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64 Member Publications for November 2012

Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations.
1. PLoS Biol - published November 28, 2012
2. Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R
An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1.
1. Mol Pharmacol - published November 28, 2012
2. DM Roden, J Meiler, CR Sanders, BF Leake, JA Smith, T Yang
BCL::Fold--de novo prediction of complex and large protein topologies by assembly of secondary structure elements.
1. PLoS One - published November 23, 2012
2. Karakaş M, Woetzel N, Staritzbichler R, Alexander N, Weiner BE, Meiler J
BCL::Score--knowledge based energy potentials for ranking protein models represented by idealized secondary structure elements.
1. PLoS One - published November 23, 2012
2. Woetzel N, Karakaş M, Staritzbichler R, Müller R, Weiner BE, Meiler J
Targeting Selective Activation of M(1) for the Treatment of Alzheimer's Disease: Further Chemical Optimization and Pharmacological Characterization of the M(1) Positive Allosteric Modulator ML169.
1. ACS Chem Neurosci - published November 21, 2012
2. CW Lindsley, MR Wood, PJ Conn, CM Niswender, JS Daniels, Z Xiang, AL Blobaum, RD Morrison, TM Bridges, MT Klein, T Pancani, R Klar, HP Cho, DJ Sheffler, TJ Utley, PR Reid, ML Turlington, JC Tarr
Overview: what are helicases?
1. Adv Exp Med Biol - published November 20, 2012
2. Wu CG, Spies M
Structure and Mechanisms of SF2 DNA Helicases.
1. Adv Exp Med Biol - published November 20, 2012
2. Beyer DC, Ghoneim MK, Spies M
Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3{varepsilon} cytoplasmic domain.
1. J Exp Med - published November 19, 2012
2. KW Wucherpfennig, HH Chu, S Gordo, DA Schubert, E Gagnon
Synthesis and biological characterization of a series of novel diaryl amide M(1) antagonists.
1. Bioorg Med Chem Lett - published November 15, 2012
2. MR Wood, CW Lindsley, PJ Conn, JS Daniels, CM Niswender, DJ Sheffler, NR Kett, RD Morrison, TM Bridges, TJ Utley, C Sevel, MS Poslusney
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
1. Nature - published November 15, 2012
2. M Connors, JR Mascola, PD Kwong, BF Haynes, R Wyatt, SA Migueles, B Zhang, Y Yang, T Wang, SM Alam, SK Sharma, B Chakrabarti, RT Bailer, H Imamichi, NS Longo, NA Doria-Rose, MK Louder, L Laub, G Ofek, J Huang
High-Density Reconstitution of Functional Water Channels into Vesicular and Planar Block Copolymer Membranes.
1. J Am Chem Soc - published November 14, 2012
2. T Walz, WP Meier, YX Shen, JE Habel, M Kumar
NMR spectroscopy: an excellent tool to understand RNA and carbohydrate recognition by proteins.
1. Chimia (Aarau) - published November 14, 2012
2. Cléry A, Schubert M, Allain FH
Structural asymmetry in the magnesium channel CorA points to sequential allosteric regulation.
1. Proc Natl Acad Sci U S A - published November 13, 2012
2. EF Pai, R Pomès, J Payandeh, N Chakrabarti, A Li, R Pfoh
Diverse Reactions of PhI(OTf)(2) with Common 2-Electron Ligands: Complex Formation, Oxidation, and Oxidative Coupling.
1. Inorg Chem - published November 13, 2012
2. JL Dutton, PJ Barnard, BJ Smith, DJ Wilson, S Ibrahim, SA Couchman, TP Pell
Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.
1. Nat Struct Mol Biol - published November 11, 2012
2. N Ban, C Montellese, D Boehringer, BJ Greber
RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.
1. Oncogene - published November 8, 2012
2. Li B, Antonyak MA, Zhang J, Cerione RA
The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis.
1. Nature - published November 8, 2012
2. Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ
Recording high-resolution images of two-dimensional crystals of membrane proteins.
1. Methods Mol Biol - published November 8, 2012
2. Avila-Sakar A, Li X, Zheng SQ, Cheng Y
Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network.
1. PLoS Comput Biol - published November 8, 2012
2. van Wijk SJ, Melquiond AS, de Vries SJ, Timmers HT, Bonvin AM
Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli.
1. Science - published November 8, 2012
2. D Kahne, E Freinkman, S Okuda
RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor.
1. Structure - published November 7, 2012
2. Nelson CA, Warren JT, Wang MW, Teitelbaum SL, Fremont DH
Role of individual positive charges in the membrane orientation and activity of transporters of the small multidrug resistance family.
1. Biochemistry - published November 6, 2012
2. Kolbusz MA, Slotboom DJ, Lolkema JS
Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses.
1. Proc Natl Acad Sci U S A - published November 6, 2012
2. Fordyce PM, Pincus D, Kimmig P, Nelson CS, El-Samad H, Walter P, DeRisi JL
The exomer cargo adaptor structure reveals a novel GTPase-binding domain.
1. EMBO J - published November 5, 2012
2. Paczkowski JE, Richardson BC, Strassner AM, Fromme JC
Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments.
1. Proc Natl Acad Sci U S A - published November 5, 2012
2. C Lin, MH Jo, A Peisley, S Hur, S Hohng, T Walz, M Orme-Johnson, B Wu
Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel.
1. Proc Natl Acad Sci U S A - published November 5, 2012
2. R Mackinnon, Y Hsiung, P Yuan, MD Leonetti
Phleboviruses encapsidate their genomes by sequestering RNA bases.
1. Proc Natl Acad Sci U S A - published November 5, 2012
2. JL Smith, G Skiniotis, SR Gerrard, ME Piper, DD Raymond
Structural insights into the substrate specificity of the Rhodopseudomonas palustris protein acetyltransferase RpPat: identification of a loop critical for recognition by RpPat.
1. J Biol Chem - published November 3, 2012
2. Crosby HA, Rank KC, Rayment I, Escalante-Semerena JC
Structural interactions between lipids, water and S1-S4 voltage-sensing domains.
1. J Mol Biol - published November 2, 2012
2. Krepkiy D, Gawrisch K, Swartz KJ
Automated solid-phase synthesis of RNA oligonucleotides containing a nonbridging phosphorodithioate linkage via phosphorothioamidites.
1. J Org Chem - published November 2, 2012
2. Li NS, Frederiksen JK, Piccirilli JA
Dynamics of intracellular clathrin/AP1- and clathrin/AP3-containing carriers.
1. Cell Rep - published November 2, 2012
2. Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
1. Biochemistry - published November 2, 2012
2. Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
α-Tubulin acetylation from the inside out.
1. Proc Natl Acad Sci U S A - published November 2, 2012
2. Al-Bassam J, Corbett KD
SnapShot: telomeres and telomerase.
1. Cell - published November 2, 2012
2. Berman AJ, Cech TR
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.
1. Cell - published November 2, 2012
2. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS
Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.
1. Cell - published November 2, 2012
2. Osmundson J, Montero-Diez C, Westblade LF, Hochschild A, Darst SA
Membrane transport metabolons.
1. Biochim Biophys Acta - published November 1, 2012
2. Moraes TF, Reithmeier RA
Expression, purification and functional reconstitution of slack sodium-activated potassium channels.
1. J Membr Biol - published November 1, 2012
2. Yan Y, Yang Y, Bian S, Sigworth FJ
Peptide binding to the PDZ3 domain by conformational selection.
1. Proteins - published November 1, 2012
2. Steiner S, Caflisch A
Pull and push: talin activation for integrin signaling.
1. Cell Res - published November 1, 2012
2. Wang JH
Bioengineered surfaces to improve the blood compatibility of biomaterials through direct thrombin inactivation.
1. Acta Biomater - published November 1, 2012
2. Freitas SC, Cereija TB, Figueiredo AC, Osório H, Pereira PJ, Barbosa MA, Martins MC
Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells.
1. Mol Cancer Ther - published November 1, 2012
2. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA
Solution structure of the C-terminal NP-repeat domain of Tic40, a co-chaperone during protein import into chloroplasts.
1. J Biochem - published November 1, 2012
2. Kao YF, Lou YC, Yeh YH, Hsiao CD, Chen C
Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.
1. J Virol - published November 1, 2012
2. Okamoto T, Campbell S, Mehta N, Thibault J, Colman PM, Barry M, Huang DC, Kvansakul M
The bacterial ribonuclease P holoenzyme requires specific, conserved residues for efficient catalysis and substrate positioning.
1. Nucleic Acids Res - published November 1, 2012
2. Reiter NJ, Osterman AK, Mondragón A
Comparison of the structures and stabilities of coiled-coil proteins containing hexafluoroleucine and t-butylalanine provides insight into the stabilizing effects of highly fluorinated amino acid side-chains.
1. Protein Sci - published November 1, 2012
2. Buer BC, Meagher JL, Stuckey JA, Marsh EN
The human metapneumovirus fusion protein mediates entry via an interaction with RGD-binding integrins.
1. J Virol - published November 1, 2012
2. Cox RG, Livesay SB, Johnson M, Ohi MD, Williams JV
Yeast CAF-1 assembles histone (H3-H4)2 tetramers prior to DNA deposition.
1. Nucleic Acids Res - published November 1, 2012
2. Winkler DD, Zhou H, Dar MA, Zhang Z, Luger K
Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics.
1. ChemMedChem - published November 1, 2012
2. Zhao H, Huang D, Caflisch A
Self-assembly of filamentous amelogenin requires calcium and phosphate: from dimers via nanoribbons to fibrils.
1. Biomacromolecules - published November 1, 2012
2. Martinez-Avila O, Wu S, Kim SJ, Cheng Y, Khan F, Samudrala R, Sali A, Horst JA, Habelitz S
Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors.
1. J Bacteriol - published November 1, 2012
2. Hadjifrangiskou M, Gu AP, Pinkner JS, Kostakioti M, Zhang EW, Greene SE, Hultgren SJ
The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors.
1. RNA - published November 1, 2012
2. Mathioudakis N, Palencia A, Kadlec J, Round A, Tripsianes K, Sattler M, Pillai RS, Cusack S
HIV-1 Gag protein can sense the cholesterol and acyl chain environment in model membranes.
1. Proc Natl Acad Sci U S A - published November 1, 2012
2. Dick RA, Goh SL, Feigenson GW, Vogt VM
Global identification of peptidase specificity by multiplex substrate profiling.
1. Nat Methods - published November 1, 2012
2. O'Donoghue AJ, Eroy-Reveles AA, Knudsen GM, Ingram J, Zhou M, Statnekov JB, Greninger AL, Hostetter DR, Qu G, Maltby DA, Anderson MO, Derisi JL, McKerrow JH, Burlingame AL, Craik CS
Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
1. J Biol Chem - published November 1, 2012
2. Veverka V, Baker T, Redpath NT, Carrington B, Muskett FW, Taylor RJ, Lawson AD, Henry AJ, Carr MD
Structure-function relationships in calpains1.
1. Biochem J - published November 1, 2012
2. PL Davies, RL Campbell
LpxI structures reveal how a lipid A precursor is synthesized.
1. Nat Struct Mol Biol - published November 1, 2012
2. Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM
Subversion of cytokine networks by virally encoded decoy receptors.
1. Immunol Rev - published November 1, 2012
2. Epperson ML, Lee CA, Fremont DH
SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly.
1. EMBO J - published November 1, 2012
2. Qiao R, Cabral G, Lettman MM, Dammermann A, Dong G
High-throughput screening system based on phenolics-responsive transcription activator for directed evolution of organophosphate-degrading enzymes.
1. Protein Eng Des Sel - published November 1, 2012
2. Jeong YS, Choi SL, Kyeong HH, Kim JH, Kim EJ, Pan JG, Rha E, Song JJ, Lee SG, Kim HS
Multimodal microtubule binding by the Ndc80 kinetochore complex.
1. Nat Struct Mol Biol - published November 1, 2012
2. Alushin GM, Musinipally V, Matson D, Tooley J, Stukenberg PT, Nogales E
An expanding role for cell biologists in drug discovery and pharmacology.
1. Mol Biol Cell - published November 1, 2012
2. Sorger PK, Schoeberl B
The μ transpososome structure sheds light on DDE recombinase evolution.
1. Nature - published November 1, 2012
2. Montaño SP, Pigli YZ, Rice PA
Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics.
1. Virulence - published November 1, 2012
2. Kostakioti M, Hultgren SJ, Hadjifrangiskou M