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68 Member Publications for November 2011

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-{Delta}7-24, 25-dihydrolanosterol.
1. J Lipid Res - published November 30, 2011
2. GI Lepesheva, WD Nes, MR Waterman, J Liu, Z Wawrzak, TY Hargrove
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
1. Nature - published November 23, 2011
2. PD Kwong, IA Wilson, AB Ward, WR Schief, GJ Nabel, JR Mascola, CA Bewley, J Arthos, LX Wang, J Orwenyo, R Wyatt, S Phogat, LM Walker, WC Koff, DR Burton, BF Haynes, NE Sam, SH Kapiga, JA Crump, M Bonsignori, ZY Yang, SD Schmidt, S Moquin, MK Louder, D Lee, Y Do Kwon, I Georgiev, D Diwanji, GY Chuang, JC Boyington, J Zhu, T Zhou, B Zhang, Y Yang, S Shahzad-Ul-Hussan, N Patel, S O'Dell, K Dai, M Sastry, R Pejchal, R Louder, R Khayat, JP Julien, J Gorman, C Carrico, M Pancera, JS McLellan
Characterization of Membrane Proteins in Isolated Native Cellular Membranes by Dynamic Nuclear Polarization Solid-State NMR Spectroscopy without Purification and Reconstitution.
1. Angew Chem Int Ed Engl - published November 23, 2011
2. B Reif, H Oschkinat, S Keller, J Broecker, U Fink, H Rose, WT Franks, T Jacso
The use of blood in obstetrics and gynecology in the developing world.
1. Rev Obstet Gynecol - published November 22, 2011
2. Schantz-Dunn J, M N
Decoding the roles of pilotins and accessory proteins in secretin escort services.
1. FEMS Microbiol Lett - published November 21, 2011
2. PL Howell, LL Burrows, J Koo
Structure of (5'S)-8,5'-Cyclo-2'-deoxyguanosine in DNA.
1. J Am Chem Soc - published November 21, 2011
2. MP Stone, AK Basu, RS Das, H Huang
Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.
1. Nat Chem Biol - published November 20, 2011
2. R Anwyl, R Lurz, MR Schmidt, Q Wang, BA Grüning, JM Lopez Del Amo, D Kleckers, F Schiele, A Boeddrich, RP Friedrich, T Wiglenda, M Herbst, J Bieschke, EE Wanker, DM Walsh, S Günther, B Reif, RF Frank, M Fändrich, S Schnoegl
Rapid selection of high-affinity binders using ribosome display.
1. Methods Mol Biol - published November 19, 2011
2. Dreier B, Plückthun A
Ribosome display: a perspective.
1. Methods Mol Biol - published November 19, 2011
2. Plückthun A
Cryo-electron microscopy of ribosomal complexes in cotranslational folding, targeting, and translocation.
1. Wiley Interdiscip Rev RNA - published November 19, 2011
2. Knoops K, Schoehn G, Schaffitzel C
Exploring symmetry as an avenue to the computational design of large protein domains.
1. J Am Chem Soc - published November 16, 2011
2. J Meiler, L Mizoue, J Harp, S Combs, B Dorr, W Proffitt, EA Bowman, C Fortenberry
The mGlu4 positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine A2A antagonist in preclinical rodent models of Parkinson's disease.
1. J Pharmacol Exp Ther - published November 16, 2011
2. CM Niswender, PJ Conn, CR Hopkins, CW Lindsley, JS Daniels, J Bode, K Italiano, DW Engers, S Jadhav, RD Morrison, TM Bridges, AL Blobaum, M Amalric, N Turle-Lorenzo, JW Dickerson, AD Thompson, M Bubser, CK Jones
Inward facing conformations of the MetNI methionine ABC transporter: Implications for the mechanism of transinhibition.
1. Protein Sci - published November 16, 2011
2. DC Rees, TO Yeates, PT Nguyen, E Johnson
AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.
1. EMBO Mol Med - published November 16, 2011
2. JD Scott, T Gonen, JE Bruce, LK Langeberg, CR Weisbrod, SE O'Neill, SL Reichow, MG Gold
Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.
1. Proc Natl Acad Sci U S A - published November 15, 2011
2. KM Reinisch, FA Barr, EM De La Cruz, D Kümmel, Y Cai, MJ Bradley, X Wu
Using systems and structure biology tools to dissect cellular phenotypes.
1. J Am Med Inform Assoc - published November 15, 2011
2. Floratos A, Honig B, Pe'er D, Califano A
Structural and Mechanistic Implications of Metal-Binding in the Small Heat-Shock Protein αB-Crystallin.
1. J Biol Chem - published November 15, 2011
2. B Reif, R Pierattelli, IC Felli, G Multhaup, F Kuppler, B Bardiaux, A Mainz
Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation.
1. J Cell Biol - published November 14, 2011
2. KL Gould, R Ohi, JF Partridge, C English, KM Creamer, MD Ohi, LX Lu, JS Chen
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.
1. Proc Natl Acad Sci U S A - published November 14, 2011
2. LJ Stern, JE Evans, Z Zavala-Ruiz, KA Kellersberger, MP Negroni, CA Painter
Structure of full-length Drosophila cryptochrome.
1. Nature - published November 13, 2011
2. BR Crane, MW Young, J Widom, D Top, AT Vaidya, BD Zoltowski
A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.
1. Nat Chem Biol - published November 13, 2011
2. S Walker, P Sliz, L Pasquina, MB Lazarus, J Jiang
An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.
1. PLoS One - published November 10, 2011
2. Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB 3rd, Sodroski JG
Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses.
1. Structure - published November 9, 2011
2. Pielak RM, Oxenoid K, Chou JJ
Structural basis of mannan-binding lectin recognition by its associated serine protease MASP-1: implications for complement activation.
1. Structure - published November 9, 2011
2. Gingras AR, Girija UV, Keeble AH, Panchal R, Mitchell DA, Moody PC, Wallis R
Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective.
1. Methods Mol Biol - published November 5, 2011
2. Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson TM
Synthesis of 2'-N-methylamino-2'-deoxyguanosine and 2'-N,N-dimethylamino-2'-deoxyguanosine and their incorporation into RNA by phosphoramidite chemistry.
1. J Org Chem - published November 4, 2011
2. Dai Q, Sengupta R, Deb SK, Piccirilli JA
DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency.
1. J Mol Biol - published November 4, 2011
2. Stefan N, Martin-Killias P, Wyss-Stoeckle S, Honegger A, Zangemeister-Wittke U, Plückthun A
Identification of potential human respiratory syncytial virus and metapneumovirus T cell epitopes using computational prediction and MHC binding assays.
1. J Immunol Methods - published November 3, 2011
2. Rock MT, McKinney BA, Yoder SM, Prudom CE, Wright DW, Crowe JE Jr
Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6.
1. Science - published November 3, 2011
2. N Ban, S Arpagaus, M Leibundgut, F Voigts-Hoffmann, S Klinge
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
1. Biochemistry - published November 2, 2011
2. Barrett PJ, Sanders CR, Kaufman SA, Michelsen K, Jordan JB
Flavin-induced oligomerization in Escherichia coli adaptive response protein AidB.
1. Biochemistry - published November 2, 2011
2. Hamill MJ, Jost M, Wong C, Elliott SJ, Drennan CL
Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.
1. J Med Chem - published November 2, 2011
2. Maciag AE, Nandurdikar RS, Hong SY, Chakrapani H, Diwan B, Morris NL, Shami PJ, Shiao YH, Anderson LM, Keefer LK, Saavedra JE
Surfactant effects on amyloid aggregation kinetics.
1. J Mol Biol - published November 2, 2011
2. Friedman R, Caflisch A
Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
1. Biochemistry - published November 2, 2011
2. Pozzi N, Chen Z, Zapata F, Pelc LA, Barranco-Medina S, Di Cera E
Molecular basis for interaction of let-7 microRNAs with Lin28.
1. Cell - published November 2, 2011
2. Nam Y, Chen C, Gregory RI, Chou JJ, Sliz P
Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins.
1. Nat Struct Mol Biol - published November 2, 2011
2. Tripsianes K, Madl T, Machyna M, Fessas D, Englbrecht C, Fischer U, Neugebauer KM, Sattler M
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex.
1. Immunity - published November 2, 2011
2. Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC
A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands.
1. Immunity - published November 2, 2011
2. Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES
The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.
1. Nat Struct Mol Biol - published November 2, 2011
2. Berman AJ, Akiyama BM, Stone MD, Cech TR
Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis.
1. Mol Syst Biol - published November 2, 2011
2. Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK
The redundancy of NMR restraints can be used to accelerate the unfolding behavior of an SH3 domain during molecular dynamics simulations.
1. BMC Struct Biol - published November 2, 2011
2. Duclert-Savatier N, Martínez L, Nilges M, Malliavin TE
The unfolded protein response: from stress pathway to homeostatic regulation.
1. Science - published November 2, 2011
2. Walter P, Ron D
A new angle on TCR activation.
1. Immunity - published November 2, 2011
2. Wang JH, Reinherz EL
Hydrolytic catalysis and structural stabilization in a designed metalloprotein.
1. Nat Chem - published November 2, 2011
2. Zastrow ML, Peacock AF, Stuckey JA, Pecoraro VL
Rigidification of the autolysis loop enhances Na(+) binding to thrombin.
1. Biophys Chem - published November 1, 2011
2. Pozzi N, Chen R, Chen Z, Bah A, Di Cera E
Transporters associated with antigen processing (TAP) in sea bass (Dicentrarchus labrax, L.): molecular cloning and characterization of TAP1 and TAP2.
1. Dev Comp Immunol - published November 1, 2011
2. Pinto RD, Pereira PJ, dos Santos NM
Allostery in trypsin-like proteases suggests new therapeutic strategies.
1. Trends Biotechnol - published November 1, 2011
2. Gohara DW, Di Cera E
A new way to see RNA.
1. Q Rev Biophys - published November 1, 2011
2. Keating KS, Humphris EL, Pyle AM
A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins.
1. Anal Biochem - published November 1, 2011
2. Berndsen CE, Wolberger C
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay.
1. Antiviral Res - published November 1, 2011
2. Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G
Charged multivesicular body protein 2B (CHMP2B) of the endosomal sorting complex required for transport-III (ESCRT-III) polymerizes into helical structures deforming the plasma membrane.
1. J Biol Chem - published November 1, 2011
2. Bodon G, Chassefeyre R, Pernet-Gallay K, Martinelli N, Effantin G, Hulsik DL, Belly A, Goldberg Y, Chatellard-Causse C, Blot B, Schoehn G, Weissenhorn W, Sadoul R
Development of a highly selective, orally bioavailable and CNS penetrant M(1) agonist derived from the MLPCN probe ML071.
1. Bioorg Med Chem Lett - published November 1, 2011
2. CW Lindsley, P Jeffrey Conn, MR Wood, J Scott Daniels, Z Xiang, TM Bridges, R Morrison, NR Miller, HP Cho, JC Tarr, BJ Melancon, DJ Sheffler, GJ Digby, EP Lebois
Dynamics in the active site of β-secretase: a network analysis of atomistic simulations.
1. Biochemistry - published November 1, 2011
2. Mishra S, Caflisch A
The Xist RNA A-repeat comprises a novel AUCG tetraloop fold and a platform for multimerization.
1. RNA - published November 1, 2011
2. Duszczyk MM, Wutz A, Rybin V, Sattler M
p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment.
1. Mol Biol Cell - published November 1, 2011
2. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK
Subunit organization in the Dam1 kinetochore complex and its ring around microtubules.
1. Mol Biol Cell - published November 1, 2011
2. Ramey VH, Wong A, Fang J, Howes S, Barnes G, Nogales E
Kinetic, Mechanistic, and Structural Modeling Studies of Truncated Wild-Type Leucine-Rich Repeat Kinase 2 and the G2019S Mutant.
1. Biochemistry - published November 1, 2011
2. MA Glicksman, GD Cuny, SA Gerber, AD Zaitsev, J Jackson, S Ray, S Kang, M Liu
Activated chemoreceptor arrays remain intact and hexagonally packed.
1. Mol Microbiol - published November 1, 2011
2. Briegel A, Beeby M, Thanbichler M, Jensen GJ
Zinc uptake by Streptococcus pneumoniae depends on both AdcA and AdcAII and is essential for normal bacterial morphology and virulence.
1. Mol Microbiol - published November 1, 2011
2. Bayle L, Chimalapati S, Schoehn G, Brown J, Vernet T, Durmort C
Selective activation of heme oxygenase-2 by menadione.
1. Can J Physiol Pharmacol - published November 1, 2011
2. JF Brien, WA Szarek, MN Rahman, BE McLaughlin, D Vukomanovic, K Nakatsu, Z Jia
Diverse ways to be specific: a novel Zn-binding domain confers substrate specificity to UTX/KDM6A histone H3 Lys 27 demethylase.
1. Genes Dev - published November 1, 2011
2. Kim E, Song JJ
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
1. Science - published November 1, 2011
2. Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H
The Chp1-Tas3 core is a multifunctional platform critical for gene silencing by RITS.
1. Nat Struct Mol Biol - published November 1, 2011
2. Schalch T, Job G, Shanker S, Partridge JF, Joshua-Tor L
Treatment and prevention of urinary tract infection with orally active FimH inhibitors.
1. Sci Transl Med - published November 1, 2011
2. Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ
Structure of cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate.
1. Acta Crystallogr Sect F Struct Biol Cryst Commun - published November 1, 2011
2. Bianchetti CM, Elsen NL, Fox BG, Phillips GN Jr
Expression, crystallization and preliminary X-ray crystallographic analysis of glucose-6-phosphate dehydrogenase from the human pathogen Trypanosoma cruzi in complex with substrate.
1. Acta Crystallogr Sect F Struct Biol Cryst Commun - published November 1, 2011
2. Ortíz C, Larrieux N, Medeiros A, Botti H, Comini M, Buschiazzo A
The phosphoglucan phosphatase like sex Four2 dephosphorylates starch at the C3-position in Arabidopsis.
1. Plant Cell - published November 1, 2011
2. Santelia D, Kötting O, Seung D, Schubert M, Thalmann M, Bischof S, Meekins DA, Lutz A, Patron N, Gentry MS, Allain FH, Zeeman SC
The control of HIV transcription: keeping RNA polymerase II on track.
1. Cell Host Microbe - published November 1, 2011
2. Ott M, Geyer M, Zhou Q