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51 Member Publications for March 2012

Encoding substrates with mass tags to resolve stereospecific reactions using Nimzyme.
1. Rapid Commun Mass Spectrom - published March 30, 2012
2. TR Northen, AK Singh, TS Lee, PD Adams, JD Keasling, W Reindl, KW George, K Deng
Rational design and characterization of D-Phe-Pro-D-Arg-derived direct thrombin inhibitors.
1. PLoS One - published March 30, 2012
2. Figueiredo AC, Clement CC, Zakia S, Gingold J, Philipp M, Pereira PJ
Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding.
1. Nucleic Acids Res - published March 28, 2012
2. M Sunnerhagen, P Lundström, CH Arrowsmith, JD Forman-Kay, LZ Penn, J Carlsson, V Csizmok, C Farès, A Lemak, S Helander, C Andresen
Substrate-transport activation is mediated through the second periplasmic loop of the transmembrane protein MalF in the maltose transport complex of Escherichia coli.
1. J Biol Chem - published March 26, 2012
2. E Schneider, T Jacso, B Reif, B Rupp
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
1. Proc Natl Acad Sci U S A - published March 26, 2012
2. PD Kwong, JG Sodroski, JR Mascola, CA Bewley, L Shapiro, AK Debnath, DA Vicic, J Zhu, T Zhou, Y Yang, J Stuckey, SD Schmidt, LR Moore, LK Lee, C Dogo-Isonagie, X Wu, A Finzi, YD Kwon
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
1. Nature - published March 25, 2012
2. KC Garcia, O Boyman, CG Fathman, VS Pande, P Novick, GR Bowman, ME Raeber, I Moraga, L Su, JT Lin, C Krieg, AM Ring, DL Bates, AM Levin
Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells.
1. J Immunol - published March 21, 2012
2. CV Carman, AH Sharpe, TA Springer, AM Dvorak, M Kamei, TE Sciuto, R Martinelli, LM Varghese, PT Sage
The Conformationally Constrained N-Methanocarba-dT Analogue Adopts an Unexpected C4'-exo Sugar Pucker in the Structure of a DNA Hairpin.
1. Biochemistry - published March 20, 2012
2. M Egli, VE Marquez, PS Pallan
Enantioselective Total Synthesis of (+)-Amabiline.
1. Org Lett - published March 20, 2012
2. CW Lindsley, OO Fadeyi, TJ Senter
Structure of the activating IL-1 receptor signaling complex.
1. Nat Struct Mol Biol - published March 18, 2012
2. KC Garcia, JF Bazan, C Thomas
Kinetics of proton transport into influenza virions by the viral M2 channel.
1. PLoS One - published March 14, 2012
2. Ivanovic T, Rozendaal R, Floyd DL, Popovic M, van Oijen AM, Harrison SC
Visualizing molecular juggling within a B(12)-dependent methyltransferase complex.
1. Nature - published March 14, 2012
2. CL Drennan, SW Ragsdale, J Seravalli, G Bender, LC Blasiak, TI Doukov, N Ando, Y Kung
Structure-Guided Design of a High-Affinity Platelet Integrin αIIbβ3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS.
1. Sci Transl Med - published March 14, 2012
2. BS Coller, TA Springer, M Filizola, CJ Thomas, R Aster, M Rasmussen, D Bougie, W Huang, M Shen, J Li, S Naini, J Zhu, A Negri, JG McCoy, WS Choi, J Zhu
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance.
1. Traffic - published March 12, 2012
2. JM Shaw, TA Rapoport, DR Voelker, CS Ejsing, M Bilgin, M Junker, DF Markgraf, JY Choi, A Lewandowska, T Nguyen
Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.
1. Proc Natl Acad Sci U S A - published March 12, 2012
2. RD Kornberg, CD Kaplan, T Wu, PJ Robinson, X Liu, S Nagai, RE Davis, BJ Gibbons, K Murakami
Structural determinants of Clostridium difficile toxin A glucosyltransferase activity.
1. J Biol Chem - published March 9, 2012
2. Pruitt RN, Chumbler NM, Rutherford SA, Farrow MA, Friedman DB, Spiller B, Lacy DB
Antifreeze protein from freeze-tolerant grass has a Beta-roll fold with an irregularly structured ice-binding site.
1. J Mol Biol - published March 9, 2012
2. F Faucher, CB Marshall, AJ Middleton, PL Davies, VK Walker, RL Campbell, I Braslavsky, M Bar-Dolev
Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.
1. Mol Cell - published March 9, 2012
2. Meiri D, Marshall CB, Greeve MA, Kim B, Balan M, Suarez F, Bakal C, Wu C, Larose J, Fine N, Ikura M, Rottapel R
Predicting posttransplantation diabetes mellitus by regulatory T-cell phenotype: implications for metabolic intervention to modulate alloreactivity.
1. Blood - published March 8, 2012
2. Engelhardt BG, Jagasia SM, Crowe JE Jr, Griffith ML, Savani BN, Kassim AA, Lu P, Weitkamp JH, Moore DJ, Yoder SM, Rock MT, Jagasia M
On docking, scoring and assessing protein-DNA complexes in a rigid-body framework.
1. PLoS One - published March 7, 2012
2. Parisien M, Freed KF, Sosnick TR
Phase transitions in the assembly of multivalent signalling proteins.
1. Nature - published March 7, 2012
2. Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK
EM-fold: de novo atomic-detail protein structure determination from medium-resolution density maps.
1. Structure - published March 7, 2012
2. Lindert S, Alexander N, Wötzel N, Karakaş M, Stewart PL, Meiler J
Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase.
1. Biochemistry - published March 6, 2012
2. Iverson TM, Panosian TD, Birmingham WR, Nannemann DP, Bachmann BO
Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins.
1. Proc Natl Acad Sci U S A - published March 6, 2012
2. Briegel A, Li X, Bilwes AM, Hughes KT, Jensen GJ, Crane BR
Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu(5) ): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.
1. ChemMedChem - published March 5, 2012
2. CW Lindsley, KA Emmitte, DG Winder, CM Olsen, PJ Conn, CM Niswender, KJ Gregory, CK Jones, AS Kane, SB Jadhav, UN Menon, JP Lamb, AS Felts, BS Bates, BA Chauder, AL Rodriguez, J Meiler, ES Dawson, R Mueller
Molecular basis for complement recognition by integrin αXβ2.
1. Proc Natl Acad Sci U S A - published March 5, 2012
2. TA Springer, T Walz, LZ Mi, Y Yu, X Chen
Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.
1. Nat Struct Mol Biol - published March 4, 2012
2. TS Jardetzky, Jr Crowe JE, JV Williams, RA Lamb, RG Cox, GP Leser, JC Krause, X Wen
TULIPs: tunable, light-controlled interacting protein tags for cell biology.
1. Nat Methods - published March 4, 2012
2. Strickland D, Lin Y, Wagner E, Hope CM, Zayner J, Antoniou C, Sosnick TR, Weiss EL, Glotzer M
Structure-guided engineering enhances a phytochrome-based infrared fluorescent protein.
1. J Biol Chem - published March 2, 2012
2. Auldridge ME, Satyshur KA, Anstrom DM, Forest KT
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
1. J Biol Chem - published March 2, 2012
2. Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS
Structural insights into methyltransferase KsgA function in 30S ribosomal subunit biogenesis.
1. J Biol Chem - published March 2, 2012
2. Boehringer D, O'Farrell HC, Rife JP, Ban N
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis.
1. EMBO J - published March 2, 2012
2. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT
Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model.
1. Cell - published March 2, 2012
2. Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.
1. Proc Natl Acad Sci U S A - published March 2, 2012
2. Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J
Structural basis for the enhanced stability of highly fluorinated proteins.
1. Proc Natl Acad Sci U S A - published March 2, 2012
2. Buer BC, Meagher JL, Stuckey JA, Marsh EN
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist.
1. Nature - published March 2, 2012
2. Manglik A, Kruse AC, Kobilka TS, Thian FS, Mathiesen JM, Sunahara RK, Pardo L, Weis WI, Kobilka BK, Granier S
Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation.
1. Nat Struct Mol Biol - published March 2, 2012
2. Hohl M, Briand C, Grütter MG, Seeger MA
Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
1. Cell Death Differ - published March 1, 2012
2. Thotala DK, Hallahan DE, Yazlovitskaya EM
Characterization of the kinetic and thermodynamic landscape of RNA folding using a novel application of isothermal titration calorimetry.
1. Nucleic Acids Res - published March 1, 2012
2. Vander Meulen KA, Butcher SE
Fluorescence strategies for high-throughput quantification of protein interactions.
1. Nucleic Acids Res - published March 1, 2012
2. Hieb AR, D'Arcy S, Kramer MA, White AE, Luger K
Persistence of circulating memory B cell clones with potential for dengue virus disease enhancement for decades following infection.
1. J Virol - published March 1, 2012
2. Smith SA, Zhou Y, Olivarez NP, Broadwater AH, de Silva AM, Crowe JE Jr
Growth and localization of polyhydroxybutyrate granules in Ralstonia eutropha.
1. J Bacteriol - published March 1, 2012
2. Beeby M, Cho M, Stubbe J, Jensen GJ
PS--a program for the analysis of helix geometry.
1. J Mol Graph Model - published March 1, 2012
2. Smith BJ
Multiple domains of human CLASP contribute to microtubule dynamics and organization in vitro and in Xenopus egg extracts.
1. Cytoskeleton (Hoboken) - published March 1, 2012
2. Patel K, Nogales E, Heald R
Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells.
1. J Immunol - published March 1, 2012
2. Kwon HS, Lim HW, Wu J, Schnölzer M, Verdin E, Ott M
Molecular mechanisms of viral inhibitors of RIG-I-like receptors.
1. Trends Microbiol - published March 1, 2012
2. Leung DW, Basler CF, Amarasinghe GK
Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H-pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1.
1. Bioorg Med Chem Lett - published March 1, 2012
2. A Taveras, T Li, S Zhao, N Pathan, M Teng, M Choi, L Zhang, L Ling, L Silvian, K Nguyen, J Fan, J Chao, JH Chong, G Claassen, D Wang, C Black, C Boykin, B Tam, A Pasis, JY Le Brazidec
Structure of the catalytic domain of the Clostridium thermocellum cellulase CelT.
1. Acta Crystallogr D Biol Crystallogr - published March 1, 2012
2. Kesavulu MM, Tsai JY, Lee HL, Liang PH, Hsiao CD
Diazeniumdiolated carbamates: a novel class of nitric oxide donors.
1. Bioorg Med Chem - published March 1, 2012
2. Nandurdikar RS, Maciag AE, Cao Z, Keefer LK, Saavedra JE
Recombinant expression and purification of the tomato defensin TPP3 and its preliminary X-ray crystallographic analysis.
1. Acta Crystallogr Sect F Struct Biol Cryst Commun - published March 1, 2012
2. Lay FT, Veneer PK, Hulett MD, Kvansakul M
Efficient Construction of Mesostate Networks from Molecular Dynamics Trajectories.
1. J Chem Theory Comput - published March 1, 2012
2. Vitalis A, Caflisch A