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125 Member Publications for May

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pH adjustment increases biofuel production from inhibitory switchgrass hydrolysates.
1. Bioresour Technol - published May 9, 2025
2. Barten LM, Crandall JG, Xie D, Serate J, Handowski E, Jen A, Overmyer KA, Coon JJ, Hittinger CT, Landick R, Zhang Y, Sato TK
The Acrolein - Lipopolysaccharide Mouse Model for Frequent Exacerbations in COPD.
1. Am J Respir Cell Mol Biol - published May 9, 2025
2. Reiter BF, Bordag N, Schnoegl D, Delbeck M, Madl T, Habisch H, Kwapiszewska G, Meding J, Marsh LM
Machine Learning and Statistical Mechanics: Shared Synergies for Next Generation of Chemical Theory and Computation.
1. J Chem Theory Comput - published May 9, 2025
2. Cersonsky RK, Cheng B, De Vivo M, Tiwary P
Import mechanism of peroxisomal proteins with an N-terminal signal sequence.
1. Nat Cell Biol - published May 9, 2025
2. Skowyra ML, Rapoport TA
SARM1 loss protects retinal ganglion cells in a mouse model of Autosomal Dominant Optic Atrophy.
1. J Clin Invest - published May 9, 2025
2. Ding C, Ndiaye PS, Campbell SR, Fry MY, Gong J, Wienbar SR, Gibbs W, Morquette P, Chao LH, Do MTH, Schwarz T
Genome-wide association studies of binge eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes.
1. medRxiv - published May 8, 2025
2. Termorshuizen JD, Davies HL, Lee SH, Dennis JK, Hübel C, Johnson JS, Lu Y, Munn-Chernoff MA, Peters T, Qi B, Schaumberg KE, Signer RH, Singh K, Ter Kuile AR, Thornton LM, Xu J, Yao S, Yilmaz Z, Zhang R, Zvrskovec J, Abdulkadir M, Ayorech Z, Corfield EC, Havdahl A, Krebs K, Mack TM, Niarchou M, Palviainen T, Sealock JM, Baker JH, Bergen AW, Birgegård A, Perica VB, Bühren K, Burghardt R, Cassina M, Collantoni E, Crowley JJ, Danner UN, Degenhardt F, DeSocio JE, Dina C, Dmitrzak-Węglarz M, Duncan LE, Egberts KM, Foretova L, Giegling I, Gonidakis F, Gordon SD, Grove J, Guillaume S, Guintivano JD, Hartman AM, Hatzikotoulas K, Herms S, Imgart H, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen LJ, Kiezebrink KM, Kolb T, Larsen JT, Li D, Lilenfeld L, Maj M, Mattingsdal M, Meneguzzo P, Miller AL, Mitchell KS, Monteleone AM, Olsen CM, Padyukov L, Pantel J, Parker R, Pinto D, Raevuori A, Ripatti S, Roberts ME, Santonastaso P, Savva A, Schmidt UH, Schosser A, Seitz J, Slachtova LL, Slopien A, Sorbi S, Straub PS, Szatkiewicz JP, Tam FI, Tenconi E, Tortorella A, Tsitsika A, van Elburg AA, Wagner G, Watson HJ, Adan RA, Alfredsson L, Andreassen OA, Ask H, Brandt HA, Crawford S, Crow S, Davis LK, de Zwaan M, Dedoussis G, Dick DM, Ehrlich S, Estivill X, Favaro A, Fernández-Aranda F, Fischer K, Forstner AJ, Gorwood P, Hakonarson H, Hebebrand J, Herpertz-Dahlmann B, Hinney A, Hudson JI, Johnson C, Jordan J, Kaplan AS, Kaprio J, Karwautz AF, Kas MJ, Kaye WH, Kennedy JL, Kennedy MA, Keski-Rahkonen A, Kim YR, Klump KL, Landén M, Hellard SL, Lehto K, Lissowska J, Maguire SL, Martin NG, Mattheisen M, Medland SE, Micali N, Mitchell JE, Monteleone P, Mortensen PB, Nacmias B, Ophoff RA, Papezova H, Pedersen NL, Petersen LV, Rajcsanyi LS, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripke S, Rujescu D, Rybakowski F, Scherer SW, Slof-Op 't Landt MC, Sullivan PF, Świątkowska B, van Furth EF, Wade TD, Werge T, Whiteman DC, Woodside DB, Zipfel S, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Estonian Biobank (EstBB), Bulik CM, Huckins LM, Breen G, Coleman JR
Deep learning-assisted analysis of single-particle tracking for automated correlation between diffusion and function.
1. Nat Methods - published May 8, 2025
2. Kæstel-Hansen J, de Sautu M, Saminathan A, Scanavachi G, Bango Da Cunha Correia RF, Juma Nielsen A, Bleshøy SV, Tsolakidis K, Boomsma W, Kirchhausen T, Hatzakis NS
An approach for coherent periodogram averaging of tilt-series data for improved contrast transfer function estimation.
1. FEBS Open Bio - published May 8, 2025
2. Khavnekar S, Wan W
De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts.
1. Science - published May 8, 2025
2. Hou K, Huang W, Qi M, Tugwell TH, Alturaifi TM, Chen Y, Zhang X, Lu L, Mann SI, Liu P, Yang Y, DeGrado WF
InDeepNet: a web platform for predicting functional binding sites in proteins using InDeep.
1. Nucleic Acids Res - published May 8, 2025
2. Mareuil F, Torchet R, Ruano LC, Mallet V, Nilges M, Bouvier G, Sperandio O
A human cytomegalovirus prefusion-like glycoprotein B subunit vaccine elicits humoral immunity similar to that of postfusion gB in mice.
1. J Virol - published May 8, 2025
2. Karthigeyan KP, Connors M, Binuya CR, Gross M, Fuller AS, Crooks CM, Wang H-Y, Sponholtz MR, Byrne PO, Herbek S, Andy C, Gerber LM, Campbell JD, Williams CA, Mitchell E, van der Maas L, Miller I, Yu D, Bottomley MJ, McLellan JS, Permar SR
Novel, potent, and orally bioavailable LSD1 inhibitors induce fetal hemoglobin synthesis in a sickle cell disease mouse model.
1. Blood - published May 7, 2025
2. Wang Y, Yu L, Deng K, Packiarajan M, Aguilar A, An S, Myers G, Oh H, Singh SA, Cho US, Wang S, Guan Y, White A, Khoriaty R, Engel JD
p97/VCP is required for piecemeal autophagy of aggresomes.
1. Nat Commun - published May 7, 2025
2. Körner M, Müller P, Das H, Kraus F, Pfeuffer T, Spielhaupter S, Oeljeklaus S, Schülein-Völk C, Harper JW, Warscheid B, Buchberger A
Evolution-guided protein design of IscB for persistent epigenome editing in vivo.
1. Nat Biotechnol - published May 7, 2025
2. Kannan S, Altae-Tran H, Zhu S, Xu P, Strebinger D, Oshiro R, Faure G, Moeller L, Pham J, Mears KS, Ni HM, Macrae RK, Zhang F
SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress.
1. Elife - published May 7, 2025
2. Karim R, Teng W, Behram CD, Lin H
Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia.
1. ACS Omega - published May 6, 2025
2. Pantouris G, Khurana L, Tilstam P, Benner A, Cho TY, Lelaidier M, Perrée M, Rosenbaum Z, Leng L, Foss F, Bhandari V, Verma A, Bucala R, Lolis EJ
Setdb1 and Atf7IP form a hetero-trimeric complex that blocks Setdb1 nuclear export.
1. J Biol Chem - published May 6, 2025
2. Kariapper L, Marathe IA, Niesman AB, Suino-Powell K, Chook YM, Wysocki VH, Worden EJ
Computationally designed proteins mimic antibody immune evasion in viral evolution.
1. Immunity - published May 6, 2025
2. Youssef N, Gurev S, Ghantous F, Brock KP, Jaimes JA, Thadani NN, Dauphin A, Sherman AC, Yurkovetskiy L, Soto D, Estanboulieh R, Kotzen B, Notin P, Kollasch AW, Cohen AA, Dross SE, Erasmus J, Fuller DH, Bjorkman PJ, Lemieux JE, Luban J, Seaman MS, Marks DS
Niclosamide: CRL4(AMBRA1) mediated degradation of cyclin D1 following mitochondrial membrane depolarization.
1. RSC Med Chem - published May 6, 2025
2. Coomar S, Gasser JA, Słabicki M, Donovan KA, Fischer ES, Ebert BL, Gillingham D, Thomä NH
Structural and biochemical studies of mobile retrotransposon proteins in action.
1. Curr Opin Struct Biol - published May 6, 2025
2. Thawani A, Collins K, Nogales E
SARS-CoV-2 spike protein: structure, viral entry and variants.
1. Nat Rev Microbiol - published May 6, 2025
2. Chen B, Farzan M, Choe H
Naturally ornate RNA-only complexes revealed by cryo-EM.
1. Nature - published May 6, 2025
2. Kretsch RC, Wu Y, Shabalina SA, Lee H, Nye G, Koonin EV, Gao A, Chiu W, Das R
Moving towards sequencing-based metabolomics.
1. Trends Genet - published May 6, 2025
2. Clark-ElSayed A, Ellington AD, Marcotte EM
Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation.
1. Adv Sci (Weinh) - published May 5, 2025
2. Zhu D, Galley J, Pizzini J, Musteata E, Douglas MV, Chazin WJ, Skaar EP, Tabor JJ, Britton RA
Where and how to house big data on small fragments.
1. Nat Commun - published May 5, 2025
2. Erlanson DA, Burley SK, Fearon D, Fraser JS, Kreitler D, Nonato MC, Sakai N, Wollenhaupt J, Weiss MS
Structures of RNA phosphotransferase Tpt1 reveal distinct binding modes for an RNA 2'-PO4 splice junction versus a 5'-PO4 mononucleotide.
1. RNA - published May 5, 2025
2. Jacewicz A, Damha MJ, Shuman S
Sharpening the lens of NMR spectroscopy to study large proteins.
1. Nat Chem - published May 5, 2025
2. Huang Y, Eliezer D
Development of Chemical Tags for Universal Lipid Nanoparticle Visualization and Tracking in 2D and 3D Imaging.
1. Nano Lett - published May 4, 2025
2. Balcorta HV, Mata Corral MY, Gallegos A, Chavez J, Perez J, Balivada S, Natividad-Diaz SL, Poon W
Arkadia and Ark2C promote substrate ubiquitylation with multiple E2 enzymes.
1. J Mol Biol - published May 3, 2025
2. Rossig C, Paluda A, Chen R, Middleton AJ, Day CL
The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells.
1. Nat Commun - published May 3, 2025
2. Gaurav N, O'Hara R, Hyder U, Qin W, Her C, Romero H, Kumar A, Marcaida MJ, Singh RK, Hovius R, Selvam K, Liu J, Martire S, Yao Y, Challa A, Dal Peraro M, Fierz B, Kono H, Cardoso MC, Debelouchina GT, Leonhardt H, D'Orso I, Banaszynski LA, Kutateladze TG
Cell division protein CdpA organises and anchors the midcell ring in haloarchaea.
1. Nat Commun - published May 3, 2025
2. Liao Y, Shinde VD, Hu D, Xu Z, Söderström B, Michie KA, Duggin IG
Author Correction: Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium.
1. Commun Biol - published May 3, 2025
2. Bruce JK, Li LY, Tang Y, Forster E, Winsor NJ, Bi PY, Krustev C, Keely S, Lee JE, Rohde JR, Gaisano HY, Philpott DJ, Girardin SE
Integrated transcriptomics and metabolomics analysis of volatiles and variations in carotenoid biosynthesis during different developmental stages of Camellia huana.
1. BMC Plant Biol - published May 3, 2025
2. Chen Z, Zhou Y, Jiang X, Li H, Liu X, Deng L, Wang G
Structure-function analysis of CNGA3-associated achromatopsia patient variants complements clinical genomics in pathogenicity determination.
1. Orphanet J Rare Dis - published May 3, 2025
2. Rasmussen DK, Sun YJ, Franco JA, Kumar A, Vu JT, Bassuk AG, Mahajan VB
Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning.
1. Sci Adv - published May 3, 2025
2. Correy GJ, Rachman MM, Togo T, Gahbauer S, Doruk YU, Stevens MGV, Jaishankar P, Kelley B, Goldman B, Schmidt M, Kramer T, Radchenko DS, Moroz YS, Ashworth A, Riley P, Shoichet BK, Renslo AR, Walters WP, Fraser JS
Fluorescent Sodium Alginate Hydrogel-Carbon Dots Sensor for Detecting Perfluorooctanoic Acid in Potable Water.
1. Anal Chem - published May 3, 2025
2. Mohammadi S, Sandoval-Pauker C, Dorado ZN, Senftle TP, Pankow R, Sharifan H
Cryo-EM structure provides insights into the unusual heptameric assembly of rice (Oryza sativa L.) ClpB1 AAA+ ATPase.
1. Int J Biol Macromol - published May 3, 2025
2. Jobichen C, Saharan K, Samal A, Choong YK, Jagdev MK, Mohapatra C, Jian S, Babbar R, Dobson RCJ, Grover A, Vasudevan D, Sivaraman J
Influenza A(H1N1)pdm09 Virus Resistance to Baloxavir, Oseltamivir and Sialic Acid Mimetics in Single and Dual therapies: Insights from Human Airway Epithelia and Murine Models.
1. Antiviral Res - published May 3, 2025
2. Fage C, Loison S, Zwygart AC, Poli R, Rosset S, Medaglia C, Hubert M, Suter-Boquete P, Vadas O, Huang S, Constant S, Silva P, Stellacci F, Clément S, Tapparel C
A generalist deep-learning volume segmentation tool for volume electron microscopy of biological samples.
1. J Struct Biol - published May 2, 2025
2. Daniel Huang Y, Jadav N, Rutter G, Szymanski L, Bostina M, Harland DP
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.
1. Mol Cell - published May 2, 2025
2. Longo MA, Ahmed SM, Chen Y, Tsai CL, Namjoshi S, Shen R, Ahmed Z, Wang X, Perera RL, Arvai A, Lee M, Kong LR, Engl W, Ng WS, Zhao ZW, Venkitaraman AR, Tainer JA, Schlacher K
Populus salicinoids: A thriving subfield in the -omics era.
1. Tree Physiol - published May 2, 2025
2. Kaufman NJ, You J, Fox BG, Mansfield SD
Response to Whop and Butler.
1. Sex Reprod Healthc - published May 2, 2025
2. Bartick M, Dahlen H, Gamble J, Walker S, Mathisen R, Gribble K
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants.
1. Nat Biomed Eng - published May 2, 2025
2. Chen G, Zhao K, Li M, Zhang Y, Li T, Yuan J, Lu L, Valdiviezo J, Liu D, Polizzi NF, DeGrado WF, Dang B
Author Correction: Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain.
1. Nat Microbiol - published May 2, 2025
2. Kim Y, Worby CJ, Acharya S, van Dijk LR, Alfonsetti D, Gromko Z, Azimzadeh PN, Dodson KW, Gerber GK, Hultgren SJ, Earl AM, Berger B, Gibson TE
High-Throughput MicroED for Probing Ion Channel Dynamics.
1. Adv Sci (Weinh) - published May 2, 2025
2. Gallenito MJ, Clabbers MT, Lin J, Hattne J, Gonen T
Development and characterization of a novel NEIL1 nanobody.
1. DNA Repair (Amst) - published May 2, 2025
2. Thompson MK, Eggers MH, Flores D, Valenzuela I, Yang Z, Andrews JF, Johnsten T, Prakash A
A CRISPR-Cas9 system for knock-out and knock-in of high molecular weight DNA enables module-swapping of the pikromycin synthase in its native host.
1. Microb Cell Fact - published May 2, 2025
2. Wang ZC, Stegall H, Miyazawa T, Keatinge-Clay AT
ACE2 from Pipistrellus abramus bats is a receptor for HKU5 coronaviruses.
1. Nat Commun - published May 2, 2025
2. Catanzaro NJ, Wu Z, Fan C, Jefferson V, Abdelgadir A, Schäfer A, Yount BL, Bjorkman PJ, Baric R, Letko M
EndoMAP.v1 charts the structural landscape of human early endosome complexes.
1. Nature - published May 2, 2025
2. Gonzalez-Lozano MA, Schmid EW, Miguel Whelan E, Jiang Y, Paulo JA, Walter JC, Harper JW
Astrocyte morphogenesis requires self-recognition.
1. Nature - published May 2, 2025
2. Lee JH, Sergeeva AP, Ahlsén G, Mannepalli S, Bahna F, Goodman KM, Xu R, Khakh BS, Weiner JA, Shapiro L, Honig B, Zipursky SL
Structural mechanisms of PIP(2) activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.
1. Elife - published May 2, 2025
2. Xue J, Zeng W, John S, Attiq N, Ottolia M, Jiang Y
Cryo-EM Structure of the relaxosome, a complex essential for bacterial mating and the spread of antibiotic resistance genes.
1. Nat Commun - published May 2, 2025
2. Williams SM, Raffl S, Kienesberger S, Ilangovan A, Zechner EL, Waksman G
CD81 is a receptor for equine arteritis virus (family: Arteriviridae).
1. mBio - published May 2, 2025
2. Maloney SM, Shaw TM, Nennig KM, Larsen MS, Shah A, Kumar A, Marcotrigiano J, Grove J, Snijder EJ, Kirchdoerfer RN, Bailey AL
Backbone and sidechain (1)H, (15)N and (13)C resonance assignments of a multidrug efflux membrane protein using solution and solid-state NMR.
1. Biomol NMR Assign - published May 2, 2025
2. Harding BD, Hiett A, Tonelli M, Wang S, Rienstra CM, Henzler-Wildman KA
Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody.
1. Structure - published May 2, 2025
2. Liu Q, Parsons RJ, Wiehe K, Edwards RJ, Saunders KO, Zhang P, Miao H, Tilahun K, Jones J, Chen Y, Hora B, Williams WB, Easterhoff D, Huang X, Janowska K, Mansouri K, Haynes BF, Acharya P, Lusso P
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization.
1. Nat Struct Mol Biol - published May 2, 2025
2. Bellaart A, Brambila A, Xu J, Mendez Diaz F, Deep A, Anzola J, Meitinger F, Ohta M, Corbett KD, Desai A, Oegema K
Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin.
1. Proc Natl Acad Sci U S A - published May 2, 2025
2. Beccari MS, Arnold-Garcia O, Baughn MW, Artates JW, McAlonis-Downes M, Lim J, Leyva-Cázares DF, Rubio-Lara HI, Ramirez-Rodriguez A, Bernal-Buenrostro CN, Murgia-Bay B, Rangel CK, Kim DH, Melamed Z, Lutz CM, Lagier-Tourenne C, Corbett KD, López-Erauskin J, Cleveland DW
A SUMO-interacting motif in the guanine nucleotide exchange factor EPAC1 is required for subcellular targeting and function.
1. J Biol Chem - published May 2, 2025
2. Yang W, Mei F, Lin W, Lee JE, Nie S, Bley CJ, Hoelz A, Cheng X
Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4.
1. J Biol Chem - published May 2, 2025
2. Frigon L, Pascal JM
The ALX4 dimer structure provides insight into how disease alleles impact function.
1. Nat Commun - published May 2, 2025
2. Cain B, Yuan Z, Thoman E, Kovall RA, Gebelein B
Safety and pharmacokinetics of N6LS, a broadly neutralising monoclonal antibody for HIV: a phase 1, open-label, dose-escalation study in healthy adults.
1. Lancet HIV - published May 2, 2025
2. Wu RL, Houser KV, Gaudinski MR, Widge AT, Awan SF, Carter CA, Holman LA, Saunders J, Hendel CS, Eshun A, Whalen WR, Wang X, Arthur A, Cunningham JE, Beck A, Casazza JP, Yamshchikov GV, Rothwell RS, Strom L, Dittakavi T, Happe M, Hickman SP, Conan-Cibotti M, Carlton K, Zhang L, Huang Y, Capparelli EV, Castro M, Lin BC, O'Connell S, Flach BS, Bailer RT, Narpala SR, Serebryannyy L, McDermott AB, Arnold FJ, Gall JG, Vazquez S, Berkowitz NM, Gordon IJ, Chen GL, Kwong PD, Huang J, Pierson TC, Connors M, Mascola JR, Zhou T, Doria-Rose NA, Koup RA, Dropulic LK, VRC 609 study team
Site-specific molecular glues for the 14-3-3/Tau pS214 protein-protein interaction via reversible covalent imine tethering.
1. RSC Med Chem - published May 2, 2025
2. Oberheide A, van den Oetelaar MCM, Scheele JJA, Borggräfe J, Engelen SFH, Sattler M, Ottmann C, Cossar PJ, Brunsveld L
Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual.
1. Nat Struct Mol Biol - published May 2, 2025
2. Kucharska I, Ivanochko D, Hailemariam S, Inklaar MR, Kim HR, Teelen K, Stoter R, van de Vegte-Bolmer M, van Gemert GJ, Semesi A, McLeod B, Ki A, Lee WK, Rubinstein JL, Jore MM, Julien JP
FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma.
1. Nat Commun - published May 2, 2025
2. Beffinger M, Schellhammer L, Taskoparan B, Deplazes S, Salazar U, Tatari N, Seehusen F, von Balthazar L, Zinner CP, Spath S, Shekarian T, Ritz MF, McDaid M, Egloff P, Zimmermann I, Okada H, Ward ES, Rohrer J, Seeger MA, Buch T, Hutter G, Vom Berg J
Author Correction: Structure and topography of the synaptic V-ATPase-synaptophysin complex.
1. Nature - published May 2, 2025
2. Wang C, Jiang W, Leitz J, Yang K, Esquivies L, Wang X, Shen X, Held RG, Adams DJ, Basta T, Hampton L, Jian R, Jiang L, Stowell MHB, Baumeister W, Guo Q, Brunger AT
Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles.
1. Proc Natl Acad Sci U S A - published May 2, 2025
2. Fan C, Keeffe JR, Malecek KE, Cohen AA, West AP Jr, Baharani VA, Rorick AV, Gao H, Gnanapragasam PNP, Rho S, Alvarez J, Segovia LN, Hatziioannou T, Bieniasz PD, Bjorkman PJ
Author Correction: A substrate binding model for the KEOPS tRNA modifying complex.
1. Nat Commun - published May 2, 2025
2. Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor.
1. Nature - published May 2, 2025
2. Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG
A Role for Two Conserved Arginine Residues in Protected Persulfide Transfer by SufE-Dependent SufS Cysteine Desulfurases.
1. Biochemistry - published May 2, 2025
2. Gogar RK, Conte JV, Chhikara N, Dunkle JA, Frantom PA
Engineering a Biosynthetic Pathway to Produce (+)-Brevianamides A and B.
1. ACS Catal - published May 2, 2025
2. Sandoval Hurtado CP, Kelly SP, Shende V, Perez M, Curtis BJ, Newmister SA, Ott K, Pereira F, Sherman DH
A tethering mechanism underlies Pin1-catalyzed proline cis-trans isomerization at a noncanonical site.
1. Proc Natl Acad Sci U S A - published May 2, 2025
2. Williams CC, Chuck J, Munoz-Tello P, Kojetin DJ
Electric field-induced pore constriction in the human K(v)2.1 channel.
1. Proc Natl Acad Sci U S A - published May 2, 2025
2. Mandala VS, MacKinnon R
Structural basis of human Na(v)1.5 gating mechanisms.
1. Proc Natl Acad Sci U S A - published May 2, 2025
2. Biswas R, López-Serrano AL, Purohit A, Ramirez-Navarro A, Huang HL, Grandinetti G, Cheng X, Heissler SM, Deschênes I, Chinthalapudi K
Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9.
1. Nat Hum Behav - published May 2, 2025
2. Zhang J, Guo Z, Pan C, Hu C, Weng X, Liu YW, Cheng X, Lv J, Cao Q, Wang H, Chen Y, Wang D, Hu S, Xun M, Zhang L, Wang Z, Tang H, Zhu B, Guo L, Yu S, Hu X, Chen L, Chen B, Chen ZY, Sun S, Xu X, Li H, Chen F, Shu Y
NMR (1)H, (13)C, and (15)N resonance assignments of the oncogenic Q61R variant of human NRAS in the active, GTP-bound conformation.
1. Biomol NMR Assign - published May 2, 2025
2. Sharma AK, Tonelli M, Dyba M, Gillette WK, Esposito D, Nissley DV, McCormick F, Maciag AE
In Situ Converting Conformal Sacrificial Layer Into Robust Interphase Stabilizes Fluorinated Polyanionic Cathodes for Aqueous Sodium-Ion Storage.
1. Adv Sci (Weinh) - published May 2, 2025
2. Gong P, Chai S, Li X, Dong Y, Zhai S, Chen X, Wang N, Li Y, Liu J
Society of Family Planning Research Practice Support: Researcher and institutional review board considerations for sexual and reproductive health research with minor adolescents.
1. Contraception - published May 2, 2025
2. Baldwin MK, Bell AJ, Hoopes AJ, Narasimhan S, Ott MA
Cryo-Electron Microscopy of BfpB Reveals a Type IVb Secretin Multimer Adapted to Accommodate the Exceptionally Wide Bundle-Forming Pilus.
1. Pathogens - published May 1, 2025
2. Little JI, Singh PK, Samsó M, Donnenberg MS
Ergosterol Peroxide Disrupts Triple-Negative Breast Cancer Mitochondrial Function and Inhibits Tumor Growth and Metastasis.
1. Int J Mol Sci - published May 1, 2025
2. Bocachica-Adorno AL, Aponte-Ramos AY, Rivera-Fuentes PS, Espinosa-Ponce NP, Arroyo-Cruz LV, Ling T, Pérez-Ríos N, Rivas-Tumanyan S, Almodóvar-Rivera IA, Barreto-Gamarra C, Domenech-García M, Rivas F, Martínez-Montemayor MM
LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels.
1. Nat Commun - published May 1, 2025
2. Novakovic M, Han Y, Kathe NC, Ni Y, Emmanouilidis L, Allain FH
Modulation of TTR gene expression in the eye using modified siRNAs.
1. Nucleic Acids Res - published May 1, 2025
2. Hu J, Gong X, Kundu J, Datta D, Egli M, Manoharan M, Mootha VV, Corey DR
A Designed Zn(2+) Sensor Domain Transmits Binding Information to Transmembrane Histidine Kinases.
1. J Am Chem Soc - published May 1, 2025
2. Hatstat AK, Kormos R, Xu V, Du G, Liu L, Zhang SQ, DeGrado WF
Conformational trajectory of the HIV-1 fusion peptide during CD4-induced envelope opening.
1. Nat Commun - published May 1, 2025
2. Thakur B, Katte RH, Xu W, Janowska K, Sammour S, Henderson R, Lu M, Kwong PD, Acharya P
Structure and mechanism of aminoacyl-tRNA-protein L/F- and R-transferases.
1. J Mol Biol - published May 1, 2025
2. Cartwright M, Jha RK, Smith AT
A broad antibody with enhanced HIV-1 neutralization via bispecific antibody-mediated prepositioning.
1. Nat Commun - published May 1, 2025
2. Kim S, Radford CE, Xu D, Zhong J, Do J, Pham DM, Travisano KA, Filsinger Interrante MV, Bruun TUJ, Rezek V, Wilder B, Palomares M, Seaman MS, Kitchen SG, Bloom JD, Kim PS
Author Correction: Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.
1. Nat Microbiol - published May 1, 2025
2. Little AS, Younker IT, Schechter MS, Bernardino PN, Méheust R, Stemczynski J, Scorza K, Mullowney MW, Sharan D, Waligurski E, Smith R, Ramaswamy R, Leiter W, Moran D, McMillin M, Odenwald MA, Iavarone AT, Sidebottom AM, Sundararajan A, Pamer EG, Eren AM, Light SH
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis.
1. Cancer Cell - published May 1, 2025
2. Dang D, Deogharkar A, McKolay J, Smith KS, Panwalkar P, Hoffman S, Tian W, Ji S, Azambuja AP, Natarajan SK, Lum J, Bayliss J, Manzeck K, Sweha SR, Hamanishi E, Pun M, Patel D, Rau S, Animasahun O, Achreja A, Ogrodzinski MP, Diessl J, Cotter J, Hawes D, Yang F, Doherty R, Franson AT, Hanaford AR, Eberhart CG, Raabe EH, Orr BA, Wechsler-Reya RJ, Chen B, Lyssiotis CA, Shah YM, Lunt SY, Banerjee R, Judkins AR, Prensner JR, Koschmann C, Waszak SM, Nagrath D, Simoes-Costa M, Northcott PA, Venneti S
Ensemble refinement of mismodeled cryo-EM RNA structures using all-atom simulations.
1. Nat Commun - published May 1, 2025
2. Posani E, Janoš P, Haack D, Toor N, Bonomi M, Magistrato A, Bussi G
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption.
1. Nat Genet - published May 1, 2025
2. Nava C, Cogne B, Santini A, Leitão E, Lecoquierre F, Chen Y, Stenton SL, Besnard T, Heide S, Baer S, Jakhar A, Neuser S, Keren B, Faudet A, Forlani S, Faoucher M, Uguen K, Platzer K, Afenjar A, Alessandri JL, Andres S, Angelini C, Aral B, Arveiler B, Attie-Bitach T, Aubert Mucca M, Banneau G, Barakat TS, Barcia G, Baulac S, Beneteau C, Benkerdou F, Bernard V, Bézieau S, Bonneau D, Bonnet-Dupeyron MN, Boussion S, Boute O, Brischoux-Boucher E, Bryen SJ, Buratti J, Busa T, Caliebe A, Capri Y, Cassinari K, Caumes R, Cenni C, Chambon P, Charles P, Christodoulou J, Colson C, Conrad S, Cospain A, Coursimault J, Courtin T, Couse M, Coutton C, Creveaux I, D'Gama AM, Dauriat B, de Sainte Agathe JM, Del Gobbo G, Delahaye-Duriez A, Delanne J, Denommé-Pichon AS, Dieux-Coeslier A, Do Souto Ferreira L, Doco-Fenzy M, Drukewitz S, Duboc V, Dubourg C, Duffourd Y, Dyment D, El Chehadeh S, Elmaleh M, Faivre L, Fennelly S, Fischer H, Fradin M, Galludec Vaillant C, Ganne B, Ghoumid J, Goel H, Gokce-Samar Z, Goldenberg A, Gonfreville Robert R, Gorokhova S, Goujon L, Granier V, Gras M, Greally JM, Greiten B, Gueguen P, Guerrot AM, Guha S, Guimier A, Haack TB, Hadj Abdallah H, Halleb Y, Harbuz R, Harris M, Hentschel J, Héron B, Hitz MP, Innes AM, Jadas V, Januel L, Jean-Marçais N, Jobanputra V, Jobic F, Jornea L, Jost C, Julia S, Kaiser FJ, Kaschta D, Kaya S, Ketteler P, Khadija B, Kilpert F, Knopp C, Kraft F, Krey I, Lackmy M, Laffargue F, Lambert L, Lamont R, Laugel V, Laurie S, Lauzon JL, Lebreton L, Lebrun M, Legendre M, Leguern E, Lehalle D, Lejeune E, Lesca G, Lesieur-Sebellin M, Levy J, Linglart A, Lyonnet S, Lüthy K, Ma AS, Mach C, Mandel JL, Mansour-Hendili L, Marcadier J, Marin V, Margot H, Marquet V, May A, Mayr JA, Meridda C, Michaud V, Michot C, Nadeau G, Naudion S, Nguyen L, Nizon M, Nowak F, Odent S, Olin V, Osei-Owusu IA, Osmond M, Õunap K, Pasquier L, Passemard S, Pauly M, Patat O, Pensec M, Perrin-Sabourin L, Petit F, Philippe C, Planes M, Poduri A, Poirsier C, Pouzet A, Prince B, Prouteau C, Pujol A, Racine C, Rama M, Ramond F, Ranguin K, Raway M, Reis A, Renaud M, Revencu N, Richard AC, Riera-Navarro L, Rius R, Rodriguez D, Rodriguez-Palmero A, Rondeau S, Roser-Unruh A, Rougeot Jung C, Safraou H, Satre V, Saugier-Veber P, Sauvestre C, Schaefer E, Shao W, Schanze I, Schlump JU, Schlüter Martin A, Schluth-Bolard C, Schuhmann S, Schröder C, Sebastin M, Sigaudy S, Spielmann M, Spodenkiewicz M, St Clair L, Steffann J, Stoeva R, Surowy H, Tarnopolsky MA, Todosi C, Toutain A, Tran Mau-Them F, Unterlauft A, Van-Gils J, Vanlerberghe C, Vasileiou G, Vera G, Verdel A, Verloes A, Vial Y, Vignal C, Vincent M, Vincent-Delorme C, Vincent-Devulder A, Vitobello A, Weber S, Willems M, Zaafrane-Khachnaoui K, Zacher P, Zeltner L, Ziegler A, Galej WP, Dollfus H, Thauvin C, Boycott KM, Marijon P, Lermine A, Malan V, Rio M, Kuechler A, Isidor B, Drunat S, Smol T, Chatron N, Piton A, Nicolas G, Wagner M, Abou Jamra R, Héron D, Mignot C, Blanc P, O'Donnell-Luria A, Whiffin N, Charbonnier C, Charenton C, Thevenon J, Depienne C
Similar Binding Mode of a 5-Sulfonylthiouracil Derivative Antagonist at Chemerin Receptors CMKLR1 and GPR1.
1. J Med Chem - published May 1, 2025
2. Schermeng T, Fürll A, Liessmann F, von Bredow L, Stichel J, Weaver CD, Tretbar M, Meiler J, Beck-Sickinger AG
Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design.
1. Cell Rep - published May 1, 2025
2. Dam KA, Gristick HB, Li YE, Yang Z, Gnanapragasam PNP, West AP Jr, Seaman MS, Bjorkman PJ
Structural clues about bridge-mediated lipid transfer.
1. Nat Struct Mol Biol - published May 1, 2025
2. De Camilli P, Reinisch KM
Surfactant-like peptide gels are based on cross-β amyloid fibrils.
1. Faraday Discuss - published May 1, 2025
2. Das A, Gnewou O, Zuo X, Wang F, Conticello VP
Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor.
1. J Med Chem - published May 1, 2025
2. Vallée F, Casás-Selves M, Bubenik M, Duplessis M, Sow B, Suarez C, Sangiorgi B, Li L, Hyer M, Papp R, Leclaire ME, Perryman AL, Liu B, Surprenant S, Mochirian P, Pau V, Maderova Z, Mader P, Yin SY, Goodfellow E, Roulston A, Stocco R, Godbout C, Baruah P, Bonneau-Fortin A, Schonhoft JD, Nejad P, Norman D, Truong VL, Crane S, Attia MA, Mao D, Sicheri F, Marshall CG, Zimmermann M, Bendahan D, Gallant M, Black WC
A specialized TFIIB is required for transcription of transposon-targeting noncoding RNAs.
1. Nucleic Acids Res - published May 1, 2025
2. Cai X, Zhai Z, Noto T, Dong G, Wang X, Liucong M, Liu Y, Agreiter C, Loidl J, Mochizuki K, Tian M
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213.
1. Nat Commun - published May 1, 2025
2. Ahel J, Balci A, Faas V, Grabarczyk DB, Harmo R, Squair DR, Zhang J, Roitinger E, Lamoliatte F, Mathur S, Deszcz L, Bell LE, Lehner A, Williams TL, Sowar H, Meinhart A, Wood NT, Clausen T, Virdee S, Fletcher AJ
A Generative Artificial Intelligence Copilot for Biomedical Nanoengineering.
1. ACS Nano - published May 1, 2025
2. Wang Y, Song H, Teng Y, Huang G, Qian J, Wang H, Dong S, Ha J, Ma Y, Chang M, Jeong SD, Deng W, Schrank BR, Grippin A, Wu A, Edwards JL, Zhang Y, Lin Y, Poon W, Wilhelm S, Bi Y, Teng L, Wang Z, Kim BYS, Jiang W
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3.
1. Nat Commun - published May 1, 2025
2. Kotikalapudi N, Ramachandran D, Vieira D, Rubio WB, Gipson GR, Troncone L, Vestal K, Maridas DE, Rosen V, Yu PB, Thompson TB, Banks AS
Specific Interactions between HIV-1 Env Cytoplasmic Tail and Gag Matrix Domain Probed by NMR.
1. J Am Chem Soc - published May 1, 2025
2. Chaubey M, Gao H, Lavine CL, Seaman MS, Chen B, Chou JJ
Radiation-induced amphiregulin drives tumour metastasis.
1. Nature - published May 1, 2025
2. Piffkó A, Yang K, Panda A, Heide J, Tesak K, Wen C, Zawieracz K, Wang L, Naccasha EZ, Bugno J, Fu Y, Chen D, Donle L, Lengyel E, Tilley DG, Mack M, Rock RS, Chmura SJ, Vokes EE, He C, Pitroda SP, Liang HL, Weichselbaum RR
Single-molecule visualization of ATP-induced dynamics of the subunit composition of an ECF transporter complex under turnover conditions.
1. Nat Commun - published May 1, 2025
2. Lefebvre SN, Nijland M, Maslov I, Slotboom DJ
Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3.
1. Nat Commun - published May 1, 2025
2. Zhou Q, Sagmeister T, Hutten S, Bourgeois B, Pavkov-Keller T, Dormann D, Madl T
Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1.
1. Cell Rep - published May 1, 2025
2. Warner K, Hunkeler M, Baek K, Schmoker A, Roy Burman SS, Overwijn D, Jin C, Donovan KA, Fischer ES
Targeting transcription factors through an IMiD independent zinc finger domain.
1. EMBO Mol Med - published May 1, 2025
2. Liu BH, Liu M, Radhakrishnan S, Dai MY, Jaladanki CK, Gao C, Tang JP, Kumari K, Go ML, Vu KAL, Kwon J, Seo HS, Song K, Tian X, Feng L, Tan JL, Melkonian AV, Liu Z, Wulf G, Arthanari H, Qi J, Dhe-Paganon S, Clohessy JG, Choong YK, Sivaraman J, Fan H, Tenen DG, Chai L
Advancements in Ligand-Based Virtual Screening through the Synergistic Integration of Graph Neural Networks and Expert-Crafted Descriptors.
1. J Chem Inf Model - published May 1, 2025
2. Liu Y, Moretti R, Wang Y, Dong H, Yan B, Bodenheimer B, Derr T, Meiler J
G Protein Selectivity in Dopamine Receptors is Determined before GDP Release.
1. Biochemistry - published May 1, 2025
2. Tawfeeq C, Hilibrand AS, Smith JS, Portillo J, Kruse AC, Abrol R
Artificial intelligence's contribution to biomedical literature search: revolutionizing or complicating?
1. PLOS Digit Health - published May 1, 2025
2. Yip R, Sun YJ, Bassuk AG, Mahajan VB
Peptide Recognition and Mechanism of the Radical S-Adenosyl-l-methionine Multiple Cyclophane Synthase ChlB.
1. J Am Chem Soc - published May 1, 2025
2. Ruel J, Nguyen TQN, Morishita Y, Usclat A, Martin L, Amara P, Kieffer-Jaquinod S, Stefanoiu MC, de la Mora E, Morinaka BI, Nicolet Y
Biological insights from integrative modeling of intrinsically disordered protein systems.
1. Curr Opin Struct Biol - published May 1, 2025
2. Liu ZH, Tsanai M, Zhang O, Head-Gordon T, Forman-Kay JD
Gasdermin-D pores induce an inactivating caspase-4 cleavage that limits IL-18 production in the intestinal epithelium.
1. Commun Biol - published May 1, 2025
2. Bruce JK, Li LY, Tang Y, Forster EG, Winsor NJ, Bi PY, Krustev C, Keely S, Lee JE, Rohde JR, Gaisano HY, Philpott DJ, Girardin SE
Molecular basis of TRPV3 channel blockade by intracellular polyamines.
1. Commun Biol - published May 1, 2025
2. Zhang J, Yuan P, Nichols CG, Maksaev G
Unveiling the multifaceted domain polymorphism of the Menshen antiphage system.
1. Nucleic Acids Res - published May 1, 2025
2. Li H, Tan Y, Basu D, Corbett KD, Zhang D
Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.
1. Proc Natl Acad Sci U S A - published May 1, 2025
2. Maciag AE, Yang Y, Sharma AK, Turner DM, DeHart CJ, Abdelkarim H, Fan L, Smith BP, Kumari V, Dyba M, Rigby M, Castillo Badillo JA, Adams L, Fornelli L, Fox S, Brafman A, Turbyville T, Gillette W, Messing S, Agamasu C, Wolfe AL, Gysin S, Chan AH, Simanshu DK, Esposito D, Chertov O, Stephen AG, Arkin M, Renslo A, Kelleher NL, Gaponenko V, Lightstone FC, Nissley DV, McCormick F
Molecular insights into de novo small-molecule recognition by an intron RNA structure.
1. Proc Natl Acad Sci U S A - published May 1, 2025
2. Liu T, Xu L, Chung K, Sisto LJ, Hwang J, Zhang C, Van Zandt MC, Pyle AM
Structural insights into the ubiquitin-independent midnolin-proteasome pathway.
1. Proc Natl Acad Sci U S A - published May 1, 2025
2. Peddada N, Zhong X, Yin Y, Lazaro DR, Wang J, Lyon S, Choi JH, Bai XC, Moresco EMY, Beutler B
Structure of the human TWIK-2 potassium channel and its inhibition by pimozide.
1. Proc Natl Acad Sci U S A - published May 1, 2025
2. Khanra NK, Wang C, Delgado BD, Long SB
Cryo-ET unravels the mystery of Ad5-nCoV vaccines.
1. Structure - published May 1, 2025
2. Liu C, Ke Z
Functional conformations or poor mimetics?
1. Structure - published May 1, 2025
2. Nury H, Efremov RG
Current and future perspectives for structural biology at the Grenoble EPN campus: a comprehensive overview.
1. J Synchrotron Radiat - published May 1, 2025
2. McCarthy AA, Basu S, Bernaudat F, Blakeley MP, Bowler MW, Carpentier P, Effantin G, Engilberge S, Flot D, Gabel F, Gajdos L, Kamps JJAG, Kandiah E, Linares R, Martel A, Melnikov I, Mossou E, Mueller-Dieckmann C, Nanao M, Nurizzo D, Pernot P, Popov A, Royant A, de Sanctis D, Schoehn G, Talon R, Tully MD, Soler-Lopez M
N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins.
1. Protein Sci - published May 1, 2025
2. Kapilan A, Bulluss M, Ziegler AR, Dabaja M, Derakhshani A, Anowai A, Armstrong V, Campden R, Young D, Sun YJ, Scott NE, Edgington-Mitchell LE, Mahajan VB, Dufour A
Structural and Functional Insights Into IgE Receptor Interactions and Disruptive Inhibition.
1. Immunol Rev - published May 1, 2025
2. Eggel A, Jardetzky TS
ATP-release pannexin channels are gated by lysophospholipids.
1. Elife - published May 1, 2025
2. Henze E, Burkhardt RN, Fox BW, Schwertfeger TJ, Gelsleichter E, Michalski K, Kramer L, Lenfest M, Boesch JM, Lin H, Schroeder FC, Kawate T
Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy.
1. Mol Cell - published May 1, 2025
2. Bianco E, Bonassera M, Uliana F, Tilma J, Winkler M, Zencir S, Gossert A, Oborská-Oplová M, Dechant R, Hugener J, Panse VG, Pilhofer M, Albert B, Kimmig P, Peter M
Quantitative spatial analysis of chromatin biomolecular condensates using cryoelectron tomography.
1. Proc Natl Acad Sci U S A - published May 1, 2025
2. Zhou H, Hutchings J, Shiozaki M, Zhao X, Doolittle LK, Yang S, Yan R, Jean N, Riggi M, Yu Z, Villa E, Rosen MK
Longitudinal profiling of low-abundance strains in microbiomes with ChronoStrain.
1. Nat Microbiol - published May 1, 2025
2. Kim Y, Worby CJ, Acharya S, van Dijk LR, Alfonsetti D, Gromko Z, Azimzadeh PN, Dodson KW, Gerber GK, Hultgren SJ, Earl AM, Berger B, Gibson TE