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78 Member Publications for December 2012

Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin.
1. Proc Natl Acad Sci U S A - published December 31, 2012
2. CR Sanders, VV Gurevich, TM Iverson, SA Vishnivetskiy, MK Cho, Q Chen, T Zhuang
Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector.
1. Proc Natl Acad Sci U S A - published December 26, 2012
2. PJ Pereira, P Fuentes-Prior, S Macedo-Ribeiro, TB Cereija, R Gutiérrez-Gallego, D de Sanctis, AC Figueiredo
Shape change in the receptor for gliding motility in Plasmodium sporozoites.
1. Proc Natl Acad Sci U S A - published December 26, 2012
2. TA Springer, C Lu, AC Koksal, G Song
Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance.
1. Proc Natl Acad Sci U S A - published December 26, 2012
2. Y Shamoo, G Saxer, C Bacorn, C Sun, AS Benitez Cardenas, K Walkiewicz
Biochemical and structural evidence in support of a coherent model for the formation of the double-helical influenza a virus ribonucleoprotein.
1. MBio - published December 26, 2012
2. YJ Tao, RM Krug, B Smith, RL Kuo, DA Mata, TS Guu, Q Ye
Peptidyl-prolyl cis/trans-Isomerase A1 (Pin1) Is a Target for Modification by Lipid Electrophiles.
1. Chem Res Toxicol - published December 24, 2012
2. LJ Marnett, NA Porter, K Tallman, JD Manna, ML Reyzer, M Boiani, K Rose, CD Aluise
A novel non-radioactive primase-pyrophosphatase activity assay and its application to the discovery of inhibitors of Mycobacterium tuberculosis primase DnaG.
1. Nucleic Acids Res - published December 24, 2012
2. OV Tsodikov, I Artsimovitch, SK Sawyer, E Resto-Roldán, T Biswas
Organocatalytic, Enantioselective Synthesis of VNI: A Robust Therapeutic Development Platform for Chagas, a Neglected Tropical Disease.
1. Org Lett - published December 21, 2012
2. JN Johnston, GI Lepesheva, MR Waterman, F Villalta, MC Dobish
Structure and Functional Analysis of the BRCT Domain of Translesion Synthesis DNA Polymerase Rev1.
1. Biochemistry - published December 20, 2012
2. MT Washington, L Gakhar, JM Pryor
Differential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysis.
1. PLoS One - published December 20, 2012
2. Stollar EJ, Lin H, Davidson AR, Forman-Kay JD
Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis.
1. Nat Cell Biol - published December 16, 2012
2. H Yu, S Rankin, H Liu
Discovery and SAR of a novel series of non-MPEP site mGlu(5) PAMs based on an aryl glycine sulfonamide scaffold.
1. Bioorg Med Chem Lett - published December 15, 2012
2. SR Stauffer, CW Lindsley, P Jeffrey Conn, CK Jones, CM Niswender, J Scott Daniels, GJ Macdonald, JM Bartolomé, C Mackie, H Lavreysen, T Steckler, ES Dawson, PN Vinson, C David Weaver, R Williams, Y Zhou, AL Rodriguez
Using RosettaLigand for small molecule docking into comparative models.
1. PLoS One - published December 15, 2012
2. Kaufmann KW, Meiler J
Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism.
1. PLoS Pathog - published December 14, 2012
2. Chumbler NM, Farrow MA, Lapierre LA, Franklin JL, Haslam DB, Goldenring JR, Lacy DB
Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration.
1. PLoS Pathog - published December 14, 2012
2. Hood MI, Mortensen BL, Moore JL, Zhang Y, Kehl-Fie TE, Sugitani N, Chazin WJ, Caprioli RM, Skaar EP
Structure of a dengue envelope protein late-stage fusion intermediate.
1. J Virol - published December 12, 2012
2. SC Harrison, JL Choi, DE Klein
Outer domain of HIV-1 gp120: Antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04.
1. J Virol - published December 12, 2012
2. GJ Nabel, PD Kwong, JR Mascola, J Zhu, T Zhou, A Zheng, B Zhang, Y Yang, ZY Yang, X Wu, W Shi, S Moquin, JC Boyington, C Biertümpfel, L Xu, M Kanekiyo, MG Joyce, ZY Yang, Y Yang
Caspase-1 and IL-1β processing in a teleost fish.
1. PLoS One - published December 11, 2012
2. Reis MI, do Vale A, Pereira PJ, Azevedo JE, Dos Santos NM
Characterization of disordered proteins with ENSEMBLE.
1. Bioinformatics - published December 11, 2012
2. JD Forman-Kay, WY Choy, C Neale, JA Marsh, M Krzeminski
Duplex RNA Activated ATPases (DRAs): Platforms for RNA sensing, signaling and processing.
1. RNA Biol - published December 10, 2012
2. AM Pyle, A Kohlway, D Luo
Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein.
1. Vaccine - published December 7, 2012
2. Avilov SV, Moisy D, Naffakh N, Cusack S
Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.
1. J Biol Chem - published December 7, 2012
2. Kormendi V, Szyk A, Piszczek G, Roll-Mecak A
Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation.
1. J Biol Chem - published December 7, 2012
2. Yurtsever Z, Sala-Rabanal M, Randolph DT, Scheaffer SM, Roswit WT, Alevy YG, Patel AC, Heier RF, Romero AG, Nichols CG, Holtzman MJ, Brett TJ
Crystal structure of the calcium release-activated calcium channel Orai.
1. Science - published December 7, 2012
2. Hou X, Pedi L, Diver MM, Long SB
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.
1. Cell - published December 7, 2012
2. Wang Y, Rattner A, Zhou Y, Williams J, Smallwood PM, Nathans J
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.
1. Nature - published December 6, 2012
2. Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio P, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC
Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction.
1. Nature - published December 6, 2012
2. Sotomayor M, Weihofen WA, Gaudet R, Corey DP
RecA-binding pilE G4 sequence essential for pilin antigenic variation forms monomeric and 5' end-stacked dimeric parallel G-quadruplexes.
1. Structure - published December 5, 2012
2. Kuryavyi V, Cahoon LA, Seifert HS, Patel DJ
Crystal structures of HIV-1 reverse transcriptase with picomolar inhibitors reveal key interactions for drug design.
1. J Am Chem Soc - published December 5, 2012
2. Frey KM, Bollini M, Mislak AC, Cisneros JA, Gallardo-Macias R, Jorgensen WL, Anderson KS
Structural mechanism of ER retrieval of MHC class I by cowpox.
1. PLoS Biol - published December 5, 2012
2. McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH
Data management challenges in three-dimensional EM.
1. Nat Struct Mol Biol - published December 5, 2012
2. GJ Kleywegt, JR Swedlow, M Winn, J Westbrook, S Subramaniam, SH Scheres, E Sanz-García, CO Sorzano, P Rosenthal, A Roseman, WJ Moore, D Mastronarde, SJ Ludtke, CL Lawson, I Lagerstedt, GJ Jensen, E Hill, JB Heymann, R Henderson, B Carragher, JM Carazo, A Patwardhan
Structural insights into the mechanism of four-coordinate Cob(II)alamin formation in the active site of the Salmonella enterica ATP:Co(I)rrinoid adenosyltransferase enzyme: critical role of residues Phe91 and Trp93.
1. Biochemistry - published December 4, 2012
2. Moore TC, Newmister SA, Rayment I, Escalante-Semerena JC
Chemogenomic approach identified yeast YLR143W as diphthamide synthetase.
1. Proc Natl Acad Sci U S A - published December 4, 2012
2. Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H
RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.
1. Sci Signal - published December 4, 2012
2. Guzzo CM, Berndsen CE, Zhu J, Gupta V, Datta A, Greenberg RA, Wolberger C, Matunis MJ
Identification and SRM Quantification of Endocytosis Factors Associated with Numb.
1. Mol Cell Proteomics - published December 4, 2012
2. CJ McGlade, MF Moran, A Guha, AS Gajadhar, P Taylor, JR Krieger
Bending rigid molecular rods: formation of oligoproline macrocycles.
1. Chemistry - published December 3, 2012
2. Scully CC, Rai V, Poda G, Zaretsky S, Burns DC, Houliston RS, Lou T, Yudin AK
Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.
1. Hum Mol Genet - published December 3, 2012
2. KS Anderson, WC Copeland, R Kasiviswanathan, CD Sohl
Structural basis of functional group activation by sulfotransferases in complex metabolic pathways.
1. ACS Chem Biol - published December 2, 2012
2. McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL
Three-dimensional localization of the α and β subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel.
1. J Biol Chem - published December 2, 2012
2. Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam KG, Samsó M
Biochemistry. Visualizing the influenza genome.
1. Science - published December 2, 2012
2. Tao YJ, Zheng W
Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up.
1. Tetrahedron - published December 2, 2012
2. LJ Marnett, GA Sulikowski, DF Stec, K Kim, AJ Liedtke
The structure of human DNase I bound to magnesium and phosphate ions points to a catalytic mechanism common to members of the DNase I-like superfamily.
1. Biochemistry - published December 2, 2012
2. Parsiegla G, Noguere C, Santell L, Lazarus RA, Bourne Y
High-resolution crystal structure of human protease-activated receptor 1.
1. Nature - published December 2, 2012
2. Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK
Mutations in the β-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.
1. Cell Rep - published December 2, 2012
2. Breuss M, Heng JI, Poirier K, Tian G, Jaglin XH, Qu Z, Braun A, Gstrein T, Ngo L, Haas M, Bahi-Buisson N, Moutard ML, Passemard S, Verloes A, Gressens P, Xie Y, Robson KJ, Rani DS, Thangaraj K, Clausen T, Chelly J, Cowan NJ, Keays DA
Tissue-specific regulatory T cells: biomarker for acute graft-vs-host disease and survival.
1. Exp Hematol - published December 1, 2012
2. Engelhardt BG, Sengsayadeth SM, Jagasia M, Savani BN, Kassim AA, Lu P, Shyr Y, Yoder SM, Rock MT, Crowe JE Jr
Structural insights into eukaryotic ribosomes and the initiation of translation.
1. Curr Opin Struct Biol - published December 1, 2012
2. Voigts-Hoffmann F, Klinge S, Ban N
The helical MreB cytoskeleton in Escherichia coli MC1000/pLE7 is an artifact of the N-Terminal yellow fluorescent protein tag.
1. J Bacteriol - published December 1, 2012
2. Swulius MT, Jensen GJ
Intermediate states during mRNA-tRNA translocation.
1. Curr Opin Struct Biol - published December 1, 2012
2. Frank J
Effect of atomic charge, solvation, entropy, and ligand protonation state on MM-PB(GB)SA binding energies of HIV protease.
1. J Comput Chem - published December 1, 2012
2. Oehme DP, Brownlee RT, Wilson DJ
Immune modulation by group B Streptococcus influences host susceptibility to urinary tract infection by uropathogenic Escherichia coli.
1. Infect Immun - published December 1, 2012
2. Kline KA, Schwartz DJ, Gilbert NM, Hultgren SJ, Lewis AL
Crystal structure of the Klebsiella pneumoniae NFeoB/FeoC complex and roles of FeoC in regulation of Fe2+ transport by the bacterial Feo system.
1. J Bacteriol - published December 1, 2012
2. Hung KW, Tsai JY, Juan TH, Hsu YL, Hsiao CD, Huang TH
The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor.
1. J Biol Chem - published December 1, 2012
2. Vela A, Fedorova O, Ding SC, Pyle AM
Interplay of DNA repair with transcription: from structures to mechanisms.
1. Trends Biochem Sci - published December 1, 2012
2. Deaconescu AM, Artsimovitch I, Grigorieff N
Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein.
1. J Biol Chem - published December 1, 2012
2. Terrasse R, Tacnet-Delorme P, Moriscot C, Pérard J, Schoehn G, Vernet T, Thielens NM, Di Guilmi AM, Frachet P
A method for integrative structure determination of protein-protein complexes.
1. Bioinformatics - published December 1, 2012
2. Schneidman-Duhovny D, Rossi A, Avila-Sakar A, Kim SJ, Velázquez-Muriel J, Strop P, Liang H, Krukenberg KA, Liao M, Kim HM, Sobhanifar S, Dötsch V, Rajpal A, Pons J, Agard DA, Cheng Y, Sali A
Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.
1. Development - published December 1, 2012
2. Yu H, Ye X, Guo N, Nathans J
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
1. Nature - published December 1, 2012
2. Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR
Distinct single-cell morphological dynamics under beta-lactam antibiotics.
1. Mol Cell - published December 1, 2012
2. Yao Z, Kahne D, Kishony R
Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K".
1. Chem Res Toxicol - published December 1, 2012
2. Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK
Different gene transfer methods at the very early, early, late and whole embryonic stages in chicken.
1. Acta Biol Hung - published December 1, 2012
2. Gong P, Yang YP, Yang Y, Feng YP, Li SJ, Peng XL, Gong YZ
Rapid prediction of multi-dimensional NMR data sets.
1. J Biomol NMR - published December 1, 2012
2. Gradmann S, Ader C, Heinrich I, Nand D, Dittmann M, Cukkemane A, van Dijk M, Bonvin AM, Engelhard M, Baldus M
Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy.
1. Biochemistry - published December 1, 2012
2. Lee GM, Balouch E, Goetz DH, Lazic A, McKerrow JH, Craik CS
An emerging consensus on voltage-dependent gating from computational modeling and molecular dynamics simulations.
1. J Gen Physiol - published December 1, 2012
2. Vargas E, Yarov-Yarovoy V, Khalili-Araghi F, Catterall WA, Klein ML, Tarek M, Lindahl E, Schulten K, Perozo E, Bezanilla F, Roux B
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
1. Proc Natl Acad Sci U S A - published December 1, 2012
2. Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK
IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
1. J Clin Invest - published December 1, 2012
2. Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ
Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic.
1. Acta Crystallogr Sect F Struct Biol Cryst Commun - published December 1, 2012
2. S Chugh, S Caria, M Kvansakul, G Lessene, D Nhu
Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of heat-stable mycobacterial proteins.
1. J Bacteriol - published December 1, 2012
2. Tiago I, Maranha A, Mendes V, Alarico S, Moynihan PJ, Clarke AJ, Macedo-Ribeiro S, Pereira PJ, Empadinhas N
Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation.
1. Genes Dev - published December 1, 2012
2. Lennon CW, Ross W, Martin-Tumasz S, Toulokhonov I, Vrentas CE, Rutherford ST, Lee JH, Butcher SE, Gourse RL
Rho and NusG suppress pervasive antisense transcription in Escherichia coli.
1. Genes Dev - published December 1, 2012
2. Peters JM, Mooney RA, Grass JA, Jessen ED, Tran F, Landick R
Themes and variations in ER/SR calcium release channels: structure and function.
1. Physiology (Bethesda) - published December 1, 2012
2. Stathopulos PB, Seo MD, Enomoto M, Amador FJ, Ishiyama N, Ikura M
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist.
1. Cell Death Dis - published December 1, 2012
2. Rautureau GJ, Yabal M, Yang H, Huang DC, Kvansakul M, Hinds MG
Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
1. Elife - published December 1, 2012
2. Kong C, Zeng W, Ye S, Chen L, Sauer DB, Lam Y, Derebe MG, Jiang Y
How infidelity creates a sticky situation.
1. Mol Cell - published December 1, 2012
2. Drummond DA
Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-κB.
1. mBio - published December 1, 2012
2. Thornburg NJ, Hayward SL, Crowe JE Jr
Morphologic diversity of cutaneous sensory afferents revealed by genetically directed sparse labeling.
1. Elife - published December 1, 2012
2. Wu H, Williams J, Nathans J
Nucleic acid structure characterization by small angle X-ray scattering (SAXS).
1. Curr Protoc Nucleic Acid Chem - published December 1, 2012
2. Burke JE, Butcher SE
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.
1. PLoS Pathog - published December 1, 2012
2. Stanley DJ, Bartholomeeusen K, Crosby DC, Kim DY, Kwon E, Yen L, Cartozo NC, Li M, Jäger S, Mason-Herr J, Hayashi F, Yokoyama S, Krogan NJ, Harris RS, Peterlin BM, Gross JD
CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds.
1. Int J Parasitol Drugs Drug Resist - published December 1, 2012
2. Hargrove TY, Kim K, de Nazaré Correia Soeiro M, da Silva CF, Batista DD, Batista MM, Yazlovitskaya EM, Waterman MR, Sulikowski GA, Lepesheva GI