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82 Member Publications for October 2012

Transient B(12)-Dependent Methyltransferase Complexes Revealed by Small-Angle X-ray Scattering.
1. J Am Chem Soc - published October 31, 2012
2. CL Drennan, SW Ragsdale, G Bender, M Can, Y Kung, N Ando
The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor.
1. PLoS Biol - published October 31, 2012
2. López-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ
Biochemical Characterization of Cardiolipin Synthase Mutations Associated with Daptomycin Resistance in Enterococci.
1. Antimicrob Agents Chemother - published October 31, 2012
2. Y Shamoo, CA Arias, W Zhang, M Davlieva
Pseudouridine Monophosphate Glycosidase: A New Glycosidase Mechanism.
1. Biochemistry - published October 30, 2012
2. SE Ealick, TP Begley, N Mahanta, S Huang
Structural basis of innate immune recognition of viral RNA.
1. Cell Microbiol - published October 30, 2012
2. Y Modis, Y Li, IC Berke
α(V)β(3) Integrin Crystal Structures and Their Functional Implications.
1. Biochemistry - published October 29, 2012
2. TA Springer, BH Luo, P Hu, W Wang, J Zhu, LZ Mi, X Dong
Biomimetic Synthesis and Biological Evaluation of Aplidiopsamine A.
1. Org Lett - published October 29, 2012
2. CW Lindsley, JD Panarese
Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor.
1. Nature - published October 28, 2012
2. TS Jardetzky, H Prinz, M Vogel, SS Tarchevskaya, A Eggel, B Kim
Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
1. Nat Chem Biol - published October 28, 2012
2. S Walker, DJ Vocadlo, GE Whitworth, WF Zandberg, TM Gloster, J Jiang, MB Lazarus
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
1. Nat Immunol - published October 28, 2012
2. KC Garcia, WJ Leonard, E Uzkan, R Spolski, I Moraga, P Li, VS Pande, GR Bowman, M Rickert, S Mitra, D Feng, JX Lin, AM Ring, E Ozkan
Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds.
1. J R Soc Interface - published October 24, 2012
2. Z Jia, K Nakatsu, WA Szarek, JZ Vlahakis, D Vukomanovic, MN Rahman
Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers.
1. AIDS - published October 23, 2012
2. MM Addo, KW Wucherpfennig, BD Walker, M Altfeld, M King, M Angin
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
1. Proc Natl Acad Sci U S A - published October 22, 2012
2. X Luo, H Yu, DR Tomchick, R Warrington, B Li, W Tian
MDA5 assembles into a polar helical filament on dsRNA.
1. Proc Natl Acad Sci U S A - published October 22, 2012
2. EH Egelman, Y Modis, X Yu, IC Berke
Potentiation of the kv1 family k(+) channel by cortisone analogues.
1. ACS Chem Biol - published October 19, 2012
2. M Zhou, M Quick, EJ Levin, Y Pan
Mammalian expression of isotopically labeled proteins for NMR spectroscopy.
1. Adv Exp Med Biol - published October 19, 2012
2. Sastry M, Bewley CA, Kwong PD
Isotope labeling and segmental labeling of larger RNAs for NMR structural studies.
1. Adv Exp Med Biol - published October 19, 2012
2. Duss O, Lukavsky PJ, Allain FH
Optimization of an ether series of mGlu(5) positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover.
1. Bioorg Med Chem Lett - published October 15, 2012
2. SR Stauffer, CW Lindsley, PJ Conn, CK Jones, CM Niswender, CD Weaver, JS Daniels, T Steckler, GJ Macdonald, JM Bartolomé, C Mackie, H Lavreysen, EJ Herman, S Jadhav, E Days, K Gogi, R Williams, Y Zhou, KJ Gregory, PN Vinson, JT Manka
Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II.
1. Proc Natl Acad Sci U S A - published October 15, 2012
2. RD Kornberg, AL Burlingame, MJ Trnka, DA Bushnell, PJ Robinson
Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.
1. PLoS Pathog - published October 12, 2012
2. Austin SK, Dowd KA, Shrestha B, Nelson CA, Edeling MA, Johnson S, Pierson TC, Diamond MS, Fremont DH
N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor.
1. PLoS One - published October 12, 2012
2. Zou Y, Weis WI, Kobilka BK
2'-Fluoro RNA Shows Increased Watson-Crick H-Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data.
1. Angew Chem Int Ed Engl - published October 10, 2012
2. M Egli, E Rozners, M Manoharan, K Charisse, M Paolillo, A Patra
Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation.
1. J Chem Theory Comput - published October 9, 2012
2. Cai Y, Yilmaz NK, Myint W, Ishima R, Schiffer CA
A Flexible, Grid-Enabled Web Portal for GROMACS Molecular Dynamics Simulations.
1. J Chem Theory Comput - published October 9, 2012
2. van Dijk M, Wassenaar TA, Bonvin AM
SQUEEZE-E: The Optimal Solution for Molecular Simulations with Periodic Boundary Conditions.
1. J Chem Theory Comput - published October 9, 2012
2. Wassenaar TA, de Vries S, Bonvin AM, Bekker H
Neck rotation and neck mimic docking in the non-catalytic Kar3-associated protein Vik1.
1. J Biol Chem - published October 7, 2012
2. JS Allingham, D Davis, D Drew, M Chan, J Brunton, M Joshi, Z Jia, D Duan
Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy.
1. Proc Natl Acad Sci U S A - published October 3, 2012
2. Soranno A, Buchli B, Nettels D, Cheng RR, Müller-Späth S, Pfeil SH, Hoffmann A, Lipman EA, Makarov DE, Schuler B
Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate.
1. J Am Chem Soc - published October 3, 2012
2. Dalmas O, Hyde HC, Hulse RE, Perozo E
Superatom Electron Configuration Predicts Thermal Stability of Au(25)(SR)(18) Nanoclusters.
1. J Am Chem Soc - published October 3, 2012
2. CJ Ackerson, MA Tofanelli
Structural insights into the function of the nicotinate mononucleotide:phenol/p-cresol phosphoribosyltransferase (ArsAB) enzyme from Sporomusa ovata.
1. Biochemistry - published October 3, 2012
2. Newmister SA, Chan CH, Escalante-Semerena JC, Rayment I
Molecular architecture of human polycomb repressive complex 2.
1. Elife - published October 3, 2012
2. Ciferri C, Lander GC, Maiolica A, Herzog F, Aebersold R, Nogales E
X-Ray Structure of a Heterodimeric ABC Transporter Crystallized in its Inward-Facing Conformation.
1. Chimia (Aarau) - published October 3, 2012
2. Hohl M, Grütter MG, Seeger MA
The Ndc80 kinetochore complex directly modulates microtubule dynamics.
1. Proc Natl Acad Sci U S A - published October 2, 2012
2. TN Davis, CL Asbury, T Gonen, BS Vollmar, JF Tien, DR Gestaut, NT Umbreit
Chemoselective palladium-catalyzed α-allylation of α-boryl aldehydes.
1. Org Biomol Chem - published October 2, 2012
2. St Denis JD, He Z, Yudin AK
Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function.
1. J Biol Chem - published October 2, 2012
2. Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP
Structure and mode of peptide binding of pheromone receptor PrgZ.
1. J Biol Chem - published October 2, 2012
2. Berntsson RP, Schuurman-Wolters GK, Dunny G, Slotboom DJ, Poolman B
Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy.
1. Proc Natl Acad Sci U S A - published October 2, 2012
2. Hofmann H, Soranno A, Borgia A, Gast K, Nettels D, Schuler B
Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
1. Proc Natl Acad Sci U S A - published October 2, 2012
2. El Moustaine D, Granier S, Doumazane E, Scholler P, Rahmeh R, Bron P, Mouillac B, Banères JL, Rondard P, Pin JP
Structure-based prediction of protein-protein interactions on a genome-wide scale.
1. Nature - published October 2, 2012
2. Zhang QC, Petrey D, Deng L, Qiang L, Shi Y, Thu CA, Bisikirska B, Lefebvre C, Accili D, Hunter T, Maniatis T, Califano A, Honig B
Identification and characterization of a compound that protects cardiac tissue from human ether-a-go-go-related gene (hERG)-related, drug-induced Arrhythmias.
1. J Biol Chem - published October 2, 2012
2. S Kupershmidt, CD Weaver, CW Lindsley, FJ Baudenbacher, M Li, JR Balser, CM Campbell, AL George, D Afshartous, B Zou, DW Engers, VY Sidorov, E Days, LM Lewis, SZ Stepanovic, R Venkataraman, CR Hopkins, S Chaigne, AN Lorinc, F Potet
Oxidative geminal functionalization of organoboron compounds.
1. Angew Chem Int Ed Engl - published October 2, 2012
2. He Z, Trinchera P, Adachi S, St Denis JD, Yudin AK
HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation.
1. Proc Natl Acad Sci U S A - published October 2, 2012
2. Park J, Lammers F, Herr W, Song JJ
De novo prediction of protein folding pathways and structure using the principle of sequential stabilization.
1. Proc Natl Acad Sci U S A - published October 2, 2012
2. Adhikari AN, Freed KF, Sosnick TR
Shack-Hartmann centroid detection using the spiral phase transform.
1. Appl Opt - published October 2, 2012
2. Vargas J, Restrepo R, Estrada JC, Sorzano CO, Du YZ, Carazo JM
Visualizing group II intron catalysis through the stages of splicing.
1. Cell - published October 2, 2012
2. Marcia M, Pyle AM
Insights from the sea: structural biology of marine polyketide synthases.
1. Nat Prod Rep - published October 1, 2012
2. Akey DL, Gehret JJ, Khare D, Smith JL
Hydration-layer models for cryo-EM image simulation.
1. J Struct Biol - published October 1, 2012
2. Shang Z, Sigworth FJ
Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity.
1. Genes Immun - published October 1, 2012
2. Briney BS, Willis JR, Crowe JE Jr
Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation.
1. Clin Infect Dis - published October 1, 2012
2. Taur Y, Xavier JB, Lipuma L, Ubeda C, Goldberg J, Gobourne A, Lee YJ, Dubin KA, Socci ND, Viale A, Perales MA, Jenq RR, van den Brink MR, Pamer EG
Enlightening molecular mechanisms through study of protein interactions.
1. J Mol Cell Biol - published October 1, 2012
2. Rizo J, Rosen MK, Gardner KH
Structures of hepatitis B virus cores presenting a model epitope and their complexes with antibodies.
1. J Mol Biol - published October 1, 2012
2. Roseman AM, Borschukova O, Berriman JA, Wynne SA, Pumpens P, Crowther RA
Transfer of engineered biophysical properties between different antibody formats and expression systems.
1. Protein Eng Des Sel - published October 1, 2012
2. Schaefer JV, Plückthun A
Do GGA adaptors bind internal DXXLL motifs?
1. Traffic - published October 1, 2012
2. Doray B, Misra S, Qian Y, Brett TJ, Kornfeld S
Go hybrid: EM, crystallography, and beyond.
1. Curr Opin Struct Biol - published October 1, 2012
2. Lander GC, Saibil HR, Nogales E
Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa.
1. J Bacteriol - published October 1, 2012
2. Ballok AE, Bahl CD, Dolben EL, Lindsay AK, St Laurent JD, Hogan DA, Madden DR, O'Toole GA
The structures of type I polyketide synthases.
1. Nat Prod Rep - published October 1, 2012
2. Keatinge-Clay AT
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.
1. Mol Cell Biol - published October 1, 2012
2. Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R
Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.
1. J Biol Chem - published October 1, 2012
2. Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A
The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms.
1. Structure - published October 1, 2012
2. Horjales S, Schmidt-Arras D, Limardo RR, Leclercq O, Obal G, Prina E, Turjanski AG, Späth GF, Buschiazzo A
Structural studies and protein engineering of inositol phosphate multikinase.
1. J Biol Chem - published October 1, 2012
2. Endo-Streeter S, Tsui MM, Odom AR, Block J, York JD
Soluble expression and purification of tumor suppressor WT1 and its zinc finger domain.
1. Protein Expr Purif - published October 1, 2012
2. Fagerlund RD, Ooi PL, Wilbanks SM
Structural basis for malfunction in complex II.
1. J Biol Chem - published October 1, 2012
2. Iverson TM, Maklashina E, Cecchini G
Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.
1. Mol Cell - published October 1, 2012
2. Wasmuth EV, Lima CD
PACSY, a relational database management system for protein structure and chemical shift analysis.
1. J Biomol NMR - published October 1, 2012
2. Lee W, Yu W, Kim S, Chang I, Lee W, Markley JL
Basis of miscoding of the DNA adduct N2,3-ethenoguanine by human Y-family DNA polymerases.
1. J Biol Chem - published October 1, 2012
2. Zhao L, Pence MG, Christov PP, Wawrzak Z, Choi JY, Rizzo CJ, Egli M, Guengerich FP
An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation.
1. J Biol Chem - published October 1, 2012
2. Wurzburg BA, Kim B, Tarchevskaya SS, Eggel A, Vogel M, Jardetzky TS
Preparative, in vitro biocatalysis of triketide lactone chiral building blocks.
1. Chembiochem - published October 1, 2012
2. Harper AD, Bailey CB, Edwards AD, Detelich JF, Keatinge-Clay AT
Direct identification of ligand-receptor interactions on living cells and tissues.
1. Nat Biotechnol - published October 1, 2012
2. Frei AP, Jeon OY, Kilcher S, Moest H, Henning LM, Jost C, Plückthun A, Mercer J, Aebersold R, Carreira EM, Wollscheid B
Expression, purification, and reconstitution of the voltage-sensing domain from Ci-VSP.
1. Biochemistry - published October 1, 2012
2. Li Q, Jogini V, Wanderling S, Cortes DM, Perozo E
Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?
1. Biochem Soc Trans - published October 1, 2012
2. P Selenko, FX Theillet, A Binolfi
Crystal structure of the redox-active cofactor dibromothymoquinone bound to circadian clock protein KaiA and structural basis for dibromothymoquinone's ability to prevent stimulation of KaiC phosphorylation by KaiA.
1. Biochemistry - published October 1, 2012
2. Pattanayek R, Sidiqi SK, Egli M
Micro-crystallography comes of age.
1. Curr Opin Struct Biol - published October 1, 2012
2. Smith JL, Fischetti RF, Yamamoto M
The genesis of Zelboraf: Targeting mutant B-Raf in melanoma.
1. J Cell Biol - published October 1, 2012
2. J Schlessinger, MJ Davis
Using intein catalysis to probe the origin of major histocompatibility complex class I-presented peptides.
1. Proc Natl Acad Sci U S A - published October 1, 2012
2. KL Rock, LJ Stern, DJ Farfán-Arribas
Purification, crystallization and preliminary crystallographic analysis of Kar9p from Saccharomyces cerevisiae.
1. Acta Crystallogr Sect F Struct Biol Cryst Commun - published October 1, 2012
2. D Hüls, D Niessing
Methicillin resistance in Staphylococcus aureus requires glycosylated wall teichoic acids.
1. Proc Natl Acad Sci U S A - published October 1, 2012
2. S Walker, A Peschel, JE Irazoqui, C Gekeler, V Winstel, C Chen, TC Meredith, J Campbell, LG Luhachack, G Xia, S Brown
Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.
1. J Med Chem - published October 1, 2012
2. Chen J, Zhou H, Aguilar A, Liu L, Bai L, McEachern D, Yang CY, Meagher JL, Stuckey JA, Wang S
How lucky can one be? A perspective from a young scientist at the right place at the right time.
1. Nat Med - published October 1, 2012
2. Vale RD
The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis.
1. Elife - published October 1, 2012
2. Kimmig P, Diaz M, Zheng J, Williams CC, Lang A, Aragón T, Li H, Walter P
[Structure of mu and delta opioid receptors].
1. Med Sci (Paris) - published October 1, 2012
2. Granier S
Structure and conformational change of a replication protein A heterotrimer bound to ssDNA.
1. Genes Dev - published October 1, 2012
2. Fan J, Pavletich NP
Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.
1. ACS Med Chem Lett - published October 1, 2012
2. Zhao H, Dong J, Lafleur K, Nevado C, Caflisch A