Member Publications

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60 Member Publications for December 2010

Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex.
1. Proc Natl Acad Sci U S A - published December 28, 2010
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase.
1. Proc Natl Acad Sci U S A - published December 28, 2010
Structural basis for proficient incorporation of dTTP opposite O6-methylguanine by human DNA polymerase iota.
1. J Biol Chem - published December 24, 2010
Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases.
1. Cell - published December 23, 2010
Kinetic analysis of the M2 proton conduction of the influenza virus.
1. J Am Chem Soc - published December 22, 2010
Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.
1. Chem Biol - published December 22, 2010
Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5α.
1. Virology - published December 20, 2010
SAM recognition and conformational switching mechanism in the Bacillus subtilis yitJ S box/SAM-I riboswitch.
1. J Mol Biol - published December 17, 2010
Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.
1. Blood - published December 16, 2010
Dimeric 2G12 as a potent protection against HIV-1.
1. PLoS Pathog - published December 16, 2010
Protein structure determination by exhaustive search of Protein Data Bank derived databases.
1. Proc Natl Acad Sci U S A - published December 14, 2010
UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region.
1. Proc Natl Acad Sci U S A - published December 14, 2010
Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR.
1. J Mol Biol - published December 10, 2010
Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains.
1. J Mol Biol - published December 10, 2010
Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch.
1. Mol Cell - published December 10, 2010
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.
1. Nature - published December 9, 2010
Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010.
1. Chimia (Aarau) - published December 9, 2010
2. Dutzler R, Ernstb B, Hediger MA, Keppler D, Mohr P, Neidhart W, Märki HP
Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.
1. Channels (Austin) - published December 9, 2010
2. Minor DL Jr, Findeisen F
Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation.
1. Structure - published December 8, 2010
2. Findeisen F, Minor DL Jr
Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody.
1. Structure - published December 8, 2010
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase.
1. Proc Natl Acad Sci U S A - published December 7, 2010
2. Koutmos M, Kabil O, Smith JL, Banerjee R
Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.
1. Proc Natl Acad Sci U S A - published December 7, 2010
S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins.
1. PLoS Biol - published December 7, 2010
2. Dorwart MR, Wray R, Brautigam CA, Jiang Y, Blount P
Structural determinants for improved stability of designed ankyrin repeat proteins with a redesigned C-capping module.
1. J Mol Biol - published December 3, 2010
2. Kramer MA, Wetzel SK, Plückthun A, Mittl PR, Grütter MG
Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation.
1. J Biol Chem - published December 3, 2010
2. Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME
Substrate-specific kinetics of Dicer-catalyzed RNA processing.
1. J Mol Biol - published December 3, 2010
Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening.
1. Blood - published December 2, 2010
Conformational remodeling of femtomolar inhibitor-acetylcholinesterase complexes in the crystalline state.
1. J Am Chem Soc - published December 2, 2010
2. Bourne Y, Radić Z, Taylor P, Marchot P
Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
1. PLoS Pathog - published December 2, 2010
2. Kvansakul M, Wei AH, Fletcher JI, Willis SN, Chen L, Roberts AW, Huang DC, Colman PM
GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors.
1. J Struct Biol - published December 1, 2010
2. Li X, Grigorieff N, Cheng Y
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.
1. Anal Biochem - published December 1, 2010
2. Padrick SB, Deka RK, Chuang JL, Wynn RM, Chuang DT, Norgard MV, Rosen MK, Brautigam CA
Dissecting the role of conserved box C/D sRNA sequences in di-sRNP assembly and function.
1. Nucleic Acids Res - published December 1, 2010
2. Bleichert F, Baserga SJ
Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.
1. J Phys Chem B - published December 1, 2010
2. Vogt AD, Bah A, Di Cera E
The role of Zn2+ on the structure and stability of murine adenosine deaminase.
1. J Phys Chem B - published December 1, 2010
2. Niu W, Shu Q, Chen Z, Mathews S, Di Cera E, Frieden C
Respiratory syncytial virus induces host RNA stress granules to facilitate viral replication.
1. J Virol - published December 1, 2010
2. Lindquist ME, Lifland AW, Utley TJ, Santangelo PJ, Crowe JE Jr
Transforming growth factor beta is a major regulator of human neonatal immune responses following respiratory syncytial virus infection.
1. J Virol - published December 1, 2010
2. Thornburg NJ, Shepherd B, Crowe JE Jr
A gain-of-function mutation of Arabidopsis cryptochrome1 promotes flowering.
1. Plant Physiol - published December 1, 2010
2. Exner V, Alexandre C, Rosenfeldt G, Alfarano P, Nater M, Caflisch A, Gruissem W, Batschauer A, Hennig L
Integrin {alpha}1{beta}1 promotes caveolin-1 dephosphorylation by activating T cell protein-tyrosine phosphatase.
1. J Biol Chem - published December 1, 2010
2. Borza CM, Chen X, Mathew S, Mont S, Sanders CR, Zent R, Pozzi A
Structural basis of local, pH-dependent conformational changes in glycoprotein B from herpes simplex virus type 1.
1. J Virol - published December 1, 2010
2. Stampfer SD, Lou H, Cohen GH, Eisenberg RJ, Heldwein EE
Domain view: a web tool for protein domain visualization and analysis.
1. J Struct Funct Genomics - published December 1, 2010
2. Pan X, Bingman CA, Wesenberg GE, Sun Z, Phillips GN Jr
Recognition of nuclear targeting signals by Karyopherin-β proteins.
1. Curr Opin Struct Biol - published December 1, 2010
2. Xu D, Farmer A, Chook YM
Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization.
1. J Mol Biol - published December 1, 2010
2. Bertin A, McMurray MA, Thai L, Garcia G 3rd, Votin V, Grob P, Allyn T, Thorner J, Nogales E
Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.
1. EMBO J - published December 1, 2010
2. Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL Jr
What is the optimal anesthetic protocol for measurements of cerebral autoregulation in spontaneously breathing mice?
1. Exp Brain Res - published December 1, 2010
2. Wang Z, Schuler B, Vogel O, Arras M, Vogel J
The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers.
1. Cancer Res - published December 1, 2010
2. Sasaki T, Okuda K, Zheng W, Butrynski J, Capelletti M, Wang L, Gray NS, Wilner K, Christensen JG, Demetri G, Shapiro GI, Rodig SJ, Eck MJ, Jänne PA
Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins.
1. Nat Methods - published December 1, 2010
2. Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, Gether U, Byrne B, Kobilka B, Gellman SH
Elucidation of inositol hexaphosphate and heparin interaction sites and conformational changes in arrestin-1 by solution nuclear magnetic resonance.
1. Biochemistry - published December 1, 2010
2. Zhuang T, Vishnivetskiy SA, Gurevich VV, Sanders CR
Genetic ablation of complement C3 attenuates muscle pathology in dysferlin-deficient mice.
1. J Clin Invest - published December 1, 2010
2. Han R, Frett EM, Levy JR, Rader EP, Lueck JD, Bansal D, Moore SA, Ng R, Beltrán-Valero de Bernabé D, Faulkner JA, Campbell KP
When whorls collide: the development of hair patterns in frizzled 6 mutant mice.
1. Development - published December 1, 2010
2. Wang Y, Chang H, Nathans J
The first structures of T cell receptors bound to peptide-MHC.
1. J Immunol - published December 1, 2010
A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.
1. Angew Chem Int Ed Engl - published December 1, 2010
2. Cushing PR, Vouilleme L, Pellegrini M, Boisguerin P, Madden DR
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.
1. Nat Rev Mol Cell Biol - published December 1, 2010
2. Gareau JR, Lima CD
Improved hidden Markov models for molecular motors, part 1: basic theory.
1. Biophys J - published December 1, 2010
2. Müllner FE, Syed S, Selvin PR, Sigworth FJ
Noncytotoxic DsRed derivatives for whole-cell labeling.
1. Methods Mol Biol - published December 1, 2010
2. Strack RL, Keenan RJ, Glick BS
Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase.
1. Proc Natl Acad Sci U S A - published December 1, 2010
2. Obeid S, Baccaro A, Welte W, Diederichs K, Marx A
Picture of the month. Uncombable hair (pili trianguli et canaliculi).
1. Arch Pediatr Adolesc Med - published December 1, 2010
2. Navarini AA, Kaufmann F, Kaech A, Trüeb RM, Weibel L
Specificity for human hemoglobin enhances Staphylococcus aureus infection.
1. Cell Host Microbe - published December 1, 2010
2. Pishchany G, McCoy AL, Torres VJ, Krause JC, Crowe JE Jr, Fabry ME, Skaar EP
Histone demethylation and timely DNA replication.
1. Mol Cell - published December 1, 2010
2. Gerace EL, Moazed D
The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation.
1. Immunity - published December 1, 2010
2. Scharf L, Li NS, Hawk AJ, Garzón D, Zhang T, Fox LM, Kazen AR, Shah S, Haddadian EJ, Gumperz JE, Saghatelian A, Faraldo-Gómez JD, Meredith SC, Piccirilli JA, Adams EJ
Glutaminase: a hot spot for regulation of cancer cell metabolism?
1. Oncotarget - published December 1, 2010
2. Erickson JW, Cerione RA