Franco D, Yu J, Oren DA, Seaman MS, Ho DD
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Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B.
- Genes Dev - published August 1, 2013
- Montellier E, Boussouar F, Rousseaux S, Zhang K, Buchou T, Fenaille F, Shiota H, Debernardi A, Héry P, Curtet S, Jamshidikia M, Barral S, Holota H, Bergon A, Lopez F, Guardiola P, Pernet K, Imbert J, Petosa C, Tan M, Zhao Y, Gérard M, Khochbin S
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Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA.
- Nature - published August 1, 2013
- Zhang J, Ferré-D'Amaré AR
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Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.
- Acta Crystallogr D Biol Crystallogr - published August 1, 2013
- Shankar M, Wilbanks SM, Nakatani Y, Monk BC, Tyndall JD
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Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.
- Cell - published August 1, 2013
- Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ
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From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.
- Cell - published August 1, 2013
- Braberg H, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ