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53 Member Publications for April

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The RAD52 double-ring remodels replication forks restricting fork reversal.
1. Nature - published April 2, 2025
2. Honda M, Razzaghi M, Gaur P, Malacaria E, Marozzi G, Di Biagi L, Aiello FA, Paintsil EA, Stanfield AJ, Deppe BJ, Gakhar L, Schnicker NJ, Spies MA, Pichierri P, Spies M
Acyltransferases that Modify Cell Surface Polymers Across the Membrane.
1. Biochemistry - published April 2, 2025
2. Schultz BJ, Walker S
RNA sculpting by the primordial Helix-clasp-Helix-Strand-Loop (HcH-SL) motif enforces chemical recognition enabling diverse KH domain functions.
1. J Biol Chem - published April 2, 2025
2. Tainer JA, Tsutakawa SE
Structural basis for plasticity in receptor engagement by an encephalitic alphavirus.
1. Cell - published April 2, 2025
2. Raju S, Palakurty S, Sariol A, Wagoner N, Adams LJ, Hui S, Klimstra WB, Fremont DH, Diamond MS
A Putative Binding Model of Nitazene Derivatives at the μ-Opioid Receptor.
1. Neuropharmacology - published April 2, 2025
2. Clayton J, Shi L, Robertson MJ, Skiniotis G, Michaelides M, Stavitskaya L, Shen J
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Forslund JME, Nguyen TVH, Parkash V, Berner A, Goffart S, Pohjoismäki JLO, Wanrooij PH, Johansson E, Wanrooij S
Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Huang QJ, Kim R, Song K, Grigorieff N, Munro JB, Schiffer CA, Somasundaran M
Structural basis of excitatory amino acid transporter 3 substrate recognition.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Qiu B, Boudker O
The pentameric chloride channel BEST1 is activated by extracellular GABA.
1. Proc Natl Acad Sci U S A - published April 2, 2025
2. Pant S, Tam SW, Long SB
Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis.
1. Cell Res - published April 2, 2025
2. Du G, Wu H
The inhibition of PPARα protein degradation alleviates the cardiotoxicity of Tiebangchui by regulating fatty acid metabolism.
1. J Ethnopharmacol - published April 1, 2025
2. Liu X, Yang L, Zhou R, Zhang T, Xu L, Liu Y, Zhang Y, Meng X
BioStruct-Africa's capacity building workshops as a model for advancing the emerging community of structural biologists in Africa.
1. Commun Chem - published April 1, 2025
2. Sankhe S, Fofana FG, Heiba W, Ogunyemi OM, Masisi K, Muiruri I, Abaah EA, Tepa A, Fru CT, Johnson JT, Tchuenguia CV, Tatchou-Nebangwa NMT, Tsafack DT, Koloko BL, Kulu-Abi TK, Ngounou I, Sovegnon TSD, Kamga RMN, Kouamo MFM, Getahun YC, Moumbock AFA, Cramer KC, Rüffin NV, Djapgne L, Sliz P, Davis J, Fodje MN, Griese JJ, Nji E
CD36-mediated endocytosis of proteolysis-targeting chimeras.
1. Cell - published April 1, 2025
2. Wang Z, Pan BS, Manne RK, Chen J, Lv D, Wang M, Tran P, Weldemichael T, Yan W, Zhou H, Martinez GM, Shao J, Hsu CC, Hromas R, Zhou D, Qin Z, Lin HK, Li HY
Itaconate modulates immune responses via inhibition of peroxiredoxin 5.
1. Nat Metab - published April 1, 2025
2. Paulenda T, Echalar B, Potuckova L, Vachova V, Kleverov DA, Mehringer J, Potekhina E, Jacoby A, Sen D, Nelson C, Stegeman R, Sukhov V, Kemper D, Lichti CF, Day NJ, Zhang T, Husarcikova K, Bambouskova M, Fremont DH, Qian WJ, Djuranovic S, Pavlovic-Djuranovic S, Belousov VV, Krezel AM, Artyomov MN
Engineering bacteriophages through deep mining of metagenomic motifs.
1. Sci Adv - published April 1, 2025
2. Huss P, Kieft K, Meger A, Nishikawa K, Anantharaman K, Raman S
Beyond peptide targeting sequences: machine learning of cellular condensate localization.
1. Cell Res - published April 1, 2025
2. Ditlev JA, Forman-Kay JD
The crystal structures of apo and tryptophan-bound tryptophanyl-tRNA synthetase from Neisseria gonorrhoeae.
1. Acta Crystallogr F Struct Biol Commun - published April 1, 2025
2. Baral J, Song D, Edwards TE, Dranow DM, Lorimer DD, Staker BL, Myler P, Smith CL
Crystal structure of the S-adenosylmethionine-dependent mycolic acid synthase UmaA from Mycobacterium tuberculosis.
1. Acta Crystallogr F Struct Biol Commun - published April 1, 2025
2. Teng S, Wang J, Sroge CD, Abendroth J, Lorimer DD, Horanyi PS, Edwards TE, Tillery L, Craig JK, Van Voorhis WC, Myler PJ, Smith CL
Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity.
1. Nat Commun - published April 1, 2025
2. Planells-Cases R, Vorobeva V, Kar S, Schmitt FW, Schulte U, Schrecker M, Hite RK, Fakler B, Jentsch TJ
Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A.
1. Nat Commun - published April 1, 2025
2. Khandelwal NK, Gupta M, Gomez JE, Barkho S, Guan Z, Eng AY, Kawate T, Balasubramani SG, Sali A, Hung DT, Stroud RM
The network response to Egf is tissue-specific.
1. iScience - published April 1, 2025
2. Awasthi BW, Paulo JA, Burkhart DL, Smith IR, Collins RL, Harper JW, Gygi SP, Haigis KM
Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection.
1. Cell Rep - published April 1, 2025
2. Perugino CA, Liu H, Feldman J, Marbourg J, Guy TV, Hui A, Ingram N, Liebaert J, Chaudhary N, Tao W, Jacob-Dolan C, Hauser BM, Mian Z, Nathan A, Zhao Z, Kaseke C, Tano-Menka R, Getz MA, Senjobe F, Berrios C, Ofoman O, Manickas-Hill Z, Wesemann DR, Lemieux JE, Goldberg MB, Nündel K, Moormann A, Marshak-Rothstein A, Larocque RC, Ryan ET, Iafrate JA, Lingwood D, Gaiha G, Charles R, Balazs AB, Pandit A, Naranbhai V, Schmidt AG, Pillai S
Antitumor activity of vebreltinib and characterization of clinicogenomic features in solid tumors with MET rearrangements.
1. Cancer Discov - published April 1, 2025
2. Nakazawa S, Pecci F, Odintsov I, Gazgalis D, Gottlieb FH, Ricciuti B, Zullo L, Alessi JV, Di Federico A, Aldea M, Garbo E, Gandhi MM, Saini A, Feng WW, Jiang J, Baldacci S, Facchinetti F, Makarem M, Locquet MA, Haratani K, Haradon D, Besse B, Italiano A, Remon J, Lavaud P, Vasseur D, Planchard D, Sato Y, Watanabe Y, Owen S, Cortot AB, Mahran H, Forster MD, Niu J, Tomasini P, Swan Swan L, Tay K, Esteban E, Minchom A, Kizilbash SH, Cruz-Correa M, Yu KP, Zhang X, Chen P, Sangem M, Che J, Sholl LM, Janne PA, Awad MM
Roquin exhibits opposing effects on RNA stem-loop stability through its two ROQ domain binding sites.
1. Proc Natl Acad Sci U S A - published April 1, 2025
2. Tants JN, Walbrun A, Kollwitz L, Friedrich K, Rief M, Schlundt A
MprF from Pseudomonas aeruginosa is a promiscuous lipid scramblase with broad substrate specificity.
1. Sci Adv - published April 1, 2025
2. Hankins MTK, Parrag M, Garaeva AA, Earp JC, Seeger MA, Stansfeld PJ, Bublitz M
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
1. Sci Adv - published April 1, 2025
2. McKenna MJ, Kraus F, Coelho JPL, Vasandani M, Zhang J, Adams BM, Paulo JA, Harper JW, Shao S
Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair.
1. Nat Commun - published April 1, 2025
2. Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R
Cat1 forms filament networks to degrade NAD(+) during the type III CRISPR-Cas antiviral response.
1. Science - published April 1, 2025
2. Baca CF, Majumder P, Hickling JH, Patel DJ, Marraffini LA
A broadly protective human antibody for GI genogroup noroviruses.
1. Nat Microbiol - published April 1, 2025
2. Rimkute I, Olia AS, Suleiman M, Woods KD, Bylund T, Morano NC, Tully ES, Verardi R, Bao S, Beddall MH, Chaimongkol N, Donaldson MM, Du R, Dulan CNM, Gorman J, Henry AR, Schramm CA, Sosnovtsev SV, Stephens T, Todd JP, Tsybovsky Y, Douek DC, Green KY, Rawi R, Shapiro L, Zhou T, Kwong PD, Roederer M
Species-specific components of the Helicobacter pylori Cag type IV secretion system.
1. Infect Immun - published April 1, 2025
2. Bryant KN, Frick-Cheng AE, Solecki LE, Kroh HK, McDonald WH, Lacy DB, McClain MS, Ohi MD, Cover TL
Structural insights into RNA-guided RNA editing by the Cas13b-ADAR2 complex.
1. Nat Struct Mol Biol - published April 1, 2025
2. Ishikawa J, Kato K, Kannan S, Okazaki S, Ishiguro S, Yamashita K, Yachie N, Nishizawa T, Zhang F, Nishimasu H
Toward a deeper understanding of dengue: novel method for quantification and isolation of envelope protein epitope-specific antibodies.
1. mSphere - published April 1, 2025
2. Lay S, Bohaud C, Sorn S, Ken S, Rey FA, Ariën KK, Ly S, Duong V, Barba-Spaeth G, Auerswald H, Cantaert T
Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease.
1. Genome Med - published April 1, 2025
2. Martin-Geary AC, Blakes AJM, Dawes R, Findlay SD, Lord J, Dong S, Walker S, Talbot-Martin J, Wieder N, D'Souza EN, Fernandes M, Hilton S, Lahiri N, Campbell C, Jenkinson S, DeGoede CGEL, Anderson ER, Candler T, Firth H, Burge CB, Sanders SJ, Ellingford J, Baralle D, Banka S, Whiffin N
Drugit: crowd-sourcing molecular design of non-peptidic VHL binders.
1. Nat Commun - published April 1, 2025
2. Scott T, Smethurst CAP, Westermaier Y, Mayer M, Greb P, Kousek R, Biberger T, Bader G, Jandova Z, Schmalhorst PS, Fuchs JE, Magarkar A, Hoenke C, Gerstberger T, Combs SA, Pape R, Phul S, Kothiwale S, Bergner A, Foldit Players, Waterson AG, Weinstabl H, McConnell DB, Meiler J, Böttcher J, Moretti R
After 75 Years, an Alternative to Edman Degradation: A Mechanistic and Efficiency Study of a Base-Induced Method for N-Terminal Peptide Sequencing.
1. J Am Chem Soc - published April 1, 2025
2. Deol H, Raeisbahrami A, Ngo PHT, Swaminathan J, Papoulas O, Marcotte EM, Anslyn EV
Author Correction: Structure of the human K(2P)13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
1. Nat Struct Mol Biol - published April 1, 2025
2. Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL Jr
A nanobody that binds to the backside of the ubiquitin conjugating enzyme Ube2G2 differentially affects interactions with its partner E3 Ligases.
1. Commun Biol - published April 1, 2025
2. Suresh P, Wijne C, Sun ZJ, Becht N, Sahay I, Pishesha N, Ploegh H
Essential lipids enrich membrane-associated condensates to rescue synaptic morpho-functional deficits in a mouse model of autism.
1. Cell Rep - published April 1, 2025
2. Arsenault J, Kong T, Saghian R, Weng OY, Pathak SS, Yang C, Chao OY, Rakhaminov G, Forman-Kay JD, Ditlev JA, Yang YM, Wang LY
Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling.
1. Nat Commun - published April 1, 2025
2. Li T, Stayrook SE, Li W, Wang Y, Li H, Zhang J, Liu Y, Klein DE
Precision oncology and genetic ancestry: The science behind population-based cancer disparities.
1. Cancer Cell - published April 1, 2025
2. Davis MB, Martini R
Author Correction: Combinatorial selective ER-phagy remodels the ER during neurogenesis.
1. Nat Cell Biol - published April 1, 2025
2. Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW
Structure and infection dynamics of mycobacteriophage Bxb1.
1. Cell - published April 1, 2025
2. Freeman KG, Mondal S, Macale LS, Podgorski J, White SJ, Silva BH, Ortiz V, Huet A, Perez RJ, Narsico JT, Ho MC, Jacobs-Sera D, Lowary TL, Conway JF, Park D, Hatfull GF
Kinetic implications of IP(6) anion binding on the molecular switch of HIV-1 capsid assembly.
1. Sci Adv - published April 1, 2025
2. Gupta M, Hudait A, Yeager M, Voth GA
A germline ETV6 mutation disrupts hematopoiesis via de novo creation of a nuclear export signal.
1. Sci Adv - published April 1, 2025
2. McConville M, Thomas T, Beckner R, Kroger B, Valadez C, Chook YM, Chung S, Liszczak G
Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA.
1. ACS Med Chem Lett - published April 1, 2025
2. Tasdan Y, Balaji GR, Akhtar N, Ilyichova O, Cunliffe T, Heras B, Strat LL, Murray J, Capuano B, Scanlon MJ, Doak BC
Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii 'GRAZ-2' from human faeces.
1. Int J Syst Evol Microbiol - published April 1, 2025
2. Weinberger V, Mohammadzadeh R, Blohs M, Kalt K, Mahnert A, Moser S, Cecovini M, Mertelj P, Zurabishvili T, Arora B, Wolf J, Shinde T, Madl T, Habisch H, Kolb D, Pernitsch D, Hingerl K, Metcalf W, Moissl-Eichinger C
The position of indole methylation controls the structure, DNA binding and cellular functions of mithramycin SA-Trp analogues.
1. Chembiochem - published April 1, 2025
2. Tsodikov OV, Hou C, Bhosale S, Yasuda K, Yetirajam R, Leggas M, Rohr J
Fibronectin-dependent integrin signaling drives EphA2 expression in vascular smooth muscle cells.
1. Am J Physiol Cell Physiol - published April 1, 2025
2. Pearson-Gallion B, Finney AC, Scott ML, Connelly Z, Alam S, Peretik JM, Ben Dhaou C, Bhuiyan MS, Traylor JG Jr, DeGrado WF, Jo H, Yu X, Rom O, Pattillo CB, Dhanesha N, Yurdagul A Jr, Orr AW
UDP-glucose dehydrogenase variants cause dystroglycanopathy.
1. Ann Clin Transl Neurol - published April 1, 2025
2. Reelfs AM, Stephan CM, Czech TM, Cox MO, Joseph S, Darbro BW, Moore SA, Campbell KP, Mathews KD
Recognition of specific PIP2-subtype composition triggers the allosteric control mechanism for selective membrane targeting of cargo loading and release functions of the intracellular sterol transporter StarD4.
1. J Mol Biol - published April 1, 2025
2. Xie H, Weinstein H
Correction: Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.
1. Chin Med - published April 1, 2025
2. Chen Y, Gao T, Bai J, Zhang W, Zhou Y, Zhao R, Deng Y, Liu X, Huang Z, Wang S, Shen C, Liu S, Guo J
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum.
1. FEBS Lett - published April 1, 2025
2. Karapanagioti F, Obermaier S, Slotboom DJ, Poolman B
An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element.
1. Sci Adv - published April 1, 2025
2. Jia H, Liu S, Rao G, Liu Q, Wu J, Cao S, Gong P