Member Publications

Jump to specific year:

90 Member Publications for January 2013

Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus.
1. FEBS Lett - published January 31, 2013
2. TJ Boggon, B Demeler, JW Murphy, X Li, R Zhang, OS Fisher
Collaboration or Coercion? Partnering to Divert Prescription Opioid Medications.
1. J Urban Health - published January 31, 2013
2. P Case, R Heimer, N Zaller, M Ray, SE Bowman, TC Green
RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors.
1. J Virol - published January 30, 2013
2. JM Hogle, DJ Filman, M Bostina, H Levy, M Strauss, HC Levy
Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50.
1. J Virol - published January 30, 2013
2. CA Schiffer, N Kurt Yilmaz, EA Nalivaika, MN Nalam, M Prabu-Jeyabalan, NM King, RM Bandaranayake, S Mittal
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.
1. Proc Natl Acad Sci U S A - published January 28, 2013
2. AD Santin, RP Lifton, J Schlessinger, TJ Boggon, S Mane, AL Stiegler, TJ Rutherford, PE Schwartz, M Azodi, E Ratner, DA Silasi, S Pecorelli, L Carrara, L Zanotti, R Tassi, P Todeschini, C Romani, E Bandiera, E Bignotti, A Ravaggi, M Abu-Khalaf, P Hui, N Buza, I Bortolomai, S Gasparrini, J Varughese, DP English, F Guzzo, E Cocco, DM Roque, S Bellone, JD Overton, M Choi, S Zhao
MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11.
1. Nat Commun - published January 24, 2013
2. Bockhorn J, Dalton R, Nwachukwu C, Huang S, Prat A, Yee K, Chang YF, Huo D, Wen Y, Swanson KE, Qiu T, Lu J, Park SY, Dolan ME, Perou CM, Olopade OI, Clarke MF, Greene GL, Liu H
A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling.
1. Mol Pharmacol - published January 24, 2013
2. PJ Conn, Z Xiang, CM Niswender, CW Lindsley, SR Stauffer, JT Manka, PN Vinson, KJ Gregory, MJ Noetzel
Simultaneous prediction of protein secondary structure and trans-membrane spans.
1. Proteins - published January 24, 2013
2. J Meiler, N Woetzel, M Karakaş, R Mueller, JK Leman
Enhanced Autointegration in Hyperstable Simian Immunodeficiency Virus Capsid Mutants Blocked After Reverse Transcription.
1. J Virol - published January 23, 2013
2. J Sodroski, C Tipper
Directed evolution of G-protein-coupled receptors for high functional expression and detergent stability.
1. Methods Enzymol - published January 22, 2013
2. Schlinkmann KM, Plückthun A
Open and shut: Crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from E. coli and H. pylori at 4.4 Å and 4.1 Å resolution.
1. Protein Sci - published January 22, 2013
2. DC Rees, JT Kaiser, YS Poon, JY Lai
Small angle X-ray scattering analysis of Clostridium thermocellum cellulosome N-terminal complexes reveals a highly dynamic structure.
1. J Biol Chem - published January 22, 2013
2. Z Jia, SP Smith, CM Fontes, EA Bayer, HL Spencer, FM Dias, K Cameron, MA Currie
Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel.
1. Proc Natl Acad Sci U S A - published January 22, 2013
2. R Mackinnon, EB Campbell, SG Brohawn
The stress protein BAG3 stabilizes Mcl-1 and promotes survival of cancer cells and resistance to ABT-737.
1. J Biol Chem - published January 22, 2013
2. M Boiani, LJ Marnett, MD Hogarty, X Liu, C Daniel
Correction to Potentiation of the Kv1 family K(+) Channel by Cortisone Analogues.
1. ACS Chem Biol - published January 18, 2013
2. M Zhou, M Quick, EJ Levin, Y Pan
Backbone resonance assignment of the HEAT1-domain of the human eukaryotic translation initiation factor 4GI.
1. Biomol NMR Assign - published January 17, 2013
2. G Wagner, SR Akabayov
High yield production of myristoylated Arf6 small GTPase by recombinant N-myristoyl transferase.
1. Small GTPases - published January 16, 2013
2. Padovani D, Zeghouf M, Traverso JA, Giglione C, Cherfils J
Isatin replacements applied to the highly selective, muscarinic M(1) PAM ML137: Continued optimization of an MLPCN probe molecule.
1. Bioorg Med Chem Lett - published January 15, 2013
2. MR Wood, CW Lindsley, PJ Conn, CM Niswender, JS Daniels, TJ Utley, TM Bridges, ME Mattmann, DJ Sheffler, JC Tarr, PR Gentry, MS Poslusney, BJ Melancon
The mannoprotein Cig1 supports iron acquisition from heme and virulence in the pathogenic fungus Cryptococcus neoformans.
1. J Infect Dis - published January 15, 2013
2. JW Kronstad, AL Creagh, ME Murphy, V Liu, G Teti, C Biondo, J Wang, G Hu, T Lian, B Cadieux
Mechanisms By Which von Willebrand Disease Mutations Destabilize the A2 Domain.
1. J Biol Chem - published January 15, 2013
2. TA Springer, AJ Xu
Crystal structure of glycoprotein C from Rift Valley fever virus.
1. Proc Natl Acad Sci U S A - published January 14, 2013
2. Y Modis, M Dessau
Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.
1. Cell Mol Life Sci - published January 11, 2013
2. M Ikura, CB Marshall, F Wang
Crystallographic snapshot of cellulose synthesis and membrane translocation.
1. Nature - published January 10, 2013
2. J Zimmer, J Strumillo, JL Morgan
Interaction of the transactivation domain of B-Myb with the TAZ2 domain of the coactivator p300: molecular features and properties of the complex.
1. PLoS One - published January 10, 2013
2. Oka O, Waters LC, Strong SL, Dosanjh NS, Veverka V, Muskett FW, Renshaw PS, Klempnauer KH, Carr MD
The adaptable major histocompatibility complex (MHC) fold: structure and function of nonclassical and MHC class I-like molecules.
1. Annu Rev Immunol - published January 10, 2013
2. Adams EJ, Luoma AM
Exponential megapriming PCR (EMP) cloning--seamless DNA insertion into any target plasmid without sequence constraints.
1. PLoS One - published January 10, 2013
2. Ulrich A, Andersen KR, Schwartz TU
Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces.
1. Sci Rep - published January 10, 2013
2. Takasuka TE, Book AJ, Lewin GR, Currie CR, Fox BG
Function of Shaker potassium channels produced by cell-free translation upon injection into Xenopus oocytes.
1. Sci Rep - published January 10, 2013
2. Jarecki BW, Makino S, Beebe ET, Fox BG, Chanda B
Cobalt Carbonyl Complexes as Probes for Alkyne-Tagged Lipids.
1. J Lipid Res - published January 10, 2013
2. NA Porter, HA Brown, LJ Marnett, SB Milne, MD Armstrong, KA Tallman
Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae.
1. Biochemistry - published January 9, 2013
2. SE Ealick, TP Begley, SE O'Leary, KA Hicks
NMR studies of the interaction of calmodulin with IQ motif peptides.
1. Methods Mol Biol - published January 9, 2013
2. Damo SM, Feldkamp MD, Chagot B, Chazin WJ
Physostigmine and galanthamine bind in the presence of agonist at the canonical and noncanonical subunit interfaces of a nicotinic acetylcholine receptor.
1. J Neurosci - published January 9, 2013
2. Hamouda AK, Kimm T, Cohen JB
Formation and Fate of a Complete, 31-Protein, RNA polymerase II Transcription Initiation Complex.
1. J Biol Chem - published January 9, 2013
2. RD Kornberg, H Boeger, RE Davis, X Liu, CR Brown, G Calero, K Murakami
Benchmarking Ligand-Based Virtual High-Throughput Screening with the PubChem Database.
1. Molecules - published January 8, 2013
2. J Meiler, CD Weaver, PL Teixeira, JL Mendenhall, R Mueller, EW Lowe, M Butkiewicz
Ubiquitin regulates CAspase Recruitment Domain mediated signaling by nucleotide binding oligomerization domain proteins NOD1 and NOD2.
1. J Biol Chem - published January 8, 2013
2. RC Piper, S Ramaswamy, A Fowler, AM Ver Heul
Single-stranded nucleic acid recognition: is there a code after all?
1. Structure - published January 8, 2013
2. Cléry A, Boudet J, Allain FH
Domain 1 of Mucosal Addressin Cell Adhesion Molecule has an I1-set Fold and a Flexible Integrin-Binding Loop.
1. J Biol Chem - published January 7, 2013
2. TA Springer, N Pullen, JH Wang, PS Huang, J Zhu, Y Yu
Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.
1. Biochem Biophys Res Commun - published January 4, 2013
2. Achour M, Mousli M, Alhosin M, Ibrahim A, Peluso J, Muller CD, Schini-Kerth VB, Hamiche A, Dhe-Paganon S, Bronner C
Discovery, Synthesis, And Structure-Based Optimization of a Series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease.
1. J Med Chem - published January 3, 2013
2. SR Stauffer, A Mesecar, P Hodder, CW Lindsley, SC Baker, AM Mielech, S Tomar, YM Baez-Santos, ES Dawson, A Eggler, P Chase, SA Saldanha, M Turlington, Y Zhou, V Grum-Tokars, J Jacobs
Light-Induced Subunit Dissociation by a Light-Oxygen-Voltage Domain Photoreceptor from Rhodobacter sphaeroides.
1. Biochemistry - published January 3, 2013
2. BR Crane, AM Bilwes, KS Conrad
A Strategy for Modulation of Enzymes in the Ubiquitin System.
1. Science - published January 3, 2013
2. C Yeh, MC Landry, YC Juang, PK Chan, L Beatty, P Garg, A Vorobyov, D Neculai, AM Neculai, JR Walker, A Persaud, P Alberts, Y Zhao, Y Fan, J Tong, G Avvakumov, A Ernst, SS Sidhu, S Dhe-Paganon, MF Moran, J Yang, D Rotin, B Raught, D Durocher, L Pelletier, F Sicheri, J Moffat, M Tyers, M Vedadi, A Allali-Hassani, K Karamboulas, E Zeqiraj
Characterization of Anopheles gambiae transglutaminase 3 (AgTG3) and its native substrate Plugin.
1. J Biol Chem - published January 3, 2013
2. RH Baxter, F Catteruccia, HP Williams, J Marcus, B Wang, S Logarajah, JB Nguyen, BV Le
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
1. Cell Rep - published January 3, 2013
2. Paul S, Kuo A, Schalch T, Vogel H, Joshua-Tor L, McCombie WR, Gozani O, Hammell M, Mills AA
Conformational coupling across the plasma membrane in activation of the EGF receptor.
1. Cell - published January 3, 2013
2. Endres NF, Das R, Smith AW, Arkhipov A, Kovacs E, Huang Y, Pelton JG, Shan Y, Shaw DE, Wemmer DE, Groves JT, Kuriyan J
Structural basis of transcriptional pausing in bacteria.
1. Cell - published January 3, 2013
2. Weixlbaumer A, Leon K, Landick R, Darst SA
HCMV gB shares structural and functional properties with gB proteins from other herpesviruses.
1. Virology - published January 2, 2013
2. Sharma S, Wisner TW, Johnson DC, Heldwein EE
Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody.
1. Proc Natl Acad Sci U S A - published January 2, 2013
2. SC Harrison, DE Shaw, HX Liao, BF Haynes, MA Moody, R Zhang, TB Kepler, PR Dormitzer, EC Settembre, A Carfi, P Suphaphiphat, H Golding, J Manischewitz, LR King, S Khurana, T O'Donnell, AR Khan, H Xu, AG Schmidt
Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.
1. J Mol Biol - published January 2, 2013
2. Xu Q, Chang A, Tolia A, Minor DL Jr
How a chemist looks at RNA.
1. Angew Chem Int Ed Engl - published January 2, 2013
2. Cech TR
Visualizing viral assemblies in a nanoscale biosphere.
1. Lab Chip - published January 2, 2013
2. Gilmore BL, Showalter SP, Dukes MJ, Tanner JR, Demmert AC, McDonald SM, Kelly DF
Loss of LARGE2 disrupts functional glycosylation of α-dystroglycan in prostate cancer.
1. J Biol Chem - published January 2, 2013
2. Esser AK, Miller MR, Huang Q, Meier MM, Beltran-Valero de Bernabé D, Stipp CS, Campbell KP, Lynch CF, Smith BJ, Cohen MB, Henry MD
Imaging a functional tumorigenic biomarker in the transformed epithelium.
1. Proc Natl Acad Sci U S A - published January 2, 2013
2. LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS
RAC1P29S is a spontaneously activating cancer-associated GTPase.
1. Proc Natl Acad Sci U S A - published January 2, 2013
2. TJ Boggon, J Schlessinger, R Halaban, EC Holman, BH Ha, MJ Davis
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
1. Proc Natl Acad Sci U S A - published January 2, 2013
2. Sun Q, Carrasco YP, Hu Y, Guo X, Mirzaei H, Macmillan J, Chook YM
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.
1. Proc Natl Acad Sci U S A - published January 2, 2013
2. Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF
From systems to structure: bridging networks and mechanism.
1. Mol Cell - published January 2, 2013
2. Fraser JS, Gross JD, Krogan NJ
A convective replica-exchange method for sampling new energy basins.
1. J Comput Chem - published January 1, 2013
2. Spill YG, Bouvier G, Nilges M
N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors.
1. J Cell Sci - published January 1, 2013
2. Chen Q, Sun X, Zhou XH, Liu JH, Wu J, Zhang Y, Wang JH
Functional asymmetry in kinesin and dynein dimers.
1. Biol Cell - published January 1, 2013
2. Rank KC, Rayment I
Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis.
1. J Virol - published January 1, 2013
2. Webster B, Wissing S, Herker E, Ott M, Greene WC
Structure of the St. Louis encephalitis virus postfusion envelope trimer.
1. J Virol - published January 1, 2013
2. Luca VC, Nelson CA, Fremont DH
Crystal structure of the cowpox virus-encoded NKG2D ligand OMCP.
1. J Virol - published January 1, 2013
2. Lazear E, Peterson LW, Nelson CA, Fremont DH
Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections.
1. Infect Immun - published January 1, 2013
2. Guiton PS, Hannan TJ, Ford B, Caparon MG, Hultgren SJ
Oligomeric properties of adeno-associated virus Rep68 reflect its multifunctionality.
1. J Virol - published January 1, 2013
2. Zarate-Perez F, Mansilla-Soto J, Bardelli M, Burgner JW 2nd, Villamil-Jarauta M, Kekilli D, Samso M, Linden RM, Escalante CR
Genomic distribution of the small multidrug resistance protein EmrE over 29 Escherichia coli strains reveals two forms of the protein.
1. FEBS J - published January 1, 2013
2. Kolbusz MA, Slotboom DJ, Lolkema JS
The β-catenin destruction complex.
1. Cold Spring Harb Perspect Biol - published January 1, 2013
2. Stamos JL, Weis WI
Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.
1. Nucleic Acids Res - published January 1, 2013
2. Zhang Y, Madl T, Bagdiul I, Kern T, Kang HS, Zou P, Mäusbacher N, Sieber SA, Krämer A, Sattler M
Discovery of a selective M(4) positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
1. Bioorg Med Chem Lett - published January 1, 2013
2. BJ Melancon, U Le, CR Hopkins, CW Lindsley, CM Niswender, PJ Conn, JS Daniels, MR Wood, AL Blobaum, CK Jones, DJ Sheffler, D Venable, AL Rodriguez, A Lamsal, TJ Utley, PN Vinson, TM Bridges
Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms.
1. Endocrinology - published January 1, 2013
2. Hamidi S, Chen CR, Murali R, McLachlan SM, Rapoport B
PrePPI: a structure-informed database of protein-protein interactions.
1. Nucleic Acids Res - published January 1, 2013
2. Zhang QC, Petrey D, Garzón JI, Deng L, Honig B
Further exploration of M(1) allosteric agonists: Subtle structural changes abolish M(1) allosteric agonism and result in pan-mAChR orthosteric antagonism.
1. Bioorg Med Chem Lett - published January 1, 2013
2. CW Lindsley, MR Wood, CR Hopkins, PJ Conn, CM Niswender, GJ Digby, HP Cho, SJ Carrington, JC Tarr, KM Lovell, U Le, C Sevel, DJ Sheffler
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
1. Nat Struct Mol Biol - published January 1, 2013
2. Guce AI, Mortimer SE, Yoon T, Painter CA, Jiang W, Mellins ED, Stern LJ
Fast multicolor 3D imaging using aberration-corrected multifocus microscopy.
1. Nat Methods - published January 1, 2013
2. Abrahamsson S, Chen J, Hajj B, Stallinga S, Katsov AY, Wisniewski J, Mizuguchi G, Soule P, Mueller F, Dugast Darzacq C, Darzacq X, Wu C, Bargmann CI, Agard DA, Dahan M, Gustafsson MG
MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion.
1. Breast Cancer Res Treat - published January 1, 2013
2. Bockhorn J, Yee K, Chang YF, Prat A, Huo D, Nwachukwu C, Dalton R, Huang S, Swanson KE, Perou CM, Olopade OI, Clarke MF, Greene GL, Liu H
Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system.
1. Nat Protoc - published January 1, 2013
2. Kyoung M, Zhang Y, Diao J, Chu S, Brunger AT
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.
1. Bioorg Med Chem Lett - published January 1, 2013
2. RM Breyer, CW Lindsley, J Scott Daniels, RD Morrison, TM Bridges, SA Saleh, JD Downey
Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology.
1. J Biomol NMR - published January 1, 2013
2. Barraud P, Allain FH
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
1. J Med Chem - published January 1, 2013
2. Friberg A, Vigil D, Zhao B, Daniels RN, Burke JP, Garcia-Barrantes PM, Camper D, Chauder BA, Lee T, Olejniczak ET, Fesik SW
Molecular mechanisms driving respiratory syncytial virus assembly.
1. Future Microbiol - published January 1, 2013
2. Shaikh FY, Crowe JE Jr
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
1. J Med Chem - published January 1, 2013
2. Lafleur K, Dong J, Huang D, Caflisch A, Nevado C
The structure of a novel glucuronoyl esterase from Myceliophthora thermophila gives new insights into its role as a potential biocatalyst.
1. Acta Crystallogr D Biol Crystallogr - published January 1, 2013
2. Charavgi MD, Dimarogona M, Topakas E, Christakopoulos P, Chrysina ED
Synthesis of multisubstituted pyridines.
1. Org Lett - published January 1, 2013
2. He Z, Dobrovolsky D, Trinchera P, Yudin AK
Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5.
1. Cell - published January 1, 2013
2. Wu B, Peisley A, Richards C, Yao H, Zeng X, Lin C, Chu F, Walz T, Hur S
Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.
1. Cell Cycle - published January 1, 2013
2. Hara MR, Sachs BD, Caron MG, Lefkowitz RJ
Structural basis for feed-forward transcriptional regulation of membrane lipid homeostasis in Staphylococcus aureus.
1. PLoS Pathog - published January 1, 2013
2. Albanesi D, Reh G, Guerin ME, Schaeffer F, Debarbouille M, Buschiazzo A, Schujman GE, de Mendoza D, Alzari PM
Regulation of small GTPases by GEFs, GAPs, and GDIs.
1. Physiol Rev - published January 1, 2013
2. Cherfils J, Zeghouf M
Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature.
1. JAMA Dermatol - published January 1, 2013
2. Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
1. Cell - published January 1, 2013
2. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T
Human TFIID binds to core promoter DNA in a reorganized structural state.
1. Cell - published January 1, 2013
2. Cianfrocco MA, Kassavetis GA, Grob P, Fang J, Juven-Gershon T, Kadonaga JT, Nogales E
Biochemical insights into the function of phage G1 gp67 in Staphylococcus aureus.
1. Bacteriophage - published January 1, 2013
2. Osmundson J, Darst SA